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Adakitic rocks in continental settings are commonly considered to be formed by partial melting of thickened or delaminated lower crust. Investigations on this kind of rocks can provide important information about crustal evolution complementary to information from other rocks. This paper reports adakitic granodiorite of the Lingxi pluton in the interior of the Cathayisa Block. LA-ICP-MS zircon U-Pb dating shows that it was formed in the late Early Cretaceous (100±1 Ma). The granodiorite has geochemical features of adakitic rocks derived from partial melting of the thickened lower crust, e.g., high SiO (mainly ranging from 64.4 to 68.9 wt.%) and Sr (624-894 ppm) contents, Sr/Y (49.9-60.8) and La/Yb (23.4-42.8) values, low Y (10.3-17.1 ppm), Ni (5.62-11.8 ppm) and MgO (mostly from 0.86 wt.% to 1.57 wt.%) contents and weak Eu anomaly. It has initial Sr/Sr ratios of 0.7086-0.7091, ε ( t) values of −6.2 to −5.9 and zircon ε ( t) values mostly of −10.1 to −7.6. Based on the geochemical characteristics and simple modelling, it is suggested that the most likely generation mechanism of the Lingxi granodiorite is partial melting of a thickened Proterozoic lower continental crust at a pressure ≥12 kbar (or crust thickness ≥40 km), leaving a garnet-bearing amphibolite residue. Combining our results and previous studies of the tectonic evolution of the Cathaysia Block, we propose that the crust was thickened to over 40 km by a compressive event occurring during the late Early Cretaceous, which is supported by the observation that there is an angular unconformity between the Upper Cretaceous Series and the early Lower Cretaceous or the Jurassic rocks. After this event, the Cathaysia Block experienced a lithospheric extension and thinning probably driven by the high-angle paleo-Pacific subduction. With the attenuation of lithosphere, the lower crust was heated to partial melting by upwelling asthenospheric materials, resulting in generation of the Lingxi granodiorite and other coeval granitoids in the Cathaysia Block. This study provides new information on the crustal evolution of the Cathaysia Block during the Early Cretaceous. [ABSTRACT FROM AUTHOR]