271 results
Search Results
2. An umbrella review of systematic reviews of the evidence of a causal relationship between periodontal microbes and respiratory diseases: Position paper from the Canadian Dental Hygienists Association.
- Author
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Lavigne, Salme E. and Forrest, Jane L.
- Subjects
CAUSALITY (Physics) ,CINAHL database ,INFORMATION storage & retrieval systems ,MEDICAL databases ,LUNG diseases ,MEDLINE ,ONLINE information services ,PERIODONTAL disease ,PERIODONTITIS ,SYSTEMATIC reviews - Abstract
Copyright of Canadian Journal of Dental Hygiene is the property of Canadian Dental Hygienists Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
3. EXAMINATION OF EROSION IN USAGE OF CHEMICAL ANTISEPTIC IN HISTORICAL PAPERS DOCUMENTS.
- Author
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KHAMSEH, Haideh
- Subjects
HISTORICAL source material ,BIODEGRADATION ,ANTISEPTICS ,EROSION ,ETHYLENE oxide ,CHEMICAL laboratories - Abstract
According to historical documents, the identity of a nation or ethnic group in each period is determined. Maintain these documents according to their structural nature that was so vulnerable to deterioration of the utmost importance. What factors should be considered Identify damaging agents and attempts to reduce it. Biological degradation is the main cause of damage to paper documents. To solve this problem, various methods were used. The most common method is using chemical antiseptic such as thymol, para chloro benzene dioxide, ethylene oxide etc. But what this study will examine the effects of abuse on the structure of these materials is cellulose paper such as ethylene oxide, indicating improper methods to remove the erosion and provide a convenient method, including freezing in order to reduce these damages. In this paper, 673 paper samples were studied, of the type of documents, which were identified first by the chemical laboratory method and then based on the information obtained from the results of tests with laboratory devices (FTIR, pH-meter). as well as by other methods. Aging, acidity and the effect of disinfectants on the structure of documents and fibers have been analyzed. In this research, which was tested on 673 paper samples, the type of dough was first identified by chemical laboratory method and then with the information obtained from the test results by laboratory devices (pH, FTIR meter) as well as methods. Aging, acidity and the effect of disinfectants on the structure of documents and fibers have been analyzed. [ABSTRACT FROM AUTHOR]
- Published
- 2021
4. AN UP-TO-DATE ON POVIDONE-IODINE WITH FOCUS ON WOUND MANAGEMNT: CURRENT AVAILABLE DATA AND NEW APPROACHES.
- Author
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CHELMUŞ-BURLACU, ALINA, PROFIRE, LENUŢA, and PIEPTU, DRAGOŞ
- Subjects
CHRONIC wounds & injuries ,POVIDONE-iodine ,WOUND infections ,WOUND care ,WOUNDS & injuries ,WOUND healing ,STANDARDIZED tests - Abstract
Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
- Full Text
- View/download PDF
5. Highlights of recent clinically relevant papers.
- Author
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Wright, S.
- Subjects
- *
HORSE diseases , *ANTISEPTICS , *ABDOMINAL diseases , *DIET , *EXERCISE - Abstract
Reviews of various articles are presented including "Hand antisepsis in equine surgery" by Nora Biermann, "Salivary alpha-amylase in abdominal disease" by Marıa Dolores Contreras-Aguilar, and "Diet and exercise for obese equids" by Nicholas Bamford.
- Published
- 2019
- Full Text
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6. Use of Ozone in Veterinary Dentistry as an Alternative to Conventional Antibiotics and Antiseptics.
- Author
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Melanie, Pierre, Niola, Carlotta, Plataroti, Ilaria, Mancini, Simone, and Fratini, Filippo
- Subjects
VETERINARY dentistry ,DENTAL scaling ,ANTISEPTICS ,OZONE ,DENTAL extraction ,PEPTIDE antibiotics - Abstract
Simple Summary: Seventy-five dogs were subjected to the surgical procedures of scaling and dental extraction using conventional antibiotics and antiseptics preventive treatment or double-distilled ozonated water. Sampling by bacteriological buffer was carried out to evaluate the bacterial count in the oral cavity and evaluate the anti-bacterial efficacy of intra-operative ozone as an alternative to pre-surgical antibiotic treatment. This paper aims to assess the disinfecting capacity of a double-distilled ozonated water solution as an alternative to common antibiotic and antiseptic devices. Seventy-five dogs were subjected to the surgical procedures of scaling and dental extraction and included in three study groups: Group 1 subjected to antibiotic pre-treatment (association amoxicillin + clavulanic acid and ampicillin + metronidazole) and disinfection with chlorhexidine, and Group 2 and 3 devoid of preventive anti-microbial treatment in which disinfection was performed, respectively, with ozonated water and chlorhexidine. Sampling by bacteriological buffer was carried out to evaluate the bacterial count in the oral cavity. The analysis of the samples determined the total mesophilic bacterial count by seeding on the culture medium via the inclusion of PCA (Plate Count Agar). The results highlighted the anti-bacterial efficacy of intra-operative ozone as an alternative to pre-surgical antibiotic treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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7. Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: Randomized Control Trial in Singapore
- Author
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Dorothy Hui Lin Ng, Kheng Sit Lim, Deborah Lai, Kwan Ki Karrie Ko, Bee Tin Goh, Preethi Balan, Moi Lin Ling, Chaminda Jayampath Seneviratne, Nadeeka S. Udawatte, Indumathi Venkatachalam, Lynette Oon, and Xiang Ying Jean Sim
- Subjects
0301 basic medicine ,Male ,Saliva ,Mouthwashes ,Cetylpyridinium chloride ,law.invention ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,Mouth rinse ,Chlorhexidine gluconate ,030212 general & internal medicine ,Povidone-Iodine ,Singapore ,Chlorhexidine ,Dental procedures ,General Medicine ,Middle Aged ,Viral Load ,Mouth-rinses ,Clinical trial ,Treatment Outcome ,Infectious Diseases ,Female ,Viral load ,medicine.drug ,Adult ,Microbiology (medical) ,medicine.medical_specialty ,Antiseptics ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,030106 microbiology ,Cetylpyridinium ,03 medical and health sciences ,Young Adult ,Internal medicine ,medicine ,Humans ,Original Paper ,SARS-CoV-2 ,business.industry ,COVID-19 ,Fold change ,COVID-19 Drug Treatment ,chemistry ,Anti-Infective Agents, Local ,business - Abstract
The presence of high SARS-coronavirus 2 (SARS-CoV-2) titres in saliva may result in transmission of the virus and increase the risk of COVID-19 infection. This is particularly important as significant amounts of aerosols are generated during dental procedures, posing risk to dental care personnel and patients. Thus, reducing the titres of SARS-CoV-2 in the saliva of infected patients could be one of the key approaches to reduce the risk of COVID-19 transmission during dental procedures. In this randomised control trial, the efficacy of three commercial mouth-rinse viz. povidone-iodine (PI), chlorhexidine gluconate (CHX) and cetylpyridinium chloride (CPC), in reducing the salivary SARS-CoV-2 viral load in COVID-19 positive patients were compared with water. A total of 36 COVID-19 positive patients were recruited, of which 16 patients were randomly assigned to four groups— PI group (n=4), CHX group (n=6), CPC group (n=4) and water as control group (n=2). Saliva samples were collected from all patients at baseline and at 5 min, 3 h and 6 h post-application of mouth-rinses/water. The samples were subjected to SARS-CoV-2 RT-PCR analysis. The fold change of Ct values were significantly increased in CPC group at 5 minutes and 6 h time points (p
- Published
- 2020
8. Electric Hand Dryers Serve as a Microbial Reservoir for Contamination.
- Author
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Nichols, Riley, Packard, Hyrum, Culumber, Michele, and Oberg, Craig
- Subjects
HAND dryers ,STERILIZATION (Disinfection) ,RESTROOMS ,ANTISEPTICS ,BACTERIAL contamination - Abstract
Electric hand dryers, particularly jet-air dryers, are a relatively new method of drying hands and claim to be a more efficient and sterile method than using paper towels. Our purpose for performing this research was to determine whether electric hand dryers in public restrooms are antiseptic, or if they could be a source of bacterial contamination to your hands during drying. Initially, restrooms at Weber State University were selected that had a high frequency of foot traffic, making them good sampling locations. Testing was done in men's and women's restrooms in three buildings on campus, testing four bathrooms for each group in each building. Samples were collected by swabbing a 25-cm² area of the top, middle, and bottom of the hand dryer chamber using a 3M Quickswab. Pour plates using TSA were used to enumerate samples. Plate counts were determined at 48 hours after incubation at 37°C. Results showed the bottom of the dryer chamber in both the men's and women's restrooms had the most bacterial contamination, with an average of 311 CFU/25 cm² in the men's rooms and an average of 299 CFU/25 cm² in the women's. The middle section was the second most contaminated averaging 144 CFU/25 cm² for men and 145 CFU/25 cm² for women, while the top section was the least contaminated, averaging 107 CFU/25 cm² for men and 51 CFU/25 cm² for women. Results showed that electric hand dryers can serve as a source of bacterial contamination after hand washing. The overall level of bacterial contamination was higher in hand dryers in men's restrooms. As a preventative measure, the inside of these dryers should be cleaned on a daily basis to prevent people from contaminating their hands immediately after washing them, thus reducing the spread of bacteria. [ABSTRACT FROM AUTHOR]
- Published
- 2020
9. A promising strategies for reducing the danger of SARS-CoV2 transmission during dentistry and medical procedures.
- Author
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Mohammed, Waleed K., Warwar, Abdul Nasser H., and Awad, Fatimah Abdulazeez
- Subjects
COVID-19 treatment ,DENTISTRY ,BENZALKONIUM chloride ,MOUTHWASHES ,ANTISEPTICS ,AEROSOLS - Abstract
Copyright of Journal of University of Anbar for Pure Science is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
- Full Text
- View/download PDF
10. Povidone-Iodine Adverse Effects and Alternatives for Ocular Procedures.
- Author
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Nair, Smriti, Zhu, Aretha, Jaffry, Mustafa, Choudhry, Hassaam, and Dastjerdi, Mohammad H.
- Subjects
POVIDONE-iodine ,CHEMICAL burns ,DATABASES ,OPERATIVE surgery ,CHLORHEXIDINE - Abstract
Purpose: Povidone-iodine (PVI), also known as Betadine, is a widely used antiseptic agent used in several fields of medicine. In ophthalmology, it is applied as a preoperative antiseptic to prevent infectious complications that can result from surgical procedures. PVI's safety and efficacy have been extensively studied and represented in the literature; however, the incidence of adverse effects has been reported in conjunction. The aim of this paper is to compile information regarding PVIs use, safety profile, adverse effects, and possible alternatives through a review of the existing literature. Methods: Literature was compiled utilizing the database PubMed and Google Scholar using specified keywords with a total of 86 reviewed articles, after excluding search results that did not meet the inclusion criteria. Results: While the allergic potential to PVI is a highly contested topic, there are several nonallergic adverse effects of PVI that should not be overlooked. These effects include chemical burn, cytotoxic effects, and general patient discomfort. In light of these adverse effects, alternatives to PVI may be considered. However, there has been little research identifying feasible alternatives in preoperative intraocular procedures. Alternatives including chlorhexidine, polyhexamethylene biguanide (polyhexanide), and octenidine were identified as potential substitutes for PVI. Conclusions: Further study is needed to provide robust evidence regarding the efficacy profiles of these alternatives in comparison with PVI and to demonstrate comparable tolerance to PVI in intraocular procedures. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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11. STUDY OF USE OF ANTISEPTIC ICE OF PLASMA-CHEMICALLY ACTIVATED AQUEOUS SOLUTIONS FOR THE STORAGE OF FOOD RAW MATERIALS.
- Author
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Pivovarov, О., Kovalova, О., Koshulko, V., and Aleksandrova, А.
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RAW materials ,ANAEROBIC microorganisms ,FOOD storage ,AQUEOUS solutions ,RAW foods ,MEAT storage ,ANTISEPTICS - Abstract
Scientists and specialists of food processing industry are increasingly focused on the technology of storage of raw materials of animal origin in antiseptic ice. The paper presents the peculiar features of plasma-chemical activation of solutions to produce antiseptic ice and their further use in the storage of meat and fish. The process of treatment leads to formation of micro-particles of hydrogen peroxide, which in contact with the raw materials are capable of generating active oxygen, allowing to disinfect the raw material surface. Concentration of hydrogen peroxide in the solutions further used to produce antiseptic ice has been determined. Study of the features of use of antiseptic ice made of plasma-chemically activated aqueous solutions showed unchanged organoleptic properties of raw materials after using the presented antiseptic agent. Suppression of viable microflora owing to antimicrobial action of plasma-chemically activated aqueous solutions was recorded. Antiseptic ice contributes to long-term disinfection of raw materials. For example, the samples show absence of microflora of mesophilic aerobic and facultative anaerobic microorganisms and bacteria of the Escherichia coli group, which allows improving the quality of stored food raw materials. At the concentration of peroxides at the level of 600–700 mg/l, pathogenic microflora in meat and fish samples is not present at all. When meat and fish raw materials are stored in ice for 30 days, pathogenic microflora does not appear, and it confirms the long-term disinfecting action of antiseptic ice. Slower accumulation of amino-ammonia nitrogen is observed during long-term storage of meat and fish raw materials. The use of plasma-chemically activated aqueous solutions for the production of antiseptic ice and storage of meat and fish raw materials in it can partially prevent the processes of protein breakdown and, accordingly, increase the product shelf life. The paper describes technological parameters of the process of storage of meat and fish in antiseptic ice, which can be used in the industrial storage of raw materials, and provides the guidance for use of ice of plasma-chemically activated aqueous solutions in the process of storage of raw materials of animal origin. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
12. Model Antiseptic Control Scheme to Torque Ripple Mitigation for DC-DC Converter-Based BLDC Motor Drives.
- Author
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Kumar, Dileep, Choudhary, Surya Deo, Tabrez, Md, Ayob, Afida, and Hossain Lipu, Molla Shahadat
- Subjects
MOTOR drives (Electric motors) ,TORQUE control ,ANTISEPTICS ,DIODES - Abstract
Although brushless direct current motor (BLDCM) drives are becoming more popular in industrial and commercial applications, there are still significant difficulties and unresolved research issues that must be addressed. In BLDCM drives, commutation current ripple (CCR) and diode freewheeling during non-commutation zone (NCZ) are the major challenges. To overcome these limitations, this paper proposes a novel PWM-Model Antiseptic Control (PWM-MAC) technique to alleviate the freewheeling of the diode. The proposed PWM technique is used to alleviate the diode freewheeling in the NCZ, whereas the DCLV circuit is utilized to obtain variable DC-link voltage to address the CCR in the CZ. The MATLAB/Simulink results are included along with experimental results obtained from a laboratory prototype of 325 W. The proposed module reduces the current ripple by 31.7% and corresponding torque ripples are suppressed by approximately 32.5%. This evidences the performance of the proposed control technique. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
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13. Liposomal Ozonated Oil in Ocular Infections: A Review of Preclinical and Clinical Studies, Focusing on Its Antiseptic and Regenerative Properties.
- Author
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Pérez-Santonja, Juan J, Güell, José Luis, Gris, Oscar, Dorrego, Xose Manuel Vázquez, Pellicer, Esther, and Benítez-Del-Castillo, Jose Manuel
- Subjects
PETROLEUM ,REGENERATION (Biology) ,CORNEAL ulcer ,ANTISEPTICS ,COMMUNICABLE diseases - Abstract
Ozonated oil has shown antimicrobial, anti-inflammatory and regenerative properties that make it useful in the prevention of infectious diseases and also as an adjuvant in wound-healing management. This review brings together most aspects of the use of liposomal ozonated oil for ocular infections and regeneration of the ocular surface. A search was performed in PubMed, Medline, Web of Science and Cochrane Library for studies published by June 2021. Search terms were combined to sort out papers on the properties and use of ozonated oil in ocular infections. A total of 25 publications were selected for this review on the composition, mechanism of action, restorative action, and preclinical and clinical studies of liposomal ozonated oil focused on ocular infections. In patients with complicated corneal pathology, liposomal ozonated oil has been found to restore corneal ulcers and improve keratitis. In patients with ocular pathologies involving inflammation and infections, liposomal ozonated oil has been found to improve and almost completely restore the signs of vernal, granulomatous and even adenoviral conjunctivitis. Liposomal ozonated oil has also been found to be effective in reducing ocular microbial flora. In conclusion, liposomal ozonated oil has an antiseptic and regenerative effect on corneoconjunctival tissues. It has demonstrated efficacy and safety profile for its use in ocular infections and can be considered as a suitable supportive strategy both alone and combined with other antimicrobial agents. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
14. Effect of electromagnetic stimulation of the active substance of selected plants on their antiseptic potential.
- Author
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KIEŁBASA, Paweł, MIERNIK, Anna, DRÓŻDŻ, Tomasz, and SZCZEGIELNIAK, Tomasz
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TEA tree oil ,MAGNETIC flux density ,ESSENTIAL oils ,ELECTROMAGNETIC fields ,ANTISEPTICS ,ECHINOCANDINS ,ENTEROCOCCUS faecalis - Abstract
Copyright of Przegląd Elektrotechniczny is the property of Przeglad Elektrotechniczny and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
- View/download PDF
15. Surface Properties of Plasma-Activated Chitosan Foils.
- Author
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Terpiłowski, Konrad and Chibowski, Emil
- Subjects
SURFACE properties ,CHITOSAN ,ANTISEPTICS ,NITROGEN plasmas ,WETTING - Abstract
Thin films of chitosan are often deposited on various surfaces to provide them with antiseptic properties. In the presented research, chitosan foils were obtained using two methods and treated with nitrogen plasma. The obtained materials were characterized by measuring the wettability of the test liquids, and the apparent surface free energy was calculated using the Tadmor equilibrium contact angles. The surface topography was characterized using optical profilometry and SEM. On the other hand, the effect of plasma on surface groups was investigated using the FTIR-ATR technique. Plasma activation of the surface increases the polarity of the surface. This is observed in the changed surface roughness and the share of functional groups on the surface. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
16. Antimicrobial activity of hemodialysis catheter lock solutions in relation to other compounds with antiseptic properties.
- Author
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Piątkowska, Elżbieta, Paleczny, Justyna, Dydak, Karolina, and Letachowicz, Krzysztof
- Subjects
DIALYSIS catheters ,VASCULAR catheters ,CATHETER-related infections ,SODIUM bicarbonate ,BACTERIAL growth ,ARTERIAL catheterization ,ANTISEPTICS - Abstract
Proper protection of vascular access after haemodialysis is one of the key measures for the prevention of catheter-related infections. Various substances with bactericidal and anticoagulant properties are used to fill catheters, but due to the unsatisfactory clinical effects and occurrence of adverse reactions, the search for new substances is still ongoing. In the present paper, we compared the in vitro antimicrobial activity of solutions used for tunnelled catheter locking (taurolidine, trisodium citrate) and solutions of substances that could potentially be used for this purpose (sodium bicarbonate, polyhexanide-betaine). The studies have been conducted on bacteria that most commonly cause catheter-related infections. The values of both minimum inhibitory concentration and minimum biofilm eradication concentration of the substances were determined. The ability of the tested substances to eradicate biofilm from the dialysis catheter surface was also evaluated. The results showed that polyhexanide-betaine inhibited the growth of all microbes comparably to taurolidine, even after ≥ 32-fold dilution. The activity of trisodium citrate and sodium bicarbonate was significantly lower. Polyhexanide exhibited the highest activity in the eradication of bacterial biofilm on polystyrene plates. The biofilm formed on a polyurethane dialysis catheter was resistant to complete eradication by the test substances. Polyhexanide-betaine and taurolidine showed the highest activity. Inhibition of bacterial growth regardless of species was observed not only at the highest concentration of these compounds but also after dilution 32–128x (taurolidine) and 32–1024x (polyhexanide-betaine). Therefore, it can be assumed that taurolidine application as a locking solution prevents catheter colonization and systemic infection development. Taurolidine displays high antimicrobial efficacy against Gram-positive cocci as well as Gram-negative bacilli. On the contrary, the lowest antibacterial effect displayed product contained sodium bicarbonate. The inhibitions of bacterial growth were not satisfactory to consider it as a substance for colonization prevention. Polyhexanidine-betaine possessed potent inhibitory and biofilm eradication properties comparing to all tested products. PHMB is applied as a wound irrigation solution worldwide. However, based on our results, we assume that the PHMB is a promising substance for catheter locking solutions thanks to its safety and high antimicrobial properties. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
17. Findings in the Area of Staphylococcus aureus Reported from National Technological Institute of Mexico (Bacterial Cellulose From Mother of Vinegar Loaded With Silver Nanoparticles As an Effective Antiseptic for Wound-healing: Antibacterial...).
- Subjects
STAPHYLOCOCCUS aureus ,SILVER nanoparticles ,SPOREFORMING bacteria ,VINEGAR ,ANTISEPTICS ,GRAM-positive bacteria - Abstract
Researchers at the National Technological Institute of Mexico have discovered that bacterial cellulose loaded with silver nanoparticles can be an effective antiseptic for wound healing. Bacterial cellulose has gained attention in recent years due to its purity and multiple applications in the biomedical and pharmaceutical fields. The researchers synthesized films of bacterial cellulose loaded with silver nanoparticles and found that they exhibited strong antibacterial activity against Staphylococcus aureus and Escherichia coli. These findings suggest that the films have potential for wound-healing purposes and can be effective with low concentrations of silver nanoparticles. [Extracted from the article]
- Published
- 2024
18. Efficacy and Safety of Preoperative Prophylaxis in Cataract Surgery with Combined Topical Antiseptics: A Microbiological Study.
- Author
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Modugno, Rocco Luigi, Fasolo, Adriano, Camposampiero, Davide, Ponzin, Diego, and Tavolato, Marco
- Subjects
ASEPTIC & antiseptic surgery ,CATARACT surgery ,OPHTHALMIC drugs ,BIGUANIDE ,ANTISEPTICS - Abstract
Introduction: To evaluate the antimicrobial efficacy of an ophthalmic formulation containing hexamidine diisethionate (HD) 0.05%, polyhexamethylene biguanide (PHMB) 0.0001%, and edetate disodium (EDTA) 0.01% (Keratosept
® , Bruschettini, Genova, Italy) on the microbial flora of a healthy ocular surface. Methods: Patients were enrolled consecutively. Each patient applied two drops of Keratosept® in the eye scheduled for cataract surgery (study eye) three times daily in the 2 days prior to surgery and one time in the morning of surgery. The contralateral eyes were considered as control (control eye). Bilateral conjunctival swabs were collected before the first administration (T0) and the morning of surgery (T1). The swabs were processed within 3 h from sampling for the automated detection of the presence of replicating microorganisms (colony-forming units, CFU/mL) and the provision of real-time growth curves. Results: Conjunctival swabs of 32 patients (n = 128) were examined. Six patients were excluded from the efficacy analysis because of microbial load < 50 CFU/mL at T0 in the study eye. No difference between study and control eyes was observed at T0 (p = 0.40). Compared with T0, 20 (76.9%) study eyes and 10 (38.5%) control eyes showed a ≥ 1 log reduction of the microbial load at T1, with a significant difference between groups (p = 0.005). Keratosept® showed good tolerability, and no adverse events or eye discomfort were recorded. Conclusions: This study showed that the low-dose combination of antiseptic agents in the Keratosept® ophthalmic solution effectively reduces the bacterial load of healthy flora on the ocular surface. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
19. New Insights Regarding the Use of Relevant Synthetic Compounds in Dentistry.
- Author
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Dumitrel, Stefania-Irina, Matichescu, Anamaria, Dinu, Stefania, Buzatu, Roxana, Popovici, Ramona, Dinu, Dorin Cristian, and Bratu, Dana Cristina
- Subjects
GINGIVAL hemorrhage ,THIRD molars ,TOOTH whitening ,DENTAL caries ,SYNTHETIC drugs - Abstract
Worldwide, synthetic compounds are used for both in-office and at-home dental care. They are a valuable resource for both prophylactic and curative treatments for various dental problems, such as tooth decay, periodontal diseases, and many more. They are typically preferred due to their broad range of actions and ability to produce targeted, rapid, and long-lasting effects. Using a 0.12% chlorhexidine mouthwash is capable of reducing the plaque index from 47.69% to 2.37% and the bleeding index from 32.93% to 6.28% after just 2 weeks. Mouthwash with 0.1% OCT is also highly effective, as it significantly lowered the median plaque index and salivary bacterial counts in 152 patients in 5 days compared to a control group (p < 0.0001), while also reducing the gingival index (p < 0.001). When povidone-iodine was used as an irrigant during the surgical removal of mandibular third molars in 105 patients, it resulted in notably lower pain scores after 2 days compared to a control group (4.57 ± 0.60 vs. 5.71 ± 0.45). Sodium hypochlorite is excellent for root canal disinfection, as irrigating with 1% NaOCl completely eliminated the bacteria from canals in 65% patients. A 0.05% CPC mouthwash proved effective for perioperative patient care, significantly decreasing gingival bleeding (p < 0.001) and suppressing Streptococcus levels even one week post-surgery. Lastly, a 6% H2O2 paint-on varnish and 6% H2O2 tray formulations successfully bleached the teeth of 40 patients, maintaining a noticeably whiter appearance up to the 6-month follow-up, with significant color differences from the baseline (p < 0.005). Synthetic compounds have a large research base, which also provides a greater awareness of their mechanism of action and potential adverse effects. For a better understanding of how they work, several methods and assays are performed. These are protocolary techniques through which a compound's efficacy and toxicity are established. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
20. Plant Organic Acids as Natural Inhibitors of Foodborne Pathogens.
- Author
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Karpiński, Tomasz M. and Ożarowski, Marcin
- Subjects
SALMONELLA enterica serovar typhimurium ,ROSMARINIC acid ,ORGANIC acids ,TARTARIC acid ,FOOD preservatives - Abstract
Background: Foodborne infections affect approximately 600 million people annually. Simultaneously, many plants contain substances like organic acids, which have antimicrobial activity. The aim of this study was to examine the effects of 21 organic acids, naturally occurring in plants, on four foodborne bacteria (Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Salmonella enterica Typhimurium) and two fungi (Geotrichum candidum and Penicillium candidum). Methods: The minimal inhibitory concentrations (MIC) of the organic acids against foodborne bacteria and in silico toxicity prediction of acids were investigated. Results: Benzoic and salicylic acids exhibit the best activity against foodborne bacteria (mean MIC < 1 mg/mL). Acetic, chlorogenic, formic, malic, nicotinic, and rosmarinic acids demonstrate slightly weaker activity (mean MICs 1–2 mg/mL). Other acids have moderate or poor activity. The effectiveness of organic acids against foodborne fungi is weaker than against bacteria. Most acids require high concentrations (from 10 to >100 mg/mL) to inhibit fungal growth effectively. The predicted LD50 of organic acids ranges from 48 to 5000 mg/kg. Those potentially safe as food preservatives (MIC < LD50) include ascorbic, chlorogenic, malic, nicotinic, rosmarinic, salicylic, succinic, tannic, and tartaric acids. The studied organic acids are not carcinogenic but many can cause adverse effects such as skin sensitization, eye irritation, and potential nephrotoxicity, hepatotoxicity, or neurotoxicity. Conclusions: Most of the investigated plant-derived organic acids exhibit good antibacterial activity and moderate or poor antifungal effects. Among 21 acids, only 9 appear to be safe as food preservatives (MIC < LD50). The relationship between MIC and LD50 is crucial in determining the suitability of organic acids as food preservatives, ensuring that they are effective against bacteria or fungi at concentrations that are not harmful to humans. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
21. Tolerability of N-chlorotaurine in comparison with routinely used antiseptics: an in vitro study on chondrocytes
- Author
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Pilz, Magdalena, Staats, Kevin, Assadian, Ojan, Windhager, Reinhard, and Holinka, Johannes
- Published
- 2024
- Full Text
- View/download PDF
22. The influence of cationic antiseptics on the processes of light energy conversion in various photosynthetic pigment-protein complexes
- Author
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Knox, Peter P., Lukashev, Eugene P., Korvatovsky, Boris N., Mamedov, Mahir D., Strakhovskaya, Marina G., Gvozdev, Daniil A., Paschenko, Vladimir Z., and Rubin, Andrew B.
- Published
- 2024
- Full Text
- View/download PDF
23. POSTĘPOWANIE PRZECIWBAKTERYJNE ?ANTYSEPTYKA? U PACJENTÓW OPARZONYCH.
- Author
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PALECZNY, JUSTYNA, JUNKA, ADAM, and BARTOSZEWICZ, MARZENNA
- Subjects
ANTI-infective agents ,SURGICAL site ,BURN patients ,ANTISEPTICS ,CAUSES of death - Abstract
Copyright of Plastic Surgery & Burns / Chirurgia Plastyczna i Oparzenia is the property of Evereth Publishing Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
- Full Text
- View/download PDF
24. Efficacy of adjunctive anti-plaque chemical agents in managing gingivitis: a systematic review and meta-analysis.
- Author
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Serrano, Jorge, Escribano, Marta, Roldán, Silvia, Martín, Conchita, and Herrera, David
- Subjects
DENTAL plaque ,GINGIVITIS ,BACTERICIDES ,CHI-squared test ,CONFIDENCE intervals ,DATABASES ,MEDLINE ,META-analysis ,ONLINE information services ,RESEARCH funding ,HEALTH self-care ,STATISTICS ,SYSTEMATIC reviews ,RANDOMIZED controlled trials ,PREVENTION ,THERAPEUTICS - Abstract
Aim The aim of this systematic review was to evaluate the efficacy of anti-plaque chemical formulations for managing gingivitis, in 6-month, home-use, randomised clinical trials ( RCTs). Material and Methods A protocol was designed, including inclusion and exclusion criteria to identify RCTs assessing gingival and/or bleeding indices. Electronic and hand-searches identified relevant papers, which were screened and evaluated for inclusion. Full-papers were retrieved and relevant information was extracted (also plaque indices), including quality and risk of bias. Mean treatment effects were calculated to obtain weighted mean differences ( WMD) and 95% confidence intervals. Results After the process of screening and selection, 87 articles with 133 comparisons, were included in the review. The additional effects of the tested products were statistically significant in terms of Löe & Silness gingival index (46 comparisons, WMD −0.217), modified gingival index ( n = 23, −0.415), gingivitis severity index ( n = 26, −14.939%) or bleeding index ( n = 23, −7.626%), with significant heterogeneity. For plaque, additional effects were found for Turesky (66 studies, WMD −0.475), Silness & Löe ( n = 26, −0.109), and plaque severity ( n = 12, −23.4%) indices, with significant heterogeneity. Conclusion Within the limitations of the present study, formulations with specific agents for chemical plaque control provide statistically significant improvements in terms of gingival, bleeding and plaque indices. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
25. Antiseptics as adjuncts to scaling and root planing in the treatment of periodontitis: a systematic literature review
- Author
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Ramanauskaite, Egle and Machiulskiene, Vita
- Published
- 2020
- Full Text
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26. Beyond antisepsis: Examining the relevance of the works of Joseph Baron Lister to the contemporary surgeon-scientist.
- Author
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Glass, Graeme E.
- Subjects
ANTISEPTICS ,TRANSLATIONAL research ,OPERATIVE surgery ,SURGEONS ,SCIENTISTS - Abstract
As the father of antispesis, the legacy of Joseph Baron Lister is assured and his influence on the development of contemporary surgical practice is recognised in the context of his achievement of predictable, infection-free surgery. However, looking beyond Lister's finest achievement and examining this work in the context of his whole career as a surgeon-scientist reveals important lessons pertinent to aspiring peers in how, by replacing surgical dogma with observation, deductive reasoning and scientific verification, by pursuing good ideas in the face of resistance and by making research directly relevant and patient-focused, lasting changes can be accomplished. This short paper aims to put Lister's developments in antisepsis in the context of his whole career, to evaluate his legacy and to commend his approach to contemporary surgeon-scientists. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
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27. Delayed-onset contact dermatitis caused by olanexidine gluconate antiseptic solution: effect of wiping off the remaining drug solution in two cases.
- Author
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Yamamoto, Kasumi Boki, Fujii, Keisuke, Mizumoto, Kazuhiro, Tanioku, Tadashi, and Kawamata, Tomoyuki
- Subjects
CONTACT dermatitis ,EPIDURAL catheters ,ANTISEPTICS ,RETENTION of urine ,DRUGS ,SKIN inflammation ,ECZEMA - Abstract
Background: Olanexidine glucuronide (Olanedine®), an antiseptic solution may cause skin dermatitis around one week after disinfection. Although removal after the procedure is recommended to avoid skin dermatitis, whether it is effective for preventing skin dermatitis has not been documented in detail in the literature. Case presentation: We encountered two cases of delayed-onset contact dermatitis by Olanedine®. In both cases, the patient's back was disinfected with Olanedine® and was covered with a surgical drape for epidural catheterization. After catheterization and removal of the surgical drape, the insertion site of the catheter was covered with a film dressing, then the epidural catheter was taped to the back. On the third postoperative day, the epidural catheter was removed. On the seventh postoperative day, the patients reported pruritus on the back, where an erythematous papule rash was observed. However, it was not observed at the site covered by the tape to secure the epidural catheter or by the tape of the surgical drape. Symptoms were relieved with oral or topical steroids by the time of discharge. Conclusion: Wiping off the remaining Olanedine® even a few days after disinfection may be helpful not only for reducing symptoms but also for preventing the development of contact dermatitis. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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28. PROFILAKTYKA ZAKAŻEŃ MIEJSCA OPEROWANEGO - PRZEGLĄD AKTUALNYCH WYTYCZNYCH.
- Author
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PIĄTKOWSKA, ELŻBIETA, MAZURKIEWICZ, JACEK, and BARTOSZEWICZ, MARZENNA
- Abstract
Copyright of Forum Zakażeń is the property of Evereth Publishing Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
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29. A Comparative Study of Poly(Azure A) Film-Modified Disposable Electrodes for Electrocatalytic Oxidation of H2O2: Effect of Doping Anion.
- Author
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Agrisuelas, Jerónimo, González-Sánchez, María-Isabel, Gómez-Monedero, Beatriz, and Valero, Edelmira
- Subjects
ELECTROSYNTHESIS ,CARBON electrodes ,ANTISEPTICS ,ANTI-infective agents ,COMPARATIVE studies - Abstract
In the present paper, poly(azure A) (PAA) films were electrosynthetized in the presence of different doping anions on disposable screen-printed carbon electrodes (SPCEs). The anions used included inorganic monoatomic (chloride and fluoride), inorganic polyatomic (nitrate and sulfate) and organic polyatomic (dodecyl sulfate, DS) species. The coated electrodes thus obtained were characterized by electrochemical techniques and SEM. They showed improved electrocatalytic activities towards hydrogen peroxide oxidation compared to that of a bare SPCE. In particular, the insertion of DS anions inside PAA films provided a special sensitivity to the electrocatalysis of H
2 O2 , which endowed these electrodes with promising analytical features for H2 O2 quantification. We obtained a wide linear response for H2 O2 within a range of 5 μM to 3 mM and a limit of detection of 1.43 ± 0.10 μM (signal-to-noise ratio of 3). Furthermore, sensitivity was 72.4 ± 0.49 nA·μM-1 ·cm-2 at a relatively low electrocatalytic oxidation overpotential of 0.5 V vs. Ag. The applicability of this boosted system was tested by the analysis of H2 O2 in commercial samples of a hair lightener and an antiseptic and was corroborated by spectrophotometric methods. [ABSTRACT FROM AUTHOR]- Published
- 2018
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30. Patulin degradation and cytotoxicity evaluation of UV irradiated apple juice using human peripheral blood mononuclear cells.
- Author
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Chandra, Sharath, Patras, Ankit, Pokharel, Bharat, Bansode, Rishipal R., Begum, Afroza, and Sasges, Michael
- Subjects
PATULIN ,MYCOTOXINS ,ANTISEPTICS ,FUNGI ,IRRADIATION - Abstract
Patulin, a mycotoxin produced by several genera of fungi, is an important concern in apple-based products due to its toxicity and health consequences. Ultraviolet (UV-C) irradiation is a method of disinfection that is effective against many microorganisms and is also applied for chemical contaminant treatment via direct photolysis and advanced oxidation with sensitizers such as hydrogen peroxide. The present study evaluates whether UV-C could be an effective method to destroy patulin in apple juice. UV-C irradiation experiments were conducted using a collimated beam system operating at 253.7 nm. It was observed that patulin was not destroyed in pure water, but was degraded in pure and diluted apple juice upon UV-C irradiation, suggesting that chromophores (such as riboflavin) in the juice were important factors in the photo degradation. From an initial patulin concentration of approximately 200 ppb, UV-C dose of 400 mJ/cm
2 successfully reduced patulin concentration by 69.47 (±0.69) % ( p < .05). In cell culture studies, our results showed that increasing UV-C dose decreased the patulin-induced cytotoxicity in human peripheral blood cells. Cell viability percentage increased from 47.3% to 81.64% as UV-C dose increased from 0 to 400 mJ/cm2 . These doses would also achieve significant inactivation of viruses, bacteria, and many molds and fungi. This study clearly shows the potential for using UV-C treatment for patulin degradation in turbid liquid foods such as apple juice. Practical applications This research paper provides scientific evidence of the potential benefits UV-C irradiation in removing patulin from apple juice. UV-C dose of 400 mJ/cm2 successfully reduced patulin concentration by 69.47%. In cell culture studies, increasing UV-C dose decreased the patulin-induced cytotoxicity in human peripheral blood cells. UV-C irradiation is an attractive food preservation technology and offers opportunities for horticultural and food processing industries to meet the growing demand from consumers for healthier and safer food products. Knowledge gained through this study will facilitate major advances in the field of food science and engineering. This study would also provide technical support for commercialization of UV-C technology for patulin degradation in turbid liquid foods such as apple juice. [ABSTRACT FROM AUTHOR]- Published
- 2017
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31. An Asian Perspective on Povidone Iodine in Wound Healing.
- Author
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Bigliardi, Paul, Langer, Stefan, Cruz, Jose Joven, Kim, Sang Wha, Nair, Harikrishna, and Srisawasdi, Gulapar
- Subjects
POVIDONE-iodine ,ANTISEPTICS ,IODOPHORS ,THERAPEUTICS ,WOUND healing ,WOUND infections ,WOUND care ,BACTERICIDES ,CONSENSUS (Social sciences) ,DRUG resistance in microorganisms ,PREVENTION - Abstract
Antiseptics, with a broader spectrum of antimicrobial efficacy, lower risk of antibiotic resistance development, and minimal collateral damage to host tissues, are important alternatives to control the bioburden in wounds. Povidone iodine (PVP-I), in use for several decades, has the broadest spectrum of activity, a persistent antimicrobial effect, an ability to penetrate biofilms, and a lack of acquired or cross-resistance. It demonstrates good skin tolerance and low cytotoxicity. However, some reports on PVP-I have raised concerns over allergy, ineffective penetration, and toxic effects on host cells. The majority of these concerns are based on in vitro or rodent wound studies with diverse study designs and outcomes; these results may not be directly applicable in the clinical reality in humans. In this paper, we discuss the efficacy and safety of PVP-I and outline its place in wound healing in Asia, based on an appraisal of recent literature and clinical practice across the region. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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32. Efficacy of Chlorhexidine Impregnated Wipes for the Local Dysbiosis in Atopic Dogs: A Multicentric Prospective Study.
- Author
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Bensignor, Emmanuel, Navarro, Christelle, Gard, Carole, Jahier, Bruno, Pressanti, Charline, and Videmont, Emilie
- Subjects
DYSBIOSIS ,CHLORHEXIDINE ,DOGS ,DRUG resistance in bacteria ,ATOPIC dermatitis ,LONGITUDINAL method - Abstract
Simple Summary: Canine atopic dermatitis (CAD) is a frequent skin disease in dogs in which a microbial dysbiosis contributes to flare ups. The use of topical products for localised areas of dermatitis is useful as it can reduce the use of antibiotics and the development of antimicrobial resistance. This study aimed to evaluate the benefits of chlorhexidine wipes in case of localised dysbiosis in atopic dogs. Twenty dogs received a daily application of wipes for 14 days and showed a clinical and cytological statistically significant improvement following the use of the tested product after 7 and 14 days of application. Antiseptic wipes are beneficial in case of localised dysbiosis in CAD. (1) Background: Dysbiosis is frequently observed in Canine Atopic Dermatitis (CAD). Antimicrobial treatment may be necessary to treat flare ups and the use of topical treatments is beneficial to prevent the development of bacterial resistance. Wipes are an easy way to apply antiseptic agents on the skin. The aim of this study was to evaluate the benefits of 3% chlorhexidine impregnated wipes (Pyoskin
® wipes, MP Labo, France) on local areas of dysbiosis in dogs with CAD. (2) Methods: A total of 20 dogs suffering from CAD presented with localised areas of dysbiosis were included in this study. Affected areas were cleansed with the daily application of chlorhexidine wipes once a day for 14 days. Follow-up visits were scheduled after one and two weeks. Clinical signs (lesions and pruritus), dysbiosis scored by cytological counts (cocci and Malassezia) and investigator and owner global appreciation were evaluated. (3) Results: A statistically significant decrease in clinical scores and cytological counts were observed as soon as D7 and until D14. Both owner and investigator appreciation were considered high (4) Conclusions: The use of chlorhexidine impregnated wipes is a useful and easy way to manage localised dysbiosis in atopic dogs and allows limiting of systemic medication to prevent bacterial resistance. [ABSTRACT FROM AUTHOR]- Published
- 2024
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- View/download PDF
33. A Low-Cost Protocol Using the Adjunctive Action of Povidone–Iodine Irrigations and Sodium Hypochlorite Rinsing Solution in Step 2 of Periodontal Therapy for Patients with Stage III–IV Periodontitis: A Single-Blind, Randomized Controlled Trial.
- Author
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Kardaras, Georgios, Christodorescu, Ruxandra, Boariu, Marius, Rusu, Darian, Belova, Alla, Chinnici, Salvatore, Vela, Octavia, Radulescu, Viorelia, Boia, Simina, and Stratul, Stefan-Ioan
- Subjects
TOOTH root planing ,SODIUM hypochlorite ,POVIDONE-iodine ,PERIODONTITIS ,GINGIVAL hemorrhage ,IRRIGATION (Medicine) - Abstract
In severe stages of periodontitis, conventional periodontal therapy and maintenance care are usually insufficient due to the viral and bacterial etiology; thus, a mechanical approach alone may not be sufficient to eliminate a substantial portion of subgingival pathogens, especially in deep periodontal sites. Background and Objectives: This single-blind, randomized clinical trial aimed to compare the clinical and microbiological efficacy of a low-cost protocol using povidone–iodine and sodium hypochlorite formulations as adjuncts to non-surgical therapy for patients with stage IV periodontitis when compared with chlorhexidine, the most commonly employed substance to date for antimicrobial regimens in periodontal therapy. Materials and Methods: Forty-five patients were randomly divided into two groups: control (subgingival instrumentation, chlorhexidine-assisted) and test (antiviral medication, subgingival instrumentation with povidone–iodine, sodium hypochlorite rinsing solution, and antibiotics). Clinical measurements and microbiological analyses were performed at baseline and after three months. Results: After three months, notable differences were found in the bacterial detection scores for Porphyromonas gingivalis (a significant reduction in detection frequency was observed in the test compared to the control (p = 0.021)), and there were significant reductions in detection in the test group for Tannerella forsythia and Treponema denticola, showing undetectable levels (p < 0.0001 for both). In the test group, the pocket probing depth median value was reduced significantly (p = 0.0005); similarly, bleeding on probing showed a marked decrease (p < 0.0001). However, changes in clinical attachment loss and full-mouth plaque score were not statistically significant. Conclusions: Using the proposed protocol, substantial improvements in clinical and microbiological parameters were obtained when compared with the current antimicrobial recommendations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
34. Effect of Chlorhexidine Digluconate on Oral Bacteria Adhesion to Surfaces of Orthodontic Appliance Alloys.
- Author
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Gergeta, Doria, Badnjevic, Matea, Karleusa, Ljerka, Maglica, Zeljka, Spalj, Stjepan, and Gobin, Ivana
- Subjects
CHLORHEXIDINE ,ORTHODONTIC appliances ,BACTERIAL adhesion ,DENTAL metallurgy ,ALLOYS ,CARIOGENIC agents ,NICKEL-titanium alloys - Abstract
This study aimed to analyse the effect of chlorhexidine digluconate (CHX DG) mouthwash on the adhesion of oral bacteria to orthodontic appliances. The interactions of four bacteria (S. mutans, A. actinomycetemcomitans, S. oralis, and V. parvula) with two alloys (stainless steel [SS] and nickel-titanium [NiTi]) and three CHX DG solutions (commercial products Curasept and Perio Plus, and pure CHX DG, all with 0.12% active substance) were tested. The adhesive effect on the orthodontic wires was evaluated after 24 h for S. oralis and after 72 h for the other bacteria. The minimum bactericidal concentration of the solution for each bacterial strain was determined using the dilution method to test the antibacterial action. Salivary-pretreated orthodontic archwires were exposed to minimal bactericidal concentrations of solution and bacteria. Commercial antiseptic products, especially Perio Plus, showed a better inhibition of bacterial adhesion to both alloys than pure CHX DG solution (p < 0.05). A. actinomycetemcomitans was most inhibited in the adhesion of all bacteria by the CHX DG products. A greater inhibition of streptococci adherence was observed on SS, while that of A. actinomycetemcomitans was observed on NiTi. V. parvula inhibition was product-dependent. Although there were differences between the strains and the tested agents, it can be concluded that Perio Plus most effectively inhibited the adhesion of all tested bacteria to the SS and NiTi alloys. A. actinomycetemcomitans was most sensitive to all tested agents, while S. mutans showed the highest resistance. The effectiveness of the tested agents was better on NiTi alloys. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
35. Umbilical Cord Care - Impact of National Recommendations.
- Author
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Nosan, Gregor
- Subjects
UMBILICAL cord ,PEDIATRIC nursing ,PARENTING education ,NAVEL ,MIDWIVES ,INPATIENT care - Abstract
Objectives -- To analyze the current umbilical cord (UC) care practice in Slovenia and to evaluate the impact of national UC care recommendations by comparing the UC care practice before and after their introduction. Materials and Methods -- A questionnaire covering the complete UC care was sent to medical nurses and midwifes involved in UC care in primary-level pediatric centers, health visiting and parent education services (outpatient group) and secondary and tertiary-level pediatric centers (inpatient care group) in Slovenia. Three different clinical conditions of the newborn's umbilicus, i.e. healthy umbilicus (HU), umbilicus at risk (RU) and unhealthy umbilicus (UU) were used. The inpatient and outpatient groups and UC care in 2013 and 2021 were compared. Results -- The sample included 396 respondents from all Slovenian regions. The odds for using UC care protocol in 2021 were 2.6 times higher compared to 2013 (P<0.001). The UC care of HU changed: the dry UC care became less frequent (P<0,001), the use of normal saline solution increased and the use of ethanol solution decreased (P<0.001). The use of ethanol solution for UU decreased (P<0.001) and the use of octenidine increased more than 200 times (P<0.001). Conclusions -- The implementation of national recommendations significantly influenced the UC care in Slovenia. The current UC care practice is more unified and consistent with international recommendations. The adjusted UC care, depending on the clinical condition of the newborn's umbilicus, puts additional value to these recommendations. Further refinements of the UC care protocol should emphasize the use of dry UC care. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
36. Adsorptive Elimination of a Cationic Dye and a Hg (II)-Containing Antiseptic from Simulated Wastewater Using a Metal Organic Framework.
- Author
-
Roy, Nilanjan, Das, Chanchal, Paul, Mohuya, Im, Jungkyun, and Biswas, Goutam
- Subjects
METAL-organic frameworks ,SEWAGE ,DYES & dyeing ,BASIC dyes ,COLOR removal (Sewage purification) ,SEWAGE purification ,MERCURY poisoning ,ANTISEPTICS ,POLLUTANTS - Abstract
Several types of pollutants have acute adverse effects on living bodies, and the effective removal of these pollutants remains a challenge. Safranin O (a biological dye) and merbromin (a topical mercury-containing antiseptic) are considered organic pollutants, and there are only a few reports on their removal. Synthesized and well-characterized (through PXRD, FTIR, FESEM, and EDS analysis) MOF-5 was used for the first time in the removal of safranin O and merbromin from simulated wastewater and real wastewater. In both cases, MOF-5 effectively removed contaminants. We found that in simulated wastewater, the highest efficiency of removal of safranin O was 53.27% (for 15 mg/L) at pH 10, and for merbromin, it was 41.49% (for 25 mg/L) at pH 6. In the case of real wastewater containing natural ions (Na
+ , K+ , F− , Cl− , SO4 2− , PO4 3− , Mg2+ , and Ca2+ ) and other molecules, the removal efficiencies of these two dyes decreased (34.00% and 26.28% for safranin O and merbromin, respectively) because of the presence of other ions and molecules. A plausible mechanism for the removal of these pollutants using MOF-5 was proposed. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
37. Physico-chemical characteristics of Ca/P ratio on the composition and structure of oxygenated apatite.
- Author
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Jerdioui, S., Bouammali, H., Mejdoubi, E., Touzani, R., Azzaoui, K., Hammouti, B., Sabbahi, R., Nandiyanto, Asep Bayu Dani, and Elansari, L. L.
- Subjects
ANTISEPTICS ,BIOMATERIALS ,PHOSPHATES ,CHEMICAL decomposition ,BIOLOGICAL products - Published
- 2024
- Full Text
- View/download PDF
38. Optimal effective concentration combinations (OPECCs) for binary application of membrane-targeting antiseptics and TMPyP-mediated antimicrobial photodynamic therapy.
- Author
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Maisch, Tim, Scholz, Konstantin J., Forster, Eva-Maria, Wenzl, Verena, Auer, David L., Cieplik, Fabian, and Hiller, Karl-Anton
- Subjects
PHOTODYNAMIC therapy ,CHLORHEXIDINE ,ANTISEPTICS ,ENTEROCOCCUS faecalis ,BENZALKONIUM chloride - Abstract
The widespread occurrence of multi-resistant bacteria is a health problem of global dimension. Infections caused by multi-resistant pathogens are difficult to treat and often associated with high mortality. Therefore, new treatment strategies are of interest, such as the use of differently acting antibacterial concepts. One of these new concepts is the use of antiseptics in combination with the antibacterial photodynamic therapy (aPDT). Currently, no method has yet been established as a standard procedure for investigating combined effects and evaluating them in a generally valid and unambiguous manner. The focus of this study was on how cationic antiseptics benzalkonium chloride (BAC) and chlorhexidine digluconate (CHX) behave in a combined application with aPDT using the photosensitizer TMPyP. For this purpose, BAC and CHX were applied in combination with the aPDT using TMPyP in non-lethal concentrations to the three bacteria Escherichia coli, Staphylococcus aureus, and Enterococcus faecalis. The results of the combination experiments with sublethal concentrations of BAC or CHX with the aPDT showed that the binary application had a lethal effect. Irrespective of the bacteria, the reduction in concentrations in OPECC, compared to individual concentrations, was more than 50% for TMPyP, 23–40% for BAC, and 18–43% for CHX. Furthermore, the optimal effective concentration combinations (OPECCs) could be determined. The latter showed that the combined application allowed the reduction of both concentrations compared to the single application. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
39. Mucoadhesive Pharmacology: Latest Clinical Technology in Antiseptic Gels.
- Author
-
Baus-Domínguez, María, Aguilera, Felipe-Rodrigo, Vivancos-Cuadras, Fernando, Ferra-Domingo, Lourdes, Torres-Lagares, Daniel, Gutiérrez-Pérez, José-Luis, Pereira-Riveros, Tanya, Vinuesa, Teresa, and Serrera-Figallo, María-Ángeles
- Subjects
ANTISEPTICS ,HYDROGELS in medicine ,CHLORHEXIDINE ,STREPTOCOCCUS mutans ,PERIODONTICS ,DRUG efficacy - Abstract
Chlorhexidine (CHX) is one of the most widely used antiseptics in the oral cavity due to its high antimicrobial potential. However, many authors have stated that the effect of CHX in nonsurgical periodontal therapy is hampered by its rapid elimination from the oral environment. The aim of this study was to determine the antibacterial efficacy of a new compound of chlorhexidine 0.20% + cymenol (CYM) 0.10% on a multispecies biofilm. For this, an in vitro study was designed using a multispecies biofilm model of Streptococcus mutans, Fusobacterium nucleatum, Prevotella intermedia, and Porphyromonas gingivalis. Quantification of the microbial viability of the biofilm was performed using 5-cyano-2,3-ditolyl tetrazolium-chloride (CTC) to calculate the percentage of survival, and the biofilms were observed using a a confocal laser scanning microscopy (CLSM). It was observed that the bactericidal activity of the CHX + cymenol bioadhesive gel was superior to that of the CHX bioadhesive gel, in addition to higher penetrability into the biofilm. Therefore, there was greater elimination of bacterial biofilm with the new compound of chlorhexidine 0.2% plus cymenol 0.1% in a bioadhesive gel form compared to the formulation with only chlorhexidine 0.2% in a bioadhesive gel form. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
40. In Vitro Evaluation of Polihexanide, Octenidine and NaClO/HClO-Based Antiseptics against Biofilm Formed by Wound Pathogens.
- Author
-
Krasowski, Grzegorz, Junka, Adam, Paleczny, Justyna, Czajkowska, Joanna, Makomaska-Szaroszyk, Elżbieta, Chodaczek, Grzegorz, Majkowski, Michał, Migdał, Paweł, Fijałkowski, Karol, Kowalska-Krochmal, Beata, and Bartoszewicz, Marzenna
- Subjects
BIOFILMS ,ANTISEPTICS ,CHRONIC wounds & injuries ,PSEUDOMONAS aeruginosa ,CANDIDA albicans ,STAPHYLOCOCCUS aureus - Abstract
Chronic wounds complicated with biofilm formed by pathogens remain one of the most significant challenges of contemporary medicine. The application of topical antiseptic solutions against wound biofilm has been gaining increasing interest among clinical practitioners and scientific researchers. This paper compares the activity of polyhexanide-, octenidine- and hypochlorite/hypochlorous acid-based antiseptics against biofilm formed by clinical strains of Candida albicans, Staphylococcus aureus and Pseudomonas aeruginosa. The analyses included both standard techniques utilizing polystyrene plates and self-designed biocellulose-based models in which a biofilm formed by pathogens was formed on an elastic, fibrinous surface covered with a fibroblast layer. The obtained results show high antibiofilm activity of polihexanide- and octenidine-based antiseptics and lack or weak antibiofilm activity of hypochlorite-based antiseptic of total chlorine content equal to 80 parts per million. The data presented in this paper indicate that polihexanide- or octenidine-based antiseptics are highly useful in the treatment of biofilm, while hypochlorite-based antiseptics with low chlorine content may be applied for wound rinsing but not when specific antibiofilm activity is required. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
41. Synthesis and antibacterial activity of new bis-quaternary ammonium compounds based on polyhydric alcohol
- Author
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Saverina, E. A., Frolov, N. A., Karpeev, D. A., Bardina, M. A., Detusheva, E. V., and Vereshchagin, A. N.
- Published
- 2024
- Full Text
- View/download PDF
42. Safety and efficacy of current alternatives in the topical treatment of cutaneous leishmaniasis: a systematic review.
- Author
-
NASSIF, PRISCILA WOLF, DE MELLO, TATIANE FRANÇA PERLES, NAVASCONI, TAÍSA ROCHA, MOTA, CAMILA ALVES, DEMARCHI, IZABEL GALHARDO, ARISTIDES, SANDRA MARA ALESSI, LONARDONI, MARIA VALDRINEZ CAMPANA, TEIXEIRA, JORGE JUAREZ VIEIRA, and SILVEIRA, THAÍS GOMES VERZIGNASSI
- Subjects
CUTANEOUS leishmaniasis ,THERMOTHERAPY ,ANTISEPTICS ,COLD therapy ,THERAPEUTICS ,ALTERNATIVE medicine - Abstract
Studies of topical treatments for leishmaniasis were systematically reviewed, to evaluate the therapeutic efficacy, safety and any adverse effects of these treatments. The papers identified in the databases PubMed and Web of Knowledge involved eight studies with a total of 1744 patients. The majority of trials was from Iran (4/8), covered a period of 8 years (2003- 2011), and included patients 4-85 years of age. The most frequent Leishmania species in the studies were L. tropica (4/8) and L. major (2/8). The treatments administered were thermotherapy, paromomycin and combinations, CO2 laser, 5-aminolevulinic acid hydrochloride (10%) plus visible red light (633 nm) and cryotherapy. Six articles reported cure rates over 80·0%. Six studies reported on failure rates, three of them reporting rates lower than 10%. Four studies did not report relapses or recurrences, while the other studies reported low rates (1·8-6·3%). The most common adverse effects of the topical treatments were redness/erythema, pain, pruritus burning, oedema, vesicles and hyper- or hypopigmentation. The results provide strong evidence that the treatments topical evaluated showed high cure rates, safety and effectiveness, with low side-effects, relapse and recurrence rates, except for cryotherapy, which showed a moderate cure rate. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
43. Greening the environment in living a new lifestyle in the COVID-19 era.
- Author
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Harida Samudro and Sarwoko Mangkoedihardjo
- Subjects
- *
COVID-19 , *ANTISEPTICS , *DISINFECTION & disinfectants , *SEWAGE , *POISONS - Abstract
The essential health protocol for living in the COVID-19 era requires antiseptic and disinfecting agents, as well as clean water for personal washing and objects related to the conditions of human activity. The results of personal hygiene measures and the cleanliness of objects are additional wastewater discharges, and increased peak discharges of wastewater, compared to conditions without the protocol. In addition, the quality of wastewater is compounded by enrichment of toxic substances for microbes. As a consequence, the wastewater needs to be treated from the source to the disposal to the environment. Various studies that have been carried out previously indicate the potential of plants in eliminating antiseptic and disinfectant substances contained in wastewater. Therefore, this paper discusses specifically the contribution of greening the environment in treating wastewater rich in these toxic substances. [ABSTRACT FROM AUTHOR]
- Published
- 2020
44. Efficiency of octenidine dihydrochloride alcohol combination compared to ethanol based skin antiseptics for preoperative skin preparation in dogs.
- Author
-
Eigner, Fabian, Keller, Stefanie, Schmitt, Sarah, Corti, Sabrina, and Nolff, Mirja C.
- Subjects
SKIN care products ,ETHANOL ,DOGS ,CLINICAL trials ,ANTISEPTICS ,ALCOHOL - Abstract
Objective: To quantify the bacterial burden after skin disinfection using an alcohol octenidine dihydrochloride combination (Octenisept®) compared to an 74.1% ethanol 10% 2-propanol combination (Softasept N®). Study design: Prospective randomized clinical trial. Material & methods: 61 dogs undergoing clean or clean-contaminated surgeries (excluding surgeries on the gastrointestinal tract) were randomly assigned to group O (skin disinfection with alcohol and octenidine dihydrochloride after washing with octenidine containing soap) or to control group C (skin disinfection using the ethanol-2-propanol combination after washing with a neutral soap without antiseptic ingredients). Samples were then taken from 8 different locations within the surgical field at four different stages: after clipping, after washing, after disinfection and one hour later. At each stage, two different sampling techniques (wet-dry swab technique (WDS) and contact plates (CP)) were used for quantitative analysis of bacterial counts. Results: WDS detected about 100-fold more bacteria compared to CP sampling in cases with high bacterial burden, but was not accurate enough to detect small numbers. CP sampling was therefore used for comparison of treatment protocols. 30 dogs were assigned to group O and 31 to group C. A relative reduction of 69% in group O and 77 percent in group C was observed after the soap wash. No significant differences were detected between both groups. Washing and disinfection resulted in a reduction of bacterial counts of 99.99% in group O versus 99.7% in group C (p = 0.018). Bacterial reduction one hour after washing and disinfection was significantly higher in group O (99.9%) than in group C (98.5%, p = 0.001). Conclusion: Additional octenidine dihydrochloride provided a slightly better decontamination effect after disinfection, particularly one hour after, which means it may only be indicated in longer surgeries. WDS is more sensitive but less specific to detect bacteria on the skin than the CP sampling. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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45. Antimicrobial Activity of Chlorhexidine and Cerium Oxide Nanoparticles Composition.
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Skrypnyk, Maksym, Ananieva, Maiia, Petrushanko, Tatiana, Neporada, Karine, and Spivak, Mykola
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CHLORHEXIDINE ,ESCHERICHIA coli ,ANTI-infective agents ,NANOPARTICLES ,STREPTOCOCCUS mutans - Abstract
Copyright of Acta Facultatis Medicae Naissensis is the property of Nis University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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46. Study Of The Effect Of "Violet K" Antiseptic On Local And Introduced Species Of Mulberry Silkworm In Azerbaijan.
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Damir, Baghirova Gulnar
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INTRODUCED species ,SILKWORMS ,DISEASE eradication ,MULBERRY ,ANTISEPTICS ,DEATH rate - Abstract
The study consisted of 3 variants. According to the results obtained from the research, in the control (dry) version treated with 0.001% solution of "Violet K", the mortality rate due to disease agents was 53.30% in the caterpillars of the Vatan breed, while in the "Sverico-yellow" breed it was 41.70%, and in the "Oragase" breed it was 17.00%. The mortality rate of the first experimental variant was 12.50% in the "Vatan" breed, 15.20% in the "Sverico-yellow" breed, and 6.70% in the "Oragase" breed. In the second control (aqueous) variant, 23.50% mortality was observed in the Sverico-yellow breed, and 8.00% in the Oragase breed, but no mortality occurred in the "Vatan" breed. According to the weight of the silk coat, the weight of the cocoon of the "Vatan" breed in the control (dry) variant was 235.7 mg, 138.2 mg in the "Sverico-yellow" breed, and 218 mg in the "Oragase" breed. The amount of the control (aqueous) variant was 340.5 mg in the "Vatan" breed, 173.5 mg in the "Sverico-yellow" breed, and 139.5 mg in the "Oragase" breed. In the experimental version, the weight of the silk coat of the "Vatan" breed was 460.5 mg, 160.5 mg in "Svericoyellow", and 169 mg in "Oragase". In the productivity of butterflies, the number of eggs in the "Vatan" breed was 300 in the control (dry) version, 265 in the control (aqueous) version, and 1,471 in the experimental version. In the "Sverico-yellow" breed, there were 270 eggs in the control (dry) variant, 306 eggs in the control (aqueous) breed, and 1235 eggs in the experimental breed. In the "Oragase" breed, the number of eggs was 239 in the control (dry) variant, 602 in the control (aqueous) variant, and 589 in the experimental variant. Scientific innovation. Scientific innovation in the research works conducted in the direction of solving 2 problems in the relevant cocoon farms was the development of methods of prevention and elimination of diseases recorded in the eggs and caterpillars of the mulberry silkworm, as well as methods of increasing the viability of eggs and caterpillars. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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47. Antimicrobial Meshes for Hernia Repair: Current Progress and Perspectives.
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Mirel, Simona, Pusta, Alexandra, Moldovan, Mihaela, and Moldovan, Septimiu
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HERNIA surgery ,PROSTHETICS ,MEDICAL supplies ,TISSUE scaffolds ,CHEMICAL decomposition ,SURGICAL meshes ,BREAST implants - Abstract
Recent advances in the development of biomaterials have given rise to new options for surgery. New-generation medical devices can control chemical breakdown and resorption, prevent post-operative adhesion, and stimulate tissue regeneration. For the fabrication of medical devices, numerous biomaterials can be employed, including non-degradable biomaterials (silicone, polypropylene, expanded polytetrafluoroethylene) or biodegradable polymers, including implants and three-dimensional scaffolds for tissue engineering, which require particular physicochemical and biological properties. Based on the combination of new generation technologies and cell-based therapies, the biocompatible and bioactive properties of some of these medical products can lead to progress in the repair of injured or harmed tissue and in tissue regeneration. An important aspect in the use of these prosthetic devices is the associated infection risk, due to the medical complications and socio-economic impact. This paper provides the latest achievements in the field of antimicrobial surgical meshes for hernia repair and discusses the perspectives in the development of these innovative biomaterials. [ABSTRACT FROM AUTHOR]
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- 2022
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48. Evaluation of multiple subgingival irrigations with 10% povidone-iodine after scaling and root planing: a randomized clinical trial.
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Kessler, Selma, Lasserre, Jérôme F., and Toma, Selena
- Subjects
IRRIGATION (Medicine) ,POVIDONE-iodine ,DENTAL scaling ,TOOTH root planing ,CHRONIC diseases ,PERIODONTITIS ,RANDOMIZED controlled trials ,GINGIVA - Abstract
Objectives: This 6-month randomized controlled study aimed at evaluating the clinical outcomes of multiple irrigations of 10% povidone-iodine (PVP-I) as an adjunct to full-mouth scaling and root planing (SRP) in the treatment of chronic periodontitis. Method and materials: Seventeen patients were included. A split-mouth design randomly assigned one side as the test side (SRP + PVP-I) and the other side as the control side (SRP + NaCl). After full-mouth SRP, the control side received subgingival irrigation with 10 mL 0.9% NaCl solution. The test side received 10 mL of PVP-I 10%. Plaque Index (PI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) parameters were assessed at baseline and after 3 and 6months. During recall visits (3 and 6 months), residual deep periodontal pockets of = 6mm were cleaned with the same protocol and randomization. Results: PI, BOP, PPD, and CAL were improved in both sides after 6 months. No significant differences were seen between control and test sides for the all clinical parameters after 6months. Conclusion: Multiple subgingival irrigations of 10% PVP-I or 0/9% NaCl combined to one-stage full mouth SRP in patients with chronic periodontitis showed a reduction of all clinical parameters until 6months. There was a trend in favor of the povidone group for PPD. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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49. MOF matrix doped with rare earth ions to realize ratiometric fluorescent sensing of 2,4,6-trinitrophenol: Synthesis, characterization and performance.
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Qiao, Xiaofang, Han, Yingbo, Tian, Dan, Yang, Zecheng, Li, Jinlong, and Zhao, Shutao
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ENERGY transfer , *RARE earth ions , *ORGANIC dyes , *ANTISEPTICS , *DICARBOXYLIC acids - Abstract
Graphical abstract Highlights • Fluorescent sensing of 2,4,6-trinitrophenol by controlling energy transfer between rare earth ions. • Bio-MOF-1 was doped with RE ions to realize ratiometric fluorescent sensing. • Good selectivity, low LOD and linear response were discussed. Abstract 2,4,6-trinitrophenol (PA) is a well-known aromatic compound, due to their higher explosive energy than TNT and their wide utilization when producing organic dyes, medicines and antiseptics. The following paper constructed a composite optical sensing system (denoted as Tb:Eu@MOF) for PA detection using [Zn 8 (ad) 4 (BPDC) 6 O·2 Me 2 NH 2 ]·G, ad = adenine, BPDC = 4,4′-biphenyl dicarboxylic acid, G = DMF and water, as supporting matrix and two rare earth ions, Tb(III) and Eu(III), as dopant. Tb:Eu@MOF was carefully characterized by means of micromorphology, XRD, N 2 adsorption and desorption. Detailed analysis on its photophysical performance indicated weak Tb emission and strong Eu emission, owing to the energy competing between two kinds of rare earth ions in Tb:Eu@MOF. After meeting PA, such energy competing was blocked, leading to enhanced Tb emission and decreased Eu emission. Ratiometric fluorescent sensing for PA detection was thus constructed with good selectivity and low LOD (limit of detection) of 0.87 μM. Linear sensing response was achieved. Its practical sensing application and naked eye detection for PA were tentatively discussed as well. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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50. Bio-friendly controllable synthesis of silver nanoparticles and their enhanced antibacterial property.
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Guan, Qingxin, Xia, Chanchan, and Li, Wei
- Subjects
- *
SILVER nanoparticles , *ANTISEPTICS , *ANTI-infective agents , *ROSELLE , *GRAM-positive bacteria , *GRAM-negative bacteria - Abstract
Graphical abstract Highlights • Size controllable silver nanoparticles were synthesized using HSE as a reductant. • The silver nanoparticles prepared using HSE have an average diameter of 15 nm. • Polyphenol compounds in HSE acts not only as reductant but also as dispersant. • Silver nanoparticles have no cytotoxicity and excellent antimicrobial activities. Abstract Silver nanoparticles have attracted much attention in the medical field in recent years due to their excellent antibacterial properties. In this paper, size controllable silver nanoparticles were synthesized using Hibiscus sabdariffa extract (HSE) as a reductant in 10 min. The silver nanoparticles prepared using HSE as reductant have an average diameter of 15 nm, which is smaller than that of using citric acid as a reductant. Characterization results show that polyphenol compounds in HSE acts not only as reductant but also as dispersant and stabilizer. Moreover, the size of silver nanoparticles is mainly affected by pH value, reaction temperature, and kind of pH regulators. Finally, the silver nanoparticles as antibacterial component was added into cataplasm. The results showed that they have almost no cytotoxicity on 3T3 cells and excellent antimicrobial activities against Gram-positive and Gram-negative bacterium. The above research opens a feasible way for the application of silver nanoparticles in the biomedical field. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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