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The spin–orbit misalignment of stellar-mass black hole (sBH) binaries provides important constraints on the formation channels of merging sBHs. Here, we study the role of secular spin–orbit resonance in the evolution of an sBH binary component around a supermassive BH (SMBH) in an AGN disk. We consider the sBH's spin precession due to the J 2 moment introduced by a circum-sBH disk within the warping/breaking radius of the disk. We find that the sBH's spin–orbit misalignment (obliquity) can be excited via spin–orbit resonance between the sBH binary's orbital nodal precession and the sBH spin precession driven by a massive circum-sBH disk. Using an α -disk model with Bondi–Hoyle–Lyttleton accretion, the resonances typically occur for sBH binaries with semimajor axis of 1 au and at a distance of ∼1000 au around a 107 M ⊙ SMBH. The spin–orbit resonances can lead to high sBH obliquities and a broad distribution of sBH binary spin–spin misalignments. However, we note that the Bondi–Hoyle–Lyttleton accretion is much higher than that of Eddington accretion, which typically results in spin precession being too low to trigger spin–orbit resonances. Thus, secular spin–orbit resonances can be quite rare for sBHs in AGN disks. [ABSTRACT FROM AUTHOR]