1. Fate and transformation of silver nanoparticles in different biological conditions
- Author
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Marija Ćurlin, Rinea Barbir, Darija Jurašin, Valerije Vrček, Jesús M. de la Fuente, Raluca M. Fratila, Ivana Vinković Vrček, Barbara Pem, Vedran Micek, European Commission, European Cooperation in Science and Technology, Croatian Science Foundation, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Diputación General de Aragón, and Ministerio de Economía y Competitividad (España)
- Subjects
Technology ,nanoparticle reformation ,silver nanoparticles ,Research groups ,Science ,QC1-999 ,General Physics and Astronomy ,TP1-1185 ,02 engineering and technology ,Pharmacy ,010402 general chemistry ,01 natural sciences ,Silver nanoparticle ,Full Research Paper ,Animal tissue ,Nanoparticle aggregation ,animal tissue ,Biological media ,Biotransformation ,In vivo ,Nanotechnology ,nanoparticle aggregation ,General Materials Science ,Electrical and Electronic Engineering ,Dissolution ,biological media ,nanoparticle dissolution ,Chemistry ,Chemical technology ,Physics ,Nanoparticle dissolution ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Nanoparticle reformation ,Transformation (genetics) ,Nanoscience ,Biophysics ,Silver nanoparticles ,0210 nano-technology ,Inorganic nanoparticles - Abstract
The exploitation of silver nanoparticles (AgNPs) in biomedicine represents more than one third of their overall application. Despite their wide use and significant amount of scientific data on their effects on biological systems, detailed insight into their in vivo fate is still lacking. This study aimed to elucidate the biotransformation patterns of AgNPs following oral administration. Colloidal stability, biochemical transformation, dissolution, and degradation behaviour of different types of AgNPs were evaluated in systems modelled to represent biological environments relevant for oral administration, as well as in cell culture media and tissue compartments obtained from animal models. A multimethod approach was employed by implementing light scattering (dynamic and electrophoretic) techniques, spectroscopy (UV–vis, atomic absorption, nuclear magnetic resonance) and transmission electron microscopy. The obtained results demonstrated that AgNPs may transform very quickly during their journey through different biological conditions. They are able to degrade to an ionic form and again reconstruct to a nanoparticulate form, depending on the biological environment determined by specific body compartments. As suggested for other inorganic nanoparticles by other research groups, AgNPs fail to preserve their specific integrity in in vivo settings., This study was based upon a collaborative work from COST Action CA 17140 "Cancer Nanomedicine from the Bench to the Bedside" supported by COST (European Cooperation in Science and Technology). It was financially supported by the Croatian Science Foundation (grant number HRZZ-IP-2016-06-2436), the Ministerio de Ciencia e Innovacion and Fondo Social Europeo/Agencia Estatal de Investigación (Spain, grant BIO2017-84246-C2-1-R and Ramón y Cajal subprogram, grant RYC-2015-17640), Fondo Social de la DGA (grupos DGA).
- Published
- 2021