1. The Role of NAD + and NAD + -Boosting Therapies in Inflammatory Response by IL-13.
- Author
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Pugel, Anton D., Schoenfeld, Alyssa M., Alsaifi, Sara Z., Holmes, Jocelyn R., and Morrison, Brad E.
- Subjects
NAD (Coenzyme) ,INFLAMMATION ,PARKINSON'S disease ,DIETARY supplements ,NICOTINAMIDE ,NIACIN - Abstract
The essential role of nicotinamide adenine dinucleotide
+ (NAD+ ) in redox reactions during oxidative respiration is well known, yet the coenzyme and regulator functions of NAD+ in diverse and important processes are still being discovered. Maintaining NAD+ levels through diet is essential for health. In fact, the United States requires supplementation of the NAD+ precursor niacin into the food chain for these reasons. A large body of research also indicates that elevating NAD+ levels is beneficial for numerous conditions, including cancer, cardiovascular health, inflammatory response, and longevity. Consequently, strategies have been created to elevate NAD+ levels through dietary supplementation with NAD+ precursor compounds. This paper explores current research regarding these therapeutic compounds. It then focuses on the NAD+ regulation of IL-13 signaling, which is a research area garnering little attention. IL-13 is a critical regulator of allergic response and is associated with Parkinson's disease and cancer. Evidence supporting the notion that increasing NAD+ levels might reduce IL-13 signal-induced inflammatory response is presented. The assessment is concluded with an examination of reports involving popular precursor compounds that boost NAD+ and their associations with IL-13 signaling in the context of offering a means for safely and effectively reducing inflammatory response by IL-13. [ABSTRACT FROM AUTHOR]- Published
- 2024
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