158 results
Search Results
2. Announcing the winner of the IJGO Prize Paper Award for 2001.
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Sciarra, John J
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RESEARCH ,AWARDS ,DEVELOPING countries ,LABOR (Obstetrics) ,OBSTETRICS ,OXYTOCIN ,MISOPROSTOL ,OXYTOCICS ,STANDARDS - Published
- 2002
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3. Identifying biomarkers of endometriosis using serum protein fingerprinting and artificial neural networks
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Wang, Liang, Zheng, Wei, Mu, Lin, and Zhang, Su-Zhan
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TIME-of-flight mass spectrometry ,BIOMARKERS ,ENDOMETRIOSIS ,HUMAN fingerprints ,DIAGNOSIS of endometriosis ,DIAGNOSIS of uterine diseases ,COMPARATIVE studies ,MASS spectrometry ,RESEARCH methodology ,MEDICAL cooperation ,ARTIFICIAL neural networks ,PAPER chromatography ,PEPTIDES ,RESEARCH ,UTERINE diseases ,PROTEOMICS ,EVALUATION research ,PROTEIN microarrays - Abstract
Objectives: To use surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) protein chip array technology to detect proteomic patterns in the serum of women with endometriosis; build diagnostic models; and evaluate their clinical significance.Methods: Serum samples from women with endometriosis and healthy women were studied using SELDI-TOF-MS protein chip technology. For every matched pair, two-thirds of the samples were used to look for different patterns and one-third was used for cross-validation.Results: Five potential biomarkers were found and the diagnostic system distinguished endometriosis from validation samples with a sensitivity of 91.7% and a specificity of 90.0%.Conclusion: This method shows great potential in identifying biomarkers to be used for endometriosis screening. [ABSTRACT FROM AUTHOR]- Published
- 2008
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4. Human papillomavirus (HPV) DNA detection in self-collected urine
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Prusty, B.K., Kumar, A., Arora, R., Batra, S., and Das, B.C.
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PAPILLOMAVIRUS diseases ,VIRUS diseases ,DNA ,VACCINES ,PAPILLOMAVIRUS disease diagnosis ,DNA analysis ,CERVIX uteri tumors ,TUMOR prevention ,CERVICAL intraepithelial neoplasia ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL screening ,PAP test ,PAPILLOMAVIRUSES ,POLYMERASE chain reaction ,RESEARCH ,HEALTH self-care ,URINALYSIS ,EVALUATION research ,PREDICTIVE tests ,PREVENTION - Abstract
Abstract: Objective: Non-invasive sampling of human genitals to identify high-risk individuals with subclinical oncogenic HPV infection remains a challenge. The study was designed to see if self-collected urine can be used as a simple, non-invasive sampling for screening HPV, particularly for screening/monitoring general population or young adolescents or infants, if they are to be immunized by HPV vaccines. Method: Self-collected urine samples from 100 sexually unexposed college going girls and cervical scrapes from 104 normal healthy sexually active married women were used in this study. Additionally, a group of 55 women were recruited for collecting first urine and later scraped cervical cells to validate urine sampling by directly comparing HPV positivity between the two types of biological specimens. A dry ‘paper smear’ method for specimen collection and a simple single tube protocol was employed for PCR detection of HPV infection. Results: Out of 100 sexually inexperienced college going girls, only 6 (6%) were positive for HPV infection as revealed by L1 consensus primer and 4 (4%) of them were positive for HPV 16 but none was found positive for HPV 18 DNA. Out of 104 sexually active married women who were cytologically reported as negative by Pap test, 11 (10.5%) were found HPV positive and 7 (6.7%) of them had infection of high-risk HPV type 16. Both urine and later cervical scrapes from a group of 55 women collected as dry ‘paper smear’ showed perfect matching positivity for HPV between urine and cervical scrape. Conclusions: The use of urine coupled with its dry collection as ‘paper smear’ facilitating their easy transport, storage and direct PCR detection of HPV DNA opens up an alternative non-invasive approach for population screening of HPV infection, at least in such cases as children and infants in whom invasive samples are difficult to obtain. [Copyright &y& Elsevier]
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- 2005
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5. Universal reporting of maternal mortality: An achievable goal?
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Graham, W.J. and Hussein, J.
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MATERNAL & infant welfare ,TRENDS ,MATERNAL mortality ,MATERNAL health services ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,PUBLIC health surveillance ,RESEARCH ,WORLD health ,EVALUATION research ,ACQUISITION of data - Abstract
Abstract: This paper aims to highlight the importance of aspiring to achieve universal reporting of maternal deaths as a part of taking responsibility for these avoidable tragedies. The paper first discusses the reasons for reporting maternal deaths, distinguishing between individual case notification and aggregate statistics. This is followed by a summary of the status of reporting at national and international levels, as well as major barriers and facilitators to this process. A new framework is then proposed — the REPORT framework, designed to highlight six factors essential to universal reporting. Malaysia is used to illustrate the relevance of these factors. Finally, the paper makes a Call to Action by FIGO to promote REPORT and to encourage health professionals to play their part in improving the quality of reporting on all maternal deaths — not just those directly in their care. [Copyright &y& Elsevier]
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- 2006
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6. The disappearing art of instrumental delivery: Time to reverse the trend
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Bailey, P.E.
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DELIVERY (Obstetrics) ,CHILDBIRTH ,OBSTETRICS ,LABOR (Obstetrics) ,CESAREAN section ,CLINICAL competence ,COMPARATIVE studies ,DEVELOPING countries ,HEALTH services accessibility ,RESEARCH methodology ,MEDICAL cooperation ,MATERNAL mortality ,OBSTETRICAL extraction ,OBSTETRICAL forceps ,RESEARCH ,DEVELOPED countries ,EVALUATION research - Abstract
Purpose: This paper focuses attention on declining rates of instrumental (vacuum or forceps) delivery. The decline often means that women must travel further to deliver in hospitals with capacity for cesarean delivery.Background: The paper illustrates recent trends in the use of vacuum extraction and forceps in low- and high-income countries. It describes some of the obstacles to the use of instrumental delivery and why the techniques, especially vacuum extraction, should be reintroduced. Over the past two decades, many countries have observed a decline in instrumental delivery rates while cesarean rates have increased. Objections to instrumental delivery are largely due to the potential harm it causes newborns. Some medical schools no longer train their professionals to perform instrumental delivery. Elsewhere, only specialists are permitted to perform the procedures.Methods and Results: As this is a policy paper rather than a research report, the methods and results sections are not applicable.Conclusions: Vacuum extraction can be taught to midlevel practitioners (midwives, nurse practitioners and general physicians), thereby increasing access to emergency obstetric care especially at the periphery. This allows women to give birth closer to home in midlevel facilities when hospitals are not easily accessible or are overcrowded. Where instrumental and cesarean delivery are both available, instrumental delivery could potentially reduce the risks associated with cesarean delivery and reduce the costs of obstetric care. [ABSTRACT FROM AUTHOR]- Published
- 2005
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7. The availability of life-saving obstetric services in developing countries: An in-depth look at the signal functions for emergency obstetric care
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Bailey, P., Paxton, A., Lobis, S., and Fry, D.
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MATERNAL mortality ,ANTI-infective agents ,ANTIBIOTICS ,BLOOD banks ,ANTICONVULSANTS ,COMPARATIVE studies ,DEVELOPING countries ,EMERGENCY medical services ,RESEARCH methodology ,MEDICAL cooperation ,OBSTETRICS ,RESEARCH ,EVALUATION research ,EQUIPMENT & supplies ,OXYTOCICS ,PARENTERAL infusions ,STANDARDS ,THERAPEUTICS - Abstract
Objective: This paper examines the frequency with which a set of life-saving interventions or signal functions was performed to treat major obstetric complications.Methods and Results: The basic signal functions include parenteral antibiotics, anticonvulsants and oxytocics, and the procedures of manual removal of the placenta, removal of retained uterine products, and assisted vaginal delivery. Comprehensive functions include the six basic functions, cesarean delivery, and blood transfusions. Data from 1906 health facilities in 13 countries indicate that the most likely functions to be reported are oxytocics and antibiotics. The basic function least likely to be reported is assisted vaginal delivery. Many of the facilities surveyed did not have the infrastructure to perform operations or provide blood transfusions.Conclusions: These data can help governments allocate their budgets appropriately, help policy makers and planners identify systemic bottlenecks and prioritize solutions. Monitoring the performance of the functions informs us of the capacity of the health system to provide key interventions when obstetric emergencies occur. [ABSTRACT FROM AUTHOR]- Published
- 2006
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8. A national review of cesarean delivery in Ethiopia
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Fesseha, Nebreed, Getachew, Atnafu, Hiluf, Mihret, Gebrehiwot, Yirgu, and Bailey, Patricia
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CESAREAN section ,DELIVERY (Obstetrics) ,HEALTH outcome assessment ,OBSTETRICAL emergencies ,RETROSPECTIVE studies ,STILLBIRTH ,MEDICAL statistics ,ANTIBIOTICS ,EMERGENCY medical services ,COMPARATIVE studies ,DECISION making ,INFANT care ,RESEARCH methodology ,EVALUATION of medical care ,MEDICAL quality control ,MEDICAL cooperation ,MEDICAL protocols ,PREGNANCY ,RESEARCH ,SURGICAL site infections ,TIME ,PRIVATE sector ,PUBLIC sector ,EVALUATION research ,ACQUISITION of data ,CROSS-sectional method ,STANDARDS ,PREVENTION - Abstract
Objective: To describe Ethiopian national population-based and institutional cesarean delivery rates by sector, and to describe indications for cesarean delivery, fetal and maternal outcomes, and aspects of quality of care.Methods: The data source was the national baseline assessment of emergency obstetric and newborn care--a cross-sectional, facility-based survey of 797 facilities. Two instruments were used to collect the data for the present paper: a retrospective record review of 267 cesarean deliveries based on the last 3 performed in each facility; and a 12-month summary of each facility's statistics on vaginal and abdominal deliveries.Results: The national population-based cesarean delivery rate was 0.6%, with regional rates varying from 0.2% to 9%. The overall institutional rate was 18%, which varied between 46% in the private for- profit sector and 15% in the public sector. Maternal indications accounted for 66% of the cesareans reviewed, and fetal indications for 34%. Three-quarters of the cesareans were recorded as emergencies, but only 12% of these had their labor monitored with a partograph. The interval between decision and delivery was within 30 minutes for 36% of the women, 31-60 minutes for 23%, and more than 5 hours for 19%. Antibiotics were given in 94% of the reviewed cases; nevertheless, 12% of the cases reported wound infection. There were 2 maternal deaths and 14% of the newborns were stillbirths or died shortly after birth.Conclusion: The study showed little progress in the proportion of all births delivered by cesarean and a high rate of cesarean among women attended in the private sector--indicating a need to monitor the appropriateness of obstetric care in all sectors and to increase access in rural areas. Clinical management protocols for obstetric and newborn care are needed, and audits of cesareans should be performed at all institutions, especially in the private sector. The importance of improving record keeping is crucial for informed local decision-making. [ABSTRACT FROM AUTHOR]- Published
- 2011
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9. Maternal mortality in low-income countries: What interventions have been evaluated and how should the evidence base be developed further?
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Burchett, Helen E. and Mayhew, Susannah H.
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MATERNAL mortality ,PREGNANCY complications ,PUBLIC health ,RESEARCH - Abstract
Abstract: Objective: This article reviews the evidence for the effectiveness of non-clinical interventions to reduce maternal mortality in low-income settings and identifies the gaps in the evidence base. Methods: A systematic search was conducted to identify reviews and evaluations of non-clinical interventions to reduce maternal mortality in lower-income countries with high maternal mortality published between 1997 and 2008. Studies were reviewed to identify the topic focus, study design, and outcomes measured. Results: There were 109 intervention evaluations and 30 reviews identified. Studies had been conducted in less than half of the countries and were generally poor quality. More studies focused on tertiary prevention (i.e., preventing death) rather than secondary prevention (i.e., preventing complications). More interventions sought to address quality of care than delays in seeking or accessing care. Conclusions: While evidence partly reflects difficulties in evaluating complex public health interventions, more robust study designs are possible to evaluate interventions to reduce maternal mortality. In addition, better standardized outcome measures are needed. This overview identifies topic areas neglected by intervention research. [Copyright &y& Elsevier]
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- 2009
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10. Strengthening emergency obstetric care in Thanh Hoa and Quang Tri provinces in Vietnam
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Otchere, S.A. and Binh, H.T.
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MATERNAL mortality ,PREGNANCY complications ,CHILDREN'S health ,OBSTETRICS ,COMPARATIVE studies ,DELIVERY (Obstetrics) ,HEALTH services accessibility ,HOSPITAL emergency services ,MATERNAL health services ,RESEARCH methodology ,EVALUATION of medical care ,MEDICAL cooperation ,PRENATAL care ,PUBLIC hospitals ,QUALITY assurance ,RESEARCH ,HOSPITAL maternity services ,MOTHERS ,EVALUATION research ,HUMAN services programs ,SOCIAL history - Abstract
Objective: Save the Children/USA and the Ministry of Health of Vietnam undertook a project between 2001 and 2004 to improve the availability of, access to, quality and utilization of emergency obstetric care (EmOC) services at district and provincial hospitals in two provinces in Vietnam.Methods: The project improved the functional capacity of 3 provincial and 1 district hospitals providing comprehensive EmOC services, and upgraded 1 district hospital providing basic EmOC into a comprehensive EmOC facility through training, infrastructure and quality improvement.Results: Data presented in this paper focus on only the 2 district hospitals even though the UN process indicators showed increases in utilization of EmOC in all 5 hospitals. In the case of Hai Lang, the proportion of births increased from 13% at baseline to 31% at the end of 2004, and met need increased significantly from 16% to 87% largely due to increased capacity of the hospital and staff. Met need in Hoang Hoa hospital more than doubled (17% at baseline versus 54% in 2004) and the proportion of births increased slightly from 19% in 2001 to 22% in 2004. Case fatality rates for the two hospitals remarkably remained at zero. Lessons from this project have been incorporated into national policy and guidelines.Conclusion: Improvements in the capacity of existing health facilities to treat complications in pregnancy and childbirth can be realized in a relatively short period of time and is an essential element in reducing maternal mortality. [ABSTRACT FROM AUTHOR]- Published
- 2007
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11. Women's perception of self-worth and access to health care
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Chamberlain, J., Watt, S., Mohide, P., Muggah, H., Trim, K., and Bantebya Kyomuhendo, G.
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MEDICAL care research ,WOMEN'S health services ,HEALTH services accessibility ,HEALTH policy ,COMPARATIVE studies ,DECISION making ,RESEARCH methodology ,MEDICAL cooperation ,POLICY sciences ,RESEARCH ,SELF-perception ,SURVEYS ,EVALUATION research ,PATIENTS' attitudes - Abstract
Objective: : Research has shown differences in health status and health care utilization related to culture, economic status, and health care development. This paper reports on a study comparing attitudes of women in three countries, at various stages of development, about their own health and self-worth and asks if these differences account for differences in health care utilization and inequities in health status.Method: : A questionnaire, administered to 100 women in each of Yemen, Uganda and Canada, explored women's perception of their own health and health care seeking behavior.Result: : Women's perception of themselves as worthy of care was positively related to utilization. The ability to make one's own health care decisions varied with her country's development level. Implementation strategies must consider women's decision-making capacity.Conclusion: : To achieve improved health status, policies and programs must commit to encouraging appropriate social and cultural changes, using a 'cross-sectoral approach', involving both gender and development issues. [ABSTRACT FROM AUTHOR]- Published
- 2007
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12. The United Nations Process Indicators for emergency obstetric care: Reflections based on a decade of experience
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Paxton, A., Bailey, P., and Lobis, S.
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OBSTETRICAL emergencies ,MATERNAL mortality ,OBSTETRICS ,TREATMENT of pregnancy complications ,EMERGENCY medical services ,CLINICAL medicine ,COMPARATIVE studies ,RESEARCH methodology ,EVALUATION of medical care ,MEDICAL cooperation ,MEDICAL protocols ,OBSTETRICS surgery ,RESEARCH ,EVALUATION research ,KEY performance indicators (Management) ,ACQUISITION of data ,RETROSPECTIVE studies ,STANDARDS - Abstract
Objective: The paper reviews the experience with the EmOC process indicators, and evaluates whether the indicators serve the purposes for which they were originally created - to gather and interpret relatively accessible data to design and implement EmOC service programs.Method: We review experience with each of the 6 process indicators individually, and monitoring change over time, at the level of the facility and at the level of a region or country. We identify problems encountered in the field with data collection and interpretation.Result: While they have strengths and weaknesses, the process indicators in general serve the purposes for which they were developed. The data are easily collected, but some data problems were identified. We recommend several relatively minor modifications to improve data collection, interpretation and utility.Conclusions: The EmOC process indicators have been used successfully in a wide variety of settings. They describe vital elements of the health system and how well that system is functioning for women at risk of dying from major obstetric complications. [ABSTRACT FROM AUTHOR]- Published
- 2006
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13. A risk reduction strategy to prevent maternal deaths associated with unsafe abortion
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Briozzo, L., Vidiella, G., Rodríguez, F., Gorgoroso, M., Faúndes, A., Pons, J.E., Rodríguez, F, and Faúndes, A
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MATERNAL mortality ,ABORTION complications ,OBSTETRICS surgery ,ANXIETY disorders treatment ,COGNITIVE therapy ,COMBINED modality therapy ,COMPARATIVE studies ,EDUCATION ,FAMILY psychotherapy ,GROUP psychotherapy ,RESEARCH methodology ,EVALUATION of medical care ,MEDICAL cooperation ,PERSONALITY assessment ,RESEARCH ,RESEARCH funding ,SCHOOL health services ,EARLY intervention (Education) ,EVALUATION research - Abstract
Abstract: Introduction: Worldwide, 13% of maternal deaths are caused by complications of spontaneous or induced abortion, 29% in Uruguay and nearly half (48%) in the Pereira Rossell Hospital. Purpose: This paper describes a risk reduction strategy for unsafe abortions in Montevideo, Uruguay, where over one-fourth of maternal deaths are caused by unsafe abortion. Methods: Although abortion is not legal in Uruguay, women desiring abortions can be counseled before and immediately after to reduce the risk of injury. Women contemplating abortion were invited to attend a “before-abortion” and an “after-abortion” visit at a reproductive health polyclinic. At the “before-abortion” visit, gestational age, condition of the fetus and pathologies were diagnosed and the risks associated with the use of different abortion methods (based on the best available scientific evidence) were described. The “after-abortion” visit allowed for checking for possible complications and offering contraception. Results: From March 2004 through June 2005, 675 women attended the “before-abortion” and 495 the “after-abortion” visit, the number increasing over time. Some women (3.5%) decided not to abort, others were either not pregnant, the fetus/embryo was dead or the woman had a condition that permitted legal termination of pregnancy in the hospital (7.5%). Most women, however, aborted. All women used vaginal misoprostol in the doses recommended in the medical literature. There were no serious complications (one mild infection and two hemorrhages not requiring transfusion). Conclusion: The strategy is effective in reducing unsafe abortions and their health consequences. [Copyright &y& Elsevier]
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- 2006
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14. Global patterns in availability of emergency obstetric care
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Paxton, A., Bailey, P., Lobis, S., and Fry, D.
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NEEDS assessment ,MATERNAL mortality ,HEALTH facilities ,MEDICAL care ,TREATMENT of pregnancy complications ,COMPARATIVE studies ,EMERGENCY medical services ,HEALTH services accessibility ,HEALTH status indicators ,MATERNAL health services ,RESEARCH methodology ,MEDICAL cooperation ,OBSTETRICS ,RESEARCH ,SURVEYS ,EVALUATION research ,STANDARDS - Abstract
Objective: This paper examines the availability of basic and comprehensive emergency obstetric care (EmOC), interventions used to treat direct obstetric complications. Determining what interventions are provided in health facilities is the first priority in analyzing a country's capabilities to treat obstetric emergencies. There are eight key interventions, six constitute basic EmOC and all eight comprehensive EmOC.Methods and Results: Based on data from 24 needs assessments, the following global patterns emerge: comprehensive EmOC facilities are usually available to meet the recommended minimum number for the size of the population, basic EmOC facilities are consistently not available in sufficient numbers, both in countries with high and moderate levels of maternal mortality, and the majority of facilities offering maternity services provide only some interventions indicating an unrealized potential.Conclusion: Upgrading maternities, health centers and hospitals to at least basic EmOC status would be a major contributing step towards maternal mortality reduction in resource-poor countries. [ABSTRACT FROM AUTHOR]- Published
- 2006
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15. Measuring progress towards the MDG for maternal health: Including a measure of the health system's capacity to treat obstetric complications
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Bailey, P., Paxton, A., Lobis, S., and Fry, D.
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MATERNAL mortality ,OBSTETRICAL emergencies ,MEDICAL emergencies ,OBSTETRICS ,TREATMENT of pregnancy complications ,LABOR complications (Obstetrics) ,COMPARATIVE studies ,EMERGENCY medical services ,MATERNAL health services ,RESEARCH methodology ,MEDICAL quality control ,MEDICAL cooperation ,PREGNANCY complications ,RESEARCH ,EVALUATION research ,THERAPEUTICS ,STANDARDS - Abstract
Objective: This paper argues for an additional indicator for measuring progress of the Millennium Development Goal for maternal health-the availability of emergency obstetric care.Methods: MDG monitoring will be based on two indicators: the maternal mortality ratio and the proportion of births attended by skilled personnel. Strengths and weaknesses of a third indicator are discussedResults: The availability of EmOC measures the capacity of the health system to respond to direct obstetric complications. Benefits to using this additional indicator are its usefulness in determining an adequate distribution of services and showing management at all levels what life-saving interventions are not being provided, and stimulate thought as to why. It can reflect programmatic changes over a relatively short period of time and data requirements are not onerous.Conclusion: A measure of strength of the health system is important since many interventions depend on the health system for their implementation. [ABSTRACT FROM AUTHOR]- Published
- 2006
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16. Reducing maternal mortality in Mozambique: challenges, failures, successes and lessons learned
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Jamisse, L., Songane, F., Libombo, A., Bique, C., Faúndes, A., and Faúndes, A
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MATERNITY nursing ,PRENATAL care ,MATERNAL mortality ,COMPARATIVE studies ,DELIVERY (Obstetrics) ,HOSPITAL emergency services ,LABOR complications (Obstetrics) ,MATERNAL health services ,RESEARCH methodology ,MEDICAL care ,MEDICAL cooperation ,RESEARCH ,EVALUATION research ,EVALUATION of human services programs ,PREVENTION - Abstract
The aim of this paper is to describe different approaches to make emergency obstetric care (EmOC) accessible to women in Mozambique. The definitions of basic (BEmOC) and comprehensive EmOC (CEmOC), proposed by the UN agencies, were adopted by FIGO and by the Mozambican Ministry of Health as a general strategy to reduce maternal mortality. Four projects are presented: (1) Jose´ Macamo and (2) Mavalane Hospitals in Maputo city, (3) Manhic¸a District in Maputo Province and (4) Sofala Province. Jose´ Macamo was staffed by physicians 24 h a day; other hospitals by non-physicians trained in surgical and anesthesiology techniques, as well as nurse-midwives. Jose´ Macamo Hospital provided CEmOC to the city of Maputo and the southern area of Maputo Province. In 2001, this hospital attended 32% of deliveries and 38% of cesarean sections in the city, up from 14 and 2.5%, respectively, in 1998. The Mavalane Hospital failed to provide CEmOC; however, the number of deliveries per year almost doubled. The Manhic¸a hospital carried out 31% of the District's C-sections in 2001, up from 9% in 1998. In Sofala Province, one additional CEmOC and four BEmOCs were installed and case fatality rates decreased. In conclusion, the strategy for ensuring provision of EmOC is feasible even in countries with minimal resources and a scarcity of physicians, such as Mozambique. [Copyright &y& Elsevier]
- Published
- 2004
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17. Labor augmentation in an Egyptian teaching hospital
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Khalil, K., Cherine, M., Elnoury, A., Sholkamy, H., Breebaart, M., and Hassanein, N.
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LABOR ,OBSTETRICS ,TEACHING hospitals ,ACADEMIC medical centers ,COMPARATIVE studies ,FETAL monitoring ,INDUCED labor (Obstetrics) ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL protocols ,OXYTOCIN ,PATIENT monitoring ,RESEARCH ,UTERINE contraction ,EVIDENCE-based medicine ,EVALUATION research - Abstract
Objectives: The study documented facility-based obstetric practices for normal labor in Egypt for the first time, to determine their relationship to evidence-based medicine. This paper describes the labor augmentation pattern observed.Methods: 176 cases of normal labor were observed by medically-trained observers using a checklist. Ward activities were also documented. Observed women were interviewed postpartum and all findings were shared with the providers for their feedback.Results: Labor was augmented in 91% (165) of the labors observed; this was inappropriate for 93% or 154 women. Reasons for inappropriateness were: oxytocin ordered at the first vaginal exam (41%); in spite of intact membranes (36%), at the time of membrane rupture (42%), in spite of good progress (24%), or a combination of these. The monitoring of oxytocin-receiving women and their babies was inadequate.Conclusions: Labor augmentation and monitoring deviated from evidence-based guidelines. Obstacles to implementing protocols need to be explored. [ABSTRACT FROM AUTHOR]- Published
- 2004
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18. Violence against women: what is the World Health Organization doing?
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Garcı́a‐Moreno, C.
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VIOLENCE against women ,DOMESTIC violence ,WOMEN'S health ,CRIMES against women ,RESEARCH & development - Abstract
Abstract: The paper summarizes the activities of the WHO in response to violence against women. These focus on research and development of norms and standards. [ABSTRACT FROM AUTHOR]
- Published
- 2002
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19. Establishing a one-stop crisis center for women suffering violence in Khonkaen hospital, Thailand.
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Grisurapong, S
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ABUSED women ,ATTITUDE (Psychology) ,COMPARATIVE studies ,COUNSELING ,HOSPITAL wards ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL personnel ,MEDICAL referrals ,PUBLIC hospitals ,RESEARCH ,WOMEN'S health ,WOMEN'S health services ,EVALUATION research ,INTIMATE partner violence - Abstract
This paper discusses the experiences of the Khonkaen provincial hospital, which has been selected as an intervention case site for a one-stop crisis service for women who have been physically or sexually assaulted. It will be compared with another provincial hospital where no intervention has taken place. [ABSTRACT FROM AUTHOR]
- Published
- 2002
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20. Prioritizing and synthesizing evidence to improve the health care of girls and women living with female genital mutilation: An overview of the process.
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Stein, Karin, Hindin, Michelle J., Chou, Doris, and Say, Lale
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- *
FEMALE genital mutilation , *WOMEN'S health services , *EMIGRATION & immigration , *META-analysis , *EVIDENCE-based medicine - Abstract
Female genital mutilation (FGM) constitutes a harmful traditional practice that can have a profound impact on the health and well-being of girls and women who undergo the procedure. In recent years, due to international migration, healthcare providers worldwide are increasingly confronted with the need to provide adequate health care to this population. Recognizing this situation the WHO recently developed the first evidence-based guidelines on the management of health complications from FGM. To inform the guideline recommendations, an expert-driven, two-step process was conducted. The first step consisted of developing and ranking a list of priority research questions for the evidence retrieval. The second step involved conducting a series of systematic reviews and qualitative data syntheses. In the present paper, we first provide the methodology used in the development and ranking of the research questions (step 1) and then detail the common methodology for each of the systematic reviews and qualitative evidence syntheses (step 2). [ABSTRACT FROM AUTHOR]
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- 2017
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21. Sleep quality based on the use of different sanitary pads during menstruation
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Hachul, Helena, Andersen, Monica L., and Tufik, Sergio
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MENSTRUAL cycle , *SANITARY napkins , *SLEEP , *ESTRONE , *SEX hormones , *POLYSOMNOGRAPHY , *ABSORPTION , *COMPARATIVE studies , *CROSSOVER trials , *LONGITUDINAL method , *RESEARCH methodology , *MEDICAL cooperation , *MENSTRUATION , *RESEARCH , *EVALUATION research , *RANDOMIZED controlled trials , *BLIND experiment - Abstract
Objective: To evaluate sleep quality among women using 2 different types of sanitary pad.Methods: Seventeen women (18-40 years) with menstrual cycles of 28-30 days and self-reported moderate-to-intense menstrual flow were enrolled in a crossover study from March to August 2009 in Sao Paulo, Brazil. Sleep assessments were made by polysomnography and by means of validated questionnaires. The first evaluation of sleep (control condition) was performed during the follicular phase (7-10th day of cycle). There were subsequent evaluations during the 2nd and 3rd day of the menstrual period, and a different type of absorbent pad (A or B) was used on each day. The participants were randomly assigned to an order of pad use (AB or BA).Results: The use of absorbent pad A or B did not affect the parameters of sleep or the quality of sleep. The results obtained with use of either absorbent pad did not differ significantly from the control condition and were within the normal limits.Conclusion: There was no significant difference in sleep quality between the follicular phase and the menstrual period; in addition, the use of different absorbent pads over consecutive nights during the same menstrual cycle was not associated with changes in sleep. [ABSTRACT FROM AUTHOR]- Published
- 2011
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22. Expanding uterotonic protection following childbirth through community-based distribution of misoprostol: Operations research study in Nepal
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Rajbhandari, Swaraj, Hodgins, Stephen, Sanghvi, Harshad, McPherson, Robert, Pradhan, Yasho V., Baqui, Abdullah H., and Misoprostol Study Group
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STIMULANTS ,COMMUNITY health services ,MISOPROSTOL ,CHILDBIRTH at home ,OPERATIONS research ,MEDICAL care ,HEMORRHAGE prevention ,PUERPERAL disorders ,OXYTOCICS ,CLINICAL trials ,COMMUNITY health workers ,COMPARATIVE studies ,DELIVERY (Obstetrics) ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,SELF medication ,SYSTEM analysis ,PILOT projects ,EVALUATION research ,PATIENTS' attitudes ,PREVENTION ,THERAPEUTICS - Abstract
Objective: To determine feasibility of community-based distribution of misoprostol for preventing postpartum hemorrhage (PPH) to pregnant woman through community volunteers working under government health services.Methods: Implemented in one district in Nepal. The primary measure of performance was uterotonic protection after childbirth, measured using pre- and postintervention surveys (28 clusters, each with 30 households). Maternal deaths were ascertained through systematic health facility and community-based surveillance; causes of death were assigned based on verbal autopsy.Results: Of 840 postintervention survey respondents, 73.2% received misoprostol. The standardized proportion of vaginal deliveries protected by a uterotonic rose from 11.6% to 74.2%. Those experiencing the largest gains were the poor, the illiterate, and those living in remote areas.Conclusion: Community-based distribution of misoprostol for PPH prevention can be successfully implemented under government health services in a low-resource, geographically challenging setting, resulting in much increased population-level protection against PPH, with particularly large gains among the disadvantaged. [ABSTRACT FROM AUTHOR]- Published
- 2010
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23. Pregnancy and perinatal health in Inner Mongolia, China, 1996–1999
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Liu, Z., Lobdell, D.T., Myers, S.L., He, L., Yang, M., Kwok, R.K., Mumford, J.L., and Mendola, P.
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MATERNAL health services ,MORTALITY ,PREGNANCY ,PREGNANT women ,LOW birth weight ,CHILD welfare ,COMPARATIVE studies ,INFANT mortality ,RESEARCH methodology ,EVALUATION of medical care ,MEDICAL cooperation ,PRENATAL care ,RESEARCH ,MOTHERS ,EVALUATION research ,SOCIAL history - Abstract
Objective: To obtain descriptive measures of maternal and perinatal health in the Ba Men Region of Inner Mongolia, China.Methods: Data collected from the Examination Chart for Pregnant Women for approximately 22,000 pregnancies in a three-county area of Inner Mongolia, China from December 1, 1996 through December 31, 1999 were analyzed for maternal, perinatal, and neonatal outcomes.Results: Compared to selected developing countries, a higher percentage of women (99%) in this region received at least one prenatal care visit. This region was also characterized by a low percentage of low birthweight (<2.5 kg) infants (1%) and neonatal mortality rate (5 deaths per 1000 live births).Conclusions: Maternal and neonatal health outcomes in this region of Inner Mongolia were better than those in selected developing countries. [ABSTRACT FROM AUTHOR]- Published
- 2007
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24. Policy change and its application to Safe Motherhood programming
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C.B. Conroy
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Economic growth ,media_common.quotation_subject ,Population ,Pilot Projects ,Public Policy ,Health Services Accessibility ,Promotion (rank) ,Pregnancy ,Humans ,Medicine ,Maternal Health Services ,Quality (business) ,education ,Developing Countries ,media_common ,education.field_of_study ,Government ,business.industry ,Research ,Public sector ,Obstetrics and Gynecology ,General Medicine ,Private sector ,Family planning ,Sustainability ,Women's Health ,Female ,business - Abstract
The status of women's health and nutrition is affected by the absence or presence of government and private sector policies to promote women's rights to access quality maternal and family planning services. While both family planning and child survival literature pays substantial attention to the ‘policy environment’, little information is available with regard to the promotion of policies to support Safe motherhood Initiatives. Through a review of the family planning and child survival literature and from lessons learned from experiences of MotherCare country projects, this paper explores the issues and processes of policy formulation, implementation and sustainability. The paper also highlights specific Safe Motherhood strategies requiring policy attention with suggestions and examples of advocacy activities, research and demonstration projects which have been successful in creating and/or stimulating policy formulation. While there is no magic formula for policy promotion, experience has shown that a ‘body of constituents’, including women themselves as beneficiaries, is the key to moving the political process in the favor of Safe Motherhood.
- Published
- 1995
25. Local application of glyceril trinitrate ointment for primary dysmenorrhea
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Ghazizadeh, S., Dadkhah, T., and Modarres, M.
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CLINICAL trials ,COMPARATIVE studies ,DRUG administration ,DYSMENORRHEA ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,NITROGLYCERIN ,OINTMENTS ,PATIENT satisfaction ,REFERENCE values ,RESEARCH ,TRANSDERMAL medication ,EVALUATION research ,PAIN measurement ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,BLIND experiment ,SEVERITY of illness index ,DIAGNOSIS - Published
- 2002
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26. Expected to deliver: Alignment of regulation, training, and actual performance of emergency obstetric care providers in Malawi and Tanzania
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Lobis, Samantha, Mbaruku, Godfrey, Kamwendo, Francis, McAuliffe, Eilish, Austin, Judy, and de Pinho, Helen
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DELIVERY (Obstetrics) ,OBSTETRICAL emergencies ,MATERNAL health services ,HEALTH policy ,HEALTH facilities utilization ,HOSPITAL medical staff ,TRAINING ,EMERGENCY medical service laws ,MATERNAL health service laws ,MEDICAL care laws ,MEDICAL care standards ,COMPARATIVE studies ,EMERGENCY medical services ,RESEARCH methodology ,MEDICAL care ,MEDICAL quality control ,MEDICAL cooperation ,RESEARCH ,EVALUATION research ,ACQUISITION of data ,STANDARDS - Abstract
Objective: Policy, regulation, training, and support for cadres adopting tasks and roles outside their historical domain have lagged behind the practical shift in service-delivery on the ground. The Health Systems Strengthening for Equity (HSSE) project sought to assess the alignment between national policy and regulation, preservice training, district level expectations, and clinical practice of cadres providing some or all components of emergency obstetric care (EmOC) in Malawi and Tanzania.Methods: A mixed methods approach was used, including key informant interviews, a survey of District Health Management Teams, and a survey of health providers employed at a representative sample of health facilities.Results: A lack of alignment between national policy and regulation, training, and clinical practice was observed in both countries, particularly for cadres with less preservice training; a closer alignment was found between district level expectations and reported clinical practice. There is ineffective use of cadres that are trained and authorized to provide EmOC, but who are not delivering care, especially assisted vaginal delivery.Conclusion: Better alignment between policy and practice, and support and training, and more efficient utilization of clinical staff are needed to achieve the quality health care for which the Malawian and Tanzanian health ministries and governments are accountable. [ABSTRACT FROM AUTHOR]- Published
- 2011
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27. User fees and maternity services in Ethiopia
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Pearson, Luwei, Gandhi, Meena, Admasu, Keseteberhan, and Keyes, Emily B.
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MATERNAL health services ,MEDICAL care costs ,HEALTH facilities utilization ,DELIVERY (Obstetrics) ,MEDICAL quality control ,PREGNANCY complications ,ECONOMIC statistics ,MEDICAL care cost statistics ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,MATERNAL mortality ,RESEARCH ,USER charges ,EVALUATION research ,PATIENTS' attitudes ,ECONOMICS - Abstract
Objectives: To examine user fees for maternity services and how they relate to provision, quality, and use of maternity services in Ethiopia.Methods: The national assessment of emergency obstetric and newborn care (EmONC) examined user fees for maternity services in 751 health facilities that provided childbirth services in 2008.Results: Overall, only about 6.6% of women gave birth in health facilities. Among facilities that provided delivery care, 68% charged a fee in cash or kind for normal delivery. Health centers should be providing maternity services free of charge (the healthcare financing proclamation), yet 65% still charge for some aspect of care, including drugs and supplies. The average cost for normal and cesarean delivery was US $7.70 and US $51.80, respectively. Nineteen percent of these facilities required payment in advance for treatment of an obstetric emergency. The health facilities that charged user fees had, on average, more delivery beds, deliveries (normal and cesarean), direct obstetric complications treated, and a higher ratio of skilled birth attendants per 1000 deliveries than those that did not charge. The case fatality rate was 3.8% and 7.1% in hospitals that did and did not charge user fees, respectively.Conclusion: Utilization of maternal health services is extremely low in Ethiopia and, although there is a government decree against charging for maternity service, 65% of health centers do charge for some aspects of maternal care. As health facilities are not reimbursed by the government for the costs of maternity services, this loss of revenue may account for the more and better services offered in facilities that continue to charge user fees. User fees are not the only factor that determines utilization in settings where the coverage of maternity services is extremely low. Additional factors include other out-of-pocket payments such as cost of transport and food and lodging for accompanying relatives. It is important to keep quality of care in mind when user fees are under discussion. [ABSTRACT FROM AUTHOR]- Published
- 2011
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28. Using a GIS to model interventions to strengthen the emergency referral system for maternal and newborn health in Ethiopia
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Bailey, Patricia E., Keyes, Emily B., Parker, Caleb, Abdullah, Muna, Kebede, Henok, and Freedman, Lynn
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MEDICAL emergencies ,MATHEMATICAL models ,MATERNAL health services ,NEWBORN infant care ,DECISION making in clinical medicine ,OBSTETRICAL emergencies ,CHILD health services ,COMMUNICATION ,COMPARATIVE studies ,COMPUTER software ,DECISION making ,EMERGENCY medical services ,GEOGRAPHIC information systems ,HEALTH services accessibility ,MANAGEMENT ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL referrals ,RESEARCH ,TIME ,EVALUATION research ,TRANSPORTATION of patients ,STANDARDS - Abstract
Objectives: To show how GIS can be used by health planners to make informed decisions about interventions to increase access to emergency services.Methods: A combination of data sources, including the 2008 national Ethiopian baseline assessment for emergency obstetric and newborn care that covered 797 geo-coded health facilities, LandScan population data, and road network data, were used to model referral networks and catchment areas across 2 regions of Ethiopia. STATA and ArcGIS software extensions were used to model different scenarios for strengthening the referral system, defined by the structural inputs of transportation and communication, and upgrading facilities, to compare the increase in access to referral facilities.Results: Approximately 70% of the population of Tigray and Amhara regions is served by facilities that are within a 2-hour transfer time to a hospital with obstetric surgery. By adding vehicles and communication capability, this percentage increased to 83%. In a second scenario, upgrading 7 strategically located facilities changed the configuration of the referral networks, and the percentage increased to 80%. By combining the 2 strategies, 90% of the population would be served by midlevel facilities within 2 hours of obstetric surgery. The mean travel time from midlevel facilities to surgical facilities would be reduced from 121 to 64 minutes in the scenario combining the 2 interventions.Conclusions: GIS mapping and modeling enable spatial and temporal analyses critical to understanding the population's access to health services and the emergency referral system. The provision of vehicles and communication and the upgrading of health centers to first level referral hospitals are short- and medium-term strategies that can rapidly increase access to lifesaving services. [ABSTRACT FROM AUTHOR]- Published
- 2011
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29. Use of routinely collected data to assess maternal mortality in seven tertiary maternity centers in Cameroon
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Mbassi, Symplice Mbola, Mbu, Robinson, Bouvier-Colle, Marie Hélène, and Bouvier-Colle, Marie Hélène
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MATERNAL mortality ,DATA analysis ,PREGNANCY complications ,RETROSPECTIVE studies ,QUESTIONNAIRES ,COMPARATIVE studies ,DELIVERY (Obstetrics) ,HOSPITAL admission & discharge ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL referrals ,PATIENTS ,RESEARCH ,EVALUATION research ,SPECIALTY hospitals ,ACQUISITION of data - Abstract
Objective: To analyze the data available on obstetric complications, maternal deaths, and types of admission in 7 tertiary maternity centers in Cameroon.Methods: A descriptive retrospective study of all obstetric complications and maternal deaths that occurred in 7 tertiary level maternity hospitals between January 2005 and December 2006. Data were collected using the same registers, file records, and standardized questionnaires.Results: During the study period there were 34898 deliveries and 4069 cesareans were performed. There were 11014 obstetric complications and 249 maternal deaths were recorded, giving an MMR of 713 per 100000 deliveries. The risk of mortality among women referred to the tertiary level facilities was higher compared with women who were directly admitted to the facilities (odds ratio 3; 95% CI, 2.2-4.0).Conclusion: The high rates of maternal mortality recorded in tertiary maternity centers among women who were referred reveal the urgent need for interventions to improve the referral system. [ABSTRACT FROM AUTHOR]- Published
- 2011
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30. Disease burden due to pre-eclampsia/eclampsia and the Ethiopian health system's response
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Gaym, Asheber, Bailey, Patricia, Pearson, Luwei, Admasu, Keseteberhan, Gebrehiwot, Yirgu, and Ethiopian National EmONC Assessment Team
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PREECLAMPSIA ,ECLAMPSIA ,MATERNAL health services ,MATERNAL mortality ,OBSTETRICAL emergencies ,MAGNESIUM sulfate ,PERINATAL care ,COMPARATIVE studies ,ECONOMIC aspects of diseases ,EMERGENCY medical services ,RESEARCH methodology ,MEDICAL quality control ,MEDICAL cooperation ,RESEARCH ,EVALUATION research ,CROSS-sectional method ,THERAPEUTICS ,STANDARDS - Abstract
Objective: To assess the maternal disease burden due to pre-eclampsia/eclampsia in Ethiopia and the national health system's readiness to respond to the needs of women with pre-eclampsia/eclampsia.Methods: The national emergency obstetric and newborn care (EmONC) assessment entailed collecting information from 112 hospitals and 685 health centers in Ethiopia, focusing on their infrastructure, the services they provided, human resources, equipment and supplies, case load, and mortality due to pre-eclampsia/eclampsia.Results: Pre-eclampsia/eclampsia complicated 1.2% of all institutional deliveries. Given the low institutional delivery rate and an expected incidence of 2%-8% of all deliveries, this implies that only a small fraction (3.8%) of all women with pre-eclampsia/eclampsia received care at health facilities. 11% of all maternal deaths and 16% of direct maternal deaths were due to this obstetric complication. The cause-specific case fatality rate was high (3.6%). Availability of urine test strips, anticonvulsants, antihypertensives, and actual service provision to treat these diseases was limited, especially at health centers.Conclusion: The salutary effects of the national EmONC assessment were immediate, as evidenced by how quickly the release of the Ethiopian report led to important national efforts to improve maternal and newborn health. Expansion of health services should be augmented with periodic assessments of logistics and quality-related issues to assure functioning facilities for women accessing obstetric services. [ABSTRACT FROM AUTHOR]- Published
- 2011
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31. Indicators for availability, utilization, and quality of emergency obstetric care in Ethiopia, 2008
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Admasu, Keseteberhan, Haile-Mariam, Abonesh, and Bailey, Patricia
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OBSTETRICAL emergencies ,HEALTH status indicators ,MEDICAL centers ,MEDICAL quality control ,PERINATAL care ,MEDICAL care use ,TREATMENT of pregnancy complications ,CHILD health services ,CHILD welfare ,COMPARATIVE studies ,DELIVERY (Obstetrics) ,EMERGENCY medical services ,MATERNAL health services ,RESEARCH methodology ,MEDICAL cooperation ,MATERNAL mortality ,PREGNANCY complications ,RESEARCH ,MOTHERS ,EVALUATION research ,CROSS-sectional method ,STANDARDS ,SOCIAL history - Abstract
Objective: To report on the availability and quality of emergency obstetric and newborn care (EmONC) in Ethiopia.Methods: All licensed hospitals and health centers were visited and standard questionnaires were administered. In addition, a nonrandom systematic sample was taken of recent cesarean deliveries, partographs, and maternal deaths-and these cases were systematically reviewed. Health facilities were geocoded using geographic positioning system devices.Results: Too few facilities provided EmONC to meet the UN standards of 5 per 500,000 population, both nationally and in all but 2 regions. Only 7% of deliveries took place in institutions of any type, and only 3% in facilities that routinely provided all the signal functions. Only 6% of women with obstetric complications were treated in any health facility, half of whom were treated in fully functional EmONC facilities. Nationwide, 0.6% of expected deliveries were by cesarean. The mortality rate for women with serious obstetric complications (case fatality rate) was 2%. The cause of death was unknown in 10% of cases, and 21% were due to indirect causes (primarily malaria, anemia, and HIV-related).Conclusion: None of the indicators met UN standards. Ethiopia faces many challenges--not least geography--with regard to improving EmONC. Nevertheless, the government places high priority on improvement and has taken (and will continue to take) action to achieve Millennium Development Goals 4 and 5. This comprehensive survey serves both as a road map for planning strategies for improvement and as a baseline for measuring the impact of interventions. [ABSTRACT FROM AUTHOR]- Published
- 2011
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32. The effect of “breathable” panty liners on the female lower genital tract
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Giraldo, Paulo C., Amaral, Rose L.G., Juliato, Cássia, Eleutério, José, Brolazo, Eliane, Gonçalves, Ana K.S., Juliato, Cássia, Eleutério, José Jr, and Gonçalves, Ana K S
- Subjects
FEMININE hygiene products ,FEMALE reproductive organs ,GENITAL microbiology ,VULVOVAGINAL candidiasis ,BACTERIAL vaginitis ,LACTOBACILLUS ,VAGINAL discharge ,BACTERIAL vaginitis diagnosis ,COLPOSCOPY ,COMPARATIVE studies ,HYDROGEN-ion concentration ,RESEARCH methodology ,MEDICAL cooperation ,MENSTRUAL cycle ,PAP test ,RESEARCH ,EVALUATION research ,VULVOVAGINITIS ,EQUIPMENT & supplies ,RANDOMIZED controlled trials ,DIAGNOSIS - Abstract
Objective: To evaluate whether the use of "breathable" panty liners (BPLs) alters the normal vaginal flora, increases the incidence of bacterial vaginosis and/or vaginal candidiasis, or causes vulvar irritation.Methods: A randomized controlled trial assessed the vaginal ecosystem of women without complaints of vaginal discharge. The study group (n=53) wore BPLs for 10-12 hours each day for 75 consecutive days, whereas the control group (n=54) wore only their usual underwear. At each of 6 visits during 3 menstrual cycles, participants underwent gynecologic examination with colposcopic evaluation and pH measurement, in addition to assessment of vaginal microbial flora, intensity of inflammatory processes, and presence of vaginal candidiasis/bacterial vaginosis in Gram-stained smears.Results: After 75 consecutive days of BPL use, 40/44 (90.9%) and 42/44 (95.5%) women reported no complaints of vaginal discharge or vulvar itching/burning, respectively. There was no significant difference between the study group and the control group with regard to positive vaginal fungus cultures (5/44 [11.4%] vs 8/50 [16.0%]; P=0.7848) or bacterial vaginosis (3/44 [6.8%] vs 2/50 [4.0%]; P=0.7974) at the end of the study period.Conclusion: After 75 days of BPL use, there was no significant increase in vulvovaginal candidiasis, bacterial vaginosis, vulvovaginal irritation, or vulvovaginal inflammation. [ABSTRACT FROM AUTHOR]- Published
- 2011
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33. Efficacy of peripartum antiviral treatment for hepatic failure due to hepatitis B virus
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Yu, Minmin, Ji, Ying, Jiang, Hongxiu, Ju, Lili, Wu, Kaihua, and Kan, Naiying
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LIVER failure ,HEPATITIS B virus ,ANTIVIRAL agents ,ANTIVIRAL nucleosides ,PREGNANCY complications ,THIRD trimester of pregnancy ,LAMIVUDINE ,PUERPERIUM ,THERAPEUTICS ,HEPATITIS B transmission ,COMMUNICABLE diseases ,COMPARATIVE studies ,DNA ,HEPATITIS B ,RESEARCH methodology ,MEDICAL cooperation ,MATERNAL mortality ,PURINES ,RESEARCH ,TIME ,UTERINE diseases ,VIRAL antigens ,EVALUATION research ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,DISEASE complications ,PREVENTION - Abstract
Objective: To investigate the efficacy of oral nucleosides in preventing hepatic failure during pregnancy (HFP) caused by hepatitis B virus (HBV) infection.Methods: Besides receiving standard treatment, 70 women with HFP caused by HBV infection joined a study group (n = 40) or a control group (n = 30) according to their preference. In the study group, 14 women were given lamivudine in the third trimester and an antiviral treatment was continued postpartum. The 26 remaining patients were treated postpartum only, with lamivudine (n = 16) or entecavir (n = 10).Results: In the study group, the values for serum HBV DNA and hepatitis B envelope antigen were markedly lower at 1 and 2 months than they were at baseline (P < 0.001 and P < 0.001, respectively). Moreover, the HBV DNA values at 1 and 2 months were significantly lower in the study than in the control group (P < 0.05). Overall mortality and incidence of intrauterine infection were also significantly lower in the study group (P < 0.05). No newborns had any apparent abnormalities in either group.Conclusion: Treatment with nucleosides suppressed the replication of HBV DNA and led to biochemical improvement. It also reduced maternal mortality and safely decreased mother-to-child HBV transmission. [ABSTRACT FROM AUTHOR]- Published
- 2011
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34. Implementation of the Zambia Electronic Perinatal Record System for comprehensive prenatal and delivery care
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Chi, Benjamin H., Vwalika, Bellington, Killam, William P., Wamalume, Chibesa, Giganti, Mark J., Mbewe, Reuben, Stringer, Elizabeth M., Chintu, Namwinga T., Putta, Nande B., Liu, Katherine C., Chibwesha, Carla J., Rouse, Dwight J., and Stringer, Jeffrey S.A.
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PRENATAL care ,DELIVERY (Obstetrics) ,NEWBORN infant care ,PREGNANT women ,HIV ,GESTATIONAL age ,PUBLIC health ,MEDICAL records ,DIAGNOSIS of HIV infections ,DIAGNOSIS of syphilis ,SYPHILIS epidemiology ,HIV infection epidemiology ,BIRTH weight ,COMPARATIVE studies ,RESEARCH methodology ,EVALUATION of medical care ,MEDICAL cooperation ,MEDICAL screening ,PREGNANCY ,RESEARCH ,RESEARCH funding ,SYPHILIS ,PILOT projects ,EVALUATION research - Abstract
Objective: To characterize prenatal and delivery care in an urban African setting.Methods: The Zambia Electronic Perinatal Record System (ZEPRS) was implemented to record demographic characteristics, past medical and obstetric history, prenatal care, and delivery and newborn care for pregnant women across 25 facilities in the Lusaka public health sector.Results: From June 1, 2007, to January 31, 2010, 115552 pregnant women had prenatal and delivery information recorded in ZEPRS. Median gestation age at first prenatal visit was 23weeks (interquartile range [IQR] 19-26). Syphilis screening was documented in 95663 (83%) pregnancies: 2449 (2.6%) women tested positive, of whom 1589 (64.9%) were treated appropriately. 111108 (96%) women agreed to HIV testing, of whom 22% were diagnosed with HIV. Overall, 112813 (98%) of recorded pregnancies resulted in a live birth, and 2739 (2%) in a stillbirth. The median gestational age was 38weeks (IQR 35-40) at delivery; the median birth weight of newborns was 3000g (IQR 2700-3300g).Conclusion: The results demonstrate the feasibility of using a comprehensive electronic medical record in an urban African setting, and highlight its important role in ongoing efforts to improve clinical care. [ABSTRACT FROM AUTHOR]- Published
- 2011
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35. Adequacy of visual inspection with acetic acid in women of advancing age
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Cremer, Miriam, Conlisk, Elizabeth, Maza, Mauricio, Bullard, Kimberley, Peralta, Ethel, Siedhoff, Matthew, Alonzo, Todd, and Felix, Juan
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ACETIC acid ,DISEASES in women ,CERVICAL cancer ,MENOPAUSE ,COLD therapy ,PAP test ,AGE distribution ,COMPARATIVE studies ,DIAGNOSTIC errors ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL screening ,PHYSICAL diagnosis ,RESEARCH ,CERVIX uteri tumors ,EVALUATION research ,PREDICTIVE tests ,CERVICAL intraepithelial neoplasia ,DIAGNOSIS - Abstract
Objective: The present study assessed the adequacy and predictive performance of visual inspection with acetic acid (VIA) in women over the age of 50 years and compared the specificity and sensitivity of VIA with that of the conventional cytology.Methods: In total, 588 Salvadoran women ages 50-79 underwent VIA, Pap smear, and cervical biopsy. VIA was considered adequate if the squamocolumnar junction was completely visible. A positive biopsy was defined as cervical intraepithelial neoplasia (CIN) 2 or worse.Results: Age was negatively correlated with VIA adequacy (P=0.04). Nevertheless, the majority of women-even in the older age groups-had adequate examinations. The adequacy of VIA was positively correlated with gravida (P=0.01) and was higher in women who had been treated by cryotherapy (P=0.02). The rate of positive biopsies was unexpectedly low (n=6 [1%]) making it difficult to assess the predictive performance of VIA. In this small sample, the sensitivities of VIA (17%) and Pap (33%) were low; the high number of false negatives could not be fully explained by inadequacy of the examinations.Conclusions: Adequacy of VIA declined with age. However, the squamocolumnar junction was visible to the naked eye in the majority of women, indicating that they are good candidates for VIA. [ABSTRACT FROM AUTHOR]- Published
- 2011
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36. A randomized clinical trial of a levonorgestrel-releasing intrauterine system and a low-dose combined oral contraceptive for fibroid-related menorrhagia
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Sayed, Gamal H., Zakherah, Mahmoud S., El-Nashar, Sherif A., and Shaaban, Mamdouh M.
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DRUG efficacy ,MENORRHAGIA treatment ,LEVONORGESTREL intrauterine contraceptives ,ORAL contraceptives ,BLOOD loss estimation ,HEMOGLOBIN polymorphisms ,RANDOMIZED controlled trials ,UTERUS ,COMPARATIVE studies ,CONTRACEPTIVE drugs ,HEMOGLOBINS ,INTRAUTERINE contraceptives ,RESEARCH methodology ,MEDICAL cooperation ,MENORRHAGIA ,RESEARCH ,STEROIDS ,UTERINE fibroids ,EVALUATION research ,TREATMENT effectiveness ,LEVONORGESTREL ,DISEASE complications - Abstract
Objective: To compare the efficacy of a levonorgestrel-releasing intrauterine system (LNG-IUS) with that of a low-dose combined oral contraceptive (COC) in reducing fibroid-related menorrhagia.Methods: In this single-center, open, randomized clinical trial, 58 women with menorrhagia who desired contraception were randomized to receive a LNG-IUS or COC. The outcomes included treatment failure, defined as the need for another treatment; menstrual blood loss (MBL) by the alkaline hematin method and a pictorial assessment chart (PBAC); hemoglobin levels; and "lost days."Results: Treatment failed in 6 women (23.1%) in the LNG-IUS group and 11 (37.9%) in the COC group, for a hazard ratio of 0.46 (95% CI, 0.17-1.17, P=0.101). Using the alkaline hematin test, the reduction of MBL was significantly greater in the LNG-IUS group (90.9% ± 12.8% vs 13.4% ± 11.1%; P<0.001). Using PBAC scores, the reduction was also significantly greater in the LNG-IUS group (88.0% ± 16.5% vs 53.5% ± 5 1.2%; P=0.02). Moreover, hemoglobin levels increased from 9.7 ± 1.9g/dL to 11.7 ± 1.2g/dL (P<0.001) and lost days decreased from 8.2 ± 3.3 days to 1.3 ± 1.5 days (P=0.003) in the LNG-IUS group.Conclusion: Although the rate of treatment failure was similar in both groups, the LNG-IUS was more effective in reducing MBL than the COC in women with fibroid-related menorrhagia. [ABSTRACT FROM AUTHOR]- Published
- 2011
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37. Administration of 400μg of misoprostol to augment routine active management of the third stage of labor
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Hofmeyr, G. Justus, Fawole, Bukola, Mugerwa, Kidza, Godi, N. Patrick, Blignaut, Quentin, Mangesi, Lindeka, Singata, Mandisa, Brady, Leanne, and Blum, Jennifer
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MISOPROSTOL ,DRUG administration ,DRUG efficacy ,MEDICATION safety ,THIRD trimester of pregnancy ,LABOR (Obstetrics) ,PROSTAGLANDINS ,HEMORRHAGE prevention ,PUERPERAL disorders ,COMPARATIVE studies ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,STATISTICAL sampling ,EVALUATION research ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,BLIND experiment ,OXYTOCICS ,SUBLINGUAL drug administration ,PREVENTION ,THERAPEUTICS - Abstract
Abstract: Objective: To assess the effectiveness and safety of the administration of misoprostol, an orally active prostaglandin, in addition to routine uterotonic therapy as part of the active management of the third stage of labor. Methods: The present study was a hospital-based, decentralized, multi-center, randomized, placebo-controlled, double-blind trial. We enrolled 1103 women (out of a target sample size of 1180) at 4 hospitals in South Africa, Uganda, and Nigeria. Participants received a sublingual dose of 400μg of misoprostol or a placebo, in addition to standard active management of the third stage of labor, after vaginal birth. Results: The baseline characteristics of the participants were comparable. The difference in the primary outcome of blood loss of 500mL or more within 1 hour of randomization was not significant between the 2 groups (misoprostol 22/546 [4.0%] versus placebo 35/553 [6.3%]; relative risk, 0.64; 95% confidence interval, 0.38–1.07). Shivering and pyrexia occurred more frequently in the misoprostol group. No maternal deaths occurred. Conclusion: The present study did not confirm a beneficial effect of administering 400μg of misoprostol, in addition to routine uterotonic therapy, during the third stage of labor, but was consistent with other trials showing a cumulative modest benefit. Where routine uterotonics are available for prophylactic use, any potential benefit of misoprostol might not outweigh the likelihood of adverse effects. Trial registered on clinical trials.gov: NCT 00124540. [Copyright &y& Elsevier]
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- 2011
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38. Adoption of HPV testing as an adjunct to conventional cytology in cervical cancer screening in Japan
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Inoue, Masaki, Okamura, Makoto, Hashimoto, Shigeru, Tango, Masahiro, and Ukita, Toshihiko
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CERVICAL cancer diagnosis ,DIAGNOSIS of cancer in female reproductive organs ,MEDICAL screening ,CYTOLOGY ,WOMEN'S health ,MEDICAL care costs ,PAPILLOMAVIRUS disease diagnosis ,CERVIX uteri ,COLPOSCOPY ,COMPARATIVE studies ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,PAP test ,PAPILLOMAVIRUS diseases ,RESEARCH ,VERTEBRATES ,VIRUS diseases ,CERVIX uteri tumors ,EVALUATION research ,EARLY detection of cancer ,CERVICAL intraepithelial neoplasia ,DIAGNOSIS ,ECONOMICS - Abstract
Objective: To assess the effectiveness of including HPV testing as an adjunct to conventional cytology in cervical cancer screening.Methods: Atypical epithelial cells (ATC) were classified according to the 2001 Bethesda classification system. The study ran for 6 years from May 2004 to November 2009 in conjunction with public cervical cancer screening for Kanazawa City residents. Patients with ATC (ASC-US, ASC-H, and AGC) underwent parallel testing for high-risk HPV types with the Hybrid Capture II system; HPV positive and cytology-ATC cases were recalled for colposcopic examination and biopsied if necessary. Results were compared with those obtained before HPV screening was initiated.Results: A total of 62645 women underwent screening over the 6-year period; of these, 3622 (5.8%) were ATC positive, among whom 527 (14.5%) tested HPV-positive. These 527 women (0.8% of the screened population) were recalled for colposcopic examination. The resulting 426 biopsies were diagnosed as CIN 1 (n = 187), CIN 2 (n = 53), CIN 3 (n = 11), and invasive cervical cancer (n = 2).Conclusion: HPV testing as an adjunct to conventional cytology in cervical cancer screening seems to increase detection sensitivity with proven cost-effectiveness. [ABSTRACT FROM AUTHOR]- Published
- 2010
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39. Paid work, domestic work, and other determinants of pregnancy outcome in Ibadan, southwest Nigeria
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Omokhodion, Folashade O., Onadeko, Modupe O., Roberts, Olumuyiwa A., Beach, Jeremy R., Burstyn, Igor, and Cherry, Nicola M.
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PREGNANCY complications ,WORK ,HEALTH outcome assessment ,LOW birth weight ,STILLBIRTH ,PREMATURE infants ,BIRTH weight ,COMPARATIVE studies ,EXERCISE ,GESTATIONAL age ,RESEARCH methodology ,MEDICAL cooperation ,PERINATAL death ,PRENATAL care ,PROTEINURIA ,RESEARCH ,VIBRATION (Mechanics) ,EVALUATION research ,CROSS-sectional method ,PARITY (Obstetrics) ,DISEASE complications ,ECONOMICS - Abstract
Objective: To identify the determinants of low birth weight (LBW), preterm birth, and stillbirth, and the factors associated with paid or domestic work that affected pregnancy outcome in Ibadan, Nigeria.Methods: A cross-sectional study of women who delivered live or stillborn singleton neonates at 4 hospitals between February and June 2008. Participants were interviewed to obtain information on paid and domestic work activities during pregnancy, as well as obstetric history. Pregnancy outcomes and other clinical data were extracted from case notes.Results: A total of 1504 mothers aged 20-45 years recorded 137 (9.1%) LBW neonates (<2.5 kg), 154 (10.2%) preterm deliveries (<37 weeks), and 56 (3.7%) stillbirths. There was no overall increased risk of these outcomes among working mothers. Multivariate logistic regression analysis of working mothers who had booked their deliveries revealed that lifting heavy objects at home, a clinical record of proteinuria, and hospital admission during pregnancy were associated with LBW. Predictors for preterm birth were self-reported exposure to vibration at work, nulliparity, history of preterm birth, 4 or fewer compared with more than 8 antenatal visits, and prolonged rupture of membranes. Predictors for stillbirth were low education and prolonged rupture of membranes.Conclusion: The results further support recommendations that physical exertion in paid and domestic work should be reduced during pregnancy. [ABSTRACT FROM AUTHOR]- Published
- 2010
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40. Long-term vaginal administration of Lactobacillus rhamnosus as a complementary approach to management of bacterial vaginosis
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Marcone, Valentina, Rocca, Giuseppe, Lichtner, Miriam, and Calzolari, Ettore
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BACTERIAL vaginitis treatment ,LACTOBACILLUS ,VAGINITIS ,METRONIDAZOLE ,DISEASE relapse ,VAGINAL medication ,DIAGNOSIS ,ANTI-infective agents ,ALTERNATIVE medicine ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,ORAL drug administration ,RESEARCH ,STATISTICAL sampling ,EVALUATION research ,RANDOMIZED controlled trials ,PROBIOTICS ,THERAPEUTICS - Abstract
Objective: To investigate the advantages of long-term vaginal administration of Lactobacillus rhamnosus after oral treatment with metronidazole to prevent the recurrence of bacterial vaginosis (BV).Methods: A total of 49 women with a diagnosis of BV were randomized into 2 groups. Group A was treated with a twice daily dose of 500 mg oral metronidazole for 7 days. Group B was treated with the same schedule followed by a once-weekly vaginal application of 40 mg of Lactobacillus rhamnosus for 6 months. A non-parametric analysis of variance for repeated measures was used to test whether there were significant changes in the vaginal ecosystems in the 2 groups.Results: During the first 6 months of follow-up, a constant percentage (96%) of patients in group B had a balanced vaginal ecosystem. Follow-up over 12 months showed no statistically significant difference among vaginal ecosystems in patients in group B (P=0.40), whereas in group A there was a significant increase in the number of women with abnormal flora over time (P=0.01).Conclusion: The vaginal administration of the probiotic Lactobacillus rhamnosus allows stabilization of the vaginal ecosystem and reduces the recurrence of BV. [ABSTRACT FROM AUTHOR]- Published
- 2010
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41. An evaluation of a national intervention to improve the postabortion care content of midwifery education in Nigeria
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Akiode, Akinsewa, Fetters, Tamara, Daroda, Ramatu, Okeke, Bridget, and Oji, Ejike
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ABORTION ,MATERNAL health services ,MIDWIFERY education ,QUANTITATIVE research ,PHYSICIAN practice patterns ,MIDWIVES ,MEDICAL education ,COMPARATIVE studies ,VACUUM curettage ,CURRICULUM ,PATIENT aftercare ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL protocols ,POSTOPERATIVE care ,RESEARCH ,MIDWIFERY ,EVALUATION research - Abstract
Objective: To examine the impact of a national intervention to improve the postabortion care (PAC) content of midwifery education in Nigeria.Methods: A 3-part quantitative assessment was carried out during and post-intervention. The first baseline component developed and examined the intervention to improve teaching capacity and improve the PAC curriculum among 6 midwifery schools that were to become regional training centers. The second survey was a pre- and post-assessment conducted among midwifery instructors from all schools of midwifery in the country. In the third component, 149 midwives graduating from the 6 regional midwifery schools were interviewed once 3-9 months after graduation to evaluate whether the intervention had improved their knowledge of PAC and clinical practice, and the likelihood that they would provide PAC after graduation.Results: Data from 6 schools of midwifery in 2003 showed that none offered PAC or had educators trained in PAC prior to the intervention. Incorporation of PAC content and teaching capacity increased in all 6 study schools during the 3 years after a national intervention. Midwifery instructors demonstrated statistically significant improvements in knowledge of and exposure to PAC and manual vacuum aspiration (MVA) after the intervention. A follow-up interview with 149 student midwives post graduation showed increased knowledge, exposure to, and use of MVA in the workplace.Conclusion: Significant changes in graduate midwives' exposure, practice, and provision of PAC services resulted from a national intervention to improve the training environment and skills of midwifery instructors and students in the 6 schools of midwifery selected for evaluation. [ABSTRACT FROM AUTHOR]- Published
- 2010
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42. Lost opportunities for effective management of obstetric conditions to reduce maternal mortality and severe maternal morbidity in Argentina and Uruguay
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Karolinski, Ariel, Mazzoni, Agustina, Belizán, José M., Althabe, Fernando, Bergel, Eduardo, Buekens, Pierre, and Belizán, José M
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MATERNAL health services ,MATERNAL mortality ,PHYSICIAN practice patterns ,EVIDENCE-based medicine ,UTILIZATION review (Medical care) ,OBSTETRICAL emergencies ,ANTICONVULSANTS ,INFECTION prevention ,MAGNESIUM sulfate ,CESAREAN section ,COMPARATIVE studies ,INFECTION ,LABOR complications (Obstetrics) ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL protocols ,PREECLAMPSIA ,PREGNANCY complications ,PUBLIC hospitals ,PUERPERAL disorders ,RESEARCH ,RESEARCH funding ,UTERINE hemorrhage ,EVALUATION research ,ANTIBIOTIC prophylaxis ,PREVENTION ,THERAPEUTICS - Abstract
Objective: To review the use of evidence-based practices in the care of mothers who died or had severe morbidity attending public hospitals in two Latin American countries.Methods: This study is part of a multicenter intervention to increase the use of evidence-based obstetric practice. Data on maternal deaths and women admitted to intensive care units whose deliveries occurred in 24 hospitals in Argentina and Uruguay were analyzed. Primary outcomes were use rates of effective interventions to reduce maternal mortality (MM) and severe maternal morbidity (SMM).Results: A total of 106 women were included: 26 maternal deaths and 80 women with SMM. Some effective interventions for severe acute hemorrhage had a high use rate, such as blood transfusion (91%) and timely cesarean delivery (75%), while active management of the third stage of labor (25%) showed a lower rate. The overall use rate of effective interventions was 58% (95% CI, 49%-67%). This implies that 42% of the women did not receive one of the effective interventions to reduce MM and SMM.Conclusion: This study shows a low use of effective interventions to reduce MM and SMM in public hospitals in Argentina and Uruguay. Dissemination and implementation of evidence-based practices must be guaranteed to effectively achieve progress on maternal health. [ABSTRACT FROM AUTHOR]- Published
- 2010
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43. Availability and quality of emergency obstetric care in Shanxi Province, China
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Gao, Yu and Barclay, Lesley
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OBSTETRICAL emergencies ,MATERNAL health services ,RURAL health ,MEDICAL quality control ,MEDICAL personnel ,CESAREAN section ,UTERINE hemorrhage ,DIAGNOSIS ,HEMORRHAGE treatment ,AUDITING ,COMPARATIVE studies ,EMERGENCY medical services ,HEALTH services accessibility ,HEMORRHAGE ,HYPERTENSION in pregnancy ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL protocols ,PUERPERAL disorders ,RESEARCH ,RURAL population ,EVALUATION research ,DISEASE incidence ,DYSTOCIA ,THERAPEUTICS - Abstract
Objective: To investigate the availability and quality of emergency obstetric care (EmOC) received by women in a rural Chinese province.Methods: The study was conducted in 7 rural counties and townships in Shanxi Province, China. Data sources included interviews with 7 hospital leaders, 5 maternal and child health workers, and 7 obstetricians; 118 records of complicated delivery were audited, 21 Maternal and Child Health Annual Reports analyzed, and observations conducted of facilities and advanced labor care.Results: The number of comprehensive EmOC facilities was adequate in all counties. Three counties had fewer basic EmOC facilities than recommended and only 4 counties reached the recommended level. Most of the existing township hospitals did not provide birthing services. All the county hospitals could perform cesarean deliveries with rates from 6.8%-40.8%. The management of complications was not evidence-based. For example, women with pre-eclampsia and eclampsia were given too little magnesium sulfate; women were not closely monitored for hemorrhage after birth and the partograph was used incorrectly with consequences for obstructed labor.Conclusion: Basic EmOC facilities are not adequate and township hospitals should be upgraded to provide birthing services. The quality of EmOC is poor and needs improvement. [ABSTRACT FROM AUTHOR]- Published
- 2010
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44. Improving maternal and perinatal health care in the Central Asian Republics
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Borchert, Matthias, Bacci, Alberta, Baltag, Valentina, Hodorogea, Stelian, and Drife, James
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MATERNAL health services ,INFANT health services ,EVIDENCE-based medicine ,QUALITY assurance ,MATERNAL mortality ,MEDICAL records ,PATIENTS ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,CONTINUING education of nurses ,OBSTETRICS ,PUBLIC health surveillance ,RESEARCH ,CONTINUING medical education ,EVALUATION research - Abstract
Objective: To describe our experience of a complex training intervention to introduce effective perinatal care, evidence-based medicine, national confidential enquiries into maternal deaths, and facility-based near-miss case reviews in the Central Asian Republics.Methods: We describe our experiences from training sessions and report on findings from data extraction from patient records, patient interviews, discussions with healthcare staff, and observation of health care during our follow-up visits.Results: Many outdated practices in perinatal care have been abandoned, and several recommended approaches have been adopted in pilot facilities. Familiarity with the concept of evidence-based medicine has increased among participants. National confidential enquiries into maternal deaths are being prepared and facility-based near-miss case reviews piloted.Conclusion: The experience of the complex training intervention to improve maternal and perinatal health care in the Central Asian Republics is encouraging, but roll-out will be challenging. The quality of care and the attitudes of healthcare providers will have to be monitored continuously. [ABSTRACT FROM AUTHOR]- Published
- 2010
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45. Seroprevalence of hepatitis B surface antigen among pregnant women in Jiangsu, China, 17years after introduction of hepatitis B vaccine
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Zhang, Shu, Li, Ruo-Tian, Wang, Yangyang, Liu, Qilan, Zhou, Yi-Hua, and Hu, Yali
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SEROPREVALENCE ,HEPATITIS B ,CELL surface antigens ,PREGNANT women ,HEPATITIS B vaccines ,COMPARATIVE studies ,EPIDEMIOLOGICAL research ,HEPATITIS viruses ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,RURAL health ,URBAN health ,VIRAL antigens ,EVALUATION research ,DISEASE prevalence - Abstract
Objective: To estimate the prevalence of hepatitis B surface antigen (HBsAg) among pregnant women in Jiangsu Province, eastern China, 17years after vaccination against hepatitis B virus (HBV) was introduced.Methods: From August 2002 to July 2004, serum samples from 6398 women between 15 and 20weeks of pregnancy and from 6 urban and 8 rural areas across Jiangsu Province were tested for markers of HBV. The results were then compared with the rates before 1980.Results: The overall rates of 6.71% for HBsAg and 36.84% for anti-HBs were significantly lower and higher, respectively, than the prevaccination rates. The rate for HBsAg was lower in urban areas than in rural areas (5.75% vs 7.14%, P=0.04). Although the rate used to be much higher in the northern part of Jiangsu Province, which is less prosperous than the southern part, the rates are now similar in both parts (6.60% vs 6.97%).Conclusion: These findings demonstrate a drop in the prevalence of HBsAg among pregnant women in Jiangsu Province since the introduction of vaccination programs in 1980, and indicate that HBV infection can also be controlled in less prosperous areas. [ABSTRACT FROM AUTHOR]- Published
- 2010
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46. Sublingual misoprostol for first trimester termination of pregnancy
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Fekih, Myriam, Fathallah, Khadija, Regaya, Lassad Ben, Bouguizane, Sassi, Chaieb, Anouar, Bibi, Mohamed, Khairi, Hedi, and Ben Regaya, Lassad
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FIRST trimester of pregnancy ,FEMALE reproductive organ diseases ,MIFEPRISTONE ,ABORTION ,ANTIULCER drugs ,BLOOD testing ,ABORTIFACIENTS ,COMPARATIVE studies ,HEMATOCRIT ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,EVALUATION research ,RANDOMIZED controlled trials ,MISOPROSTOL ,SUBLINGUAL drug administration - Abstract
Objectives: To compare blood loss, efficiency, and acceptability of repeated doses of sublingual misoprostol with the standard Tunisian regimen of mifepristone-misoprostol for first trimester medical abortion.Methods: A prospective randomized trial of 252 healthy pregnant women requesting medical abortion in the first trimester (up to 56 days). Participants were randomized to receive 200mg of oral mifepristone followed by 400 microg of oral misoprostol (group 1) or 800 microg of sublingual misoprostol repeated every 4 hours for up to a maximum of 3 doses (group 2). Primary outcome was blood loss assessed by decrease in hematocrit.Results: Mean decrease in hematocrit at follow-up was significantly greater in group 1 than in group 2 (3.65%+/-1.18% vs 2.69%+/-1.89%, respectively; P=0.02). There was no difference in efficiency rates between groups 1 and 2 (94.5% vs 92.1%; P=0.7). Comparable proportions of women experiencing at least one adverse effect after misoprostol administration were reported in groups 1 and 2 (81.7% vs 79.4%; P=0.75).Conclusion: Compared with the most widely used regimen in Tunisia (mifepristone-misoprostol), sublingual misoprostol alone induces less blood loss (although not clinically significant); it is less expensive and offers reduced interval time to expulsion. [ABSTRACT FROM AUTHOR]- Published
- 2010
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47. Effectiveness of an instructional DVD on third- and fourth-degree laceration repair for obstetrics and gynecology postgraduate trainees
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Chao, Tamara T., Wendel, George D., McIntire, Donald D., Corton, Marlene M., and Wendel, George D Jr
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VIDEO tapes in education ,OBSTETRICS ,GRADUATE students ,SPHINCTERS ,QUESTION (Logic) ,CONTINUING medical education ,WOUNDS & injuries ,TRAINING ,ANAL surgery ,ANUS ,TRAUMA surgery ,AUDIOVISUAL materials ,COMPARATIVE studies ,DELIVERY (Obstetrics) ,GYNECOLOGY ,RESEARCH methodology ,MEDICAL cooperation ,MEDICAL education ,RESEARCH ,VIDEO production & direction ,EVALUATION research ,RANDOMIZED controlled trials - Abstract
Objective: To assess the effectiveness of an instructional DVD on the anatomy and repair of anal sphincter lacerations to improve postgraduate trainees' understanding.Methods: A total of 71 obstetrics and gynecology trainees completed a pretest of third- and fourth-degree lacerations to assess baseline knowledge and perceptions. Question categories included anatomy, antibiotics, anesthesia, repair methods, complications, postoperative care, and risk factors. After 1 year of clinical experience, 67 trainees (94%) were randomly assigned into DVD (intervention) and non-DVD (control) groups. A post-test was administered 4 weeks later.Results: In the DVD group (n=34), mean scores on the pretest versus the post-test were 65% vs 74% for postgraduate year (PGY)-1 (P=0.09); 72% vs 83% for PGY-2 (P=0.06); 67% vs 83% for PGY-3 (P=0.01); and 75% vs 87% for PGY-4 (P<0.001). In the non-DVD group (n=33), mean scores did not change significantly for any year level. The increase in score from pretest to post-test was significantly different between the 2 groups, independent of year (P<0.001). DVD group scores improved significantly over non-DVD group scores in anatomy (P=0.005) and repair methods (P=0.042) subscales.Conclusion: An educational video is an effective tool for improving understanding of third- and fourth-degree lacerations for physicians-in-training. [ABSTRACT FROM AUTHOR]- Published
- 2010
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48. A comparative study of the non-pneumatic anti-shock garment for the treatment of obstetric hemorrhage in Egypt
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Miller, Suellen, Fathalla, Mohamed M.F., Youssif, Mohammed M., Turan, Janet, Camlin, Carol, Al-Hussaini, Tarek K., Butrick, Elizabeth, and Meyer, Carinne
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WOMEN'S health services ,HEMORRHAGE ,PRESSURE suits ,UTERINE surgery ,MATERNAL mortality ,REGRESSION analysis ,COMPARATIVE studies ,HEMORRHAGE treatment ,CLINICAL trials ,PROTECTIVE clothing ,RESEARCH methodology ,MEDICAL cooperation ,PUERPERAL disorders ,RESEARCH ,EVALUATION research ,SHOCK (Pathology) ,PREVENTION ,THERAPEUTICS - Abstract
Objective: To assess the impact of the non-pneumatic anti-shock garment (NASG) on maternal outcome following severe obstetric hemorrhage.Methods: A non-randomized pre-intervention/intervention study was conducted in 2 tertiary hospitals in Egypt from June 2006 to May 2008. Women with obstetric hemorrhage (estimated blood loss >or=1000 mL and/or >or=1 sign of shock [systolic blood pressure <100 mm Hg or pulse >100 beats per minute]) were treated with either a standardized protocol (pre-intervention) or a standardized protocol plus the NASG (intervention). The primary outcome was extreme adverse outcome (EAO), combining maternal mortality and severe morbidity (cardiac, respiratory, renal, or cerebral dysfunction). Secondary outcomes were measured blood loss, urine output, emergency hysterectomy, and (individually) mortality or morbidity. Analyses were performed to examine independent association of the NASG with EAO.Results: Mean measured blood loss decreased from 379 mL pre-intervention to 253 mL in the intervention group (P<0.01). In a multiple logistic regression model, the NASG was associated with reduced odds of EAO (odds ratio 0.38; 95% confidence interval, 0.17-0.85).Conclusion: The NASG, in addition to standardized protocols at tertiary facilities for obstetric hemorrhage and shock, resulted in lower measured blood loss and reduced EAO. [ABSTRACT FROM AUTHOR]- Published
- 2010
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49. Transabdominal amnioinfusion in preterm premature rupture of membranes
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Singla, Anshuja, Yadav, Poonam, Vaid, Neelam B., Suneja, Amita, and Faridi, Mohammad M.A.
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PREMATURE labor ,PREMATURE rupture of fetal membranes ,FETAL membranes ,SEPSIS ,PUERPERAL disorders ,FETAL distress ,RANDOMIZED controlled trials ,AMNIOTIC liquid ,TREATMENT of pregnancy complications ,COMPARATIVE studies ,PREMATURE infants ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,SALT ,EVALUATION research ,TREATMENT effectiveness ,PARENTERAL infusions ,PREVENTION - Abstract
Objective: To evaluate the effect of transabdominal amnioinfusion on prolongation of pregnancy, and maternal and neonatal outcomes in preterm premature rupture of membranes (pPROM).Methods: We conducted a prospective randomized controlled study of women with pPROM during singleton live pregnancy-between 26 and 33+6weeks-whose amniotic fluid index (AFI) was less than the 5th percentile. The study group underwent transabdominal amnioinfusion at admission and then weekly if their AFI fell below the 5th percentile again. The control group received expectant management.Results: The difference in the mean interval from pPROM to delivery between the groups was not statistically significant. Neonatal and maternal outcomes were significantly improved in the study group compared with the control group (fetal distress [10% vs 37%]; early neonatal sepsis [17% vs 63%]; neonatal mortality [17% vs 63%]; spontaneous delivery [83% vs 53%]; and postpartum sepsis [7% vs 33%]).Conclusion: Transabdominal amnioinfusion reduced fetal distress, early neonatal sepsis, and neonatal mortality. In the study group, more participants delivered spontaneously and there were fewer cases of postpartum sepsis, although the pPROM-delivery interval was not increased. [ABSTRACT FROM AUTHOR]- Published
- 2010
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50. Prevention of postpartum hemorrhage at home birth in Afghanistan
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Sanghvi, Harshadkumar, Ansari, Nasratullah, Prata, Ndola J.V., Gibson, Hannah, Ehsan, Aftab T., and Smith, Jeffrey M.
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PUERPERAL disorders ,HEMORRHAGE prevention ,CHILDBIRTH at home ,MISOPROSTOL ,COMMUNITY-based family planning ,PLACE-based education ,OXYTOCICS ,COMMUNITY health workers ,COMPARATIVE studies ,HEALTH education ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,SELF medication ,PILOT projects ,EVALUATION research ,EVALUATION of human services programs ,PATIENTS' attitudes ,PREVENTION ,THERAPEUTICS - Abstract
Objective: To test the safety, acceptability, feasibility, and effectiveness of community-based education and distribution of misoprostol for prevention of postpartum hemorrhage at home birth in Afghanistan.Methods: A nonrandomized experimental control design in rural Afghanistan.Results: A total of 3187 women participated: 2039 in the intervention group and 1148 in the control group. Of the 1421 women in the intervention group who took misoprostol, 100% correctly took it after birth, including 20 women with twin pregnancies. Adverse effect rates were unexpectedly lower in the intervention group than in the comparison group. Among women in the intervention group, 92% said they would use misoprostol in their next pregnancy. In the intervention area where community-based distribution of misoprostol was introduced, near-universal uterotonic coverage (92%) was achieved compared with 25% coverage in the control areas.Conclusion: In Afghanistan, community-based education and distribution of misoprostol is safe, acceptable, feasible, and effective. This strategy should be considered for other countries where access to skilled attendance is limited. [ABSTRACT FROM AUTHOR]- Published
- 2010
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