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Higher output of competitive and high-quality agricultural products implies the more efficient use of the resource potential held by agricultural organizations. In the modern conditions, it is essential to substantiate indicators and conditions in order to improve the efficiency of the resource potential and to determine resource potential needs for the manufacture of agricultural products. The agroindustrial complex resource system aims to improve the efficiency of its use. The entry into the resource potential system includes the attraction of main production factors (labor, land, capital, entrepreneurship). The resource potential system is used as a subsystem of a region’s economic potential. The exit from the system constitutes the more efficient use of the resource potential. The exit from the resource potential system is the entry into the production potential system with a view to manufacturing agricultural products. An agricultural organization’s resource potential is a transparent production system, in which entrepreneurship, taking into account the prevailing market conditions, the modern development level of production forces and production relations, unites, in an optimal combination, in an organization of the relevant organizational-legal form and puts into action technologically dependent factors of agricultural production (labor, land, capital). In the article, the authors substantiate conditions and targets for the efficient use of the resource potential. Taking into account innovative development and achievements of leading companies, resource needs for grain and milk output have been determined. [ABSTRACT FROM AUTHOR]