1. Rational construction of deep-red fluorescent probe for rapid detection of HClO and its application in bioimaging and paper-based sensing.
- Author
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Fang, Xingliang, Jin, Xilang, Ma, Xuehao, Guan, Li, Chen, Weixing, and She, Mengyao
- Subjects
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BIO-imaging sensors , *FLUORESCENT probes , *HYPOCHLORITES , *DETECTION limit , *HELA cells , *CELL phones , *SENSES - Abstract
Hypochlorous acid (HClO), the core bactericidal substance of the human immune system, plays a vital role in many physiological and pathological processes in the human body. In this work, we designed and synthesized a novel deep-red fluorescent probe TCF-ClO for the determination of hypochlorous acid through theoretical analysis. The results showed that probe TCF-ClO exhibited excellent characteristics of long-wavelength emission (635 nm), fast response (< 1 min), and low detection limit (24 nM). In addition, it had been successfully used for imaging of HClO in living HeLa cells. More importantly, the TCF-ClO composited paper-based sensing material was successfully constructed. The RGB/gray value was obtained from a mobile phone and computer, which could achieve the quantitative detection of HClO, with a linear detection range of 0–50 μM and a detection limit of 1.09 μM (RGB mode)/3.38 μM (gray mode). The function of the paper-based sensor extended from qualitative to quantitative detection of HClO, and it is expected to become a portable device widely used in the environmental area. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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