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There are increasing challenges for optimally distributing fresh products while adequately considering the uncertain demand of customers and maintaining the freshness of products. Taking the nature of fresh products and the characteristics of urban logistics systems into consideration, this paper proposes an improved genetic algorithm for effectively solving this problem in a computationally efficient manner. Such an algorithm can adequately account for the uncertain demand of customers to select the optimal distribution route to ensure the freshness of the product while minimizing the total distribution cost. Iterative optimization procedures are utilized for determining the optimal route by reducing the complexity of the computation in the search for an optimal solution. An illustrative example is presented that shows the improved algorithm is more effective with respect to the distribution cost, the distribution efficiency, and the distribution system's reliability in optimally distributing fresh products. [ABSTRACT FROM AUTHOR]