1. Design and Development of a Robot-Based Automation System for Cryogenic Crystal Sample Mounting at the Advanced Photon Source.
- Author
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Shu, D., Preissner, C., Nocher, D., Han, Y., Barraza, J., Lee, P., Lee, W-K., Cai, Z., Ginell, S., Alkire, R., Lazarski, K., Schuessler, R., Joachimiak, A., and Warwick, T.
- Subjects
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AUTOMATION , *X-ray crystallography , *PHOTONS , *CRYSTALS , *ROBOTICS , *THREE-dimensional display systems , *ELECTRONIC data processing , *BIOLOGICAL stations - Abstract
X-ray crystallography is the primary method to determine the 3D structures of complex macromolecules at high resolution. In the years to come, the Advanced Photon Source (APS) and similar 3rd-generation synchrotron sources elsewhere will become the most powerful tools for studying atomic structures of biological molecules. One of the major bottlenecks in the x-ray data collection process is the constant need to change and realign the crystal sample. This is a very time- and manpower-consuming task. An automated sample mounting system will help to solve this bottleneck problem. We have developed a novel robot-based automation system for cryogenic crystal sample mounting at the APS. Design of the robot-based automation system, as well as its on-line test results at the Argonne Structural Biology Center (SBC) 19-BM experimental station, are presented in this paper. © 2004 American Institute of Physics [ABSTRACT FROM AUTHOR]
- Published
- 2004
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