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As one of the most important staple crops in China,wheat production target both high yield and high quality is very essential to simultaneously meeting the demands for food security and life quality. It has been found that both contents of key chemicals and processing quality vary greatly within different layers of wheat kernels. This provides a potential approach to achieve both high-yield and high-quality of wheat. In this paper,we detailly reviewed the spatial distributions of protein and its components,starch,dietary fiber and microelements. We further discussed the underlying mechanisms on the formation of protein and starch spatial distribution in the views of supply of substrate and synthetic capacity of protein and starch. The paper also summarized the regulation effects of cultivation practices on quality spatial distribution. Finally,we proposed the breakthrough solutions for exploring the underlying mechanisms on quality spatial distribution. This paper will provide research views for achieving the production of wheat with both high yield and high quality. [ABSTRACT FROM AUTHOR]