Hymenaea verrucosa (formerly Trachylobium hornemannianum) is a tree that exudes a resin known as Zanzibar copal in Africa and Sundrus in Unani (Greeko-Arab) medicine. It shows various therapeutic properties such as astringent, anthelminthic, antiobesogenic, antilipidemic and emmenagogue. It has been used in the treatment of obesity, headache, sinusitis, wounds, cataract, otitis, palpitations, worm infestations, taenia, haemorrhage, hyperhidrosis, haemorrhoids, diarrhoea, etc. since ancient times. This paper is intended for the documentation of the biological properties of Hymenaea verrucosa and the chemical compounds found in it as it is an indigenous Unani as well as African origin medicinal tree with much potential. This will also prompt the need for scientific clinical studies on its various pharmacological actions as it has not been fully evaluated. Data sources were authentic Unani literature, modern pharmacology books, and published works including various research and review papers available on PubMed, Science Direct and Google Scholar. The eligibility criteria were all relevant articles up to 2023 that described the pharmacology and clinical effects of Hymenaea verrucosa. Hymenaea verrucosa resin contains diterpenes and their derivative terpenoids such as caryophyllenes, sesquiterpenes, trachylobanes, kaurenes, diterpene acids, such as trachylolic acid, isotrachylolic acid, α and β selinene, α cubebene, α copaene, α and β resenes, essential oils etc. These constituents have shown anti-inflammatory, antioxidant, anticarcinogenic, metabolic, antidiabetic, neuroprotective, antimicrobial, antiparasitic activities in various in vitro and in vivo studies which conform with the old medical literature. The major limitation is that no in vivo or in vitro study has been conducted using the chemical constituents extracted from the resin. Therefore, this paper discusses the bioequivalence of the chemical components found in Hymenaea verrucosa resin through various studies. Zanzibar copal or Sundrus is a promising drug that has been effectively used in Unani medicine to treat various metabolic and phlegmatic disorders. Many potentially bioactive compounds are found in its resin, but no detailed studies of their biological activity are yet available. Therefore, there is a further need to focus research on Hymenaea verrucosa and its ingredients through advanced scientific methods. [Display omitted] • Sundrus is the resin of hymenaea verrucosa, previously trachylobium hornemannianum. • It has been used to treat obesity, sinusitis, haemorrhage, etc. since ancient times. • Zanzibar copal contains caryophyllene, diterpenes and trachylobanes. • They have apoptotic, antidiabetic, antiobesity and anticancer properties. • It can be concluded that gum copal can be used as a remedy for various ailments. [ABSTRACT FROM AUTHOR]