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This document is a position paper that provides updates to guidelines on lipid therapy in patients with diabetes mellitus. It emphasizes the importance of lipid therapy in reducing cardiovascular risk in patients with diabetes and provides recommendations for lipid diagnostics and treatment targets. The paper discusses various therapy strategies for lowering LDL cholesterol levels based on the patient's risk group, including the use of statins as the primary therapy and the addition of other lipid-lowering drugs if necessary. The document also highlights the importance of lifestyle measures and blood glucose control in the treatment of hypertriglyceridemia. Overall, it concludes that risk stratified patient-related LDL cholesterol reduction is an important part of diabetes therapy and can improve patient outcomes. [Extracted from the article]

This editorial discusses the latest Journal Impact Factor (IF) for Seminars in Thrombosis and Hemostasis (STH), which has decreased from 6.938 in 2021 to 5.7 in 2022. The decrease in IF can be attributed to changes in calculation methods, the inclusion of more journals in the database, and the impact of the COVID-19 pandemic. The editorial also highlights the development of COVID-19 vaccines and the increase in COVID-19-related research and publications. STH primarily publishes review articles, but also includes commentaries and original studies. The most highly cited papers in recent years have focused on COVID-19, and the article provides a list of these influential articles. The submission and acceptance rates for unsolicited manuscripts are also discussed, indicating that STH publishes a limited number of original studies each year. The article concludes by mentioning the upcoming 50th anniversary of STH and the special issues planned to commemorate this milestone. [Extracted from the article]

The article discusses the synthesis and catalytic properties of Donor-Acceptor Stenhouse Adducts (DASAs). DASAs are triene substances that can be prepared using specific reagents and conditions. The study explores the use of Lewis acids as catalysts for transforming DASAs into their ring isomers, and suggests potential applications as photosensors and Lewis acid sensors. The document provides detailed experimental procedures and results for the synthesis and characterization of various compounds, as well as a general procedure for the one-pot cyclization of DASAs. [Extracted from the article]

Introduction The informed consent is the legal basis for research with human subjects. Therefore, the consent form (CF) as legally binding document must be valid, that is, be completely filled-in stating the person's decision clearly and signed by the respective person. However, especially paper-based CFs might have quality issues and the transformation into machine-readable information could add to low quality. This paper evaluates the quality and arising quality issues of paper-based CFs using the example of the Baltic Fracture Competence Centre (BFCC) fracture registry. It also evaluates the impact of quality assurance (QA) measures including giving site- specific feedback. Finally, it answers the question whether manual data entry of patients' decisions by clinical staff leads to a significant error rate in digitalized paper-based CFs. Methods Based on defined quality criteria, monthly QA including source data verification was conducted by two individual reviewers since the start of recruitment in December 2017. Basis for the analyses are the CFs collected from December 2017 until February 2019 (first recruitment period). Results After conducting QA internally, the sudden increase of quality issues in May 2018 led to site-specific feedback reports and follow-up training regarding the CFs' quality starting in June 2018. Specific criteria and descriptions on how to correct the CFs helped in increasing the quality in a timely matter. Most common issues were missing pages, decisions regarding optional modules, and signature(s). Since patients' datasets without valid CFs must be deleted, QA helped in retaining 65 datasets for research so that the final datapool consisted of 840 (99.29%) patients. Conclusion All quality issues could be assigned to one predefined criterion. Using the example of the BFCC fracture registry, CF-QA proved to significantly increase CF quality and help retain the number of available datasets for research. Consequently, the described quality indicators, criteria, and QA processes can be seen as the best practice approach. [ABSTRACT FROM AUTHOR]

Therapy of hypertension in patients with PAD In general, all patients with arterial hypertension benefit from a reduction in blood pressure [13], and patients with PAD (i. e., high-risk patients) in particular have an improved cardiovascular prognosis. This allows PCSK-9 inhibitors to be used in patients with progressive PAD on statin therapy or in patients with statin intolerance within the scope of the statutory health insurance funds' prescription ability and subject to the proviso of high therapy costs. Patients with diabetes have a 2 to 4-time higher risk of developing PAD than patients without diabetes. This position paper is based on the current German and international guideline recommendations [1][2][3] and serves as a short, clinically-oriented guideline for the diagnosis and treatment of patients with diabetes mellitus and peripheral arterial disease (PAD). [Extracted from the article]

This document is an editorial celebrating the 50th anniversary of Seminars in Thrombosis and Hemostasis (STH), a medical journal that first published in 1974. The editorial discusses the various celebratory issues that have been published over the years, which contain historical content related to the fields of thrombosis and hemostasis. The document also mentions the republishing of highly cited and downloaded papers from STH, along with accompanying commentaries from experts in the respective fields. Additionally, the document provides a list of the 50 most highly downloaded papers from STH between 2014 and 2023. [Extracted from the article]

Risk stratified patient-related LDL cholesterol reduction is an evidence-based integral part of diabetes therapy and can improve the clinical prognosis of our patients. For patients who meet the LDL cholesterol target but not the non-HDL cholesterol target, the non-HDL cholesterol level can be achieved by either lowering the triglyceride level (reduction of VLDL/remnant cholesterol) or further reducing the LDL cholesterol. The non-HDL cholesterol value (=total cholesterol minus HDL cholesterol) also approximately reflects this and includes VLDL cholesterol and remnant cholesterol in addition to LDL cholesterol. In normotriglyceridemia, the VLDL/remnant cholesterol concentration is<30 mg/dl (0.8 mmol/l) (which corresponds to a triglyceride value of approximately 150 mg/dl; 1.7 mmol/l), which is why non-HDL cholesterol target values are each 30 mg/dl (0.8 mmol/l) above the LDL cholesterol target value (Tab. [Extracted from the article]

This article is a commentary celebrating the 50th anniversary of Seminars in Thrombosis and Hemostasis (STH), a journal that first published in 1974. The commentary focuses on the historical significance of a paper titled "Description of an in vitro platelet function analyzer–PFA-100," which was published in a supplementary issue of STH in 1995 and is one of the most highly cited papers in the journal's history. The paper describes the PFA-100, an instrument that has since evolved into the PFA-200 and has been widely used for various purposes in the field of hemostasis. The commentary also mentions the impact of the PFA-100 on research and its potential applications in different areas, such as screening for von Willebrand disease and monitoring platelet function in animals. The article concludes by acknowledging the 30th anniversary of the PFA-100 in 2024 and its significant contributions to the hemostasis community. [Extracted from the article]

1 Endoscopic views in an elderly woman with melena showing: a a large ulcer with a visible vessel in the rectum; b a 2-cm square of synthetic paper that was found in the rectum after hemostasis had been achieved; c confirmation that hemostasis had been achieved the following day; d a detachable snare being used to change the foreign body into a cylindrical shape so that it can be safely removed from the rectum. An emergency lower gastrointestinal endoscopy revealed a large ulcer in the rectum and a visible vessel in the same area, which was bleeding (Fig. [Extracted from the article]

Background Timely and reliable data are crucial for clinical, epidemiologic, and program management decision making. Electronic health information systems provide platforms for managing large longitudinal patient records. Nigeria implemented the National Data Repository (NDR) to create a central data warehouse of all people living with human immunodeficiency virus (PLHIV) while providing useful functionalities to aid decision making at different levels of program implementation. Objective We describe the Nigeria NDR and its development process, including its use for surveillance, research, and national HIV program monitoring toward achieving HIV epidemic control. Methods Stakeholder engagement meetings were held in 2013 to gather information on data elements and vocabulary standards for reporting patient-level information, technical infrastructure, human capacity requirements, and information flow. Findings from these meetings guided the development of the NDR. An implementation guide provided common terminologies and data reporting structures for data exchange between the NDR and the electronic medical record (EMR) systems. Data from the EMR were encoded in extensible markup language and sent to the NDR over secure hypertext transfer protocol after going through a series of validation processes. Results By June 30, 2021, the NDR had up-to-date records of 1,477,064 (94.4%) patients receiving HIV treatment across 1,985 health facilities, of which 1,266,512 (85.7%) patient records had fingerprint template data to support unique patient identification and record linkage to prevent registration of the same patient under different identities. Data from the NDR was used to support HIV program monitoring, case-based surveillance and production of products like the monthly lists of patients who have treatment interruptions and dashboards for monitoring HIV test and start. Conclusion The NDR enabled the availability of reliable and timely data for surveillance, research, and HIV program monitoring to guide program improvements to accelerate progress toward epidemic control. [ABSTRACT FROM AUTHOR]