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【Objective】The present paper aimed to provide theoretical basis for the rational application of potassium and chlorine fertilizer in the flue-cured tobacco production in Yunnan raw material base of Yunyan brand.【Method】 1130 soil samples from 37 counties of Kunming, Qujing, Honghe, Baoshan, Wenshan were used as materials to determine the content of potassium and chlorine in tobacco samples. The characteristics of potassium and chlorine ratio in different regions, main varieties, soils at different altitudes and tobacco leaves in Yunnan raw material base of Yunyan brand were analyzed. The potassium chlorine ratio of tobacco leaves was regionalized by ArcGIS. 【Result】The results showed that the samples with potassium chloride ratio more than 10 % were the most, accounting for 43.2 %; The samples with potassium chloride ratio between 4.0 % and 6.0 % were the least, accounting for 11.7 %. Qujing had the largest number of towns with low K/C ratio(< 4 %) and Wenshan had the smallest; Qujing had the largest number of towns with high K/C ratio(> 10 %), while other cities had the same number. The main cultivar with the highest mean of K/C ratio in middle tobacco leaves was Yunyan 85, which was 14.41; The lowest was Yunyan 97, which was 7.30; The others were between 8.44 and 12.73. The highest mean of K/C ratio of middle tobacco leaves in different altitude areas was 11.72, which was mainly distributed in the altitude area of 1100-1400 meters; The lowest was 8.91, which was mainly distributed in the altitude area of 2000-2300 meters. 【Conclusion】In order to production of high-quality flue-cured tobacco in Yunnan raw material base of Yunyan brand, areas with high K/C ratio of tobacco leaves in Kunming, Qujing, Honghe, Baoshan and Wenshan could be selected. K326, Yunyan 87, Yunyan 85 and other high efficient flue-cured tobacco varieties for potassium accumulation and utilization could be selected. It could be planted at the altitude of 1100-2000 meters. [ABSTRACT FROM AUTHOR]