Search

Copyright of Regional Science Policy & Practice is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Although epidemiological data on heart failure (HF) with preserved ejection fraction (HFpEF) are scarce in the Middle East, North Africa and Turkey (MENAT) region, Lancet Global Burden of Disease estimated the prevalence of HF in the MENAT region in 2019 to be 0.78%, versus 0.71% globally. There is also a high incidence of HFpEF risk factors and co‐morbidities in the region, including coronary artery disease, diabetes, obesity, hypertension, anaemia and chronic kidney disease. For instance, 14.5–16.2% of adults in the region reportedly have diabetes, versus 7.0% in Europe. Together with increasing life expectancy, this may contribute towards a higher burden of HFpEF in the region than currently reported. This paper aims to describe the epidemiology and burden of HFpEF in the MENAT region, including unique risk factors and co‐morbidities. It highlights challenges with diagnosing HFpEF, such as the prioritization of HF with reduced ejection fraction (HFrEF), the specific profile of HFpEF patients in the region and barriers to effective management associated with the healthcare system. Guidance is given on the diagnosis, prevention and management of HFpEF, including the emerging role of sodium‐glucose co‐transporter‐2 inhibitors. Given the high burden of HFpEF coupled with the fact that its prevalence is likely to be underestimated, healthcare professionals need to be alert to its signs and symptoms and to manage patients accordingly. Historically, HFpEF treatments have focused on managing co‐morbidities and symptoms, but new agents are now available with proven effects on outcomes in patients with HFpEF. [ABSTRACT FROM AUTHOR]

Even though resilience and sustainability are the two overarching strategic goals of contemporary supply chain management, very few studies have investigated the relationship between resilience and sustainability practices. To increase our theoretical understanding of this important relationship, this paper examines the extent to which supply chain managers perceive tensions and complementarities between both sets of practices. Using a paradox theory lens, the paper conducted in‐depth interviews with 31 supply chain managers in Western Europe and the Middle East that reveal a complex and multifaceted relationship. Namely, our findings indicate that some supply chain managers perceive the relationship as conflictive, others as synergistic, whereas a third group sees them as fundamentally orthogonal to each other. Furthermore, our findings uncover specific perceived complementarities and tension areas. Taken together, in responding to calls for research on the topic, our findings contribute to the advancement of theory regarding supply chain resilience and supply chain sustainability practices and address the need to shed more light on the tensions faced by supply chain managers when implementing distinct sets of supply chain practices. [ABSTRACT FROM AUTHOR]

This paper presents a command‐filter‐based formation control scheme for the leader‐follower omnidirectional mobile robots (OMRs) subject to the absence of the velocity measurements, input saturation and unknown bounded disturbances. First, an adaptive velocity observer is designed based on a novel state transformation of the OMR dynamics. Then, a finite‐time command filtering strategy is proposed, where the Levant filter is used to estimate the time derivative of the virtual control law, and an error compensator with finite time convergence is constructed to eliminate the filtering error correspondingly. Moreover, the anti‐saturation module and adaptive law are designed to attenuate the influence caused by input saturation and external disturbances. The proposed control scheme can ensure that all signals of the closed‐loop system including the formation error are uniformly bounded, and the effectiveness is verified by the simulations results. [ABSTRACT FROM AUTHOR]

This paper investigates the impact of the disruption of the Ottoman Empire on the integration of regional and colonial commodity markets in the Near East. Exploiting a novel dataset on commodity prices in Syria, Egypt, Turkey, France, and the United Kingdom covering the 1787–1939 period, it assesses the extent of price dispersion across markets before and after the end of the Ottoman Empire and investigates the causes behind the change in market integration. The results indicate that, while regional markets disintegrated during 1923–39, reflecting the anti‐global environment of the interwar era, colonial market linkages strengthened. The empirical findings also highlight that border effects, rather the rise of protection per se, were the main drivers behind the increase of regional price dispersion. [ABSTRACT FROM AUTHOR]

The COVID‐19 pandemic presented numerous challenges to acute malnutrition screening and treatment. To enable continued case identification and service delivery while minimising transmission risks, many organisations and governments implemented adaptations to community‐based management of acute malnutrition (CMAM) programmes for children under 5. These included: Family mid‐upper arm circumference (MUAC); modified admission and discharge criteria; modified dosage of therapeutic foods; and reduced frequency of follow‐up visits. This paper presents qualitative findings from a larger mixed methods study to document practitioners' operational experiences and lessons learned from these adaptations. Findings reflect insights from 37 interviews representing 15 organisations in 17 countries, conducted between July 2020 and January 2021. Overall, interviewees indicated that adaptations were mostly well‐accepted by staff, caregivers and communities. Family MUAC filled screening gaps linked to COVID‐19 disruptions; however, challenges included long‐term accuracy of caregiver measurements; implementing an intervention that could increase demand for inconsistent services; and limited guidance to monitor programme quality and impact. Modified admission and discharge criteria and modified dosage streamlined logistics and implementation with positive impacts on staff workload and caregiver understanding of the programme. Reduced frequency of visits enabled social distancing by minimising crowding at facilities and lessened caregivers' need to travel. Concerns remained about how adaptations impacted children's identification for and progress through treatment and programme outcomes. Most respondents anticipated reverting to standard protocols once transmission risks were mitigated. Further evidence, including multi‐year programmatic data analysis and rigorous research, is needed in diverse contexts to understand adaptations' impacts, including how to ensure equity and mitigate unintended consequences. Key messages: COVID‐19 CMAM programme adaptations enabled service continuity despite pandemic‐related challenges. Further evidence is needed on long‐term impacts.Family MUAC was well‐accepted and addressed screening gaps from COVID‐19 disruptions. Challenges included sustaining caregiver measurement accuracy; handling inaccurate self‐referrals to encourage health‐seeking behaviours; and limited programme design and monitoring guidance and tools.Modified admission criteria and therapeutic food dosage reduced contact between staff and children and streamlined logistics and implementation. Concerns remained about effects on programme admissions and outcomes.Reduced frequency of follow‐up visits successfully reduced facility crowding and need for caregiver travel. However, infrequent monitoring of childrenmay miss deterioration. [ABSTRACT FROM AUTHOR]

The ongoing discoveries of natural‐gas reserves in the eastern Mediterranean region significantly affect international relations. Since their viability has been increasingly confirmed, they have attracted public attention in the international energy market. Focusing on current gas production and trading in the Middle East, this paper studies the anticipated impact of gas production in the sea on geopolitical relations in the Middle East and investigates how these results may change the geoeconomic strategies of global energy‐market players as well as nearby countries. In addition, our analyses provide comprehensive insights into the evolution of gas discoveries in the Eastern Mediterranean. [ABSTRACT FROM AUTHOR]

This paper seeks to unpack China's grand energy policy in the Middle East. It examines the proposed Iran‐China deal, to which China's great game in Iran presents new challenges. Beijing sees Iran as a key potential asset in Western Asia. Regional experts argue that, given Iran's extensive natural resources and human capital, as well as a relatively untapped market, the country is seen by the Chinese ruling class as a potentially valuable ally. Uncertainty, pessimism, and a deeply rooted culture of resistance against foreign influence and intervention help explain why skepticism about this deal is so pervasive in Iran. A closer look at Iran's history also illustrates that the country's interests would likely be more effectively served if it diversified its economic and political relations with both the West and the East, thus allowing the government to balance its relationship with those countries while retaining a degree of political independence. [ABSTRACT FROM AUTHOR]

Objectives: There are limited case series reporting the impact on women affected by coronavirus during pregnancy. In women affected by severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), the case fatality rate appears higher in those affected in pregnancy compared with non-pregnant women. We conducted a rapid review to guide health policy and management of women affected by COVID-19 during pregnancy, which was used to develop the Royal College of Obstetricians and Gynaecologists' (RCOG) guidelines on COVID-19 infection in pregnancy.Methods: Searches were conducted in PubMed and MedRxiv to identify primary case reports, case series, observational studies and randomized controlled trials describing women affected by coronavirus in pregnancy. Data were extracted from relevant papers. This review has been used to develop guidelines with representatives of the Royal College of Paediatrics and Child Health (RCPCH) and RCOG who provided expert consensus on areas in which data were lacking.Results: From 9965 search results in PubMed and 600 in MedRxiv, 21 relevant studies, all of which were case reports or case series, were identified. From reports of 32 women to date affected by COVID-19 in pregnancy, delivering 30 babies (one set of twins, three ongoing pregnancies), seven (22%) were asymptomatic and two (6%) were admitted to the intensive care unit (ICU), one of whom remained on extracorporeal membrane oxygenation. No maternal deaths have been reported to date. Delivery was by Cesarean section in 27 cases and by vaginal delivery in two, and 15 (47%) delivered preterm. There was one stillbirth and one neonatal death. In 25 babies, no cases of vertical transmission were reported; 15 were reported as being tested with reverse transcription polymerase chain reaction after delivery. Case fatality rates for SARS and MERS were 15% and 27%, respectively. SARS was associated with miscarriage or intrauterine death in five cases, and fetal growth restriction was noted in two ongoing pregnancies affected by SARS in the third trimester.Conclusions: Serious morbidity occurred in 2/32 women with COVID-19, both of whom required ICU care. Compared with SARS and MERS, COVID-19 appears less lethal, acknowledging the limited number of cases reported to date and that one woman remains in a critical condition. Preterm delivery affected 47% of women hospitalized with COVID-19, which may put considerable pressure on neonatal services if the UK's reasonable worst-case scenario of 80% of the population being affected is realized. Based on this review, RCOG, in consultation with RCPCH, developed guidance for delivery and neonatal care in pregnancies affected by COVID-19, which recommends that delivery mode be determined primarily by obstetric indication and recommends against routine separation of affected mothers and their babies. We hope that this review will be helpful for maternity and neonatal services planning their response to COVID-19. © 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

The oil reservoir of Mishrif Formation is of strong heterogeneity vertically and laterally, and its single‐well production rate after conventional acidizing is low and declines fast. Therefore, we intend to carry out the pilot test on diverting acid fracturing so as to improve the stimulation effect of acid fracturing by enlarging the lateral and vertical stimulation range. In this paper, a series of experimental studies (eg, rock mechanics, acid rheology, acid‐rock reaction kinetics, and full‐diameter core etching diversion) were carried out to deal with the reservoir characteristics and stimulation demand of Mishrif Formation, the principal oil reservoir in Halfaya Oilfield in Iraq, the Middle East. It is shown that calcite content of Mishrif Formation reservoir is higher than 95%, indicating the strong acid dissolution. As for rock mechanics, the characteristics of "low Young's modulus and high Poisson's ratio" are presented, and the stress‐strain curves show certain elastic‐plastic characteristics. Additionally, a large number of wormholes appear on the surface of the full‐diameter cores after acid etching, so it is necessary to consider the serious filtration of acidizing fluid near the wellbore. The mechanical strength of rock plates decreases after acid etching, so it is recommended to adopt and optimize the closed acidizing technology so as to avoid excessive etching. Furthermore, the self‐support flow conductivity of etched fractures is weak, so it is recommended to adopt the sand fracturing or the combined stimulation technology of acid fracturing + sand fracturing to improve the reservoir stimulation effects. [ABSTRACT FROM AUTHOR]

The aerosphere is utilized by billions of birds, moving for different reasons and from short to great distances spanning tens of thousands of kilometres. The aerosphere, however, is also utilized by aviation which leads to increasing conflicts in and around airfields as well as en‐route. Collisions between birds and aircraft cost billions of euros annually and, in some cases, result in the loss of human lives. Simultaneously, aviation has diverse negative impacts on wildlife. During avian migration, due to the sheer numbers of birds in the air, the risk of bird strikes becomes particularly acute for low‐flying aircraft, especially during military training flights. Over the last few decades, air forces across Europe and the Middle East have been developing solutions that integrate ecological research and aviation policy to reduce mutual negative interactions between birds and aircraft. In this paper we 1) provide a brief overview of the systems currently used in military aviation to monitor bird migration movements in the aerosphere, 2) provide a brief overview of the impact of bird strikes on military low‐level operations, and 3) estimate the effectiveness of migration monitoring systems in bird strike avoidance. We compare systems from the Netherlands, Belgium, Germany, Poland and Israel, which are all areas that Palearctic migrants cross twice a year in huge numbers. We show that the en‐route bird strikes have decreased considerably in countries where avoidance systems have been implemented, and that consequently bird strikes are on average 45% less frequent in countries with implemented avoidance systems in place. We conclude by showing the roles of operational weather radar networks, forecast models and international and interdisciplinary collaboration to create safer skies for aviation and birds. [ABSTRACT FROM AUTHOR]

The detrital zircon records significant information in the 'source‐sink' system. With the application of in situ laser ablation technology, a large number of high‐quality detrital zircon data have been published since 2000. In this study, a total of 41,342 detrital zircon U–Pb ages and 6,129 Hf isotopes were compiled from the published literatures of the Middle East (Iranian and Arabian plates). Through data filtering and recalculation, valid data were employed for further analysis. The detrital zircons from the Middle East show a Cambrian–Precambrian age population of 500–1,000 Ma, with a major age peak of ~620 Ma and dispersed εHf(t) values of −35 to +20. The Alborz Mountains and central Iran terrane show a Permo–Triassic age range of 200–300 Ma. The Mesozoic–Cenozoic detrital zircons are mostly occurred in the Zagros orogenic belt and Makran accretionary complex, with three obvious age ranges of 145–180 Ma, 80–110 Ma and 15–65 Ma. The Mesozoic zircons yield positive εHf(t) values, while Cenozoic zircons have varied εHf(t) values. This database allows for the further exploration of the provenance analysis and application in constraining the timing of the major tectonic events in the Middle East, and may also help to explore the affinities of plates, thus guiding future palaeogeographic research efforts. [ABSTRACT FROM AUTHOR]

ABSTRACT The goal of this paper is to empirically assess the level of banking competition in selected Middle East and Northern African (MENA) countries. The analysis employs the estimation of a non-structural indicator (H-statistic) introduced by Panzar and Rosse and draws upon a panel dataset of eight MENA countries (Algeria, Egypt, Israel, Jordan, Morocco, Oman, Saudi Arabia, and United Arab Emirates) over the period 1997-2012. The empirical findings are robust towards three different panel data econometric techniques (Ordinary Least Squares, Pooled Generalized Least Squares with Fixed Effects, and Generalized Method of Moments) and consistent with other similar studies, providing sufficient evidence in favour of a banking monopolistic competition regime. Furthermore, the estimation of three other alternative measures of competition (Lerner index, adjusted Lerner index, and conduct parameter) provides similar results, revealing that the banking sector in the MENA region is characterized by a low level of Significant Market Power (SMP). Overall, the analysis shows that, despite similarities in the process of financial regulatory reforms undertaken in the eight MENA countries, the observed competition levels of banks vary substantially, with Algeria and Morocco consistently outperforming the rest of the region. [ABSTRACT FROM AUTHOR]

Projected trends in population aging have forecasted a massive increase in the number of people with dementia, in particular in sub‐Saharan Africa and the Middle East and North Africa (MENA) region. Cognitive decline is a significant marker for dementia, typically assessed with standardized neuropsychological tools that have been validated in some well‐researched languages such as English. However, with the existing language diversity, current tools cannot cater to speakers of understudied languages, putting these populations at a disadvantage when it comes to access to early and accurate diagnosis of dementia. Here, we shed light on the detrimental impact of this language gap in the context of the MENA region, highlighting inadequate tools and an unacceptable lack of expertise for a MENA population of a half billion people. Our perspective calls for more research to unravel the exact impact of the language gap on the quality of cognitive decline assessment in speakers of understudied languages. Highlights: Cognitive decline is a marker for dementia, assessed with neuropsychological tests.There is a lack of culturally valid tests for speakers of understudied languages.For example, suboptimal cognitive tests are used in the Middle East and North Africa region.Linguistic diversity should be considered in the development of cognitive tests. [ABSTRACT FROM AUTHOR]

Background: The Composite International Diagnostic Interview (CIDI) has been clinically reappraised in several studies conducted mainly in the US and Europe. This report describes the methodology used to conduct one of the Middle East's largest clinical reappraisal studies. The study was carried out in conjunction with the World Mental Health Qatar—the first national psychiatric epidemiological study of common mental disorders in the country. This study aimed to evaluate the diagnostic consistency of core modules of the newly translated and adapted Arabic version of the CIDI 5.0 against the independent clinical diagnoses based on the Structured Clinical Interview for DSM‐5 (SCID‐5). Methods: Telephone follow‐up interviews were administered by trained clinicians using the latest research edition of the SCID for DSM‐5. Telephone administered interviews were key in the data collection, as the study took place during the COVID‐19 pandemic. Results: Overall, within 12 months, 485 interviews were completed. The response rate was 52%. Quality control monitoring documented excellent adherence of clinical interviews to the rating protocol. Conclusions: The overall methods used in this study proved to be efficient and effective. For future research, instrument cultural adaptation within the cultural context is highly recommended. [ABSTRACT FROM AUTHOR]

North Atlantic Oscillation (NAO) has a significant impact on surrounding winter weather and climate. However, the causes of its occasional reversal between early and late winter remain unclear. This study proposes a mechanism for the mid‐winter reversal of NAO from the perspective of local midlatitude air‐sea interaction. Strong sea surface temperature (SST) tripole events, which are defined by empirical orthogonal function of winter‐mean interannual North Atlantic SST anomalies, are primarily induced by NAO in early winter and peak in January. In late winter, the persistent SST tripole exerts active feedback on atmosphere through diabatic heat and transient eddy forcing. The resulting atmospheric circulation anomalies exhibit an almost reversed NAO pattern in February, which forms a wavetrain originating above the Gulf Stream and propagating to the Middle East and weakens the former SST tripole. Consequently, significant reversals of air temperature anomalies occur in Europe and the Caspian Sea area between February and December. Plain Language Summary: The North Atlantic Oscillation (NAO) is a crucial atmospheric system that significantly impacts the weather and climate of the surrounding regions during winter. However, it often reverses between early and late winter, and the reasons for its mid‐winter reversal remain unclear. The NAO behavior can be influenced by multiple factors, such as atmospheric internal processes, underlying surface, and remote climate system, which makes the issue more complex. This study highlights the role of underlying sea surface temperature anomalies (SSTAs) in the mid‐winter reversal of NAO. The North Atlantic SSTAs are closely associated with the NAO and exhibit a tripole pattern. For strong sea surface temperature (SST) tripole events, the NAO primarily induces the early winter North Atlantic SST tripole. The SSTAs develop in early winter, peak in January, and feedback on the atmospheric circulation in late winter. The atmospheric circulation anomalies exhibit an almost reversed NAO pattern in February, forming a wavetrain that propagates above the Gulf Stream to the Middle East. As a result, during the warm phase of the SST tripole, Europe experiences colder temperatures, and the Caspian Sea experiences warmer temperatures in February than usual, as opposed to the positive NAO's control over warm Europe and cold Caspian Sea in December. Key Points: In early winter, North Atlantic Oscillation (NAO) forces a North Atlantic sea surface temperature (SST) tripole, which persists and tends to induce a nearly reversed NAO pattern in FebruarySST tripole induces a wavetrain over the Gulf Stream to the Middle East via diabatic heating and transient eddy forcing in FebruaryAs a result, there are remarkable reversals of air temperature anomalies in Europe and Caspian Sea area between February and December [ABSTRACT FROM AUTHOR]

Background: Upper respiratory disease was reported over many seasons in Arabian foals on a single stud farm in the Middle East. Affected foals were noted to have mucopurulent nasal discharge, cough, fever and tachypnea. All affected foals had been empirically treated with a macrolide and rifampicin, by the referring veterinarian without improvement. On endoscopic examination, all affected foals had significant guttural pouch empyema (GPE). Objectives: (1) To document a previously unreported presentation of guttural pouch empyema (GPE) in a family of juvenile Arabian foals; (2) To document the cytological and microbial composition of the empyema; (3) To identify clinical signs significantly correlated with the presence of GPE, as predictors for the need for guttural pouch (GP) endoscopy; (4) To demonstrate successful resolution of the identified syndrome with mechanical GP lavage and evidence based antimicrobial use, improving antibiotic stewardship and the one‐health approach to respiratory disease in this demographic of foals. Methods: Evaluation and scoring of clinical signs, upper airway endoscopy and thoracic ultrasound were performed in 14 affected foals and 10 age‐matched controls, followed by comparative tracheal and guttural pouch sputum culture and cytological evaluation. Therapeutic GP lavage was performed and response to therapy monitored. Results: GPE, cranioventrally distributed ultrasonographic lesions and opportunistic pathogen infection suggested a primary lesion of GPE with aspiration of GP discharge into the lungs. GP lavage resolved the empyema and associated clinical signs in all cases. Conclusions: Cytological examination of tracheal and guttural pouch aspirates revealed a neutrophilic exudate with lipid‐laden phagocytes, suggestive of engulfed milk. Bacteriology revealed a high prevalence of Streptococcus equi ssp. zooepidemicus admixed with other opportunistic pathogens. Streptococcus equi ssp. equi was not isolated in any case. [ABSTRACT FROM AUTHOR]

We study the effects of an early introduction of agriculture (Neolithic Transition) on modern agglomeration, using a new dataset on carbon dated organic materials found at archeological sites in Northern Europe. We find a positive effect of early agriculture, in particular within countries, which contrasts with a negative or zero correlation found in studies using older data, covering a larger region that includes both Europe and the Middle East. We argue that this reflects a mix of positive long‐run effects on urban agglomeration, and negative effects on state institutions, which show up to different degrees depending on context. [ABSTRACT FROM AUTHOR]

The article discusses that desperate to improve the standing of the U.S. in the Middle East region, late president of the U.S. Dwight D. Eisenhower sought to recast the U.S. s an unbiased broker of Middle East disputes with the goal of promoting regional stability and containing Soviet expansion. Topics include by focusing on the Cold War threat, the administration is stated to have done more to foment Arab- Israeli unrest than build lasting peace.

Background: Type I interferons (IFNs) are essential antiviral cytokines induced upon respiratory exposure to coronaviruses. Defects in type I IFN signaling can result in severe disease upon exposure to respiratory viral infection and are associated with worse clinical outcomes. Neutralizing autoantibodies (auto‐Abs) to type I IFNs were reported as a risk factor for life‐threatening COVID‐19, but their presence has not been evaluated in patients with severe Middle East respiratory syndrome (MERS). Methods: We evaluated the prevalence of type I IFN auto‐Abs in a cohort of hospitalized patients with MERS who were enrolled in a placebo‐controlled clinical trial for treatment with IFN‐β1b and lopinavir‐ritonavir (MIRACLE trial). Samples were tested for type I IFN auto‐Abs using a multiplex particle‐based assay. Results: Among the 62 enrolled patients, 15 (24.2%) were positive for immunoglobulin G auto‐Abs for at least one subtype of type I IFNs. Auto‐Abs positive patients were not different from auto‐Abs negative patients in age, sex, or comorbidities. However, the majority (93.3%) of patients who were auto‐Abs positive were critically ill and admitted to the ICU at the time of enrollment compared to 66% in the auto‐Abs negative patients. The effect of treatment with IFN‐β1b and lopinavir‐ritonavir did not significantly differ between the two groups. Conclusion: This study demonstrates the presence of type I IFN auto‐Abs in hospitalized patients with MERS. [ABSTRACT FROM AUTHOR]

Aim: To investigate the perception of undergraduate nursing students in different countries in the Middle East about caring. Design: A cross‐sectional, descriptive, comparative design. Methods: A total of 1,582 nursing students from six different countries in the Middle East completed the Caring Dimensions Inventory. Results: The total mean score of caring was 138.8 (± 15.8), indicating a high level of caring. The highest mean score was for nursing students from Egypt (M = 145.37 ± 15.97), whereas the lowest was for nursing students from Palestine (M = 135.36 ± 13.48). The caring perception was more significant for female students than male students, and no significant correlation was found between students' ages and caring scores. Conclusions: The high level of caring among nursing students reflects the involvement of caring behaviour in the nursing curricula, which motivates nursing schools to continue stressing the importance of caring and to enhance this behaviour among their graduates. Patient or Public Contribution: Improving the students' caring competencies as recommended by the study will influence the caregiving quality in the future that will be reflected in nurse–patient caring relationships and raise the patients' and public satisfaction with nursing care. [ABSTRACT FROM AUTHOR]

Increasing population size and economic dependence on the coastal zone, coupled with the growing need for residential, agricultural, industrial, commercial and green space infrastructure, are key drivers of land reclamation. Until now, there has been no comprehensive assessment of the global distribution of land use on reclaimed space at the coast. Here, we analyze Landsat satellite imagery from 2000 to 2020 to quantify the spatial extent, scale, and land use of urban coastal reclamation for 135 cities with populations in excess of 1 million. Findings indicate that 78% (106/135) of these major coastal cities have resorted to reclamation as a source of new ground, contributing a total 253,000 ha of additional land to the Earth's surface in the 21st century, equivalent to an area the size of Luxembourg. Reclamation is especially prominent in East Asia, the Middle East, and Southeast Asia, followed by Western Europe and West Africa. The most common land uses on reclaimed spaces are port extension (>70 cities), followed by residential/commercial (30 cities) and industrial (19 cities). While increased global trade and the rapid urbanization have driven these uses, we argue that a city's prestigious place‐making effort to gain global reputation is emerging as another major driver underlying recent reclamation projects to create tourist and green spaces Meanwhile, the study suggests that 70% of recent reclamation has occurred in areas identified as potentially exposed to extreme sea level rise (SLR) by 2100 and this presents a significant challenge to sustainable development at the coast. Plain Language Summary: Coastal regions face enormous pressure from growing human footprints, especially given the current rates of sea‐level rise. It is now recognized that seawards extension of the land through land reclamation and infrastructure development, at least partly in response to increased vulnerability induced by extreme storm surge events, is also a feature of recent coastal dynamics, especially in the world's coastal megacities Despite its growing global importance and reach worldwide, coastal reclamation is regarded as a local issue. Subsequently, the scale, intensity, and justification are not globally known, rather they are documented through localized case studies. By leveraging advanced satellite and cloud computing technology, this study aims to map the global state of 21st coastal land reclamation and to highlight the risk of such an anthropogenic footprint at the coast in the era of SLR. Key Points: 253,000 ha of additional land to the Earth's coastal surface in the 21st century, equivalent to an area the size of LuxembourgCoastal Reclamation is especially prominent in East Asia, the Middle East, and Southeast Asia, followed by Western Europe and West AfricaWe suggest that 70% of recent reclamation has occurred in areas identified as high risk to extreme SLR by 2100 [ABSTRACT FROM AUTHOR]

Introduction: Cervical cancer is a major cause of mortality and morbidity. We aimed to estimate the association between sociodemographic factors and cervical neoplasia. Material and methods: In this Swedish nationwide open cohort study, 4 120 557 women aged ≥15 years at baseline were included between January 1, 2002 and December 31, 2018. The two outcomes were cervical cancer and carcinoma in situ identified in the Swedish Cancer Register. Sociodemographic factors (age, education level, family income level, region of residency, country of origin) were the main predictors. Incidence rates per 10 000 person‐years were calculated. Cox regression was used to estimate hazard ratios. Sensitivity analyses were conducted, including parity, urogenital infections, alcohol‐ and drug‐use disorders, and chronic obstructive pulmonary disease (used as a proxy for tobacco abuse). Results: In 38.9 million person‐years of follow‐up, 5781 (incidence rate: 1.5, 95% confidence interval [CI] 1.4–1.5) and 62 249 (incidence rate 16.9, 95% CI 15.9–16.1) women were diagnosed with cervical cancer and carcinoma in situ, respectively. Women from Eastern Europe had a hazard ratio of 1.18 (95% CI 1.05–1.33) for cervical cancer compared with Swedish‐born women, while women from non‐Western regions were inversely associated with cervical cancer and carcinoma in situ. Women with a low education level had a hazard ratio of 1.37 (95% CI 1.29–1.45) for cervical cancer compared with women with a high education level. Conclusions: Women from the Middle East and Africa living in Sweden seem to suffer less from cervical neoplasia, whereas women with low education and women from Eastern Europe seem to suffer more from cervical cancer. [ABSTRACT FROM AUTHOR]

The purpose of this study is to explore the impact of ownership concentration on banks' credit risk. The study employs a dynamic panel approach using data from 98 banks listed in the 10 Middle East and North African (MENA) emerging stock markets between 2003 and 2016. To better understand the nature of the relationship between ownership concentration and bank credit risk and how this relationship is shaped by the recent financial crisis, we conducted a pre‐ and postcrisis analysis. Our findings document a positive relationship between ownership concentration and nonperforming loans in the precrisis period, which surprisingly reverses during the postcrisis period. We argue that the reversal of this relationship is driven by changes in controlling shareholders' risk aversion, behavior, and attitude prompted by the financial crisis. Given that central banks are entrusted with forestalling banks' failure, incorporating ownership concentration, as a fundamental determinant of banks' credit risk, is crucial to anticipate future financial calamities. Our findings highlight the gravity of agency problems in emerging MENA markets. Reinforcing firm‐level as well as country‐level governance mechanisms is crucial to restore a sound banking system, enhance markets' integrity, and increase investors' confidence. [ABSTRACT FROM AUTHOR]

Summary: Although some nucleotide binding, leucine‐rich repeat immune receptor (NLR) proteins conferring resistance to specific viruses have been identified in dicot plants, NLR proteins involved in viral resistance have not been described in monocots.We have used map‐based cloning to isolate the CC‐NB‐LRR (CNL) Barley stripe mosaic virus (BSMV) resistance gene barley stripe resistance 1 (BSR1) from Brachypodium distachyon Bd3‐1 inbred line. Stable BSR1 transgenic Brachypodium line Bd21‐3, barley (Golden Promise) and wheat (Kenong 199) plants developed resistance against BSMV ND18 strain. Allelic variation analyses indicated that BSR1 is present in several Brachypodium accessions collected from countries in the Middle East.Protein domain swaps revealed that the intact LRR domain and the C‐terminus of BSR1 are required for resistance. BSR1 interacts with the BSMV ND18 TGB1 protein in planta and shows temperature‐sensitive antiviral resistance. The R390 and T392 residues of TGB1ND (ND18 strain) and the G196 and K197 residues within the BSR1 P‐loop motif are key amino acids required for immune activation.BSR1 is the first cloned virus resistance gene encoding a typical CNL protein in monocots, highlighting the utility of the Brachypodium model for isolation and analysis of agronomically important genes for crop improvement. [ABSTRACT FROM AUTHOR]

Violent struggles in the Middle East and North Africa have led many experts to compare this era to the Thirty Years' War, a set of interlinked and extremely deadly and destructive conflicts in Europe (1618‐48). Like that conflagration four centuries ago, they involve internal uprisings, civil conflicts, proxy wars, foreign intervention, geopolitical struggles, great‐power competition, and the participation of many regional political players. At root, all these conflicts are fights for sovereignty, one of the most important pillars upon which the state is based, the violation of which often leads to the outbreak of war. For this reason, many assert that the time is right to try to solve contemporary problems by forging a new Westphalia treaty. This study analyzes the Thirty Years' War and the groundbreaking treaty that emerged from it, then presents a strategy to preserve state sovereignty and seek peace in the region. [ABSTRACT FROM AUTHOR]

Global interdependence was supposed to herald a new age of peaceful cooperation. America's global leadership in many ways derives from its ability to maintain, augment, and protect mutually advantageous interactions. Yet the United States has also tried to use its dominance in networks of finance, trade, and communications as a tool of coercion. No region has been more affected by such weaponized interdependence (WI) than the Middle East. But WI, enacted through various forms of direct and indirect sanctions and embargoes, has a spotty record of success. WI is typically coupled with military force and usually targeted against isolated and weak opponents. WI has contributed to several of the region's gravest humanitarian crises, including Iraq in the 1990s and Yemen since 2014. This has cost the United States support from regional states and from the proverbial "street." Moreover, targets often find ways to upgrade and deepen their repression as they adapt to network restrictions. The United States must be prudent in selecting targets for WI sanctions, broader in recruiting allies for its WI campaigns, and transparent about the humanitarian costs that WI imposes. [ABSTRACT FROM AUTHOR]

The aim of this study was to identify the epidemiology, aetiology as well as the knowledge, attitudes, and practices relating to burn injuries in Palestine. A mixed‐method approach was used. A survey was distributed to a total of 1500 households selected by randomised approach. The survey was standardised based on World Health Organisation's guidelines for conducting community surveys on injury. Additionally, there were 12 focus group discussions and 10 key informant interviews to collect rich qualitative data. In the West Bank and Gaza, 1.5% of Palestinians had experienced serious burn injuries in the 12 months. The total sample of 1500 yields a margin of error (plus/minus) = 2.5% at a 95% level of confidence and a response distribution (P = 50%) with 3% non‐response rate. Of the 1500 households approached, 184 reported a total of 196 burn injuries, with 87.2% occurring inside the home: 69.4% were females and 39.3% were children. The main source of reported cause of burn was heat and flame (36%), electric current (31.6%), hot liquid (28.6%), and chemicals (2.7%). The most common first aid for burns was pouring water (74.7%). People in rural, refugee, and Bedouin settings had the highest incidence of burns. This study provides the burn prevalence rate, explanatory factors that contribute to the frequency of burns in Palestine. Making burn prevention a higher priority within the national policy is crucial. [ABSTRACT FROM AUTHOR]

XAFS/XRF is a general-purpose absorption spectroscopy beamline at the Synchrotron-light for Experimental Science and Applications in the Middle East (SESAME), Jordan. Herein, its optical layout is presented along with its powerful capabilities in collecting absorption and fluorescence spectra within a wide energy range (4.7-30 keV). The beamline is equipped with a conventional fixed-exit double-crystal monochromator that allows the collection of an X-ray absorption spectrum within a few minutes in step-by-step mode. An on-the-fly scanning mode will be implemented shortly where the acquisition time will be reduced to less than a minute per scan. The full automation of the beamline allows performing successive measurements under different conditions. The different experimental setups and special features available to users are reported. Examples of XRF and XAFS measurements are presented, showing the performance of the beamline under different standard conditions. [ABSTRACT FROM AUTHOR]

Introduction: To date, COVID‐19 has claimed 4.9 million lives. Diabetes has been identified as an independent risk factor of serious outcomes in people with COVID‐19 infection. Whether that holds true across world regions uniformly has not been previously assessed. Methods: This study offers the first umbrella systematic review and meta‐analysis to analyse the collective and geographically stratified mortality, ICU admission, ventilation requirement, illness severity and discharge rate amongst patients with diabetes. Five databases (EMBASE, MEDLINE, CAB Abstracts, PsychInfo and Web of Science) and 3 additional sources (SSRN's eLibrary, Research Square and MedRxiv) were searched from inception to 30 August 2021. Prospective and retrospective cohort studies, reporting the association between diabetes and one or more COVID‐19 hospitalization outcomes, were included. This meta‐analysis was registered on PROSPERO, CRD42021278579. Abbreviated MeSH terms used for search were as follows: (Diabetes) AND (2019 Novel Coronavirus Disease), adapted per database requirements. Exclusion criteria exclusion criteria were as follows: (1) none of the primary or secondary outcomes of meta‐analysis reported, (2) no confirmed COVID‐19 infection (laboratory or clinical) and (3) no unexposed population (solely patients with diabetes included). Quality of the included studies were assessed using the Newcastle‐Ottawa Scale (NOS) whilst quality of evidence by the GRADE framework. Studies that were clinically homogeneous were pooled. Summative data and heterogeneity were generated by the Cochrane platform RevMan (V. 5.4). Results: Overall, 158 observational studies were included, with a total of 270,212 of participants, median age 59 [53–65 IQR] of who 56.5% were male. A total of 22 studies originated from EU, 90 from Far East, 16 from Middle East and 30 from America. Data were synthesized with mixed heterogeneity across outcomes. Pooled results highlighted those patients with diabetes were at a higher risk of COVID‐19‐related mortality, OR 1.87 [95%CI 1.61, 2.17]. ICU admissions increased across all studies for patients with diabetes, OR 1.59 [95%CI 1.15, 2.18], a result that was mainly skewed by Far East‐originating studies, OR 1.94 [95%CI 1.51, 2.49]. Ventilation requirements were also increased amongst patients with diabetes worldwide, OR 1.44 [95%CI 1.20, 1.73] as well as their presentation with severe or critical condition, OR 2.88 [95%CI 2.29, 3.63]. HbA1C levels under <70 mmol and metformin use constituted protective factors in view of COVID‐19 mortality, whilst the inverse was true for concurrent insulin use. Conclusions: Whilst diabetes constitutes a poor prognosticator for various COVID‐19 infection outcomes, variability across world regions is significant and may skew overall trends. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Diabetes is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The local climatic impacts of historical expansion of irrigation are substantial, but the distant impacts are poorly understood, and their governing mechanisms generally have not been rigorously analyzed. Our experiments with an earth‐system model suggest that irrigation in the Middle East and South Asia may enhance rainfall in a large portion of the Sahel‐Sudan Savanna (SSS) to an extent comparable and opposite to its suppression by other anthropogenic climate drivers during the last several decades. The enhancement arises through a reduction in the meridional gradient of moist static energy from the Sahara Desert to the tropical rainforests. An implication of this study is that remote irrigation is a possible factor affecting the risk of drought and famine and, thus, future water security in the SSS region. Plain Language Summary: The impacts of historical expansion of agricultural irrigation on local precipitation are robust and profound, but whether irrigation can change precipitation in remote areas is poorly understood, and governing mechanisms responsible for the remote links generally have not been rigorously analyzed. Our numerical experiments with an earth‐system model suggest that irrigation in the Middle East and South Asia may enhance rainfall in a large portion of the Sahel‐Sudan Savanna (SSS). The magnitude of the enhancement is comparable to the suppression of precipitation induced by other anthropogenic climate drivers such as greenhouse emissions. The enhancement arises through a change in the large‐scale patterns of atmospheric moisture and temperature from the Sahara Desert to the tropical rainforests. Growth of remote irrigation should be considered as a possible factor affecting the risk of drought and famine in the SSS such as that experienced in the 1970s–1980s. Future regional water security in the SSS could be affected by distant water management‐groundwater depletion in South Asia and the pace of rehabilitation of war‐damaged irrigation infrastructure in the Tigris‐Euphrates valley. Key Points: Irrigation in the Middle East and South Asia may considerably enhance rainfall in the Sahel‐Sudan Savanna (SSS)The enhancement of precipitation arises through a reduction in the gradient of moist static energy from the Sahara to the tropicsThe risk and severity of drought in the SSS may be reduced by remote irrigation [ABSTRACT FROM AUTHOR]

Cystic fibrosis is the most common life‐limiting autosomal recessive disease in western countries with an incidence of 1:2500 in United States and 1:1000 in some European countries. Similar incidences were noted for the Middle East with variations from 1 in 2560 to 1 in 15,876 according to the degree of consanguinity. This is a preliminary systematic study that aims to assess the incidence and carrier rate of cystic fibrosis in the Middle Eastern Lebanese population; known for a high frequency of consanguinity. One hundred thirteen DNA samples were collected from neonatal blood cards obtained from newborns to healthy unrelated families with no previous history of Cystic fibrosis. Screening for Cystic Fibrosis‐causing pathogenic variants was performed using next generation sequencing, and 17 different single nucleotide variants were detected, including six pathogenic and likely pathogenic. 5.5%–7% newborns were found to be carriers of a variant strongly suggestive of pathogenicity and comparable to published literature worldwide. This pilot analysis highlights the challenging interpretation of CFTR variants in a country underrepresented by large ethnic population analyses, and stresses the importance of premarital screening programs for Cystic fibrosis. [ABSTRACT FROM AUTHOR]

This article analyzes the logic of recent instability and disorder in the Middle East. It offers two interrelated arguments. First, the region has turned into a battle zone in the aftermath of US retrenchment. The United States and other external powers refrained from direct engagement in shaping Middle Eastern order and, therefore, aspirant regional powers were prompted to redesign that order. Second, what makes instability and disorder a geopolitical feature of the Middle East is the "regional‐supremacy trap," the seduction of a power vacuum and a desire for regional hegemony, a trap that draws all influential actors into a series of endless and cumulative conflicts. According to our findings, there is a meaningful relationship between the instability and the regional power struggle for supremacy in the post‐American Middle East. As there is no sign of cooperative mechanisms for shaping the regional order by the major Middle Eastern actors, the syndrome of disorder will continue for the foreseeable future. [ABSTRACT FROM AUTHOR]

For many years, there has been discussion of the idea of creating an inclusive regional cooperation and security system in the Middle East. This discussion is gathering increased interest today as several events and trends have focused attention on the rapid changes in the region and how they may be dealt with. These include profound socioeconomic and political pressures in the region; the violent breakdown of governing authority in places like Syria and Yemen; the Iran nuclear issue; perceptions that the regional roles of major external powers, most notably the United States and China, may be changing; and the evolving relationship between Israel and certain Arab countries. This article outlines the ideas and concepts that arose from a multi‐year series of studies on this issue by regional experts as to how such a system might be established and what its key provisions and structures might be. The article describes and proposes a model of an inclusive, multi‐tiered regional process that will encourage regional dialogue on key social, economic, security, and political issues. [ABSTRACT FROM AUTHOR]

Nuclear energy, the new frontier of China's cooperation with the Middle East, carries both geoeconomic and geopolitical implications. The development of civil nuclear energy is conducive to the diversification of the energy structure of Middle Eastern countries, meets their increasing needs for electricity at home, and improves their seawater desalinization. Giving full play to its incremental advantage, China's diplomacy strives to expand the market share of its nuclear‐power enterprises in the Middle East, elevate its image as a rising nuclear‐energy power, and advance nuclear‐energy cooperation between China and Saudi Arabia, the UAE, Iran, Algeria, Turkey, Egypt, Jordan, and Sudan through multilateral or bilateral mechanisms. These can be classified into three categories: in‐depth cooperation, active participation, and preliminary exploration. Nuclear‐energy diplomacy aims to expand political influence through civil nuclear activity. Its aim is to enrich the toolkit of China's Middle East diplomacy and is conducive to a multipolar world in terms of civil nuclear research, development, and industries. [ABSTRACT FROM AUTHOR]

This article analyzes the underlying human insecurities and changing geopolitical alliances in the Middle East during the past decade to assess the most likely short‐ and medium‐term impacts of Covid‐19 on the global security environment. In particular, it focuses on the "pre‐existing conditions" for instability in the Middle East, and the opportunity that the pandemic might have to exacerbate them. The region will likely face a growing regional‐security dilemma compounded by challenges that are now too familiar: the further entrenchment of political authoritarianism, violent sectarian conflicts, regional rivalries, and the radicalization and recruitment efforts by terrorist and extremist groups. While the pandemic has not led to a significant rise in terrorism and extremist violence, it has worsened fragility and accelerated economic decline. This has increased political instability, which, in turn, makes violence more likely. The civil wars in Syria and Yemen, continued threats from Salafi‐Jihadi extremism, massive displacement, sectarianism, and rising inequalities between the rich and the extremely poor are to blame for such fragility. Given the lack of economic resilience and the significant fragility of many Arab states, as well as the availability of advanced military technology in the region, the resulting political, socioeconomic, humanitarian, and security challenges could be devastating. [ABSTRACT FROM AUTHOR]

To date, there has been no genomewide association study (GWAS) from the Middle East and North African (MENA) region to identify genetic variants associated with warfarin dose variability using this approach. In this study, we aimed to conduct the first GWAS of warfarin dose requirements in patients from the MENA region. A total of 132 Qatari (discovery) and 50 Egyptians (replication) were genotyped using Illumina Multi‐Ethnic Global BeadChip Array. A GWAS was performed on log‐transformed weekly warfarin dose in the studied population, adjusting for clinical characteristics and ancestry. The genomewide signals from the discovery cohort were tested in the Egyptian cohort. A GWAS meta‐analysis, including the Qatari and Egyptian cohorts, was also performed and the output from this analysis was used in a gene‐based analysis. The discovery analysis in Qatari identified five genomewide single‐nucleotide polymorphisms (SNPs) in chromosome 16. These signals were replicated in the Egyptian cohort. Combining the two data through a GWAS meta‐analysis strengthened the association in chromosome 16 with VKORC1 rs9934438 being the lead genomewide signal (β = −0.17, 6 × 10−15). Other SNPs were identified in chromosome 10 at a p value less than 1 × 10−5. The genetic variants within VKORC1 rs9934438 and CYP2C9 rs4086116 explained 39% and 27% of the variability in the weekly warfarin dose requirement in the Qatari and Egyptians, respectively. This is the first GWAS of warfarin dose variability in the MENA region. It confirms the importance of VKORC1 and CYP2C9 variants in warfarin dose variability among patients from the MENA region. [ABSTRACT FROM AUTHOR]

Camel milk has been considered as an important source of nutrients and is commercialized in many countries of the world including the Middle East. This study aimed to investigate the presence of mycotoxins in camel feed and milk samples in comparison with the cow milk. Fumonisins (FUM), ochratoxin A (OTA), and zearalenone (ZEN) were detected in 14%, 39%, and 39% of the tested camel feed samples, respectively. Among the tested camel feed samples, 8.3% and 5.6% were co‐contaminated with OTA+FUM and FUM+ZEN, respectively. In the case of milk samples, 46.15% of camel and 63.63% of cow were found contaminated with aflatoxin M1 (AFM1). In total, 16.2% and 8.1% of the milk samples were simultaneously contaminated with two and three mycotoxins, respectively. Although the levels of individual mycotoxins in the camel feed and milk samples were within the European Union (EU) permissible limits, their co‐occurrence may pose severe risk to human and animal health due to possible additive and/or synergistic toxicities. [ABSTRACT FROM AUTHOR]

The importance of the effects of anthropogenic activities on modulating the global dust cycle has been increasingly recognized. Over the Middle East, we find in observations that there has been a significant decrease in dust optical depth from 2007 to 2019 during which global irrigated areas especially in the Middle East and South Asia have rapidly expanded. Whether irrigation expansion contributes to the decrease of dust in the Middle East is investigated based on observations/reanalyses and global climate model simulations with and without irrigation. Results show that irrigation over the northeast Middle East and Pakistan supplements water to the soil. By increasing local evaporation and moisture advection, irrigation enhances precipitation over the whole Middle East and the northwest Indian subcontinent. As a result, dust wet deposition by precipitation is elevated. Owing to irrigation‐induced land surface cooling, surface wind speed decreases as the planetary boundary layer becomes stable. Along with increased soil moisture, reduced surface wind speed suppresses local dust emissions. Enhanced dust wet deposition and suppressed dust emissions cause atmospheric dust reduction over the Middle East. Vegetation greening in the Middle East as the climate warms has no contribution because there is no obvious trend found in observations. Plain Language Summary: Atmospheric dust absorbs and reflects solar and terrestrial radiation, and alters cloud lifetime and cloud albedo, which affects the earth's radiative budget and the hydrologic cycle. As one of the major dust source regions over the globe, dust emissions over the Middle East from wind erosion have a large contribution to the global dust loading. Anthropogenic land cover changes (e.g., deforestation) directly perturb the underlying land surface, thus affecting dust emissions and transport. However, the impacts of anthropogenic land use such as irrigation on dust are unclear. During recent decades, it is observed that dust optical depth is decreasing over the Middle East, simultaneously with an increase of irrigated areas over the Middle East and South Asia. Whether there is a linkage between them is explored in this study. By analyzing observations/reanalyses and global climate model simulations with and without irrigation, irrigation expansion over the northeast Middle East and Pakistan does reduce dust burden over the Middle East by increasing dust wet removal and decreasing dust emissions. The altered dust processes result from increased precipitation, soil moisture, and decreased surface wind speed by irrigation. Key Points: A decreasing trend of dust over the Middle East from 2007 to 2019 is found in observationsObserved significant decreasing dust in the Middle East can be partly attributed to irrigation expansionEnhanced dust wet deposition and suppressed dust emissions by irrigation are responsible for atmospheric dust reduction [ABSTRACT FROM AUTHOR]

SESAME (Synchrotron‐light for Experimental Science and Applications in the Middle East) is the only synchrotron light facility in the Middle East and neighboring regions, officially opened in 2017. Among the identification and construction of the first operational beamlines, infrared spectromicroscopy was selected as one of the two beamlines to be opened to the general users' program (the so‐called Day‐1 beamlines). Being one of the most demanded techniques by various scientific communities in the Middle East, the beamline has been designed and implemented in the framework of a collaboration agreement with the French synchrotron facility, SOLEIL. The design, construction and initial performances of the IR beamline (D02‐IR), nowadays operational, are reported. [ABSTRACT FROM AUTHOR]

Aim: In the Mediterranean biodiversity hotspot, freshwater fishes are key biogeographic indicators, while their habitats are vulnerable to ongoing anthropogenic pressures. The freshwater blenny is a widespread endemic taxon in this area. However, our understanding of the overall diversity of specific populations and their phylogenetic relationships is sparse. Thus, we aim to investigate the genetic diversity, infer relationships among sampled populations related to major palaeoenvironmental changes and suggest insights for future research and conservation targets. Location: Mediterranean Basin Methods: We studied 171 Salaria specimens from 51 rivers and lakes, and from 13 countries surrounding the Mediterranean Sea. For assessing the phylogenetic relationships among different locations, we used mtDNA d‐loop and intron S7 sequences. Furthermore, we inferred absolute divergence times and demographic changes using secondary calibrations and investigated the diversity within major lineages using haplotype networks and several geographical and genetic clustering methods. Results: We found eight well‐differentiated lineages, each of which being confined to a particular geographical region. The onset of the freshwater blenny radiation was dated around the Messinian salinity crisis. Further differentiation happened during the Plio‐ and Pleistocene with signatures of population expansion after the Last Glacial Maximum in some of the main lineages. Main conclusions: Due to their unusually widespread distribution, the freshwater blennies represent an excellent model for studying phylogeographic structure across the Mediterranean basin biodiversity hotspot. The extant diversity and distribution of the freshwater Salaria species mirrors palaeoenvironmental changes in the region, but there are still large gaps in knowledge, particularly in the Levant. Even though the main lineages described are statistically well supported, the phylogenetic relationship among several of them remains poorly resolved. Despite the fact that the most widespread species, S. fluviatilis, is not globally threatened, it harbours some distinct populations that are of conservation concern. [ABSTRACT FROM AUTHOR]

Equilibrium models (EMs) are frequently employed to examine the potential impacts of economic, energy, and trade policies as well as form the foundation of most integrated assessment models. Despite their central role coupling economic and environmental systems, environmental scientists are largely unfamiliar with the structure and methodology underpinning EMs, which serves as a barrier to interdisciplinary collaboration and model improvement. In this study we systematically extract data from 10 years of published EMs with a focus on how these models have been extended beyond their economic origins to encompass environmentally relevant sectors of interest. The results indicate that there is far greater spatial coverage of high income countries compared to low income countries, with notable gaps in Central America, Africa, the Middle East, and Central Asia. We also find a high degree of aggregation within production inputs and sectoral outputs, particularly within the context of global socioeconomic scenarios. For example, we were unable to identify a single temporally dynamic study that distinguished between products arising from managed versus natural forest, or pastures relative to natural grasslands. Due to the necessary breadth and associated knowledge gaps within a model of the entire global economy, we see considerable potential for cross‐disciplinary innovation as natural scientists gain familiarity into the role these models play in bridging the nexus between socioeconomic systems and environmental change. Plain Language Summary: This analysis of studies using equilibrium models provides an introduction to how they have been employed across a wide range of disciplines with an emphasis on their application within environmental analyses. We find that many model components are represented in a highly aggregated form, hampering their usefulness in policy‐making. This problem is particularly acute in low income geographic areas as well as within key production inputs. Key Points: Heterogeneity in ecologically consequential production inputs are rarely represented in temporally dynamic studiesSpatial aggregation disproportionately affects low income countries, notably Central America, Africa, the Middle East, and Central AsiaKey socioeconomic drivers within global socioeconomic scenarios have largely not been implemented within equilibrium studies [ABSTRACT FROM AUTHOR]

Zoonotic diseases cause repeated outbreaks in humans globally. The majority of emerging infections in humans are zoonotic. COVID‐19 is an ideal example of a recently identified emerging zoonotic disease, causing a global pandemic. Anthropogenic factors such as modernisation of agriculture and livestock farming, wildlife hunting, the destruction of wild animal habitats, mixing wild and domestic animals, wildlife trading, changing food habits and urbanisation could drive the emergence of zoonotic diseases in humans. Since 2001, Bangladesh has been reporting many emerging zoonotic disease outbreaks such as nipah, highly pathogenic avian influenza, pandemic H1N1, and COVID‐19. There are many other potential zoonotic pathogens such as Ebola, Middle East respiratory syndrome coronavirus, Kyasanur forest disease virus and Crimean–Congo haemorrhagic fever that may emerge in the future. However, we have a limited understanding of zoonotic diseases' overall risk in humans and associated factors that drive the emergence of zoonotic pathogens. This narrative review summarised the major emerging, re‐emerging, neglected and other potential zoonotic diseases in Bangladesh and their associated risk factors. Nipah virus and Bacillus anthracis caused repeated outbreaks in humans. More than 300 human cases with Nipah virus infection were reported since the first outbreak in 2001. The highly pathogenic avian influenza virus (H5N1) caused more than 550 outbreaks in poultry, and eight human cases were reported so far since 2007. People of Bangladesh are frequently exposed to zoonotic pathogens due to close interaction with domestic and peri‐domestic animals. The rapidly changing intensified animal–human–ecosystem interfaces and risky practices increase the risk of zoonotic disease transmission. The narrative review's findings are useful to draw attention to the risk and emergence of zoonotic diseases to public health policymakers in Bangladesh and the application of one‐health approach to address this public health threat. [ABSTRACT FROM AUTHOR]

Background: Fanconi anemia (FA) is an inherited bone marrow failure syndrome associated with characteristic dysmorphology primarily caused by biallelic pathogenic germline variants in any of 22 different DNA repair genes. There are limited data on the specific molecular causes of FA in different ethnic groups. Methods: We performed exome sequencing and copy number variant analyses on 19 patients with FA from 17 families undergoing hematopoietic cell transplantation evaluation in Pakistan. The scientific literature was reviewed, and we curated germline variants reported in patients with FA from South Asia and the Middle East. Results: The genetic causes of FA were identified in 14 of the 17 families: seven FANCA, two FANCC, one FANCF, two FANCG, and two FANCL. Homozygous and compound heterozygous variants were present in 12 and two families, respectively. Nine families carried variants previously reported as pathogenic, including two families with the South Asian FANCL founder variant. We also identified five novel likely deleterious variants in FANCA, FANCF, and FANCG in affected patients. Conclusions: Our study supports the importance of determining the genomic landscape of FA in diverse populations, in order to improve understanding of FA etiology and assist in the counseling of families. [ABSTRACT FROM AUTHOR]

Invasive mosquitoes are expanding their ranges into new geographic areas and interacting with resident mosquito species. Understanding how novel interactions can affect mosquito population dynamics is necessary to predict transmission risk at invasion fronts. Mosquito life‐history traits are extremely sensitive to temperature, and this can lead to temperature‐dependent competition between competing invasive mosquito species. We explored temperature‐dependent competition between Aedes aegypti and Anopheles stephensi, two invasive mosquito species whose distributions overlap in India, the Middle East, and North Africa, where An. stephensi is currently expanding into the endemic range of Ae. aegypti. We followed mosquito cohorts raised at different intraspecific and interspecific densities across five temperatures (16–32°C) to measure traits relevant for population growth and to estimate species' per capita growth rates. We then used these growth rates to derive each species' competitive ability at each temperature. We find strong evidence for asymmetric competition at all temperatures, with Ae. aegypti emerging as the dominant competitor. This was primarily because of differences in larval survival and development times across all temperatures that resulted in a higher estimated intrinsic growth rate and competitive tolerance estimate for Ae. aegypti compared to An. stephensi. The spread of An. stephensi into the African continent could lead to urban transmission of malaria, an otherwise rural disease, increasing the human population at risk and complicating malaria elimination efforts. Competition has resulted in habitat segregation of other invasive mosquito species, and our results suggest that it may play a role in determining the distribution of An. stephensi across its invasive range. [ABSTRACT FROM AUTHOR]

Predator-prey interactions are amongst the strongest selective forces that promote the evolution of local phenotypes in both predators and prey. However, intraspecific spatial covariation in phenotypic traits between predators and prey has been rarely investigated, especially at a large geographic scale. Here, we studied the covariation between prey composition and some phenotypic traits, such as wing length, bill length and plumage colour, of a widely-distributed nocturnal predator, the western barn owl Tyto alba. By using 3100 specimens collected across its entire range of distribution, spanning from Europe to Middle East and Africa, we showed that wing length positively covaries with prey size, but not with taxonomic composition. This finding suggests that larger prey might have selected for larger body size and/or that larger individuals might be more selective in hunting large prey. In addition, we also found that paler-plumaged populations generally hunt larger prey. Paler barn owls might be thus better specialized in capturing averagely larger prey and/or mainly hunt in habitats where larger prey are more abundant. In addition, considering that paler individuals are generally larger than brownish ones, it is possible that paler plumage colour might have evolved as a by-product of selection towards a large body size, which in turn have emerged in response to prey size composition. However, irrespectively of the direction of causality and the phenotypic target of selection, we showed that predator-prey interactions can affect spatial phenotypic variation by promoting the evolution of local adaptations. [ABSTRACT FROM AUTHOR]

Water shortages are a global problem; the world is moving fast toward a fresh‐water crisis. Water resources are unevenly and irregularly distributed, and the Middle East is one of the driest regions in the world. Three‐quarters of its land mass is arid, and most water resources originate outside the region. Continuing current practices will plunge the region deeper into crisis, creating conditions where conflicts and wars over scarce resources at local or national levels become inevitable. [ABSTRACT FROM AUTHOR]

Great‐power competition has once again assumed primacy in the international arena. Facing a rising China and a resurgent Russia, the United States formally reoriented its National Security Strategy in 2017 to place more emphasis on the return of great‐power politics and global multipolarity. With the resumption of such competition, the Middle East has rightfully been noted as a regional theater where Russia and China have sought to exploit US policy blunders and retrenchment (real or perceived) to push for increased regional multipolarity. Although the Middle East has been recognized as a prime theater for great‐power competition, the approaches adopted by most existing studies are primarily one‐sided: they examine great‐power competition in the region from the outside, stressing how global powers are manipulating affairs in the Middle East in order to advance their own interests. Often missing from this conversation is how external engagement in the Middle East is being exploited and shaped by regional powers and endogenous developments. This study seeks to fill this gap by using the conceptual lens of omnialignment to examine how regional powers are manipulating the return of great‐power competition to advance their own strategic imperatives, both at home and abroad. [ABSTRACT FROM AUTHOR]

The continuing economic stagnation of the Middle East and North Africa (MENA) has typically been explained in terms of the resource‐curse thesis. Yet, without analyzing the geographical constraints of MENA and the institutions of the region, particularly ones that pertain to land and property rights, this explanation is partial at best. Specifically addressing the structural constraints on using land for economic transformation, we offer a new explanation for the underdevelopment of MENA. We show that transformation in agriculture is inhibited by fuzzy property rights in land that were inherited from colonial and post‐colonial agricultural policies. Political‐economic transformation in MENA could unleash the power of land in the region. [ABSTRACT FROM AUTHOR]