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Copyright of Atomic Energy Science & Technology is the property of Editorial Board of Atomic Energy Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and its high morbidity, high mortality rate, and low survival rate are the basic features of the epidemiology of HCC in China. It has been found that phospholipase A2 (PLA2) is involved in the complex processes of phospholipid digestion and metabolism, immune defense and signaling, and actively participates in the inflammatory response of liver tissue, hepatocyte survival, proliferation and apoptosis, and the process of hepatocellular carcinogenesis and development. This paper introduces the role of PLA2 in the development of HCC and points out that PLA2 can be used as a new idea and drug target for drug development and clinical control of HCC. [ABSTRACT FROM AUTHOR]

China has a huge output of vegetables and fruits, and processed vegetable and fruit residue is rich in nutrients, rich in crude protein, crude fiber, vitamins, polyphenols, polysaccharides, flavonoids and other components, but it is not easy to preserve and has poor palatability, so it can not be directly used as animal feed. Screening of high-quality yeast and other probiotics can improve the nutritional value of vegetable and fruit residue feed and reduce feed cost, which has a positive effect on fruit and vegetable processing industry and livestock and poultry breeding industry. The paper reviewed the yeast species screening, fermentation technology and application of fermented vegetable and fruit residue in animal feed, aiming to provide reference for the research and application of fermented vegetable and fruit residue in livestock and poultry breeding. [ABSTRACT FROM AUTHOR]

Crop straw resources are abundant in China, but the low nutritional value, poor palatability and other problems limit its application in feed. Microbial fermentation provides an effective way to reduce the cost and increase the efficiency of straw utilization. Saccharomyces cerevisiae, as the core component of fermentation compound, plays an important role in improving protein content, optimizing amino acid composition, improving palatability and increasing utilization rate of fermented feed. In the paper, the development of enabling feed saccharomyces cerevisiae, the effect of Saccharomyces cerevisiae on the quality of straw fermented feed and its application in ruminants were summarized, in order to provide reference for further research and application of straw fermented feed. [ABSTRACT FROM AUTHOR]

Based on the design practice of the interchange between Shenzhen-Zhongshan Link and the airport — the first large underground interchange in the sea in China, the paper investigates the key design technologies in view of the project characteristics, such as the interchange hub selection, bridge and tunnel conversion, construction operation, operation guarantee, complex hydrogeology and surrounding constraints. The results show that: 1) A large underground interchange in the sea is adopted to effectively solve the traffic conversion demand of airport hub under complex conditions. 2) The scheme of a "one body with two wings" artificial island and double-row steel sheet pile short cofferdam is adopted, which effectively solve the conversion of large underground interchange with the tube tunnel, construction on land and the operational support needs. 3)A supporting structure of impact-cone cast-in-place pile + pilot-hole with clay replacement and high-pressure jet grouted pile is adopted, which effectively solve the construction of foundation pit in complex marine silt with riprapped rock and sand fill and water-stopping problem. 4) A locking steel pipe pile integrated enclosure scheme is adopted, which provides effective protection for the highway bridge piers during the construction of the artificial island and the excavation of the foundation pit. 5)A double exhaust shaft scheme is adopted, which effectively solve the problem of building of longitudinal through exhaust ducts in ramp tunnels in complex marine environment. [ABSTRACT FROM AUTHOR]

China’s marine environment has enormous volumes of oil and gas (O＆G) resources and immense “blue carbon” potential. In the 14th Five-Year Plan, developing the marine economy, using marine resources, and protecting the marine ecological environment are one of China’s important socioeconomic development goals. However, the relationship between the exploitation of offshore O＆G resources, the protection of the marine ecosystem, and the goal of carbon peak and carbon neutrality has not been fully elucidated. This study expounds on the importance and vulnerability of marine ecosystems. Then it combines the status of offshore O＆G exploration and exploitation to present a conceptual model of offshore O＆G-ecology carbon feedback cycle, the pathway of deep connection, and the necessity of synergic development in carbon neutrality process. This paper advocates strategies such as closer combination of marine protection with offshore O＆G design and development, evaluating the carbon budget in the regional ecological assessment and developing low-carbon green oilfield materials to improve the sustainable development and utilization scheme of marine resources. This study aims to provide scientific and theoretical support for relevant institutions and promote in-depth collaboration across marine departments. [ABSTRACT FROM AUTHOR]

Land is the spatial carrier and basic condition for guaranteeing regional development, and its regulation effects tend to affect the direction of long-term development and innovation potential of cities. This paper constructed an evaluation index system of land regulation in line with China' s national conditions from the perspective of the land system with Chinese characteristics. In addition, based on panel data for 280 prefecture-level cities in China from 2008 to 2019, this study used the spatial Durbin model and parallel multiple mediation model to empirically estimate the effects and mechanisms of land regulation and its spatial strategy interaction on city innovation. The results showed that: ① The impact of land regulation on city innovation was dynamic and multiplied. In terms of direct effects, land regulation and city innovation presented a typical U-shaped curve relationship with an inflection point of 4.833. Specifically, low-level land regulation significantly reduced city innovation, while high-level land regulation that exceeded the threshold could promote city innovation. ② Due to the strategic interactions of local governments, the impact of land regulation on city innovation had a significant spatial spillover effect. The relationship between adjacent urban land regulation and local city innovation followed a similar U-shaped curve to the direct effect. ③ In terms of indirect effects, the relationship between land regulation and local industrial structure showed an inverted U-shaped curve with an inflection point of 6.214. The spatial spillover effect of land regulation on industrial structures in neighboring cities had the same inverted U-shaped trend. During the study period, the level of land regulation in China had not reached the threshold, and the imbalance of the industrial structure inhibited city innovation. ④ There was an obvious Ushaped curve relationship between land regulation and local industrial agglomeration, and the inflection point value was 5.750. The spatial spillover effect was the same U-shaped trend. During the study period, industrial agglomeration promoted city innovation in China. ⑤ Land regulation had effects on urban innovation through industrial structure changes and industrial agglomeration. The relationship was affected by the multiple effects of mediating variables. Under the mediating effect, land regulation and city innovation showed a Ushaped direct relationship, and the inflection point value was 4.167. The promoting effect of land regulation on city innovation could be realized more quickly through the intermediary mechanism. In order to strengthen the supporting role of land regulation on city innovation, the scope and degree of land management and industrial guidance should be reasonably determined according to the land regulation threshold. At the same time, attention should be paid to spatial interaction and to the co-governance mode across the cities. [ABSTRACT FROM AUTHOR]

With the entry of digital technology into government, enterprises, and society, China' s economic and social development is undergoing profound changes and transformations. The empowerment of digital technology has promoted the transformation and innovation of environmental governance models and methods, as well as the improvement of environmental regulatory efficiency. In this context, using the fixed effect model of panel data, the mediating effect model, and the spatial Durbin model, this paper empirically tested the substitution effect of the digital technology development level of 104 prefecture-level cities in China from 2008 to 2020 on the number of traditional labor environmental supervisions/inspections. This research found that: ① The application of digital technology in environmental governance could realize a 'substitution' of traditional labor supervisions, that is, with the improvement of digital technology at the local level, the frequency of the superiors' labor supervisions accepted locally would ultimately decrease. ② The 'substitution' effect of digital technology in labor supervision could be realized through the reduction of important pollutants. The application of digital technology affected the frequency of superiors' labor supervisions through the reduction effect of pollutants in the jurisdiction. ③ The 'substitution' effect of digital technology application on labor supervision showed an inverted U-shaped relationship that increased first and then decreased. The research results indicated that digital technology empowered environmental governance, greatly improving the issues of inadequate regulation, resource waste, and low efficiency and achieving improvements in regulatory efficiency and precision. This research suggests that in the digital era, enhancing the efficiency of environmental supervision requires strengthening the capacity of digital environmental supervision, promoting the scientific level of environmental supervision, continuously increasing the application of digital technology in the fields of production and regulation, promoting the transformation of industrial structure, enhancing the emission reduction effect of digital technology and the government' s ability to obtain pollution information, and utilizing the advantages of digital technology to expand the breadth and depth of public participation in environmental governance. [ABSTRACT FROM AUTHOR]

Green credit is an important financial tool to promote the transformation of the low-carbon economy. On the basis of clarifying the theoretical mechanism of the impact of green credit on carbon emission reduction, this paper used the fixed effect stochastic frontier model containing unexpected output to measure the total factor carbon productivity of 156 cities in China from 2000 to 2019 and empirically tested the carbon emission reduction effect of green credit and its mechanism from the three dimensions of productivity, intensity, and total amount. The research found that: ① Green credit development significantly improved total factor carbon productivity and reduced carbon emission intensity, but the average impact on total carbon emissions was not significant. The above conclusions were still valid after a series of robustness tests and treatments of endogeneity problems. ② The carbon emission reduction effect of green credit was heterogeneous due to differences in regional location, resource endowment, and financial efficiency. In the central region, non-resource-based cities, and cities with higher financial efficiency, green credit had significant carbon reduction effects in both carbon productivity and carbon intensity dimensions, while green credit in the eastern region, resource-based cities, and cities with lower financial efficiency only reduced carbon intensity. ③ The stimulation of green innovation and the reduction of energy intensity were the most effective channels for green credit to reduce carbon emissions, whereas the mediating effect of the structural transformation channel was not yet significant. Green credit was more effective in promoting green innovation and generating positive spillovers in the green innovation channel. However, green credits were more effective in improving carbon emission efficiency in the energy intensity channel, but the role of supporting low-carbon technologies must be enhanced. ④ Environmental regulations had two moderating mechanisms, 'positive compensation' and 'negative offset,' for the carbon reduction effect of green credit. When the demand and supply of financial resources were low, strengthening environmental regulations would weaken the incentive effect of green credit on low-carbon economic transformation. The above conclusion not only provides a new research perspective and supplementary empirical evidence for understanding the environmental effects of green credit, but also provides a useful reference for further improving green credit policies and promoting the development of a low-carbon economy. [ABSTRACT FROM AUTHOR]

Saving energy resources and reducing energy intensity are crucial to promoting China' s major strategic goals of reaching peak carbon emissions and achieving carbon neutrality, and are hence key to the promotion of green transformation and development in the new development stage. As an important practice, the policy of establishing pilot zones for green finance reform and innovations in China aims to promote green finance reform in depth, construct ecological civilization, and realize green economic transformation. Can the policy reduce energy intensity and contribute to energy conservation? What is its impact mechanism? There is a shortage of systematic analysis in academia on these issues. With panel data from Chinese cities from 2007 to 2020 and a generalized synthetic control method, this paper evaluated how the establishment of pilot zones for green finance reform and innovations affected energy intensity and analyzed its impact mechanisms. The results showed that: ① The implementation of the policy significantly reduced the energy intensity of the pilot zones, and the energy-saving effect exhibited 'policy first' and timeliness characteristics. ② The policy-induced energysaving effect was achieved by improving green innovation, easing financing constraints, optimizing industrial structure, and strengthening environmental governance. ③ The policy' s energy-saving effect was more remarkable in areas with better marketization and a higher education level. The findings suggest that the government should fully consider the differences in aspects such as institutional environment and resource endowment among varying regions, design distinct measures to attract more market players to participate in the green finance system oriented by energy efficiency improvement, energy structure transformation, and environmental governance, and create a much better market-oriented environment for green innovation and corporate financing. [ABSTRACT FROM AUTHOR]

The report to the 20th National Congress of the Communist Party of China further clarifies the major development goal of accelerating the transition to a model of green development. Improving carbon emission efficiency is undoubtedly a necessary way to achieve this goal. At present, with the pressing goals of reaching peak carbon emissions and achieving carbon neutrality and the tendency of the financial industry to be diverted out of the real economy, the high-quality development of the financial industry has become an objective need to improve carbon emission efficiency and promote the realization of the 'dual carbon' goals as scheduled. However, there are obvious differences in carbon emission efficiency and financial industry high-quality development between different regions, which makes it urgent to realize efficient collaboration between inter-regional carbon emission efficiency and high-quality development in the financial industry. This paper used the coupling coordination degree model, the Dagum Gini coefficient decomposition method, and the spatial Kernel density estimation method to measure the coupling coordination degree between China' s carbon emission efficiency and the high-quality development in the financial industry and to fully reveal its spatio-temporal evolution characteristics. The results showed that: ① The coupling coordination degree between carbon emission efficiency and high-quality development in the financial industry basically stabilized at the intermediate coordination level. The key to advancing this coupling coordination degree to a high-quality coordination level was to improve the level of high-quality development in the financial industry. The eastern region rose to a good coordination level. The western and central regions were stable at the intermediate coordination level. The northeastern region was mainly at the primary coordination level. ② The coupling coordination of carbon emission efficiency and high-quality development in the financial industry had a problem of spatial distribution imbalance. Inter-regional differences were the main source of spatial differences. The contribution rates of intra-regional differences and the intensity of transvariation to spatial differences were relatively low. ③ There was a multipolar differentiation phenomenon in the coupling coordination between carbon emission efficiency and high-quality development in the financial industry in the central region. The coupling coordination in both the western and northeast regions showed a polarization trend. ④ Under the condition of considering spatial factors and time span, most provinces and their neighboring provinces had a spatial connection between the coupling coordination of carbon emission efficiency and high-quality development of the financial industry. These findings are conducive to the promotion of the construction of a collaborative linkage pattern between inter-regional carbon emission efficiency and the high-quality development in the financial industry. They can serve as an important decision-making reference for realizing the overall transition to a model of green development. [ABSTRACT FROM AUTHOR]

As a class of broad-spectrum insecticides, pyrethroids have been widely used in agriculture, forestry and health fields, and are frequently detected in aquatic environments in various regions. Meanwhile, pyrethroids are easy to be accumulated in aquatic organisms and cause high toxicity. Pyrethroids are highly hydrophobic compounds, and their environmental risks are often overestimated if their total concentrations in environmental media are analyzed using conventional chemical analysis methods. In recent 20 years, bioavailability has been widely used in environmental risk assessment of hydrophobic organic pollutants. Passive sampling technology as a sampling technology in which the analytes spontaneously transmitted from the sampling medium to the sampler. The free dissolved concentrations of pyrethroids determined by passive sampling technology can reflect their bioavailability more accurately than the total concentrations. In this paper, the latest research progress in the evaluation of the bioavailability of pyrethroids in aquatic environments using passive sampling techniques was reviewed. Firstly, the principle of passive sampling technology for evaluating the bioavailability of pyrethroids in aquatic environments was briefly summarized. Then, the basic performances and application characteristics of the commonly used passive samplers were discussed. Meanwhile, the application of passive sampling technology in the residue monitoring, aquatic organism toxicity evaluation, and residue accumulation prediction of pyrethroid in water were introduced in detail. Finally, the future development direction of this technology in China was prospected. [ABSTRACT FROM AUTHOR]

Biodiversity is the material basis for human survival. At present, the conservation of biodiversity is mainly carried out through nature reserves. As an essential supplement to the existing nature reserve systems in China, the mini reserve is an essential means to connect fragmented habitats for animals and plants and maintain the integrity of ecosystems. This study systematically collates and analyzes the organizational structure, system construction, daily work, and preliminary results of the community-based Qu'nan mini reserve through a literature review and field investigations. The results are as follows: (1) The construction of the Qu'nan mini reserve is based on the mindset of “self-construction, self-financing, self-management, and self-benefit”. It is managed mainly by “equal discussion and democratic consultation” which has been recognized and supported by local community residents, the local government, and the outside world. (2) The establishment, construction, and development of the mini reserve have not only enhance the protection awareness of community residents and increase the number and diversity of surrounding animal and plant populations. It also improves the living environment of the Qu'nan community and enriches the spiritual culture of residents, significantly contributing to the protection of local biodiversity and traditional culture. In addition, this paper also discusses the hidden dangers in the construction of conservation communities. Some feasible suggestions are proposed to provide a reference for developing biodiversity conservation and other mini reserves in China. [ABSTRACT FROM AUTHOR]

Under the leadership of the Chinese presidency, the second part of the 15th Conference of the Parties to the United Nations Convention on Biological Diversity (CBD) adopted 62 decisions, in particular Kunming-Montreal Global Biodiversity Framework(KM-GBF), which is based on the theory of transformative changes. KM-GBF, its achievements, gaps, and lessons learned, and the experience and achievements of other relevant multilateral environmental agreements, sets out an ambitious plan to implement broad-based action to bring about a transformation in our societies' relationship with biodiversity by 2030, and draws a new blueprint for global biodiversity governance. This paper provides an interpretation of the three core targets of the framework — the “3030 target” for protected areas, resource mobilisation, and digital sequence information of genetic resources, a brief introduction to the relevant decisions to ensure the implementation of the framework, and recommendations for future conservation actions in China: (1) To strengthen the mainstreaming of biodiversity conservation. Revision of China's Biodiversity Conservation Strategy and Action Plan(2011-2030) is an opportunity to involve the whole government and society in the process and to take action to promote the goals and targets of the KM-GBF; (2) To further develop detailed conservation plans, clarify the scopes, purposes and management measures of conservation areas, and implement responsible authorities and specific measures for implementing the plans. Researches on the Other Effective area-based Conservation Measures (OECMs) are needed to incorporate into the management system for biodiversity conservation; (3) To develop an operational indicator system and monitoring plan in accordance with the monitoring requirements of the framework targets; (4) To continue to strengthen awareness and education on biodiversity conservation, raise public awareness and attention to biodiversity conservation, and promote sustainable production and sustainable consumption in society as a whole; (5) To promote international cooperation vigorously to explore and promote Nature-based Solutions on a larger scale, and find pathways for economic and social development that have positive and beneficial effects on nature. [ABSTRACT FROM AUTHOR]

Copyright of World Nuclear Geoscience is the property of World Nuclear Geoscience Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of World Nuclear Geoscience is the property of World Nuclear Geoscience Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of World Nuclear Geoscience is the property of World Nuclear Geoscience Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Pearl River is the property of Pearl River Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Rolling Stock (1002-7602) is the property of Rolling Stock Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Natural Gas Industry is the property of Natural Gas Industry Journal Agency and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Chongqing University of Technology (Natural Science) is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With the development of China's society and economy, the demand for the construction of cross-sea channel project is becoming more and more urgent, especially the Bohai Strait Channel Project, which has attracted wide attention from all parties in recent years. In order to promote the construction of the Bohai Strait Channel Project, this paper summarized the research results of the Bohai Strait Channel over the years, analyzed the necessity and feasibility of the Bohai Strait Channel construction, studied the construction of the Bohai Strait Channel. Conclusion: (1) The Bohai Strait Channel is an important part of the north-south coastal corridor in China's comprehensive three-dimensional transportation network planning. It can save more than 1 million tons of fuel oil and reduce carbon emissions by more than 8 million tons of carbon oil every year. The construction of the Bohai Strait Channel project is necessary for energy conservation and emission reduction and optimizing the regional spatial layout; (2) In recent years, China has developed rapidly in the field of transportation infrastructure construction, and has the technical and equipment conditions for the construction of the Bohai Strait channel; (3) It is suggested to adopt the construction of railway channel in advance, reserve the highway channel scheme, and adopt passenger and freight mixed transportation. The speed target value of passenger cars is 250 km/h, and the traction mass of trucks is 5 000 t; (4) It is suggested to use the tunnel through the Bohai Strait and use the roadmachine method for construction. [ABSTRACT FROM AUTHOR]

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This paper briefly introduces the analysis technology and characteristics of inductively coupled plasma mass spectrometry (ICP-MS), and summarizes the application of rare earth, rare scattering and precious elements detection in minerals in the past three years. For the analysis of different kinds of elements, the key points are briefly mentioned in sample processing and mass spectrum interference. Moreover, the current or upcoming standards for the analysis of ore and minerals by ICP-MS are introduced. Besides, the application direction of ICP-MS in mineral analysis is prospected. [ABSTRACT FROM AUTHOR]

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Copyright of Automotive Digest is the property of Automotive Digest Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Automotive Digest is the property of Automotive Digest Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Soft soil has low bearing capacity and poor engineering characteristics, so it can not be directly used as foundation for engineering construction. In addition, China's industrial waste residue has a huge output and low utilization rate. In order to promote the requirements of high-quality development, this paper uses fly ash as precursor, carbide slag and sodium sulfate as activators to study the solidification mechanism and microstructure development of soft soil. The results show that the optimal mix ratio is 17. 3% (mass fraction, the same below) of fly ash, 7. 3% of carbide slag and 5. 0% of sodium sulfate. The 7 and 28 d unconfined compressive strength of solidified soil under the optimal ratio are 2 474. 0 and 3 134. 0 kPa, respectively, and the error is small compared with the predicted strength. The response surface method is effective and scientific to optimize the mix ratio. The water stability coefficients of solidified soil at 7 and 28 d are 0. 73 and 0. 85, respectively, indicating that the solidified soil has good water erosion resistance. The hydration products of 28 d solidified soil are mainly hydrated calcium silicate (C-S-H) and ettringite (AFt), which fill and wrap the internal pores of solidified soil. The microstructure of solidified soil is gradually dense and the mechanical properties are improved. [ABSTRACT FROM AUTHOR]

Copyright of Asian Journals of Ecotoxicology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Chinese Institute of Food Science & Technology is the property of Journal of Chinese Institute of Food Science & Technology Periodical Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Stem cells play an important role in liver regeneration and self-repair ability, which is of great significance for clinical diagnosis and treatment of liver diseases. OBJECTIVE: To summarize the current clinical trials and basic research in this field in and outside China, review the types of stem cells used to treat liver diseases in the past, and the treatment programs of various types of stem cells for various types of liver diseases, outline the clinical application prospects of various types of stem cells in the future application of liver diseases, and provide a research basis for the treatment of clinical liver diseases. METHODS: Using “stem cells, mesenchymal stem cells, hepatic stem cell, embryonic stem cell, induced pluripotent stem cell, hematopoietic stem cell, hepatopathy, non-alcoholic fatty liver disease, liver cirrhosis, liver failure, autoimmune hepatitis, hepatocellular carcinoma” as search words, the relevant articles in PubMed, Web of Science and Wiley e-journal databases were searched, and 71 articles were selected for review according to the inclusion criteria. RESULTS AND CONCLUSION: (1) Mesenchymal stem cells, liver stem cells, embryonic stem cells, induced pluripotent stem cells and hematopoietic stem cells are the main stem cells for the treatment of liver diseases. The characteristics, expression period and application of these stem cells in differentiation after liver injury are summarized in this paper. (2) In general, mesenchymal stem cells can repair liver through exosomes, matrix metalloproteinase and anti-inflammatory response. Liver stem cells can differentiate liver oval cells and small hepatocellular progenitor cells to form mature liver cells and promote liver injury repair. Induced pluripotent stem cells, embryonic stem cells and hematopoietic stem cells can transform into mature hepatocytes through rapid proliferation and differentiation. (3) The treatment of various liver diseases by stem cells is mainly achieved by inducing endogenous cell proliferation, immune regulation, inhibiting inflammation, promoting liver cell regeneration and repairing damaged tissues. (4) On the whole, at present, mesenchymal stem cells are relatively easy to obtain, have the broadest application prospects, and do not involve ethical issues. They are transforming from preclinical research to clinical research. Because mesenchymal stem cells can differentiate into various adult stem cells, they have the advantages of low immunogenicity, strong self-proliferation and differentiation ability. Especially for the treatment of immune hepatitis, liver cirrhosis and hepatocellular carcinoma and other liver diseases, mesenchymal stem cells have the most ideal effect. (5) Induced pluripotent stem cells are more effective in the treatment of end-stage liver disease because they can differentiate into specific somatic cells and hepatocytes without immune rejection. (6) However, stem cell transplantation can induce acute rejection, such as diarrhea, jaundice, and skin rashes. Poor histocompatibility between donors and recipients can easily lead to adverse reactions such as graft-versus-host reactions. After stem cell transplantation, the use of stem cells and its clinical safety assessment still need the support of more clinical trials and evidence-based medicine data. [ABSTRACT FROM AUTHOR]