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Rutin is a flavonoid present in numerous fruits and vegetables and therefore widely consumed by humans. It is also a popular dietary supplement of 250–500 mg/day. There is considerable consumer interest in rutin due to numerous reports in the biomedical literature of its multi-system chemo-preventive properties. The present paper provides the first assessment of rutin-induced hormetic concentration/dose responses, their quantitative features and mechanistic basis, along with their biological, biomedical, clinical, and public health implications. The findings indicate that rutin-induced hormetic dose responses are widespread, being reported in numerous biological models and cell types for a wide range of endpoints. Of critical importance is that the optimal hormetic findings shown in in vitro systems are currently not achievable for human populations due to low gastrointestinal tract bioavailability. These findings have the potential to strengthen future experimental studies with rutin, particularly concerning study design parameters. [Display omitted] • Rutin is a flavonoid present in fruits and vegetables consumed by humans. • Rutin displays multi-system chemo-preventive properties. • First assessment of rutin-induced hormetic dose responses and its implications. • Several biological models and cells show rutin-induced hormetic dose responses. • Findings have the potential to strengthen future experimental studies with rutin. [ABSTRACT FROM AUTHOR]