10 results
Search Results
2. Antifungal effect of electrospun nanofibers containing cetylpyridinium chloride against Candida albicans.
- Author
-
Alves dos SANTOS, Valdirene, Aulestia VIERA, Patricia Verônica, Marim de OLIVEIRA, Adriano, Ambrosio ZANIN, Maria Helena, and Aparecida BORSATTI, Maria
- Subjects
CANDIDA albicans ,NANOFIBERS ,ANTISEPTICS ,BIOAVAILABILITY ,CETYLPYRIDINIUM chloride ,THERAPEUTICS - Abstract
It is known that cetylpyridinium chloride (CPC) has in vitro and in vivo antifungal action against Candida albicans, with advantages over other common antiseptics. A CPC delivery-controlled system, transported in polymer nanofibers (PVP/PMMA), was developed to increase the bioavailability of the drug in contact with the oral mucosa. The objectives of this study were to determine if CPC in nanofiber has antifungal action against C. albicans, and in what concentration it must be incorporated, so that the fraction released can yield an inhibitory concentration. The nanofiber was prepared by electrospinning, and sterilized with gamma irradiation. Nanofiber disks with 0.05%, 1.25%, 2.5% and 5% CPC, with 5% miconazole (MCZ) and with no drug, as well as filter paper disks with 5% CPC, with 5% MCZ and with no drug were used in this study. A Candida albicans suspension (ATCC 90028) was inoculated in Mueller-Hinton Agar plates. The disks were placed on the plates and the inhibition zone diameters were measured 48h later. The nanopolymeric disks contracted in contact with the agar. All the concentrations of CPC incorporated in the nanofiber presented inhibitory action against C. albicans. Concentrations of 2.5% and 5% CPC presented a significant advantage over the nanofiber with no drug, proving the antifungal action of CPC. Under these experimental conditions, 5% CPC has greater inhibitory action against C. albicans than 5% MCZ, both in nanofiber and in filter paper. A modification made in the polymer to decrease the contraction rate may allow a larger inhibition zone to be maintained, thereby increasing the clinical usefulness of the polymer. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
3. Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity.
- Author
-
Strydom, Schalk J., Rose, Warren E., Otto, Daniel P., Liebenberg, Wilna, and de Villiers, Melgardt M.
- Subjects
POLYAMIDOAMINE dendrimers ,NANOSTRUCTURED materials synthesis ,SILVER nanoparticles ,DENDRIMERS in medicine ,ANTIBACTERIAL agents ,SILVER sulfadiazine ,ANTISEPTICS ,BURNS & scalds - Abstract
Abstract: Silver sulfadiazine (AgSD) is a topical antibiotic with limited aqueous solubility. In this study, it was shown that poly(amido amine) (PAMAM) dendrimer complexes with SD (SDZ) and silver (Ag) could be used for a bottom-up approach to synthesize highly-soluble AgSD nanoparticles (NPs). These NPs were stabilized against crystal growth by electrostatic layer-by-layer (LBL) coating with various PAMAM dendrimers. Additionally, AgNPs can be incorporated in the dendrimer shells that augmented AgSD release. NP formulation in a cream base provided a topical drug-delivery platform with enhanced antibacterial properties against burn-wound infections, comprising three nanostructures i.e., nano-AgSD, AgNPs as well as PAMAM dendrimers, in one efficient, elegant nanosystem. From the Clinical Editor: In this paper an elegant silver sulfadiazine-based nanoparticle complex is demonstrated with enhanced antibacterial properties and improved solubility for the treatment of burn-wound infections in a topical crème formulation. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
4. Uniform contamination in the dental environment.
- Author
-
Leivers, Margarita, Tangri, Ekta, Kanji, Noren N., Hirji, Safia K., Hernandez, German, Kaminska, Beata D., and Do, Hang LT.
- Subjects
MICROBIAL contamination ,ANTISEPTICS ,CROSS infection prevention ,DENTAL hygiene ,DENTAL hygienists ,HEALTH occupations students ,HYGIENE ,MEDLINE ,ONLINE information services ,QUESTIONNAIRES ,STERILIZATION (Disinfection) ,UNIFORMS ,PREVENTION - Abstract
Copyright of Canadian Journal of Dental Hygiene is the property of Canadian Dental Hygienists Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2012
5. Increasing the Microbial Pathogen Stability as the Factor of the Development of Novel Antiseptic Means.
- Author
-
Todosiychuk, T. S., Strelets, T. I., and Konopatska, S. V.
- Subjects
ANTISEPTICS ,CELL growth ,BACTERIOPHAGES ,BACTERIOLYSIS ,BIOTECHNOLOGY ,ENZYMATIC analysis ,DRUG development ,MICROBIOLOGY - Abstract
This paper demonstrates the role of major mechanisms of resistance and additional factors in the process of increasing the stability of microbial pathogenes. We describe the approaches to prevention of microorganisms resistance formation as well as ways and perspectives of developing novel antiseptic means. Among promising directions of new antiseptics development are preparations that specifically inhibit the mechanisms of cell's growth (QS-system etc.), bacteriophage substances and its derivatives, modified bacteriolytic enzymes. [ABSTRACT FROM AUTHOR]
- Published
- 2011
6. Painless Acanthamoeba Keratitis in a Soft Contact Lens Wearer - Case Report.
- Author
-
Elabjer, Biljana Kuzmanović, Bušić, Mladen, Sviben, Mario, Elabjer, Esmat, and Predović, Jurica
- Subjects
KERATITIS ,ACANTHAMOEBA ,SOFT contact lenses ,EYE inflammation ,CORNEA diseases ,CHLORHEXIDINE ,ANTISEPTICS - Abstract
Copyright of Collegium Antropologicum is the property of Croatian Anthropological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2009
7. Primena periočipa sa hlorheksidinom u terapiji parodontopatije.
- Author
-
Luković, Natalija, Zelić, Obrad, and Čakić, Saša
- Subjects
PERIODONTAL disease treatment ,GINGIVAL diseases ,CHLORHEXIDINE ,ANTISEPTICS ,DISINFECTION & disinfectants - Abstract
Copyright of Serbian Dental Journal / Stomatološki Glasnik Srbije is the property of National Library of Serbia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2006
- Full Text
- View/download PDF
8. Um manuscrito inédito do naturalista José Bonifácio de Andrada e Silva: o parecer sobre o método de desinfetar as cartas vindas de países estrangeiros.
- Author
-
Varela, Alex Gonçalves and Lopes, Maria Margaret
- Subjects
CHLORINE ,ANTISEPTICS ,ASEPSIS & antisepsis ,YELLOW fever ,VINEGAR ,THERAPEUTICS - Abstract
Copyright of História, Ciências, Saúde - Manguinhos is the property of Casa de Oswaldo Cruz and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2006
- Full Text
- View/download PDF
9. Biological Implant Complications and Their Management.
- Author
-
Yung-Ting Hsu, Mason, Suzanne A., and Hom-lay Wang
- Subjects
DENTAL implants ,PROFESSIONAL peer review ,ANTISEPTICS ,BONE regeneration ,ANTI-infective agents - Abstract
Background: Background: With the increasing popularity of dental implants the presence of implant complications is rising, and the question of how to best manage these complications still lingers in most clinicians' minds. This paper aims to provide clinicians with an overview of the most commonly encountered biologic implant complications as well as to provide guide- lines as to how to treat them. Methods: Available English literature was reviewed, including peer-reviewed journal publications and online resources. Several treatment modalities have been proposed to manage these complications, including non-surgical mechanical debridement, antiseptics, local and/or systemic antibiotics, lasers, resection with or without implantoplasty and regenerative approaches. Results: In this guideline, it is suggested that the treatment modalities should be chosen based on the severity of pen-implant diseases, amount of bone loss and the morphology of pen-implant bony defects. For pen-implant mucositis or pen-implant defects with less than 2 mm destruction, non-surgical treatments are recommended. For pen-implant defects with more than 2 mm destruction, surgical treatments (e.g., resection with or without implantoplasty, guided bone regeneration) are suggested that include removal of the implant if the bone loss is beyond repair. Conclusion: The prevention of biological implant complications relies on careful planning, a thorough examination to assess etiological factors and a regular maintenance recall schedule. With early diagnosis, biological implant complications should be managed based on the severity of pen-implant disease, the amount of bone loss and the morphology of the pen-implant bony defects. [ABSTRACT FROM AUTHOR]
- Published
- 2014
10. Top Five Germ-Busters.
- Subjects
ANTISEPTICS ,HEALTH ,CLEANING ,DISHWASHING - Abstract
Provides tips on preventing germs. Washing dishes and refrigerating left-overs; Percentage of germs removed by paper towels; How to clean surfaces.
- Published
- 2000
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.