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Purpose: There are major gaps in our knowledge of hereditary ocular conditions in the Asia-Pacific population, which comprises approximately 60% of the world's population. Therefore, a concerted regional effort is urgently needed to close this critical knowledge gap and apply precision medicine technology to improve the quality of lives of these patients in the Asia-Pacific region., Design: Multi-national, multi-center collaborative network., Methods: The Research Standing Committee of the Asia-Pacific Academy of Ophthalmology and the Asia-Pacific Society of Eye Genetics fostered this research collaboration, which brings together renowned institutions and experts for inherited eye diseases in the Asia-Pacific region. The immediate priority of the network will be inherited retinal diseases (IRDs), where there is a lack of detailed characterization of these conditions and in the number of established registries., Results: The network comprises 55 members from 35 centers, spanning 12 countries and regions, including Australia, China, India, Indonesia, Japan, South Korea, Malaysia, Nepal, Philippines, Singapore, Taiwan, and Thailand. The steering committee comprises ophthalmologists with experience in consortia for eye diseases in the Asia-Pacific region, leading ophthalmologists and vision scientists in the field of IRDs internationally, and ophthalmic geneticists., Conclusions: The Asia Pacific Inherited Eye Disease (APIED) network aims to (1) improve genotyping capabilities and expertise to increase early and accurate genetic diagnosis of IRDs, (2) harmonise deep phenotyping practices and utilization of ontological terms, and (3) establish high-quality, multi-user, federated disease registries that will facilitate patient care, genetic counseling, and research of IRDs regionally and internationally., Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to disclose., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)

Accurate risk assessment of international scientific and technological (S&T) cooperation is significant to international cooperation. In this paper, 5 risk dimensions with respect to the political, economic, social, cultural as well as technological of the regional comprehensive economic partnership countries (RCEP) are selected to establish a proper S&T cooperation index system for risk assessment. To calculate the weight of each index, a cross-entropy combination weighting method is proposed based on the combination weighting method of game theory. Furthermore, the standard cloud model is constructed by using the golden ratio, and the risk of S&T cooperation among the RCEP countries is analyzed by the cloud model. The results show that the combination weighting method proposed in this paper is effective, and its calculation is simpler than that of the game theory combination weighting method. Besides, compared with political, social, cultural, and technological indicators, economic indicators have a greater impact on S&T cooperation risk. Furthermore, it is also obtained from the results that the risk of S&T cooperation with China and the Philippines is at a lower to low level and medium to higher level, respectively, and the risk of S&T cooperation with other countries is all at a lower to medium level. [ABSTRACT FROM AUTHOR]

Some observers expected a drastic change in the Philippines' diplomacy toward China when Rodrigo Duterte said goodbye to the United States in 2016. However, after six years, the Philippines has remained an allied partner of the United States. The Philippines' defense establishment bolstered its maritime domain awareness capacity thanks to financial and technical support from the United States. Department of Foreign Affairs (DFA) maintained the award from the Permanent Court of Arbitration (PCA) favoring the Philippines over China. This paper sheds light on the Philippines' policymaking process by framing the politics of grand strategy in an emerging state. The grand strategy is an intellectual architecture to clarify the general direction of foreign policy shaped by multiple state actors who are not limited by the foreign affairs office. Neither asymmetrical power relations nor presidential power can dominate the direction of the Philippines' diplomacy. The president, the DFA, and the defense establishment have developed institutional foundations to craft particular policies. Once they designed the grand strategy in the 1990s, successive policymakers did not remove it but rather incrementally changed it, especially in the 2010s, when they faced a series of assertive actions from China. In an emerging state with limited state capacity, Filipino policymakers do not always coordinate well with each other but still maintain a certain level of autonomy to create particular policies. Against the dominant framework of the weak state, this paper argues that Filipino policymakers demonstrate the state's capacity to achieve their policy goals, even with limitations. [ABSTRACT FROM AUTHOR]

How does the Philippines form its foreign policy toward the People's Republic of China (PRC)? Existing work on the Philippine foreign policy toward China explains the country's stance solely through geopolitical or domestic factors. By examining the political calculus of, and the policy formulation by, the Benigno Aquino III (2010–2016), Rodrigo Duterte (2016–2022), and Ferdinand Marcos Jr. (2022-) administrations, I argue that a combination of domestic politics, geopolitical considerations, and economic realities have shaped the approach of the Philippines toward China. Rather than focus on one factor to explain the Philippines' foreign policy, I suggest that the combination and interaction of these three factors accounting for how various Philippine administrations have operated explains the Philippines' China policies. Furthermore, I nuance these three factors through the lens of political survival. I suggest that leaders stay in power by accumulating political power and staving off challengers. In the Philippines, I suggest that leaders capitalize on criticizing or deviating from the prior administration's China policies, which have resulted in economic or political effects that generate resentment from the population. As a result, Presidents often reverse or modify the policies set about by the previous administration, resulting in a new set of approaches toward China. Data on this paper was facilitated by years of fieldwork conducted in the Philippines between 2017 to 2020. I interviewed officials in the Aquino, Duterte, and Marcos administrations, Filipino oligarchs, political brokers, lawyers, political party representatives, and in-country observers. [ABSTRACT FROM AUTHOR]

The Philippines’ foreign policy is anchored on three pillars: the protection of territorial integrity and sovereignty; economic development; and the protection of overseas Filipinos. Since these tenets were first enunciated by the Ramos administration (1992–98), they have remained constant despite perceptions that subsequent presidents have gravitated towards a closer partnership with the United States or China. Alternatively, it has been said that Manila partners with a particular foreign power to advance a particular pillar, thus creating a de facto division of roles: the United States is an ally that protects the Philippines’ territorial integrity and sovereignty, while China is a partner that advances economic development. However, the notion of a division of responsibilities is somewhat superficial. In reality, the Philippines’ relations with both the United States and China contribute to all three pillars. [ABSTRACT FROM AUTHOR]

This article explores the Philippines’ evolving and changing grand strategies in confronting China’s maritime expansion in the South China Sea. From 2010 to 2016, under the Aquino administration, the Philippines challenged China’s extensive claim over the disputed waters by adopting a hard-balancing approach. In 2016, the succeeding Duterte administration pursued an appeasement policy; in 2018, it shifted to a limited hard balancing policy because of (a) continuing Chinese coercive actions against Armed Forces of the Philippines units in Philippines-occupied land features in the South China Sea and (b) China’s failure to deliver on its promised public investments in the country’s infrastructure building programme. President Ferdinand Marcos Jr initially adhered to his predecessor’s strategy of limited hard-balancing. Seeing no change in China’s stance on the maritime issue, he resorted to a hard-balancing policy. He has vigorously supported the steady modernisation of the Philippine military and strengthened the country’s defence ties with the United States and other like-minded security partners while maintaining cordial diplomatic and economic relations with China. This article argues that the Philippines’ evolving grand strategy has the following elements: (a) Admitting that China’s maritime expansion is the quintessential threat to Philippine national security; (b) pursuing a policy of maintaining the status quo in the West Philippine Sea/South China Sea; (c) acknowledging the urgency to shift the focus of the Philippine military from internal security to territorial defence; and (d) fostering its alliance with the United States and its security partnerships with other American allies and partners. [ABSTRACT FROM AUTHOR]

While ChatGPT has recently become very popular, AI has a long history and philosophy. This paper intends to explore the promises and pitfalls of the Generative Pre-trained Transformer (GPT) AI and potentially future technologies by adopting a speculative methodology. Speculative future narratives with a specific focus on educational contexts are provided in an attempt to identify emerging themes and discuss their implications for education in the 21st century. Affordances of (using) AI in Education (AIEd) and possible adverse effects are identified and discussed which emerge from the narratives. It is argued that now is the best of times to define human vs AI contribution to education because AI can accomplish more and more educational activities that used to be the prerogative of human educators. Therefore, it is imperative to rethink the respective roles of technology and human educators in education with a future-oriented mindset.

Governance and regulation of the use of live animals in research and teaching is examined in Australia, Malaysia, Indonesia, the Philippines, Singapore, Thailand, China, Japan and India. A comparison of the systems in different countries will enable the determination of best practice and fit-forpurpose regulation. The most comprehensive government regulation of animal welfare in institutions covers a broad range of animals and institutions are required to have an Institutional Animal Care and Use Committee, whose membership is specified in guidelines or regulations. The work of the Committees is rigorously overseen by government and facilities that use live animals are audited externally. All countries examined have legislation governing the use of live animals in research, although only Australia and Malaysia have a fully equivalent mandated oversight of teaching. Teaching that uses live animals is partly covered in the Philippines, Japan, Singapore and Thailand This paper thus aims to review the regulation of animal use in different Asian jurisdictions in order to determine best practices that are appropriate to those settings. The most comprehensive oversight is provided in Australia and Malaysia that essentially use the same regulatory framework.

What are the prospects for the Belt and Road (BRI) in the Philippines? How will Marcos' foreign policy impact BRI projects in the country? The authors argue that the BRI's prospects are less optimistic now because (i) the Philippines' experience with Chinese infrastructure projects during Duterte's time was not overwhelmingly positive and (ii) China continues to occupy the West Philippine Sea. China's BRI missed its chance of capitalising on the political climate during the Duterte administration. [ABSTRACT FROM AUTHOR]

This paper seeks to identify the teaching strategies used in Grade 4 Culture and Heritage lessons in a Chinese-Filipino School. Further, it is important to effectively address these with constructivist-based teaching strategies to help maximize the learning experience. This study used qualitative method where Ethnographic research design and Descriptive method were used to conduct classroom observations. The instruments used to obtain the results were patterned and modified from Craig Kissock's (1981) Curriculum Planning for Social Studies Teaching: A Cross-cultural Approach, a self-made Teachers' Self-evaluation form and Peer Observation form participated by nine teachers of a Chinese-Filipino School in Quezon City, Philippines. The analysis of the results identified five teaching strategies with Discussion and Lecture strategy as the most applied alongside Game strategy, Question and Answer strategy, and Project method. Other activities that strengthened the Culture and Heritage awareness were integrated through a collaborative effort with other subject areas. As a result, the study supported that Social Development theory affects the teaching-learning process where opportunities for social interaction helps in the development of a child. Using various teaching strategies encouraged students to interact with one another, to freely express their thoughts, and to participate in fun and healthy competition. It also encouraged students to think and to unleash their creativity and imagination. At the same time, the use of tools and other resources helped increase student engagement.

Based on 35-year (1981–2015) ensemble (24 members) hindcasts of the IAP/LASG global seasonal prediction system named FGOALS-f2 V1.0 (FGOALS-f2), the tropical cyclone (TC) seasonal prediction skills over the South China Sea (SCS) during the TC peak season (July–November) are evaluated. Starting the prediction from June 20th, FGOALS-f2 can well capture the seasonal mean characteristics for both the genesis location and track of TCs over the SCS. For seasonal anomalous TC numbers, FGOALS-f2 underestimates the maximum and minimum of the TC number compared to the observation. The temporal correlation coefficients (TCCs) between FGOALS-f2 and the observation are 0.39 for the TC number and 0.51 for accumulated cyclone energy (ACE) over the SCS, respectively, which are both above the 95% significant level. Additionally, FGOALS-f2 has acceptable prediction skill for the seasonal mean number of TCs landing on three areas (coastal southeastern China, Indochina Peninsula, and Philippines) surrounding the SCS. The skillful prediction of SCS TCs could be ascribed to the well-predicted tropical anomaly of sea surface temperature (SSTA), TC and El Niño-Southern Oscillation (TC-ENSO) relations, and Genesis potential index (GPI). [ABSTRACT FROM AUTHOR]

Based on precipitation data from 60 stations in South China (SC) and NCEP reanalysis data, the Hybrid Single-Particle Lagrangian Integrated Trajectory model (HYSPLIT_4.9) is used to analyze the difference of water vapor transport tracks, water vapor sources, and their precipitation contribution rate to frontal/monsoon precipitation, with four combinations of ENSO and PDO phase for a period of 53 years (1960–2012). The results show that: (1) For the frontal precipitation, in the Pacific Decadal Oscillation positive phase (PDO+), there is a great positive water vapor difference between ENSO+ (the positive ENSO phase) and ENSO− (the negative ENSO phase) over the tropical Indian Ocean (IO), the Bay of Bengal (BOB), the South China Sea (SCS) and the western Pacific (WP), the distribution of the difference is adjusted for PDO− (the negative PDO phase). For monsoon precipitation, when PDO and ENSO are in phase resonance, water vapor gathers over IO-BOB-SCS. (2) For the frontal precipitation, both PDO+ and PDO−, compare with ENSO+, more water vapor from SCS for ENSO−, but the southward water vapor transport anomaly over the western part of BOB-SCS-ocean east of the Philippines, which leads a decline in precipitation contribution rate of SCS water vapor. Both ENSO+ and ENSO−, compare with PDO−, more water vapor comes from IO-BOB for PDO+, but their precipitation contribution rates are lower. (3) For the summer monsoon precipitation, SCS and IO are important rain contributor sources. Regardless of the PDO phase, compared with ENSO+, there is more water vapor from the IO and WP for ENSO−, the easterly anomaly in the south of the stronger subtropical high brings more water vapor from WP to SC, the strong westerly anomalies in the IO-BOB-SCS increases IO water vapor transporting to SC, so water vapor precipitation contribution rates of IO and WP are higher. Both ENSO+ and ENSO−, compare with PDO−, more water vapor comes from SCS and EC for PDO+, but their precipitation contribution rates are lower. (4) The water vapor transport process of precipitation in PFS over SC is jointly affected by ENSO and PDO. [ABSTRACT FROM AUTHOR]

Globally, populations are ageing and the estimated number of hip fractures will increase from 1.7 million in 1990 to more than 6 million in 2050. The greatest increase in hip fractures is predicted in Low- and Middle-Income Countries (LMICs), largely in the Asia-Pacific region where direct costs are expected to exceed $US15 billion by 2050. The aims of this qualitative study are to identify barriers to, and enablers of, evidence-informed hip fracture care in LMICs, and to determine if the Blue Book standards, developed by the British Orthopaedic Association and British Geriatrics Society to facilitate evidence-informed care of patients with fragility fractures, are applicable to these settings. This study utilized semi-structured interviews with clinical and administrative hospital staff to explore current hip fracture care in LMICs. Transcribed interviews were imported into NVivo 12 and analysed thematically. Interviews were conducted with 35 participants from 11 hospitals in 5 countries. We identified five themes-costs of care and the capacity of patients to pay, timely hospital presentation, competing demands on limited resources, delegation and defined responsibility and utilization of available data-and within each theme, barriers and enablers were distinguished. We found a mismatch between patient needs and provision of recommended hip fracture care, which in LMICs must commence at the time of injury. This study describes clinician and administrator perspectives of the barriers to, and enablers of, high-quality hip fracture care in LMICs; results indicate that initiatives to overcome barriers (in particular, delays to definitive treatment) are required. While the Blue Book offers a starting point for clinicians and administrators looking to provide high-quality hip fracture care to older people in LMICs, locally developed interventions are likely to provide the most successful solutions to improving hip fracture care. [ABSTRACT FROM AUTHOR]

After five years of pursuing a policy of appeasement towards China, the Philippines is incrementally and reluctantly shifting to "limited hard balancing." The goal is to constrain China's revisionist agenda in the South China Sea. This strategy entails building up the Philippine military's territorial defence capabilities, maintaining its alliance with the U.S., and forging security partnerships with other middle power like South Korean, Japan, and Australia. During his six-year term, the late President Benigno Aquino III stood up to China's expansive claim in the South China Sea. When Rodrigo Roa Duterte assumed the presidency in June 2016, he unravelled his predecessor's balancing policy towards China. Nonetheless, recent developments such as the People's Liberation Army Navy's hostile moves against the Armed Forces of the Philippines units on Philippine-occupied islands in the South China Sea and the delays in the promised Chinese public investments in the country prompted the Duterte Administration to review the appeasement approach and to mull over on a limited hard balancing policy. In conclusion, this article contends that the Duterte Administration is at the crossroads, figuring out if it will continue its appeasement stance or adopt a limited hard balancing policy towards China. [ABSTRACT FROM AUTHOR]

There is limited information on the feeding practices of 9.42 million children living within institution‐based care (IBC) worldwide. Poor feeding practices can predispose or exacerbate malnutrition, illness and disability. Here we describe the feeding practices of children living within IBC based on a retrospective analysis of records from 3335 children, 0–18 years old, participating in Holt International's Child Nutrition Program (CNP), from 36 sites in six countries. Data analysed included demographic information on age, sex, feeding practices, disabilities and feeding difficulties. Descriptive statistics were produced. A generalised linear model explored associations between feeding difficulties and disability and 2 × 2 tables examined feeding difficulties over time. An additional set of feeding observations with qualitative and quantitative data was analysed. At baseline, the median age of children was 16 months (0.66–68 months) with 1650/3335 (49.5%) females. There were 757/3335 (22.7%) children with disabilities; 550/984 (55.9%) were low birth weight; 311/784 (39.7%) were premature; 447/3113 (14.4%) had low body mass index and 378/3335 (11.3%) had feeding difficulties. The adjusted risk of having a feeding difficulty was 5.08 ([95% confidence interval: 2.65–9.7], p ≤ 0.001) times greater in children with disabilities than those without. Many children saw their feeding difficulties resolve after 1‐year in CNP, 54/163 (33.1%) for children with disabilities and 57/106 (53.8%) for those without disabilities. Suboptimal hygiene, dietary and feeding practices were reported. In conclusion, feeding difficulties were common in IBC, especially among children with disabilities. Supporting safe interactive mealtimes for children living within IBC should be prioritised, to ensure overall health and development. Key points: Feeding difficulties are common among children living in institution‐based care (IBC), particularly but not exclusively among those children with disabilities.Suboptimal feeding practices were common in IBC and encompassed inadequate hygiene, limited support for self‐feeding, reading children's feeding cues (especially around pacing and satiety), addressing feeding difficulties, such as difficulty chewing or swallowing. These should be prioritised in training and supervision for caregivers.Addressing the needs of this vulnerable group should include support for safe feeding techniques. These should be prioritised to help ease the transition into eventual family‐based care if we are to move towards deinstitutionalizing children and strengthening families. [ABSTRACT FROM AUTHOR]

Background: A study conducted in China on patients with coronavirus disease 2019 (COVID-19) showed that cancer conferred a five times increased risk for needing intensive care admission and mortality; No data has yet been collected and published from the Philippines. Thus, the investigators conducted this substudy to determine the association of having a history of cancer with clinical outcomes among patients included in the Philippine CORONA Study. Methodology: Multi-center, retrospective cohort design Results: A total of 244 patients had a history of cancer, out of 10,881 COVID-19 hospital admissions. After adjusting for different confounding variables of interest, having cancer was significantly associated with a 75% increased odds of having severe/critical COVID-19 at nadir (CI 95% 1.32, 2.33; p < 0.001). After adjusting for different confounding variables of interest, having cancer was significantly associated with the following time-to-event outcomes: 72% increase in hazard of in-hospital mortality (CI 95% 1.37, 2.16; p < 0.001), 65% increase in hazard of respiratory failure (CI 95% 1.31, 2.08; p < 0.001), and 57% increase in hazard of being admitted to ICU (CI 95% 1.24, 1.97; p < 0.001). Conclusion: A history of cancer conferred poorer clinical outcomes on adult, hospitalized COVID-19 patients. [ABSTRACT FROM AUTHOR]

The track of tropical cyclones (TCs) formed in the South China Sea (SCS) can be divided into eastward and westward directions. Significant decadal variation during 1980–2020 only exists in the number of eastward‐moving TCs, especially during July–September, with 47% TCs moving eastward during 1994–2004 (Period II), 22% during 1980–1993 (Period I) and only 15% during 2005–2020 (Period III). This decadal change is related to the zonal shift of Western Pacific Subtropical High (WPSH). An eastward‐retreated WPSH during 1994–2004 leads to upward motion and westerly flow anomaly over the northern SCS, and therefore favors TC genesis and eastward motion. The eastward‐retreated WPSH is associated with a warm sea surface temperature anomaly over the tropical western‐central Pacific which induces a cyclonic flow and weakens the WPSH. With the weaker modulation of WPSH, stronger intraseasonal oscillation (ISO) in the SCS during Period II favors eastward‐moving TCs due to the westerly flow associated with the ISO. Plain Language Summary: Tropical cyclones (TCs) formed over the South China Sea (SCS) can move either eastward or westward. Eastward‐moving TCs can make landfall along the eastern coast of China, the Philippines, and Taiwan Island, or entering western North Pacific. Meanwhile, westward‐moving TCs usually make landfall along the coasts of southern China and Vietnam. Our study reveals a significant decadal variation of eastward‐moving TCs. More TCs moved eastward during 1994–2004 due to enhanced westerly and convective activity associated with an eastward‐retreated Western Pacific Subtropical High, which is caused by the Gill‐pattern response to the warm sea surface temperature anomaly over the western‐central Pacific. The other reason for a decadal variation of eastward‐moving TCs over the SCS is the stronger intraseasonal oscillation activity during 1994–2004, which induces the convective activities and westerly flow anomaly over the main TC genesis region. Key Points: The number of eastward‐moving tropical cyclones (TCs) in the South China Sea has experienced a decadal variation since 1980The zonal shift of Western Pacific Subtropical High (WPSH) is the main factor of the decadal variation of eastward‐moving TCsThe eastward‐retreated WPSH together with strong intraseasonal oscillation favors TCs moving eastward during 1994–2004 [ABSTRACT FROM AUTHOR]

Mahayana Buddhism is well known for being successfully implanted in various cultures. Chinese Buddhism, considered one of the three great religions of China along with Confucianism and Taoism, is a classic example. From China, Buddhism traveled further and, in the twentieth century, developed a particular way of engaging the world. Humanistic Buddhism, a particular form of engaged Buddhism that grew out of twentieth-century Chinese Buddhism, has been present in the Philippines since the 1990s and signaled a new phase in the growth of Buddhism in the country. In particular, the Philippine initiators of Foguangshan and Ciji did not limit themselves to the ethnic Chinese community from the outset, and both movements have achieved modest success in the last thirty years. By building on previous research with new inputs from key informants, this article explores the emerging localization of Foguangshan and Ciji in the predominantly Catholic Philippines, identifying the particular ways in which the two groups adapted their missions in the country. [ABSTRACT FROM AUTHOR]

Background: Bacterial blight (BB), caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most devastating bacterial diseases of rice in temperate and tropical regions. Breeding and deployment of resistant cultivars carrying major resistance (R) genes has been the most effective approach for BB management. However, because of specific interaction of each R gene with the product of the corresponding pathogen avirulence or effector gene, new pathogen strains that can overcome the deployed resistance often emerge rapidly. To deal with ever-evolving Xoo, it is necessary to identify novel R genes and resistance quantitative trait loci (QTL). Results: BB resistance of a diverse panel of 340 accessions from the 3000 Rice Genomes Project (3 K RGP) was evaluated by artificial inoculation with four representative Xoo strains, namely Z173 (C4), GD1358 (C5), V from China and PXO339 (P9a) from Philippines. Using the 3 K RG 4.8mio filtered SNP Dataset, a total of 11 QTL associated with BB resistance on chromosomes 4, 5, 11 and 12 were identified through a genome-wide association study (GWAS). Among them, eight resistance loci, which were narrowed down to relatively small genomic intervals, coincided with previously reported QTL or R genes, e.g. xa5, xa25, xa44(t). The other three QTL were putative novel loci associated with BB resistance. Linear regression analysis showed a dependence of BB lesion length on the number of favorable alleles, suggesting that pyramiding QTL using marker-assisted selection would be an effective approach for improving resistance. In addition, the Hap2 allele of LOC_Os11g46250 underlying qC5–11.1 was validated as positively regulating resistance against strain C5. Conclusions: Our findings provide valuable information for the genetic improvement of BB resistance and application of germplasm resources in rice breeding programs. [ABSTRACT FROM AUTHOR]

Pharmaceutical and personal care products (PPCPs) recently defined as emerging pollutants that widespread in surface water all around the world. This study investigated the distribution, and ecological risk of PPCPs in urban rivers of Hanoi, Vietnam, and Metro Manila, the Philippines. Of the 56 investigated PPCPs, 48 and 33 compounds were detected in the river water in Hanoi and in Metro Manila, respectively. The individual PPCP concentrations ranged from a few ng L -1 to thousands of ng L -1 . The total concentration of PPCPs detected in water samples ranged from 7.5 to 20,789 ng L -1 in Hanoi and 118 to 3,394 ng L -1 in Manila. The predominant antibiotics was sulfamethoxazole detected in 27/28 samples with a maximum concentration up to 2,778 ng L -1 in Hanoi and presented in all samples with a maximum concentration up to 261 ng L -1 in Metro Manila. In Hanoi, the level of PPCPs in urban canals of Kim Nguu and To Lich Rivers was as high as that detected in domestic wastewater. The PPCP concentrations in tributaries and mainstream were lower than those found in urban canals. In rivers of both sites, PPCPs tended to increase along the stream. The concentration ratio of the labile marker caffeine to recalcitrant marker carbamazepine indicated that untreated domestic wastewater is the significant source of PPCPs in river water in Hanoi and Metro Manila. The ecological risk estimated by the risk quotient of the obtained maximum residue of PPCPs in investigated river water predicted a high risk of PPCPs to the aquatic organism in both Hanoi and Manila., (© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Coxsackievirus A6 (CVA6) is emerging as the dominant serotype among enteroviruses (EVs) responsible for hand, foot, and mouth disease (HFMD) outbreaks in multiple countries. However, details regarding this serotype in the Philippines are limited. In this study, we investigated the epidemiological and molecular characteristics of laboratory-confirmed CVA6 HFMD cases in the Philippines between 2012 and 2017. Data collected from case report forms submitted to the National Reference Laboratory for Poliovirus and other Enteroviruses were used to determine the distribution and clinical findings of laboratory-confirmed CVA6 HFMD. Phylogenetic analyses of the complete viral protein 1 (VP1) and partial 3D polymerase (3D pol ) gene sequences were performed to determine the genotype and recombinant (RF) form of the selected samples. An increase in the detection rate of CVA6 among enterovirus-positive HFMD cases was observed from 61.9% (140/226) in 2012 to 88.1% (482/587) in 2017, with most cases coming from the Luzon island group. Among the detected cases, the majority were children, with a median age of 2 years old (interquartile range: 1.17-3.40). Respiratory-related morbidities were the commonly reported complications (7.9%; 72/907). Based on the VP1 and 3D pol gene sequence analysis, the CVA6 strains in this study were classified as genotype D3b and RF-A group, respectively. This study elucidated that CVA6 was the most prevalent enterovirus serotype causing HFMD in the Philippines in 2012-2017, with genotype D3b/RF-A circulating within this period. This study highlights the importance of viral surveillance and molecular epidemiological analysis to broaden our understanding of HFMD in the Philippines., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)

This paper investigated the health risks due to metal concentrations in soil and vegetables from the island province in the Philippines and the potential ecological risks. The concentrations of Cd, Cr, Cu, Fe, Mn, Ni, Pb, and Zn in vegetables and soil in six municipalities of the province were analyzed using the Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) Perkin Elmer Optima 8000. It was recorded that all metal concentrations in the soil, except for Cd, exceeded the soil quality standard (SQS). The concentration of Fe and Mn was highest among other metals. The Nemerow synthetical pollution index (P n ) in all soil samples was under Class V which means severe pollution level. Likewise, the risk index (RI) of soil ranged from high to very high pollution risk. Most of the metal concentrations in the vegetables analyzed also exceeded the maximum permissible limit (MPL). All health hazard indices (HHIs) were less than 1, which means potential low non-carcinogenic risk to human population by vegetable consumption. However, it was found that concentration of Cr and Ni in vegetables is a potential health hazard having concentrations exceeding the maximum threshold limit. A 75% temporary consumption reduction of bitter melon, eggplant, sweet potato tops, and string beans produced from two municipalities may be helpful in reducing exposure to target metals. Additional studies are needed to confirm this recommendation. Spatial correlation analysis showed that six out of target metals had datasets that were more spatially clustered than would be expected. The recorded data are useful for creation of research direction, and aid in developing strategies for remediation, tools, and programs for improving environmental and vegetable quality monitoring.