1. Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trial.
- Author
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Palmer, D. J., Sullivan, T., Gold, M. S., Prescott, S. L., Heddle, R., Gibson, R. A., and Makrides, M.
- Subjects
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ALLERGIES , *CONFIDENCE intervals , *ECZEMA , *FOOD allergy , *PROBABILITY theory , *RESEARCH funding , *UNSATURATED fatty acids , *RANDOMIZED controlled trials , *RELATIVE medical risk , *DESCRIPTIVE statistics , *CHILDREN , *PREGNANCY - Abstract
STUDY QUESTION: Does dietary n-3 long chain polyunsaturated fatty acid (LCPUFA) supplementation of pregnant women with a fetus at high risk of allergic disease reduce immunoglobulin E associated eczema or food allergy at 1 year of age? SUMMARY ANSWER: n-3 LCPUFA supplementation in pregnancy did not reduce the overall incidence of immunoglobulin E associated allergies in the first year of life, although immunoglobulin E associated eczema was lower. WHAT IS KNOWN AND WHAT THIS PAPER ADDS: Several mechanistic studies have suggested that higher intakes of n-3 LCPUFA during pregnancy modulate the neonatal immune response towards a less allergenic phenotype. n-3 LCPUFA supplementation in pregnancy did not reduce the incidence of immunoglobulin E associated food allergies in the first year of life, but the incidence of atopic eczema was lower. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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