1. Photoresponsive Delivery Microcarriers for Tissue Defects Repair
- Author
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Yuanjin Zhao, Qian Huang, Changmin Shao, Yuxiao Liu, Lingyun Sun, Xin Zhao, Min Nie, and Jieshou Li
- Subjects
Nir light ,General Chemical Engineering ,Microfluidics ,microfluidics ,General Physics and Astronomy ,Medicine (miscellaneous) ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Umbilical vein ,microcarriers ,tissue defects ,General Materials Science ,lcsh:Science ,Tube formation ,Full Paper ,Chemistry ,Photothermal effect ,technology, industry, and agriculture ,General Engineering ,Microcarrier ,In vitro experiment ,Full Papers ,021001 nanoscience & nanotechnology ,vascular endothelial growth factors (VEGFs) ,0104 chemical sciences ,Drug delivery ,drug delivery ,lcsh:Q ,0210 nano-technology ,Biomedical engineering - Abstract
Intelligent responsive microcarriers have emerged as a promising class of biomaterials for therapeutic delivery and tissue regeneration, since they can respond to external stimuli and release the loaded drugs in an active manner. Among various available stimuli, near‐infrared (NIR) light is particularly attractive because it can penetrate biotic tissues with sufficient intensity and minimal damage. In this work, a kind of photoresponsive delivery microcarriers (PDMs) is developed using microfluidics. The microcarriers consist of NIR‐absorbing graphene oxide, thermosensitive poly(N‐isopropylacrylamide), and biocompatible gelatin methacrylate. Under NIR light, the PDMs exhibit an evident volume shrinkage and effectively trigger the drug release. After the NIR light is switched off, the shrunken microcarriers return to their original size. This reversible process can be stably repeated for many cycles. An in vitro experiment demonstrates that the NIR‐radiated PDMs can actively release vascular endothelial growth factors and improve the tube formation of human umbilical vein endothelial cells. The results from the in vivo experiment also show an obvious photothermal effect and superior therapeutic efficacy of these PDMs in a rat model of tissue defects. These features make the PDMs an excellent drug delivery system and represent a great potential for clinical applications in tissue repair., Photoresponsive delivery microcarriers are developed using microfluidics, which consist of graphene oxide, poly(N‐isopropylacrylamide), and gelatin methacrylate. These microcarriers can actively respond to near‐infrared light and release the encapsulated drugs according to the irradiation frequency. After being implanted into a rat model of abdominal wall defects, they also exhibit potential value in tissue repair.
- Published
- 2022