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In this paper, we investigate the unmanned aerial vehicle (UAV)-aided simultaneous uplink and downlink transmission networks, where one UAV acting as a disseminator is connected to multiple access points (AP), and the other UAV acting as a base station (BS) collects data from numerous sensor nodes (SNs). The goal of this paper is to maximize the system throughput by jointly optimizing the 3D UAV trajectory, communication scheduling, and UAV-AP/SN transmit power. We first consider a special case where the UAV-BS and UAV-AP trajectories are pre-determined. Although the resulting problem is an integer and non-convex optimization problem, a globally optimal solution is obtained by applying the polyblock outer approximation (POA) method based on the problem’s hidden monotonic structure. Subsequently, for the general case considering the 3D UAV trajectory optimization, an efficient iterative algorithm is proposed to alternately optimize the divided sub-problems based on the successive convex approximation (SCA) technique. Numerical results demonstrate that the proposed design is able to achieve significant system throughput gain over the benchmarks. In addition, the SCA-based method can achieve nearly the same performance as the POA-based method with much lower computational complexity. [ABSTRACT FROM AUTHOR]