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Effectively utilizing low-grade thermal energy is a promising approach to mitigating greenhouse gas emissions while reducing the burden on centralized power grids. Current thermoacoustic heat pumps and power generators face challenges such as high onset temperature differentials and low performance. This paper addresses these challenges by introducing a gas-liquid resonator into a thermoacoustic combined heat and power systems to recover low-grade thermal energy in residential buildings. Through Sage modeling and calculations, the internal characteristics of the proposed system and its output performance under different operating conditions are explored. At a heating temperature of 350 °C, the system can generate 6.4 kW of output thermal power, 0.9 kW of electricity, and overall exergy efficiency is 79.3 %. Combining neural network models with case studies conducted in Spain and Finland, the system can annually save 5.6 MWh and 20.7 MWh in fuel energy, reduce emissions of 1374 kg and 5180 kg of carbon dioxide, and save a total cost of €611 and €2324, respectively. Furthermore, comparisons with other emerging micro-CHP systems highlight the efficiency of the proposed system. These results indicate the high potential of thermoacoustic combined heat and power systems in recovering low-grade thermal energy and achieving energy savings and emission reductions. • Introducing an innovative thermoacoustic micro-CHP system. • Achieving an exergy efficiency of 79.3 % under standard operating conditions. • One system can annually reduce household CO 2 emissions by 5180 kg. • Ideal for households, balancing lower output levels for both heat and electricity. [ABSTRACT FROM AUTHOR]