1. Towards sound epistemological foundations of statistical methods for high-dimensional biology.
- Author
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Mehta, Tapan, Tanik, Murat, and Allison, David B.
- Subjects
THEORY of knowledge ,STATISTICS ,BIOLOGY ,LIFE sciences ,SCIENTISTS ,BIOMETRY - Abstract
A sound epistemological foundation for biological inquiry comes, in part, from application of valid statistical procedures. This tenet is widely appreciated by scientists studying the new realm of high-dimensional biology, or 'omic' research, which involves multiplicity at unprecedented scales. Many papers aimed at the high-dimensional biology community describe the development or application of statistical techniques. The validity of many of these is questionable, and a shared understanding about the epistemological foundations of the statistical methods themselves seems to be lacking. Here we offer a framework in which the epistemological foundation of proposed statistical methods can be evaluated. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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