9,509 results
Search Results
2. Paper waste from instructions for use brochures in cataract surgery implant packaging in Europe and the United States.
- Author
-
Stern, Benjamin, Rampat, Radhika, Shahnazaryan, David, and Gatinel, Damien
- Subjects
- *
WASTE paper , *CATARACT surgery , *BROCHURES , *INTRAOCULAR lenses , *PACKAGING , *PHACOEMULSIFICATION - Abstract
Purpose: To assess the extent of paper waste generated per year by instructions for use (IFUs) brochures included in intraocular lens (IOL) packaging in Europe and the U.S. Setting: Rothschild Foundation Hospital, Paris, France; Royal Free London NHS Foundation Trust; Center for Sight, London, United Kingdom. Design: Experimental study. Methods: A sample of IOLs were collected and each IFU was weighed. In addition, the cumulative weight of these brochures used in cataract surgeries performed annually in Europe and the U.S. was estimated, and the potential annual paper conservation that could be achieved if all manufacturers adopted electronic IFUs (e-IFUs) in Europe and the U.S. was determined. Results: The mean and standard deviation of the weight for overall IFUs, classic IFUs, and e-IFUs were 17.6 ± 13.8 g, 23.5 ± 13.2 g, and 2.9 ± 1.9 g, respectively. The estimated cumulative weight of paper generated from the IFUs accompanying implants used in European and U.S. cataract surgeries is 153 tons. If all manufacturers transition to e-IFUs, the cumulative weight saved would be 128 tons (-84%), equivalent to 120 tons of carbon dioxide equivalent and the preservation of more than 2000 trees annually. Conclusions: The classic IFUs in IOL packaging result in a significant amount of paper waste annually. Therefore, there is an urgent need for a rapid transition to e-IFU technology. The adoption of e-IFUs has already been authorized in Europe and the U.S., and it is crucial to expedite this process. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Muslim Jurisprudence on Withdrawing Treatment from Incurable Patients: A Directed Content Analysis of the Papers of the Islamic Fiqh Council of the Muslim World League.
- Author
-
Muishout, George, El Amraoui, Abdessamad, Wiegers, Gerard Albert, and van Laarhoven, Hanneke Wilma Marlies
- Subjects
- *
QUALITATIVE research , *PALLIATIVE treatment , *TERMINATION of treatment , *CONTENT analysis , *LAWYERS , *PSYCHOLOGY & religion , *DECISION making in clinical medicine , *MUSLIMS , *ATTITUDE (Psychology) , *EUTHANASIA , *THEMATIC analysis , *RELIGION , *INFORMED consent (Medical law) , *CONCEPTUAL structures , *PHYSICIAN-patient relations , *DESPAIR , *PAIN , *TERMINALLY ill , *DISCLOSURE , *HOPE , *MEDICAL ethics - Abstract
This study investigates the views of contemporary Muslim jurists about withdrawing treatment of the terminally ill. Its aim is threefold. Firstly, it analyses jurists' views concerning core themes within the process of withdrawing treatment. Secondly, it provides insight into fatwas about withdrawing treatment. Thirdly, it compares these views with current medical standards in Europe and the Atlantic world on withdrawing treatment. The data consisted of six papers by Muslim jurists presented at the conference of the Islamic Fiqh Council in 2015. We conducted a directed content analysis (DCA) through a predetermined framework and compiled an overview of all previous fatwas referred to in the papers, which are also analysed. The results show that the general consensus is that if health cannot be restored, treatment may be withdrawn at the request of the patient and/or his family or on the initiative of the doctor. The accompanying fatwa emphasizes the importance of life-prolonging treatment if this does not harm the patient. It becomes apparent in the fatwa that the doctor has the monopoly in decision-making, which is inconsistent with current medical standards in Europe. Managing disclosure in view of the importance of maintaining the hope of Muslim patients may challenge the doctor's obligation to share a diagnosis with them. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Flow‐based basophil activation test in immediate drug hypersensitivity. An EAACI task force position paper.
- Author
-
Mayorga, C., Çelik, G. E., Pascal, M., Hoffmann, H. J., Eberlein, B., Torres, M. J., Brockow, K., Garvey, L. H., Barbaud, A., Madrigal‐Burgaleta, R., Caubet, J. C., and Ebo, D. G.
- Subjects
- *
DRUG allergy , *ALLERGIES , *TASK forces , *NEUROMUSCULAR blocking agents , *BASOPHILS - Abstract
Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe and reliable tests. Evidence has emerged that the basophil activation test (BAT), an in vitro assay that mirrors the in vivo response, can be a complementary test for many drugs. In this position paper, members of Task Force (TF) "Basophil activation test in the evaluation of Drug Hypersensitivity Reactions" from the European Academy of Allergy and Clinical Immunology (EAACI) present the data from a survey about the use and utility of BAT in IDHRs in Europe. The survey results indicate that there is a great interest for using BAT especially for diagnosing IDHRs. However, there are still main needs, mainly in the standardization of the protocols. Subsequently consensus‐based recommendations were formulated for: (i) Technical aspects of BAT in IDHRs including type of sample, management of drugs, flow cytometry protocols, interpretation of the results; and (ii) Drug‐specific aspects that should be taken into account when performing BAT in relation to betalactams, neuromuscular blocking agents, fluoroquinolones, chlorhexidine, opioids, radio contrast media, chemotherapeutics, biological agents, nonsteroidal anti‐inflammatory drugs, COVID vaccine, and excipients. Moreover, aspects in the evaluation of pediatric population have also been considered. All this indicates that BAT offers the clinician and laboratory a complementary tool for a safe diagnostic for IDHRs, although its place in the diagnostic algorithm depends on the drug class and patient population (phenotype, geography, and age). The standardization of BAT is important for generalizing this method beyond the individual laboratory. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
5. White paper on psychodermatology in Europe: A position paper from the EADV Psychodermatology Task Force and the European Society for Dermatology and Psychiatry (ESDaP).
- Author
-
Misery, Laurent, Schut, Christina, Balieva, Flora, Bobko, Svetlana, Reich, Adam, Sampogna, Francesca, Altunay, Ilknur, Dalgard, Florence, Gieler, Uwe, Kupfer, Jörg, Lvov, Andrey, Poot, Françoise, Szepietowski, Jacek C., Tomas‐Aragones, Lucia, Vulink, Nienke, Zalewska‐Janowska, Anna, and Bewley, Anthony
- Subjects
- *
TASK forces , *DERMATOLOGY , *PSYCHIATRY , *DERMATOLOGISTS - Abstract
Psychodermatology is a subspecialty of dermatology that is of increasing interest to dermatologists and patients. The case for the provision of at least regional psychodermatology services across Europe is robust. Psychodermatology services have been shown to have better, quicker and more cost‐efficient clinical outcomes for patients with psychodermatological conditions. Despite this, psychodermatology services are not uniformly available across Europe. In fact many countries have yet to establish dedicated psychodermatology services. In other countries psychodermatology services are in development. Even in countries where psychodermatolgy units have been established, the services are not available across the whole country. This is especially true for the provision of paediatric psychodermatology services. Also whilst most states across Europe are keen to develop psychodermatology services, the rate at which this development is being implemented is very slow. Our paper maps the current provision of psychodermatology services across Europe and indicates that there is still very much more work to be done in order to develop the comprehensive psychodermatology services across Europe, which are so crucial for our patients. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. Decarbonization Prospects for the European Pulp and Paper Industry: Different Development Pathways and Needed Actions.
- Author
-
Lipiäinen, Satu, Apajalahti, Eeva-Lotta, and Vakkilainen, Esa
- Subjects
- *
PAPER industry , *CARBON dioxide mitigation , *FUEL switching , *ENERGY consumption , *RENEWABLE energy sources , *RURAL electrification , *INDUSTRIAL energy consumption - Abstract
The pulp and paper industry (PPI) has several opportunities to contribute to meeting prevailing climate targets. It can cut its own CO2 emissions, which currently account for 2% of global industrial fossil CO2 emissions, and it has an opportunity to produce renewable energy, fuels, and materials for other sectors. The purpose of this study is to improve understanding of the decarbonization prospects of the PPI. The study provides insights on the magnitude of needed annual renewal rates for several possible net-zero target years of industrial fossil CO2 emissions in the PPI and discusses decarbonization opportunities, namely, energy and material efficiency improvement, fuel switching, electrification, renewable energy production, carbon capture, and new products. The effects of climate policies on the decarbonization opportunities are critically evaluated to provide an overview of the current and future business environment of the European PPI. The focus is on Europe, but other regions are analyzed briefly to widen the view. The analysis shows that there are no major technical barriers to the fossil-free operation of the PPI, but the sector renovates slowly, and many new opportunities are not implemented on a large scale due to immature technology, poor economic feasibility, or unclear political environment. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
7. Paper Review of External Integrated Systems as Photovoltaic Shading Devices.
- Author
-
Corti, Paolo, Bonomo, Pierluigi, and Frontini, Francesco
- Subjects
- *
PHOTOVOLTAIC power systems , *LITERATURE reviews , *CARBON emissions , *SOLAR radiation , *THERMAL comfort - Abstract
The building sector contributes to 40% of the total final energy consumption and 36% of CO2 emissions in Europe, and these are set to increase in the coming years. International directives are pushing towards a decarbonisation roadmap to improve the quality of cities and the health of citizens. Buildings have a potentially central role in terms of energy transition as a means to produce and save energy. Photovoltaic shading devices (PVSDs) protect buildings from direct solar radiation and overheating while producing renewable electricity onsite and increasing the users' thermal comfort. Even though the potential of the PVSD is considerable, the sector is still unexplored, and few studies on the topic are available in the literature. This systematic review aims to present an exhaustive overview of the current literature on state-of-the-art PVSDs by analysing the scientific framework in terms of the status of the research. It presents a performance-based approach focusing on innovative products, PVSD design strategies, and energetic performance in distinct climate conditions and configurations. In particular, 75 articles and about 250 keywords were identified, selected, and analysed. The literature review serves as a basis for further R&D activities led by both the industrial and the academic sectors. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
8. Trasformare i risultati in informazioni, armonizzazione del referto.
- Author
-
Buoro, Sabrina, Da Rin, Giorgio, and Ceriotti, Ferruccio
- Subjects
- *
MEDICAL laboratories , *ELECTRONIC paper , *UNITS of measurement , *ACRONYMS , *SIMPLICITY , *HEALTH websites - Abstract
The report of the medical laboratory is the final result of the complex analytical activity that requires technology, automation, organization and competence. The content of the report has been defined since 2015, but the application of the legislative requirements is still incomplete. The need for interoperability of the medical laboratory reports in order to be easily accessible and understandable throughout Europe, increases the requirements for the development of standards for reporting of test names, units of measurement, qualitative expressions. The adoption of LOINC codes may improve interoperability, but the codes have to be used correctly and a stewardship from Scientific Societies is needed. The laboratory reports are moving from paper to electronic format, and this should help the readability and simplicity favoring the interpretation, but the increasing amount of data and information may make them more difficult to read. This aspect together with the rapid development of new analytical technologies increases the need for interpretative comments, that should be clear, avoid acronyms or excessive technical terms and tackle the real relevant aspects. Being the final product of our activity, the report deserves more attention from our profession. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
9. A practical toolbox for the effective transition of adolescents and young adults with asthma and allergies: An EAACI position paper.
- Author
-
Vazquez‐Ortiz, Marta, Gore, Claudia, Alviani, Cherry, Angier, Elizabeth, Blumchen, Katharina, Comberiati, Pasquale, Duca, Bettina, DunnGalvin, Audrey, Garriga‐Baraut, Teresa, Gowland, M. Hazel, Egmose, Britt, Knibb, Rebecca, Khaleva, Ekaterina, Mortz, Charlotte G., Pfaar, Oliver, Pite, Helena, Podesta, Marcia, Santos, Alexandra F., Sanchez‐Garcia, Silvia, and Timmermans, Frans
- Subjects
- *
YOUNG adults , *ALLERGIES , *MEDICAL personnel , *ASTHMA , *TEENAGERS - Abstract
Introduction: Adolescence is a critical stage of rapid biological, emotional and social change and development. Adolescents and young adults (AYA) with asthma and allergies need to develop the knowledge and skills to self‐manage their health independently. Healthcare professionals (HCP), parents and their wider network play an essential role in supporting AYA in this process. Previous work showed significant limitations in transition care across Europe. In 2020, the first evidence‐based guideline on effective transition for AYA with asthma and allergies was published by EAACI. Aim: We herein summarize practical resources to support this guideline's implementation in clinical practice. Methods: For this purpose, multi‐stakeholder Task Force members searched for resources in peer review journals and grey literature. These resources were included if relevant and of good quality and were pragmatically rated for their evidence‐basis and user friendliness. Results: Resources identified covered a range of topics and targeted healthcare professionals, AYA, parents/carers, schools, workplace and wider community. Most resources were in English, web‐based and had limited evidence‐basis. Conclusions: This position paper provides a valuable selection of practical resources for all stakeholders to support effective transitional care for AYA with asthma and allergies. Future research should focus on developing validated, patient‐centred tools to further assist evidence‐based transition care. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
10. An EANM position paper on the application of artificial intelligence in nuclear medicine.
- Author
-
Hustinx, Roland, Pruim, Jan, Lassmann, Michael, and Visvikis, Dimitris
- Subjects
- *
ARTIFICIAL intelligence , *NUCLEAR medicine , *DIAGNOSTIC imaging , *MEDICAL societies - Abstract
Artificial intelligence (AI) is coming into the field of nuclear medicine, and it is likely here to stay. As a society, EANM can and must play a central role in the use of AI in nuclear medicine. In this position paper, the EANM explains the preconditions for the implementation of AI in NM and takes position. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
11. Physicians' responsibility toward environmental degradation and climate change: A position paper of the European Federation of Internal Medicine.
- Author
-
Campos, Luís, Barreto, J. Vasco, Bassetti, Stefano, Bivol, Monica, Burbridge, Amie, Castellino, Pietro, Correia, João Araújo, Durusu-Tanriöver, Mine, Fierbinteanu-Braticevici, Carmen, Hanslik, Thomas, Heleniak, Zbigniew, Hojs, Radovan, Lazebnic, Leonid, Mylona, Maria, Raspe, Matthias, Melo, João Queirós e, Pietrantonio, Filomena, Gans, Reinold, Pálsson, Runólfur, and Montano, Nicola
- Subjects
- *
ENVIRONMENTAL degradation , *INTERNISTS , *CLIMATE change , *INTERNAL medicine , *PHYSICIANS , *CLIMATE change & health - Abstract
• EFIM publishes a position paper about Environment Degradation and Climate Change. • Health industry should reduce its ecological footprint. • Internists should be involved in policy decisions related to climate change. • Internists must be active agents in advocating sustainable practices for the environment. • Internists should be role models in the adoption of environmentally friendly behavior. The current data on climate change and environmental degradation are dramatic. The consequences of these changes are already having a significant impact on people's health. Physicians — as advocates of the patients, but also as citizens — have an ethical obligation to be involved in efforts to stop these changes. The European Federation of Internal Medicine (EFIM) strongly encourages the Internal Medicine societies and internists across Europe to play an active role in matters related to climate change and environmental degradation. At a national level, this includes advocating the adoption of measures that reduce greenhouse gas (GHG) emissions and environmental degradation and contributing to policy decisions related to these issues. At a hospital level and in clinical practice, supporting actions by the health sector to reduce its ecological footprint is vital. At the level of EFIM and its associated internal societies, promoting educational activities and developing a toolkit to prepare internists to better care for citizens who suffer from the consequences of climate change. In addition to advocating and implementing effective actions to reduce the ecological footprint of the health industry, recommending the introduction of these themes in scientific programs of Internal Medicine meetings and congresses and the pre- and postgraduate medical training. At a personal level, internists must be active agents in advocating sustainable practices for the environment, increasing the awareness of the community about the health risks of climate change and environmental degradation, and being role models in the adoption of environmentally friendly behaviour. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
12. Care in Europe after presenting to the emergency department with a seizure; position paper and insights from the European Audit of Seizure Management in Hospitals.
- Author
-
Taylor, Claire, Tudur‐Smith, Catrin, Dixon, Pete, Linehan, Christine, Gunko, Aleksei, Christensen, Jakob, Pearson, Mike, Tomson, Torbjorn, Marson, Anthony, Trinka, Eugen, Visee, Helene, Depondt, Chantal, Santos, Susana Ferrao, Van Dycke, Annelies, Van Paesschen, Wim, Conway, Cara, O'Rourke, Geraldine, Flynn, Cora, McCarthy, Allan, and Cunningham, Denise
- Subjects
- *
HOSPITAL administration , *HOSPITAL emergency services , *SEIZURES (Medicine) , *WEB databases , *DIAGNOSIS of epilepsy , *EMERGENCY nursing , *MEDICAL audit - Abstract
Background and purpose: This position paper makes recommendations following an audit of care provided to people presenting with a seizure to emergency departments (EDs) in Europe. Methods: Participating countries were asked to include five hospitals agreeing to identify 50 consecutive seizure patients presenting to their ED between 1 August 2016 and 31 August 2017. Anonymous data were collected to a web database. Where quoted, percentages are mean site values and ranges are the 10th–90th centile. Results: Data were collected on 2204 ED visits (47 sites, up to six per country, across 15 countries): 1270 (58%) known epilepsy, 299 (14%) previous blackouts but no epilepsy diagnosis, 634 (29%) with a first seizure. Wide variability was identified for most variables. Of those with known epilepsy, 41.2% (range 26.2%–59.6%) attended the ED in the previous 12 months, but only 64.7% (range 37.2%–79.8%) had seen an epilepsy specialist in the previous 12 months. 67.7% (range 34.0%–100%) were admitted, 53.1% to a neurology ward (range 0.0%–88.9%). Only 37.5% first seizure patients (range 0.0%–71.4%) were given advice about driving. Conclusions and recommendations: It is recommended that in Europe guidance is agreed on the management and onward referral of those presenting to the ED with a seizure; a referral process is created that can be easily implemented; it is ensured that the seizure services receive referrals and see the patients within a short time period; and a simple system is developed and implemented to allow continuous monitoring of key indices of epilepsy care. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
13. The health of detainees and the role of primary care: Position paper of the European Forum for Primary Care.
- Author
-
Groenewegen, Peter, Dirkzwager, Anja, van Dam, Anke, Massalimova, Dina, Sirdifield, Coral, and Smith, Lauren
- Subjects
- *
HEALTH services accessibility , *PRISONERS , *PRIMARY health care , *CONTINUUM of care , *POLICY sciences , *MEDICAL needs assessment - Abstract
This position paper aims to increase awareness among primary care practitioners and policymakers about the specific and complex health needs of people who experience incarceration. We focus on the importance of primary care and of continuity of care between prison and community. We highlight what is known from the literature on the health of people who experience incarceration, on the organisation of prison health care, and on the role of primary care both during and after detention. We present three case descriptions of detainees' encounters with the organisation of prison health care in three European countries. Finally, we describe the position that the European Forum for Primary Care takes. Prisoners and ex-prisoners have a worse physical and mental health compared with a cross-section of the population. However, access to good quality treatment and care is often worse than in the outside situation. In particular, well-organised primary care in the prison context could benefit prisoners and, indirectly, society at large. Moreover, continuity of care between the community and the prison situation needs improvement. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
14. Tiled Interiors on Paper: Trade Catalogues as a Key Source to Understand the Use of Floor and Wall Tiles in European Interiors.
- Author
-
Baeck, Mario
- Subjects
- *
TILES , *FLOOR tiles , *TILE flooring , *CATALOGS , *CERAMIC tiles , *CATALOGING - Abstract
The enormous popularity of decorated industrial wall and floor tiles in Europe in the years 1840–1940 is strongly linked to the standardization, technical quality, and aesthetic variety of the products that were well marketed through often lavishly colored trade catalogues. More than the study of existing tile schemes in interiors, a systematic study of these trade catalogues leads to a better understanding of the general use of tile in the nineteenth- and twentieth-century interior. They inform us about factories and offer invaluable information on the technical and aesthetic evolution of tiles. They help us to date the designs and acquire a better knowledge of changes in taste in applying them. They are also a valuable source for documenting differences and similarities between factories and countries in matters of tile design and reveal opportunities to better understand the global export success or stylistic influence of many European factories in other countries on the continent as well as overseas. In this paper a general and theoretical approach is elucidated by referring to concrete cases based on a research collection of more than 600 tile catalogues from all over the world. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
15. Analysis of Paper Sludge Pellets for Energy Utilization.
- Author
-
Nosek, Radovan, Holubcik, Michal, Jandacka, Jozef, and Radacovska, Lucia
- Subjects
- *
BIOENERGETICS , *PAPER industry , *THERMOGRAVIMETRY , *PULP mills , *WOOD pellets - Abstract
The pulp and paper industry in Europe produces over 11 million tons of waste per year. Given high landfill operational costs, thermal coprocessing with biomass may be a viable management and valorisation option for such wastes. In this work, the analysis of biomass (wood sawdust), mixture of primary and secondary pulp mill sludge and their respective blends (50 wt.%, 60 wt.%, 70 wt.% of sludge) was assessed by thermogravimetric analysis. One of the possibilities to ensure valorisation of paper pulp mill sludge is its combustion in the form of pellets containing a different amount of sludge. Production of pellets samples was realised on laboratory experimental device. The measurements showed that increasing the content of paper sludge in the produced pellets reduced the calorific value and increased the ash content. This research deals also with the effect of paper sludge on the ash melting temperatures. The results indicated that a higher content of paper sludge in the pellets increased the ash melting temperatures. This advantage of paper sludge can be utilized in co-combustion of biomass with a low ash melting temperature. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
16. Tracing the origins of hybrids through history: monstrous cultivars and Napoléon Bonaparte's exiled paper daisies (Asteraceae; Gnaphalieae).
- Author
-
Collins, Timothy L, Bruhl, Jeremy J, Schmidt-Lebuhn, Alexander N, Telford, Ian R H, and Andrew, Rose L
- Subjects
- *
DAISIES , *ASTERACEAE , *EXILE (Punishment) , *CULTIVATED plants , *NATIVE plants , *CULTIVARS - Abstract
Golden everlasting paper daisies (Xerochrysum , Gnaphalieae, Asteraceae) were some of the earliest Australian native plants to be cultivated in Europe. Reputedly a favourite of Napoléon Bonaparte and Empress Joséphine, X. bracteatum is thought to have been introduced to the island of St Helena in the South Atlantic during Napoléon's exile there. Colourful cultivars were developed in the 1850s, and there is a widely held view that these were produced by crossing Xerochrysum with African or Asian Helichrysum spp. Recent molecular phylogenetic analyses and subtribal classification of Gnaphalieae cast doubt on this idea. Using single-nucleotide polymorphism (SNP) data, we looked for evidence of gene flow between modern cultivars, naturalized paper daisies from St Helena and four Xerochrysum spp. recorded in Europe in the 1800s. There was strong support for gene flow between cultivars and X. macranthum. Paper daisies from St Helena were genotypically congruent with X. bracteatum and showed no indications of ancestry from other species or from the cultivars, consistent with the continuous occurrence of naturalized paper daisies introduced by Joséphine and Napoléon. We also present new evidence for the origin of colourful Xerochrysum cultivars and hybridization of congeners in Europe from Australian collections. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
17. Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)
- Author
-
de Boer, Rudolf A., Heymans, Stephane, Backs, Johannes, Carrier, Lucie, Coats, Andrew J. S., Dimmeler, Stefanie, Eschenhagen, Thomas, Filippatos, Gerasimos, Gepstein, Lior, Hulot, Jean-Sebastien, Knöll, Ralph, Kupatt, Christian, Linke, Wolfgang A., Seidman, Christine E., Tocchetti, C. Gabriele, van der Velden, Jolanda, Walsh, Roddy, Seferovic, Petar M., and Thum, Thomas
- Subjects
- *
HOMEOSTASIS , *X-linked genetic disorders , *CARDIAC hypertrophy , *TREATMENT effectiveness , *GENETIC engineering , *GENE therapy , *ARRHYTHMIA , *HEART failure , *MEDICAL societies , *PHENOTYPES - Abstract
Genetic cardiomyopathies are disorders of the cardiac muscle, most often explained by pathogenic mutations in genes encoding sarcomere, cytoskeleton, or ion channel proteins. Clinical phenotypes such as heart failure and arrhythmia are classically treated with generic drugs, but aetiology-specific and targeted treatments are lacking. As a result, cardiomyopathies still present a major burden to society, and affect many young and older patients. The Translational Committee of the Heart Failure Association (HFA) and the Working Group of Myocardial Function of the European Society of Cardiology (ESC) organized a workshop to discuss recent advances in molecular and physiological studies of various forms of cardiomyopathies. The study of cardiomyopathies has intensified after several new study setups became available, such as induced pluripotent stem cells, three-dimensional printing of cells, use of scaffolds and engineered heart tissue, with convincing human validation studies. Furthermore, our knowledge on the consequences of mutated proteins has deepened, with relevance for cellular homeostasis, protein quality control and toxicity, often specific to particular cardiomyopathies, with precise effects explaining the aberrations. This has opened up new avenues to treat cardiomyopathies, using contemporary techniques from the molecular toolbox, such as gene editing and repair using CRISPR-Cas9 techniques, antisense therapies, novel designer drugs, and RNA therapies. In this article, we discuss the connection between biology and diverse clinical presentation, as well as promising new medications and therapeutic avenues, which may be instrumental to come to precision medicine of genetic cardiomyopathies. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
18. Defining dental operative skills curricula: An ADEE consensus paper.
- Author
-
Field, James, Dixon, Jonathan, Towers, Ashley, Green, Rachel, Albagami, Hathal, Lambourn, Guy, Mallinson, Julie, Fokkinga, Wietske, Tricio‐Pesce, Jorge, Crnić, Tin, and Vital, Sibylle
- Subjects
- *
CLINICAL competence , *ABILITY , *SURGICAL education , *CURRICULUM , *TEACHER effectiveness , *DENTAL education - Abstract
This paper reports on the recent activity of the pan‐European consensus of the ADEE Special Interest Group for Pre‐Clinical Operative Skills. Following the previous recommendations from the group, and in order to support teachers and to harmonise the delivery of skills training across Europe, a more formal curriculum relating to pre‐clinical operative skills needs to be created. This paper reports European consensus surrounding the categorisation (level of importance, and difficulty) of basic operative dental clinical skills within the undergraduate curriculum and provides recommendations relating to session structure and timing of curricular elements for basic operative dental clinical skills teaching. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
19. Using the Delphi technique to achieve consensus on bereavement care in palliative care in Europe: An EAPC White Paper.
- Author
-
Keegan, Orla, Murphy, Irene, Benkel, Inger, Limonero, Joaquim T, Relf, Marilyn, and Guldin, Mai-Britt
- Subjects
- *
CONSENSUS (Social sciences) , *MEMBERSHIP , *SCALE analysis (Psychology) , *DESCRIPTIVE statistics , *QUESTIONNAIRES , *BEREAVEMENT , *PALLIATIVE treatment , *DELPHI method , *EMAIL - Abstract
Background: The WHO definition of palliative care includes bereavement support as integral to palliative care, yet a previous survey of bereavement support in palliative care in Europe has shown a range of service responses to loss. A rigorous approach to agreeing and implementing a palliative care bereavement framework was required. Aim: The aim of this study was to develop consensus on best-practice recommendations for bereavement care principles, structures, processes and delivery based on current practice and evidence. Design: In accordance with Guidance on Conducting and Reporting Delphi Studies, a consensus-building five-round Delphi technique was performed. A scoping review of research literature informed drafting of 54 statements by the EAPC Bereavement Task Force. Evaluation of the statements was performed by an expert panel using a 5-point Likert scale. ⩾80% agreement were defined as essential items and 75%–79% agreement were defined as desirable items. Items with a consensus rating <75% were revised during the process. Setting/participants: The Delphi study was carried out by an expert panel among membership organisations of the European Association for Palliative Care. Results: In total, 376 email requests to complete Delphi questionnaire were distributed with a response rate of 23% (n = 87) and a follow-up response-rate of 79% (n = 69). Of the initial 54 statements in six dimensions, 52 statements were endorsed with 26 essential statements and 26 desirable statements. Conclusions: The six dimensions and 52 statements agreed through this Delphi study clarify a coherent direction for development of bereavement services in palliative care in Europe. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
20. European white paper: oropharyngeal dysphagia in head and neck cancer.
- Author
-
Baijens, Laura W. J., Walshe, Margaret, Aaltonen, Leena-Maija, Arens, Christoph, Cordier, Reinie, Cras, Patrick, Crevier-Buchman, Lise, Curtis, Chris, Golusinski, Wojciech, Govender, Roganie, Eriksen, Jesper Grau, Hansen, Kevin, Heathcote, Kate, Hess, Markus M., Hosal, Sefik, Klussmann, Jens Peter, Leemans, C. René, MacCarthy, Denise, Manduchi, Beatrice, and Marie, Jean-Paul
- Subjects
- *
HEAD & neck cancer , *GOVERNMENT report writing , *MEDICAL personnel as patients , *DEGLUTITION disorders , *MEDICAL societies - Abstract
Purpose: To develop a European White Paper document on oropharyngeal dysphagia (OD) in head and neck cancer (HNC). There are wide variations in the management of OD associated with HNC across Europe. Methods: Experts in the management of specific aspects of OD in HNC across Europe were delegated by their professional medical and multidisciplinary societies to contribute to this document. Evidence is based on systematic reviews, consensus-based position statements, and expert opinion. Results: Twenty-four sections on HNC-specific OD topics. Conclusion: This European White Paper summarizes current best practice on management of OD in HNC, providing recommendations to support patients and health professionals. The body of literature and its level of evidence on diagnostics and treatment for OD in HNC remain poor. This is in the context of an expected increase in the prevalence of OD due to HNC in the near future. Contributing factors to increased prevalence include aging of our European population (including HNC patients) and an increase in human papillomavirus (HPV) related cancer, despite the introduction of HPV vaccination in various countries. We recommend timely implementation of OD screening in HNC patients while emphasizing the need for robust scientific research on the treatment of OD in HNC. Meanwhile, its management remains a challenge for European professional associations and policymakers. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
21. 5 Interesting Facts about Containerboard (and Its Future).
- Author
-
Sharp, Stuart
- Subjects
- *
PAPER industry , *COVID-19 pandemic , *SULFATE pulping process , *INVESTMENT management - Published
- 2023
22. The Critical Need to Build a European Governance Model for Online Access to Medical Information Services: A Position Paper.
- Author
-
Pienaar, Stefne, Dunnett, Sarah, Flores, Angela, Hamilton, Ian, Mohamed, Susan, and De Wit, Jan
- Subjects
- *
INFORMATION services , *BASIC needs , *ACCESS to information , *INFORMATION resources , *MEDICAL personnel - Abstract
European pharmaceutical companies have a legal requirement to provide non-promotional Medical Information (MI) services to support healthcare professionals (HCPs) who are using their medicinal products. While the industry has self-regulating bodies with established Codes of Practice, these mainly focus on promotional messaging and commercial activities. In the absence of similar frameworks for MI, such services struggle to understand how to meet HCP digital expectations, often in fear of breaching the promotional codes. This is limiting access to the wealth of non-promotional patient-focussed information held within the industry. Meanwhile, a large volume of unregulated, low-quality information can be readily found on the internet. To understand the current status, the Medical Information Leaders in Europe (MILE) industry association performed a benchmarking survey which explored the online MI service provision of 13 mid-large pharmaceutical companies across Europe. This highlighted a great diversity in approach in terms of geographical coverage and content. Visibility and access for HCPs is complex, compromising online engagement and website utilisation. This MILE position paper highlights the critical need to establish a clear governance model, which empowers pharmaceutical company MI functions to provide unbranded, non-promotional, medicinal product information sources to support HCP online information needs. It is essential to build confidence, transparency and trust by establishing a practical quality framework with principles and standards for online MI services for HCPs. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
23. (Un)folding places with care: Migrant caregivers 'dwelling‐in‐folds'.
- Subjects
- *
PAPER arts , *CAREGIVERS , *HOUSEHOLD employees , *IMMIGRANTS , *HOUSEKEEPING , *MOTHERHOOD - Abstract
This paper is based on longitudinal ethnographic work among Bulgarian migrant women who work as live‐in caregivers and domestic workers in Italian households and explores the analytical potential of place and place making for transmigration literature by conceptualizing the co‐production of place with subjectivities. Such approach sensitizes to mundane practices of care and belonging, which actively create migratory lives of meaning. Drawing on Deleuze's concept of the fold as subjectivity and Clifford's notion of dwelling‐in‐travelling, I propose the term 'dwelling‐in‐folds' – and its mechanism 'folding place' – in order to make sense of temporary migrants' experience of place(s) that foregrounds their ability to connect and reconcile fractures and discontinuities, particularly when doing transnational motherhood. In doing so, the paper folds place empirically – showing how 'dwelling‐in‐folds' is achieved and unfolds place analytically – demonstrating the potential of this concept for sociology and transmigration studies. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
24. Cepi Annual Statistics Show Factors Behind Resilience and Strong Performance of European Pulp and Paper Industry.
- Subjects
- *
INDUSTRIAL statistics , *PAPER product manufacturing , *INDUSTRIAL capacity , *PAPER industry , *INTERNATIONAL trade - Published
- 2022
25. Life cycle assessment of pharmaceutical packaging addressing end-of-life alternatives.
- Author
-
Bassani, Fabiana, Rodrigues, Carla, and Freire, Fausto
- Subjects
- *
PRODUCT life cycle assessment , *GLASS recycling , *PACKAGING waste , *PAPER recycling , *LIFE cycles (Biology) , *PACKAGING - Abstract
[Display omitted] • Sensitivity analysis in packaging EoL modeling to evaluate influence in EoL impacts. • Take-back presents environmental benefits due to paper and glass recycling. • Incineration with energy recovery reduces EoL impacts from pharmaceutical packaging. • Smaller pharmaceutical packaging and EoL valorization reduces impacts. • Decisions at packaging early design stage influence EoL impacts. Pharmaceutical packaging waste has increased due to a higher global demand for pharmaceutical products, leading to more waste generation and associated environmental impacts. The main goal of this article is to present a cradle-to-grave life cycle assessment of pharmaceutical packaging, evaluating end-of-life (EoL) alternatives, aiming to identify hotspots and opportunities for improvement. A life cycle model was implemented for three types of pharmaceutical packaging (blisters, sachets, bottles; 23 packaging). The functional unit is the storage and delivery of medicines containing the same active pharmaceutical ingredient, dosage, and amount of medicines. Two EoL analyses were performed: 1) compare take-back (recycling and incineration) with domestic waste collection (landfill or incineration); and 2) assess different EoL situations of pharmaceutical packaging in Europe. A life cycle impact assessment was performed for 13 categories. Analysis 1 shows that take-back presents lower environmental impacts than domestic waste collection for seven out of 13 categories due to paper and glass recycling benefits. Analysis 2 shows that in the take-back, higher amounts of packaging are recycled or incinerated, which leads to lower EoL impacts. A sensitivity analysis was performed to evaluate the influence of parameters and assumptions in packaging EoL impacts. Packaging production contributes significantly to life cycle impacts, followed by transportation, EoL, and packing process. Ecodesign initiatives are recommended, such as packaging with less material and volume, using materials with lower impacts to significantly reduce the impacts of pharmaceutical packaging. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
26. The need for Pan‐European automatic pollen and fungal spore monitoring: A stakeholder workshop position paper.
- Author
-
Tummon, Fiona, Arboledas, Lucas Alados, Bonini, Maira, Guinot, Benjamin, Hicke, Martin, Jacob, Christophe, Kendrovski, Vladimir, McCairns, William, Petermann, Eric, Peuch, Vincent‐Henri, Pfaar, Oliver, Sicard, Michaël, Sikoparija, Branko, and Clot, Bernard
- Subjects
- *
FUNGAL spores , *POLLEN , *CLIMATOLOGY , *ENVIRONMENTAL management , *UNITS of measurement - Abstract
Background: Information about airborne pollen concentrations is required by a range of end users, particularly from the health sector who use both observations and forecasts to diagnose and treat allergic patients. Manual methods are the standard for such measurements but, despite the range of pollen taxa that can be identified, these techniques suffer from a range of drawbacks. This includes being available at low temporal resolution (usually daily averages) and with a delay (usually 3–9 days from the measurement). Recent technological developments have made possible automatic pollen measurements, which are available at high temporal resolution and in real time, although currently only scattered in a few locations across Europe. Materials & Methods: To promote the development of an extensive network across Europe and to ensure that this network will respond to end user needs, a stakeholder workshop was organised under the auspices of the EUMETNET AutoPollen Programme. Participants discussed requirements for the groups they represented, ranging from the need for information at various spatial scales, at high temporal resolution, and for targeted services to be developed. Results: The provision of real‐time information is likely to lead to a notable decrease in the direct and indirect health costs associated with allergy in Europe, currently estimated between €50–150 billion/year.1 Discussion & Conclusion: A European measurement network to meet end user requirements would thus more than pay for itself in terms of potential annual savings and provide significant impetus to research across a range of disciplines from climate science and public health to agriculture and environmental management. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
27. Non-wood Fibre as a New Innovation Frontier for Europe's Paper and Board Sector, Shows Nova-Institute Study.
- Subjects
- *
PAPER industry , *NON-timber forest products - Published
- 2023
28. An EAPC white paper on multi-disciplinary education for spiritual care in palliative care.
- Author
-
Best, Megan, Leget, Carlo, Goodhead, Andrew, and Paal, Piret
- Subjects
- *
CLINICAL competence , *CURRICULUM planning , *DECISION making , *PHILOSOPHY of education , *FEAR , *HEALTH care teams , *PALLIATIVE treatment , *PREJUDICES , *SPIRITUAL care (Medical care) , *STAKEHOLDER analysis - Abstract
Background: The EAPC White Paper addresses the issue of spiritual care education for all palliative care professionals. It is to guide health care professionals involved in teaching or training of palliative care and spiritual care; stakeholders, leaders and decision makers responsible for training and education; as well as national and local curricula development groups. Methods: Early in 2018, preliminary draft paper was written by members of the European Association for Palliative Care (EAPC) spiritual care reference group inviting comment on the four core elements of spiritual care education as outlined by Gamondi et al. (2013) in their paper on palliative care core competencies. The preliminary draft paper was circulated to experts from the EAPC spiritual care reference group for feedback. At the second stage feedback was incorporated into a second draft paper and experts and representatives of national palliative care organizations were invited to provide feedback and suggest revisions. The final version incorporated the subsequent criticism and as a result, the Gamondi framework was explored and critically revised leading to updated suggestions for spiritual care education in palliative care. Results: The EAPC white paper points out the importance of spiritual care as an integral part of palliative care and suggests incorporating it accordingly into educational activities and training models in palliative care. The revised spiritual care education competencies for all palliative care providers are accompanied by the best practice models and research evidence, at the same time being sensitive towards different development stages of the palliative care services across the European region. Conclusions: Better education can help the healthcare practitioner to avoid being distracted by their own fears, prejudices, and restraints and attend to the patient and his/her family. This EAPC white paper encourages and facilitates high quality, multi-disciplinary, academically and financially accessible spiritual care education to all palliative care staff. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
29. Manufacture and Combustion Characteristics of Cellulose Flame-Retardant Plate through the Hot-Press Method.
- Author
-
Hwang, Jeo, Park, Dongin, and Rie, Dongho
- Subjects
- *
HEAT release rates , *SMOKE , *FIREPROOFING agents , *PAPER recycling , *POISONOUS gases , *CONSTRUCTION materials , *WASTE paper - Abstract
This study focuses on the increased risk of high heat release and asphyxiation (toxic gas poisoning) in the event of a fire involving polyurethane (PU)- and MDF-based building materials, which are commonly used in buildings. Among them, polyurethane (PU) building materials are very commonly used in buildings, except in Europe and some other countries, due to their excellent thermal insulation performance. Still, problems of short-term heat release and the spread of toxic gases in the event of a fire continue to occur. To overcome these problems, researchers are actively working on introducing various flame retardants into building materials. Therefore, in this study, we produced a laboratory-sized (500 mm × 500 mm) plate-like flame-retardant board that can be utilized as a building material with a lower heat release rate and a lower toxicity index. The material was made by mixing expanded graphite and ceramic binder as flame retardants in a material that is formulated based on the cellulose of waste paper, replacing the existing building materials with a hot-press method. According to the ISO-5660-1 test on the heat release rate of the plate-like flame-retardant board, the Total Heat Release (THR) value was 2.9 (MJ/m2) for 10 min, showing an effect of reducing the THR value by 36.3 (MJ/m2) compared to the THR value of 39.2 (MJ/m2) of the specimen made using only paper. In addition, the toxicity index of the flame-retardant board was checked through the NES (Naval Engineering Standards)-713 test. As a result, the test specimen showed a toxicity index of 0.7, which is 2.4 lower than the toxicity index of 3.1 of MDF, which is utilized as a conventional building material. Based on the results of this study, the cellulose fire-retardant board showed the effect of reducing the heat release rate and toxicity index of building materials in a building fire, which reduces the risk of rapid heat spread and smoke toxicity. This has the potential to improve the evacuation time (A-SET) of evacuees in fires. It is also important to show that recycling waste paper and utilizing it as the main material for building materials can be an alternative in terms of sustainable development. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
30. Evidence of Fungal Spreading by the Grey Silverfish (Ctenolepisma longicaudatum) in Austrian Museums.
- Author
-
Querner, Pascal and Sterflinger, Katja
- Subjects
- *
GRAPHIC arts , *PAPER arts , *MUSEUMS , *ALTERNARIA , *MODERN art - Abstract
The grey silverfish Ctenolepisma longicaudatum is a new and serious pest spreading rapidly across Europe. Compared to the silverfish Lepisma saccharinum, it does not depend on relative humidity above 70% and thrives also in new museum buildings, modern storage depositories, apartments, and office buildings. Especially collections of graphic art, modern art on paper, photographs, but also archives and libraries are increasingly affected by this pest. Damage of paper objects has been reported by different authors and institutions across Europe. As these animals live in inaccessible cracks and crevices inside the buildings, we investigated the spread of microorganisms on living grey silverfish, to show a potential additional threat posed by this pest. In 8 locations in Austria living animals were collected with traps and placed for 10 min on agar plates which were incubated for 2 weeks. After incubation of 50 agar plates, between 2 and 20 colonies of fungi were growing on each plate. The most dominant fungal genera were Cladosporium (Cladosporium cladosporioides clade) and Penicillium (Penicillium glabrum, Penicillium decumbens); also, species of the genera Aspergillus, Alternaria, Botrytis, Bartalinia, Byssochlamis, Chaetomium and Mycothypha were found. The diversity of fungi reflects the common fungal community of museums and archives. The spores and mycelial fragments of the fungi are obviously travelling on the legs and bodies of the silverfish. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
31. Therapeutic strategies for severe COVID-19: a position paper from the Italian Society of Infectious and Tropical Diseases (SIMIT).
- Author
-
Mussini, Cristina, Falcone, Marco, Nozza, Silvia, Sagnelli, Caterina, Parrella, Roberto, Meschiari, Marianna, Petrosillo, Nicola, Mastroianni, Claudio, Cascio, Antonio, Iaria, Chiara, Galli, Massimo, Chirianni, Antonio, Sagnelli, Evangelista, Iacobello, Carmelo, Di Perri, Giovanni, Mazzotta, Francesco, Carosi, Giampiero, Tinelli, Marco, Grossi, Paolo, and Armignacco, Orlando
- Subjects
- *
COVID-19 , *COMMUNICABLE diseases , *PANDEMICS , *CORONAVIRUS disease treatment , *TROPICAL medicine , *COVID-19 treatment - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become pandemic, reaching almost one million death worldwide. At present standard treatment for coronavirus disease 2019 (COVID-19) is not well defined because the evidence, either from randomized or observational studies, with conflicting results, has led to rapid changes in treatment guidelines. Our aim was to narratively summarize the available literature on the management of COVID-19 in order to combine current evidence and interpretation of the data by experts who are treating patients in the frontline setting. The panel conducted a detailed review of the literature and eventual press releases from randomized clinical trials for each possible available treatment. Inductive PubMed search waws performed for publications relevant to the topic, including all clinical trials conducted. The result was a flowchart with treatment indications for patients with COVID-19. After 6 months of a pandemic situation and before a possible second coronavirus wave descends on Europe, it is important to evaluate which drugs proved to be effective while also considering that results from many randomized clinical trials are still awaited. Indeed, among treatments for COVID-19, only glucocorticoids have resulted in an association with a significant decrease in mortality in published randomized controlled trials. New therapeutic strategies are urgently needed. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
32. State‐of‐the‐art in marketed adjuvants and formulations in Allergen Immunotherapy: A position paper of the European Academy of Allergy and Clinical Immunology (EAACI).
- Author
-
Jensen‐Jarolim, Erika, Bachmann, Martin F., Bonini, Sergio, Jacobsen, Lars, Jutel, Marek, Klimek, Ludger, Mahler, Vera, Mösges, Ralph, Moingeon, Philippe, O´Hehir, Robyn E., Palomares, Oscar, Pfaar, Oliver, Renz, Harald, Rhyner, Claudio, Roth‐Walter, Franziska, Rudenko, Michael, Savolainen, Johannes, Schmidt‐Weber, Carsten B., Traidl‐Hoffmann, Claudia, and Kündig, Thomas
- Subjects
- *
CLINICAL immunology , *ALLERGENS , *ALLERGIES , *IMMUNOTHERAPY , *PATIENT compliance - Abstract
Since the introduction of allergen immunotherapy (AIT) over 100 years ago, focus has been on standardization of allergen extracts, with reliable molecular composition of allergens receiving the highest attention. While adjuvants play a major role in European AIT, they have been less well studied. In this Position Paper, we summarize current unmet needs of adjuvants in AIT citing current evidence. Four adjuvants are used in products marketed in Europe: aluminium hydroxide (Al(OH)3) is the most frequently used adjuvant, with microcrystalline tyrosine (MCT), monophosphoryl lipid A (MPLA) and calcium phosphate (CaP) used less frequently. Recent studies on humans, and using mouse models, have characterized in part the mechanisms of action of adjuvants on pre‐existing immune responses. AIT differs from prophylactic vaccines that provoke immunity to infectious agents, as in allergy the patient is presensitized to the antigen. The intended mode of action of adjuvants is to simultaneously enhance the immunogenicity of the allergen, while precipitating the allergen at the injection site to reduce the risk of anaphylaxis. Contrasting immune effects are seen with different adjuvants. Aluminium hydroxide initially boosts Th2 responses, while the other adjuvants utilized in AIT redirect the Th2 immune response towards Th1 immunity. After varying lengths of time, each of the adjuvants supports tolerance. Further studies of the mechanisms of action of adjuvants may advise shorter treatment periods than the current three‐to‐five‐year regimens, enhancing patient adherence. Improved lead compounds from the adjuvant pipeline are under development and are explored for their capacity to fill this unmet need. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
33. Trauma-informed responses in addressing public mental health consequences of the COVID-19 pandemic: position paper of the European Society for Traumatic Stress Studies (ESTSS).
- Author
-
Javakhishvili, Jana Darejan, Ardino, Vittoria, Bragesjö, Maria, Kazlauskas, Evaldas, Olff, Miranda, and Schäfer, Ingo
- Subjects
- *
COVID-19 pandemic , *MENTAL health , *COVID-19 , *PUBLIC health , *CAPACITY building , *EMOTIONAL trauma - Abstract
The COVID-19 pandemic has changed life in Europe and globally. The pandemic affects both individuals and the broader society across many domains, including physical and psychological health, the economy and general welfare. The measures taken to counteract the pandemic have significantly altered daily life and, along with the threat of contracting the coronavirus and uncertainties surrounding future developments, created a complex system of stressors with a negative impact on public mental health. This paper aims to outline the ESTSS strategy to address mental health issues related to COVID-19 and focuses on (1) trauma-informed policies, (2) capacity building, (3) collaborative research and (4) knowledge-exchange. To facilitate implementation of a trauma-informed approach and appropriate measures, ESTSS has developed a toolkit of recommendations on mental health and psychosocial assistance to be provided during the different phases of crisis and its aftermath. To promote capacity building, ESTSS offers a certification programme based on a curriculum in psychotraumatology and corresponding on-line training to the European community of mental health professionals. To assure evidence-based approaches and methods tailored to current circumstances, ESTSS has initiated a pan-European research project with international cooperation aimed at studying the mental health consequences of the pandemic, with a focus on psychological trauma and other stress-related reactions. To foster knowledge-exchange, the European Journal of Psychotraumatology (EJPT), the official journal of ESTSS, is publishing a special issue on COVID-19. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
34. EANM position paper on article 56 of the Council Directive 2013/59/Euratom (basic safety standards) for nuclear medicine therapy.
- Author
-
Konijnenberg, Mark, Herrmann, Ken, Kobe, Carsten, Verburg, Frederik, Hindorf, Cecilia, Hustinx, Roland, and Lassmann, Michael
- Subjects
- *
NUCLEAR medicine , *RADIATION dosimetry , *ABSORBED dose , *MEDICAL practice , *MEDICAL physics , *UNITS of measurement , *SAFETY standards - Abstract
Executive Summary: The EC Directive 2013/59/Euratom states in article 56 that exposures of target volumes in nuclear medicine treatments shall be individually planned and their delivery appropriately verified. The Directive also mentions that medical physics experts should always be appropriately involved in those treatments. Although it is obvious that, in nuclear medicine practice, every nuclear medicine physician and physicist should follow national rules and legislation, the EANM considered it necessary to provide guidance on how to interpret the Directive statements for nuclear medicine treatments. For this purpose, the EANM proposes to distinguish three levels in compliance to the optimization principle in the directive, inspired by the indication of levels in prescribing, recording and reporting of absorbed doses after radiotherapy defined by the International Commission on Radiation Units and Measurements (ICRU): Most nuclear medicine treatments currently applied in Europe are standardized. The minimum requirement for those treatments is ICRU level 1 ("activity-based prescription and patient-averaged dosimetry"), which is defined by administering the activity within 10% of the intended activity, typically according to the package insert or to the respective EANM guidelines, followed by verification of the therapy delivery, if applicable. Non-standardized treatments are essentially those in developmental phase or approved radiopharmaceuticals being used off-label with significantly (> 25% more than in the label) higher activities. These treatments should comply with ICRU level 2 ("activity-based prescription and patient-specific dosimetry"), which implies recording and reporting of the absorbed dose to organs at risk and optionally the absorbed dose to treatment regions. The EANM strongly encourages to foster research that eventually leads to treatment planning according to ICRU level 3 ("dosimetry-guided patient-specific prescription and verification"), whenever possible and relevant. Evidence for superiority of therapy prescription on basis of patient-specific dosimetry has not been obtained. However, the authors believe that a better understanding of therapy dosimetry, i.e. how much and where the energy is delivered, and radiobiology, i.e. radiation-related processes in tissues, are keys to the long-term improvement of our treatments. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
35. Bridging the Mediterranean without papers: Tunisian francophone illiterature's representation of irregular immigration in the age of globalisation.
- Author
-
Kebsi, Jyhene
- Subjects
- *
GLOBALIZATION , *CAPITAL movements , *IDENTITY (Psychology) , *EMIGRATION & immigration , *PUNISHMENT - Abstract
My essay illuminates the plights of those who live on the southern shore of the Mediterranean under the antagonistic forces of globalisation, according to which the free movement of capital between Europe and North Africa is matched by a criminalisation of immigrants from the southern bank. My analysis of the discrepancy between the borderless economics and the bordered movement of people explores the representation of clandestine immigration in Fawzi Mellah's Clandestin en Méditerranée/Clandestine in the Mediterranean (2000), which depicts illicit passages from North Africa to Europe. Criticising European democracies' containment of the heralded dynamism of the global age and their diffusion of a discourse feeding fear about migrants, I show that globalisation has turned into a 'globalization of punitiveness' [Barker, Vanessa. 2012. 'Global Mobility and Penal Order: Criminalizing Migration, A View from Europe.' Sociology Compass 6 (2): 113–121]. My exploration of the migrants featured in the text demonstrates that globalisation's failure to achieve the spatial decentralisation ideal on which it has based its flat-planet premise makes undocumented immigration the last resort of those to whom the Schengen Area closes its borders. My spatial analysis of the paperless migratory enterprise reads the irregular crossing as an attempt to construct defiant identities that resist the global structure of domination. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
36. Saving 50% Energy in Paper Industry Through Heat Pumps.
- Subjects
- *
PAPER industry , *HEAT pumps , *ENERGY conservation , *CLEAN energy - Published
- 2023
37. In‐vivo diagnostic test allergens in Europe: A call to action and proposal for recovery plan—An EAACI position paper.
- Author
-
Klimek, Ludger, Hoffmann, Hans J., Kalpaklioglu, Ayse F., Demoly, Pascal, Agache, Ioana, Popov, Todor A., Muraro, Antonella, Schmid‐Grendelmeier, Peter, Bonini, Sergio, Bonertz, Andreas, Mahler, Vera, Vieths, Stefan, Pfaar, Oliver, Zuberbier, Torsten, Jutel, Marek, Schmidt‐Weber, Carsten, Hellings, Peter W., Dreborg, Sten, Bonini, Matteo, and Brough, Helen A.
- Subjects
- *
ALLERGENS , *IN vivo studies , *DIAGNOSIS methods , *ALLERGIES , *RESPIRATORY allergy , *ALLERGIC conjunctivitis - Abstract
Diagnostic allergens are defined as medicinal products in the EU. Marketing authorization by national authorities is necessary; however, diagnostic allergens are not homogeneously regulated in different EU member states. Allergen manufacturers argue with increasing costs forcing them to continuously reduce the diagnostic allergen portfolios offered to allergists. In contrast, EAACI and national European Allergy Societies see the need for the availability of a wide range of high‐quality diagnostic allergens for in vivo diagnosis of IgE‐mediated allergies not only covering predominant but also less frequent allergen sources. In a recent EAACI task force survey, the current practice of allergy diagnosis was shown to rely on skin tests as first option in almost 2/3 of all types of allergic diseases and in 90% regarding respiratory allergies. With the need to ensure the availability of high‐quality diagnostic allergens in the EU, an action plan has been set up by EAACI to analyse the current regulatory demands in EU member states and to define possible solutions stated in this document: (a) simplification of authorization for diagnostic allergens; (b) specific regulation of special types of diagnostic allergens; (c) new models beyond the current model of homologous groups; (d) simplification of pharmacovigilance reporting; (e) reduction of regulation fees for diagnostic allergens; (f) reimbursement for diagnostic allergens. Joining forces of allergists, manufacturers and authorities are of high importance to ensure remaining relevant allergens in the EU markets to facilitate a sustainable and comprehensive service for the diagnosis and treatment of allergic diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
38. How to Apply European and American Guidelines on High Blood Pressure in Children and Adolescents. A Position Paper Endorsed by the Italian Society of Hypertension and the Italian Society of Pediatrics.
- Author
-
Genovesi, Simonetta, Parati, Gianfranco, Giussani, Marco, Bona, Gianni, Fava, Cristiano, Maffeis, Claudio, Ferri, Claudio, and Giordano, Ugo
- Subjects
- *
BLOOD pressure , *HYPERTENSION , *MEDICAL protocols , *CHILDHOOD obesity , *PEDIATRICS , *REFERENCE values , *ADOLESCENCE , *CHILDREN - Abstract
Children are defined as hypertensive when their blood pressure values equal or exceed the 95th percentile of the blood pressure value distribution in a pediatric population, according to gender, age and height. The population on which reference tables are based is of fundamental importance to establish the threshold values for the diagnosis of hypertension in pediatric age. Before 2017, both American and European guidelines used nomograms created in the same reference population which included children of all weight classes. Given the close and well-known association between hypertension and excess weight in childhood, the 2017 American guidelines proposed new reference nomograms excluding subjects with overweight and obesity from the "historical" reference population. Furthermore, the new American guidelines suggested a fixed cut-off of 130/80 mmHg, starting from 13 years and regardless of gender and height, to make the diagnosis of hypertension. In this document, the Italian Hypertension Society (SIIA) and the Italian Pediatric Society (SIP) jointly discuss a number of issues raised by the new American guidelines that involve the entire medical community, and also address the definition of arterial hypertension in the transition phase between childhood and adulthood. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
39. Evaluating emissions and air quality implications of residential waste incineration.
- Author
-
Mentes, Dóra, Jordán, Anikó, Farkas, László, Muránszky, Gábor, Fiser, Béla, Viskolcz, Béla, and Póliska, Csaba
- Subjects
- *
AIR quality , *WASTE products as fuel , *WOOD waste , *AIR pollutants , *ENERGY shortages , *INCINERATION , *POLYESTER fibers , *FUELWOOD - Abstract
In Europe mainly at winter season the PM levels exceed air quality limits, which correlated with the operation of solid-fired boilers. More and more people are returning to using these devices due to energy shortage caused by the pandemic and regional conflicts. In addition, the phenomena of co-burning fuels and municipal waste in residential boilers in primarily fuel poverty households increases further the amount of pollutants in the atmosphere. This study aims to correlate the quantity and quality of air pollutants with the type of fuel (wood and wastes) burned. Combustion experiments were conducted using oak fuel mixed with three waste groups: (1) plastics (PP, HDPE, PET); (2) textiles (polyester—PES, cotton—COT); and (3) papers (cardboard—CARD, glossy coated paper—GCP, 84C/PAP). The addition of waste to wood fuel altered the morphology of emitted particles. While waste burning doesn't always increase particle quantity, it significantly raises PAH concentrations. A strong relationship exists between waste type, particle morphology, and PAH quality, where with lower molecular weight PAHs linked to tar agglomerates and higher ones to soot agglomerates with inorganic crystals. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
40. Climate and carbon risk of tourism in Europe.
- Author
-
Steiger, Robert, Demiroglu, O. Cenk, Pons, Marc, and Salim, Emmanuel
- Subjects
- *
TOURISM , *TOURISTS , *CLIMATE change , *GREENHOUSE gas mitigation - Abstract
Europe accounts for 51% of international tourist arrivals and the tourism industry provides about 10% of workplaces in Europe. Tourism will be impacted by climate change in a diverse number of ways. At the same time, tourism is also a significant contributor of greenhouse gas emissions. The aim of this article is, therefore, to provide an assessment of climate and carbon risks for the European tourism industry based on a systematic literature review. Climate risk is the dominant category with 313 papers (74%), while 110 papers (26%) were on carbon risks. The following gaps were identified: geographical gaps, especially in countries of the former Soviet Union and former Yugoslavia; a lack of coherent studies on national tourism's and its sub-sectors' emissions; research addressing how climate policies might affect tourism demand; assessments of the integrated carbon and climate risks; lack of evidence on the link between tourism climate indicators and tourism demand; lack of climate change and tourism studies addressing policy and institutional tools for adaptation and implementation of adaptation measures in destinations; and research on rising sea levels and coastal erosion and its impacts on tourism destinations and demand. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
41. All roads lead to Rome? Analysing the electoral performance of populist radical left parties in Europe (2008-2018): a fuzzy-set qualitative comparative analysis.
- Author
-
Ramos-González, Jorge
- Subjects
- *
POPULIST parties (Politics) , *RADICALISM , *RIGHT-wing populism , *LIBERALISM - Abstract
In the last decade, there have been numerous studies on the rise, characteristics, and consequences of the emergence of populist parties in Western liberal democracies. However, most analyses of European populist parties have focused on the right-wing populist parties. Although some scholars have made valuable efforts to understand left-wing populism in Europe, these studies have paid attention to their ideological-organizational idiosyncrasies or the characteristics of their electoral bases. This paper aims to fill the gap in the economic and political contexts in which Radical Left Populist Parties have achieved significant electoral results putting into practice a fsQCA analysis and examining their uneven electoral performance in Europe. Following some previous work applying QCA techniques, this paper tests the theory on the importance of economic and political factors. Findings indicate that the electoral performance of radical left populism cannot be explained in a univocal way, highlighting the crucial role of equifinality in understanding this political phenomenon. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
42. The construction of social Europe through transnational equality.
- Author
-
Rieder, Clemens M
- Subjects
- *
EUROPEAN integration , *EQUALITY , *MARKET design & structure (Economics) , *SOCIAL structure , *SOCIAL integration , *SOCIAL marketing - Abstract
This paper examines the relationship between equality and social Europe, which has remained underdeveloped in the process of European integration. In contrast to the social dimension of the EU, the principle of equality has been significant from the beginning of European integration. The paper opens with an overview of how equality functions as the basis for a social Europe. Next, two interpretations of equality are introduced. The EU's preferred interpretation, which is based on merit, is in sync with market ideals. One of the shortcomings of merit-based equality as a foundation of social Europe, however, is its inability to properly disconnect the vulnerable person from the employment market. This paper argues that an alternative interpretation of equality based on value is more suitable, because value-based equality can challenge the potentially harmful social structure of the market. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
43. Vascularized composite allotransplantation – a Council of Europe position paper.
- Author
-
Thuong, Marie, Petruzzo, Palmina, Landin, Luis, Mahillo, Beatriz, Kay, Simon, Testelin, Sylvie, Jablecki, Jerzy, Laouabdia‐Sellami, Karim, Lopez‐Fraga, Marta, and Dominguez‐Gil, Beatriz
- Subjects
- *
ORGAN donation , *ARM , *CLINICAL trials , *HEALTH , *TRANSPLANTATION of organs, tissues, etc. , *FACIAL transplantation - Abstract
Summary: After more than 120 hand‐upper extremity and 37 face transplant procedures performed worldwide, vascularized composite allotransplantation (VCA) now falls under the scope of organ transplant legislation in Europe and the United States. While in the USA, VCA has been considered as standard care since 2014, VCA in Europe is still performed through clinical research trials, except in United Kingdom. However, after two decades of favourable experience with upper extremity transplantation (UET), professionals in Europe are proposing hand allotransplantation as "controlled standard" care, as opposed to face transplantation (FT), which is still a challenging activity. The European Committee on Organ Transplantation (CD‐P‐TO) has elaborated a position paper to provide recommendations concerning regulatory aspects for UET and FT. It is aimed at Health Authorities in charge of the oversight – and coordination – of organ donation and transplantation, and at professional groups to help them manage such complex and costly programs dedicated to properly selected patients. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
44. ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure.
- Author
-
Madonna, Rosalinda, Laake, Linda W Van, Botker, Hans Erik, Davidson, Sean M, Caterina, Raffaele De, Engel, Felix B, Eschenhagen, Thomas, Fernandez-Aviles, Francesco, Hausenloy, Derek J, Hulot, Jean-Sebastien, Lecour, Sandrine, Leor, Jonathan, Menasché, Philippe, Pesce, Maurizio, Perrino, Cinzia, Prunier, Fabrice, Linthout, Sophie Van, Ytrehus, Kirsti, Zimmermann, Wolfram-Hubertus, and Ferdinandy, Peter
- Subjects
- *
CYTOLOGY , *TISSUE engineering , *HEART diseases , *HEART failure , *TEAMS in the workplace , *ISCHEMIC preconditioning , *RADIOEMBOLIZATION - Abstract
Morbidity and mortality from ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and are increasing worldwide. Patients with IHD or HF might benefit from novel therapeutic strategies, such as cell-based therapies. We recently discussed the therapeutic potential of cell-based therapies and provided recommendations on how to improve the therapeutic translation of these novel strategies for effective cardiac regeneration and repair. Despite major advances in optimizing these strategies with respect to cell source and delivery method, the clinical outcome of cell-based therapy remains unsatisfactory. Major obstacles are the low engraftment and survival rate of transplanted cells in the harmful microenvironment of the host tissue, and the paucity or even lack of endogenous cells with repair capacity. Therefore, new ways of delivering cells and their derivatives are required in order to empower cell-based cardiac repair and regeneration in patients with IHD or HF. Strategies using tissue engineering (TE) combine cells with matrix materials to enhance cell retention or cell delivery in the transplanted area, and have recently received much attention for this purpose. Here, we summarize knowledge on novel approaches emerging from the TE scenario. In particular, we will discuss how combinations of cell/bio-materials (e.g. hydrogels, cell sheets, prefabricated matrices, microspheres, and injectable matrices) combinations might enhance cell retention or cell delivery in the transplantation areas, thereby increase the success rate of cell therapies for IHD and HF. We will not focus on the use of classical engineering approaches, employing fully synthetic materials, because of their unsatisfactory material properties which render them not clinically applicable. The overall aim of this Position Paper from the ESC Working Group Cellular Biology of the Heart is to provide recommendations on how to proceed in research with these novel TE strategies combined with cell-based therapies to boost cardiac repair in the clinical settings of IHD and HF. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
45. Paper Value Chain is Ready to Take Circularity to A New Level with 2030 Recycling Rate Target.
- Subjects
- *
PAPER recycling , *VALUE chains , *STRATEGIC planning , *MANUFACTURING processes , *PAPER product manufacturing - Published
- 2022
46. Analysing the potential for implementation of CCS within the European pulp and paper industry
- Author
-
Jönsson, Johanna and Berntsson, Thore
- Subjects
- *
PAPER industry , *EMISSIONS (Air pollution) , *ENERGY levels (Quantum mechanics) , *POTENTIAL energy , *PULP mills , *BIOMASS , *CARBON sequestration , *CARBON dioxide , *CARBON dioxide mitigation , *EMISSIONS trading , *SULFATE waste liquor , *BIOMASS gasification - Abstract
In this paper an approach for analysing the potential for implementation of different technology pathways for the European pulp and paper industry (PPI) is presented. The approach is based on detailed technical research and aggregates the knowledge from previous studies to incorporate the whole European PPI. Thus, the potential for different technology pathways can be estimated on a European level whilst still considering important characteristics of individual mills. The usefulness of the approach was exemplified by applying it to a case study of the potential for introduction of carbon capture and storage (CCS) within the European PPI. The results from the case study show that for the European PPI, CCS has an up-hill road in order to be a viable, large scale alternative for reduction of CO2 emissions. If CCS is to be introduced in large scale within the European PPI, large biomass-based point sources of CO2 emissions need to be included when planning for CCS infrastructure and also the infrastructure needs to be built out for clusters emitting <20 MtCO2/yr. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
47. Chronic nodular prurigo: clinical profile and burden. A European cross‐sectional study.
- Author
-
Pereira, M.P., Hoffmann, V., Weisshaar, E., Wallengren, J., Halvorsen, J.A., Garcovich, S., Misery, L., Brenaut, E., Savk, E., Potekaev, N., Lvov, A., Bobko, S., Szepietowski, J.C., Reich, A., Bozek, A., Legat, F.J., Metz, M., Streit, M., Serra‐Baldrich, E., and Gonçalo, M.
- Subjects
- *
CROSS-sectional method , *ELECTRONIC paper , *MENTAL illness , *ITCHING , *SYMPTOMS , *EDUCATIONAL attainment - Abstract
Background: Chronic nodular prurigo (CNPG) is a condition characterized by chronic itch, a prolonged scratching behaviour and the presence of pruriginous nodules. A comprehensive understanding of this condition, especially regarding its clinical characteristics and impact on quality of life is still lacking. Objectives: Aim of this pan‐European multicentre cross‐sectional study was to establish the clinical profile of CNPG, including its associated burden. Methods: Fifteen centres from 12 European countries recruited CNPG patients presenting at the centre or using the centres' own databases. Patients were asked to complete a questionnaire in paper or electronic format. Demography, current co‐morbidities, underlying disease, itch intensity, additional sensory symptoms, quality of life, highest burden and emotional experience of itch were assessed. Results: A total of 509 patients (210 male, median age: 64 years [52; 72]) were enrolled. Of these, 406 reported itch and CNPG lesions in the previous 7 days and qualified to complete the whole questionnaire. We recorded moderate to severe worst itch intensity scores in the previous 24 h. Scores were higher in patients with lower educational levels and those coming from Eastern or Southern Europe. Most patients experience itch often or always (71%) and report that their everyday life is negatively affected (53%). Itch intensity was considered to be the most burdensome aspect of the disease by 49% of the patients, followed by the visibility of skin lesions (21%) and bleeding of lesions (21%). The majority of patients was unaware of an underlying condition contributing to CNPG (64%), while psychiatric diseases were the conditions most often mentioned in association with CNPG (19%). Conclusions: This multicentre cross‐sectional study shows that itch is the dominant symptom in CNPG and reveals that the profile of the disease is similar throughout Europe. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
48. A new species of the paper wasp genus Polistes (Hymenoptera, Vespidae, Polistinae) in Europe revealed by morphometrics and molecular analyses.
- Author
-
Neumeyer, Rainer, Baur, Hannes, Guex, Gaston-Denis, and Praz, Christophe
- Subjects
- *
PAPER wasps , *MORPHOMETRICS , *CYTOCHROME oxidase , *GENETIC barcoding , *MULTIVARIATE analysis , *PRINCIPAL components analysis - Abstract
We combine multivariate ratio analysis (MRA) of body measurements and analyses of mitochondrial and nuclear data to examine the status of several species of European paper wasps (Polistes Latreille, 1802) closely related to P. gallicus. Our analyses unambiguously reveal the presence of a cryptic species in Europe, as two distinct species can be recognized in what has hitherto been considered Polistes bischoffi Weyrauch, 1937. One species is almost as light coloured as P. gallicus, and is mainly recorded from Southern Europe and Western Asia. The other species is darker and has a more northern distribution in Central Europe. Both species occur syntopically in Switzerland. Given that the lost lectotype of P. bischoffi originated from Sardinia, we selected a female of the southern species as a neotype. The northern species is described as P. helveticus sp. n. here. We also provide a redescription of P. bischoffi rev. stat. and an identification key including three more closely related species, P. biglumis, P. gallicus and P. hellenicus. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
49. Human papillomavirus vaccination: The ESGO–EFC position paper of the European society of Gynaecologic Oncology and the European Federation for colposcopy.
- Author
-
Joura, Elmar A., Kyrgiou, Maria, Bosch, Francisco X., Kesic, Vesna, Niemenen, Pekka, Redman, Charles WE., and Gultekin, Murat
- Subjects
- *
HUMAN papillomavirus vaccines , *AGE distribution , *COLPOSCOPY , *COST effectiveness , *GYNECOLOGY , *MEDICAL societies , *PAPILLOMAVIRUS diseases , *SEX distribution , *VACCINATION , *DISEASE complications , *TUMOR risk factors , *THERAPEUTICS ,PAPILLOMAVIRUS disease prevention ,CERVIX uteri tumors ,TUMOR prevention ,VAGINAL tumors - Abstract
Vaccines against human papillomavirus (HPV) are available in Europe since 2006. They have been highly effective in preventing infection and disease caused by the vaccine types. Clinical efficacy data are available for cervical, vulvovaginal and anal precancer and invasive cervical cancer. Disease reduction is best with early vaccination and a coverage of more than 70%. Gender-neutral vaccination provides direct protection for all men and improves the coverage. A good coverage is followed by herd protection of the unvaccinated men and women. School-based programs appear to be most effective; under the age of 15 years, two doses with an interval of 6–12 months are sufficient. From the age of 15 years, the standard regimen with three doses is recommended. A broad catch-up program for young adult women and men improves the effectiveness. The vaccines are also effective in sexually active women and men with previous but cleared infections. Vaccination in addition to local treatment of HPV-related disease appears to reduce recurrent or subsequent HPV-related disease. Combination of HPV vaccination and screening with HPV testing is the most effective approach to prevention of cervical cancer. The screening intervals may increase in the vaccinated cohorts. The upper age limit for vaccination remains to be evaluated, is country specific and depends on cost-effectiveness. The European Society of Gynaecologic Oncology and the European Federation for Colposcopy strongly support gender-neutral vaccination programs for children and young adolescents, with a catch-up program for young adults. • Human papillomavirus (HPV) vaccination is highly effective in preventing cervical disease caused by the vaccine types. • It further reduces the burden of other HPV-related cancers, such as anal, oropharyngeal, vulvar and vaginal cancer. • School-based programs appear to be more cost-effective. • The vaccines have excellent safety profile. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
50. The roadmap for the Allergology specialty and allergy care in Europe and adjacent countries. An EAACI position paper.
- Subjects
- *
ALLERGIES , *CLINICAL immunology , *DISEASE prevalence , *MEDICAL care - Abstract
The high prevalence of allergic diseases warrants for sufficient health care provisions available to patients with allergic diseases. Allergy care should be delivered by well‐trained specialists. However, the current status of allergy care is not well documented. For this reason a survey among European and a few non‐European countries was launched by the National Allergy Society Committee from the European Academy of Allergy and Clinical Immunology and the Union Européenne des Médecins Spécialistes section and board of Allergology. The survey shows that in the vast majority of countries allergy care services are available. However, a substantial heterogeneity is reported regarding recognition of the full specialty, the number of practicing specialists or subspecialists, and training aspects. Growth but also decline of specialty and subspecialties is reported. In addition, the survey gives insight in strengths, weaknesses, opportunities and threats in this field. It appears that the recognition of the full specialty determines strength as well as weakness. Aging of specialists combined with a decline in the number of trainees form a major threat. Opportunities are seen in creating awareness for allergy, focus on attracting young physicians. The conclusion is that harmonization of allergy services across Europe is needed. Investment in young doctors, creating new opportunities and lobbying for the full specialty is required. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.