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Celiac disease is an autoimmune disease primarily affecting the small intestine that is caused by the ingestion of gluten in genetically susceptible individuals. The development of celiac disease is based on a complex immune response to gluten proteins. The global average prevalence in the general population is about 1%. In recent years, it has become clear that celiac disease is not less common in Asian countries than in Western countries but often remains undiagnosed. Although the number of patients with celiac disease in Asia is expected to increase with improving disease recognition and advances in diagnostic techniques, there remain few reports of celiac disease in the Far East region of Asia, especially in Japan. In this paper, we outline the epidemiology, diagnosis, and treatment of celiac disease. In addition, we summarize the reported Japanese cases of celiac disease with an overview in Japan. [ABSTRACT FROM AUTHOR]

This paper demonstrates and assesses the capability of the advanced three-dimensional (3-D) ionosphere tomography technique, during severe conditions. The study area is northeast Asia and quasi-Japan-centred. Reconstructions are based on total electron content data from a dense ground-based global navigation satellite system receiver network and parameters from operational ionosondes. We used observations from ionosondes, Swarm satellites and radio occultation (RO) to assess the 3-D picture. Specifically, we focus on St. Patrick's day geomagnetic storm (17–19 March 2015), the most intense in solar cycle 24. During this event, the energy ingested into the ionosphere resulted in Dst and Kp and reaching values ~ − 223 nT and 8, respectively, and the region of interest, the East Asian sector, was characterized by a ~ 60% reduction in electron densities. Results show that the reconstructed densities follow the physical dynamics previously discussed in earlier publications about storm events. Moreover, even when ionosonde data were not available, the technique could still provide a consistent picture of the ionosphere vertical structure. Furthermore, analyses show that there is a profound agreement between the RO profiles/in-situ densities and the reconstructions. Therefore, the technique is a potential candidate for applications that are sensitive to ionospheric corrections. [ABSTRACT FROM AUTHOR]

The westerly jet (WJ) is an important component of atmospheric circulation, which is characterized by prominent seasonal variations in intensity and position. However, the response of the WJ over Asia during the Last Glacial Maximum (LGM) is still not clear. Using general circulation model experiments, the seasonal behaviors of the WJ over central Asia and Japan are analyzed in this paper. The results show that, compared to the present day (PD), the WJ presents a complicated response during the LGM, both in intensity and position. Over central Asia, it becomes weaker in both summer and winter. But over Japan, it is enhanced in summer but becomes diminished in winter. In terms of position, the WJ over central Asia shifts southward in both summer and winter, whereas the WJ over Japan moves southward in summer but does not change obviously relative to PD in winter. Such WJ changes are well explained by meridional temperature gradients in high troposphere, which is closely linked to seasonal thermal anomalies over the Tibetan Plateau (TP). Despite cooler LGM conditions, the anomalous warming center over the TP becomes stronger in summer. Derived from the heat budget equation, the stronger heating center is mainly caused by the weaker adiabatic cooling generated from ascending motion over the area south of the TP. In winter, the cooling over the TP is also strengthened, mostly owing to the subsidence-induced weaker adiabatic heating. Due to the importance of the WJ, the potential role of TP thermal effects should be a focus when explaining the East Asian climate change during the LGM. [ABSTRACT FROM AUTHOR]