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The problematic of scientific research is the absence in domestic practice of systemic approaches to justified digital transformation in science-intensive organizations. This paper evaluates the implementation of a digitalization strategy using the example of science-intensive enterprises in strategic industries, substantiates the need for a sustainable digital transformation program in a science-intensive company. The level of digitalization of companies in Russia and the world is analyzed, synergistic effects from the implementation of digital initiatives and the advantages of their mutual aggregate interaction are revealed. Conclusions were made about the impact of the implementation of digital solutions on the competitiveness of knowledge-intensive industries, about the effects and effectiveness of the implementation of innovative digital projects. They also noted the risks, difficulties and problems arising in the implementation of digital solutions in enterprises. Strategic sectors of the economy were selected as the basis for the analysis: traditional sectors of the fuel and energy complex in terms of their contribution to the economy (PJSC Lukoil, PJSC Tatneft, State Corporation Rosatom) and in terms of development prospects (State Corporation Roskosmos). [ABSTRACT FROM AUTHOR]