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Background and purpose: This position paper makes recommendations following an audit of care provided to people presenting with a seizure to emergency departments (EDs) in Europe. Methods: Participating countries were asked to include five hospitals agreeing to identify 50 consecutive seizure patients presenting to their ED between 1 August 2016 and 31 August 2017. Anonymous data were collected to a web database. Where quoted, percentages are mean site values and ranges are the 10th–90th centile. Results: Data were collected on 2204 ED visits (47 sites, up to six per country, across 15 countries): 1270 (58%) known epilepsy, 299 (14%) previous blackouts but no epilepsy diagnosis, 634 (29%) with a first seizure. Wide variability was identified for most variables. Of those with known epilepsy, 41.2% (range 26.2%–59.6%) attended the ED in the previous 12 months, but only 64.7% (range 37.2%–79.8%) had seen an epilepsy specialist in the previous 12 months. 67.7% (range 34.0%–100%) were admitted, 53.1% to a neurology ward (range 0.0%–88.9%). Only 37.5% first seizure patients (range 0.0%–71.4%) were given advice about driving. Conclusions and recommendations: It is recommended that in Europe guidance is agreed on the management and onward referral of those presenting to the ED with a seizure; a referral process is created that can be easily implemented; it is ensured that the seizure services receive referrals and see the patients within a short time period; and a simple system is developed and implemented to allow continuous monitoring of key indices of epilepsy care. [ABSTRACT FROM AUTHOR]

Aim: This paper introduces the Surveillance of Cerebral Palsy in Europe (SCPE) classification of events contributing to postneonatally acquired cerebral palsy, presents its interrater reliability, and describes the cases identified in the SCPE database. Method: The development of the classification, based on literature review and expert discussions, resulted in six main categories and 19 subcategories. The first chronological event designated as the primary event was mainly reported. Interrater reliability was assessed through online exercise providing 24 clinical vignettes representing single/complex pathways. Percent agreement and Gwet's AC1 index of reliability were estimated. Primary events were described using data of 221 children born between 2008 and 2012. Results: Thirty‐nine professionals (21 registries) participated in the reliability exercise. Substantial overall agreement was reached (0.75), with some contrast between complex (0.48, moderate agreement) and single events involved (0.89, almost perfect). The distribution of primary events showed that 32.1% were infections (category A), 23.1% head injuries (B), 15.4% related to surgery or medical interventions (C), 13.1% cerebrovascular accidents (D), 9.1% hypoxic brain damaging events of other origins (E), and 7.2% miscellaneous (F). Interpretation: This classification allows all the events involved to be recorded while consistently reporting the primary event, and may be used in different settings. What this paper adds: A standardized classification enables the description of the events contributing to postneonatal cerebral palsy (CP).The first chronological event in complex pathway leading to CP is coded.Category choice and coding of the primary event identify preventable situations.The detailed 2‐level classification is easy to use in various settings.Substantial overall interrater reliability shows that main categories can be consistently differentiated. [ABSTRACT FROM AUTHOR]

The aim of this paper is to examine the status of national learned societies in social sciences and humanities (SSH) in Europe. Previous research shows that learned societies serve diverse roles in higher education and suggests that national societies come under pressure given different developments, such as internationalization or open science adoption. We investigate a comprehensive range of aspects within national learned societies: primary goals, activities, internationalization, organization, funding, membership, and recent changes, addressing potential pressures arising from them. Using a cross‐national survey involving 194 learned societies across eight European countries, we study: (a) do the previous findings from individual countries or small selections of national societies hold for a broad range of learned societies in SSH across Europe, and (b) are national learned societies coming under pressure due to internationalization and commercialization processes? Our findings confirm previous results from single countries and single disciplines and expand them as our results show that national learned societies in SSH play an important role in Europe in promoting multilingualism in science, collaborating with many stakeholders, and fostering interdisciplinarity. Contrary to previous research, most SSH societies in our study have not undergone significant changes in the past 5 years, challenging expectations of their declining role. [ABSTRACT FROM AUTHOR]

Background and purpose: Neurology residency programmes, which were first established at the beginning of the 20th century, have become mandatory all over Europe in the last 40–50 years. The first European Training Requirements in Neurology (ETRN) were published in 2005 and first updated in 2016. This paper reports the most recent revisions of the ETRN. Methods: Members of the EAN board performed an in depth revision of the ETNR 2016‐version, which was reviewed by members of the European Board and Section of Neurology of the UEMS, the Education and Scientific Panels, the Resident and Research Fellow Section and the Board of the EAN, as well as the presidents of the 47 European National Societies. Results: The new (2022) ETRN suggest a 5‐year training subdivided in three phases: a first phase (2 years) of general neurology training, a second phase (2 years) of training in neurophysiology/neurological subspecialties and a third phase (1 year) to expand clinical training (e.g., in other neurodisciplines) or for research (path for clinical neuroscientist). The necessary theoretical and clinical competences as well as learning objectives in diagnostic tests have been updated, are newly organized in four levels and include 19 neurological subspecialties. Finally, the new ETRN require, in addition to a programme director, a team of clinician‐educators who regularly review the resident's progress. The 2022 update of the ETRN reflects emerging requirements for the practice of neurology and contributes to the international standardization of training necessary for the increasing needs of residents and specialists across Europe. [ABSTRACT FROM AUTHOR]

Background: The implementation science literature acknowledges a need for engagement of key stakeholders when designing, delivering and evaluating implementation work. To date, the literature reports minimal or focused stakeholder engagement, where stakeholders are engaged in either barrier identification and/or barrier prioritisation. This paper begins to answer calls from the literature for the development of tools and guidance to support comprehensive stakeholder engagement in implementation research and practice. The paper describes the systematic development of the Implementation‐STakeholder Engagement Model (I‐STEM) in the context of an international, large‐scale empirical implementation study (ImpleMentAll) aimed at evaluating the effectiveness of a tailored implementation toolkit. The I‐STEM is a sensitising tool that defines key considerations and activities for undertaking stakeholder engagement activities across an implementation process. Methods: In‐depth, semistructured interviews and observations were conducted with implementers who were tailoring implementation strategies to integrate and embed internet‐based cognitive behavioural therapy (iCBT) services in 12 routine mental health care organisations in nine countries in Europe and Australia. The analytical process was informed by principles of first‐ and third‐generation Grounded Theory, including constant comparative method. Results: We conducted 55 interviews and observed 19 implementation‐related activities (e.g., team meetings and technical support calls). The final outcome of our analysis is expressed in an initial version of the I‐STEM, consisting of five interrelated concepts: engagement objectives, stakeholder mapping, engagement approaches, engagement qualities and engagement outcomes. Engagement objectives are goals that implementers plan to achieve by working with stakeholders in the implementation process. Stakeholder mapping involves identifying a range of organisations, groups or people who may be instrumental in achieving the engagement objectives. Engagement approaches define the type of work that is undertaken with stakeholders to achieve the engagement objectives. Engagement qualities define the logistics of the engagement approach. Lastly, every engagement activity may result in a range of engagement outcomes. Conclusion: The I‐STEM represents potential avenues for substantial stakeholder engagement activity across key phases of an implementation process. It provides a conceptual model for the planning, delivery, evaluation and reporting of stakeholder engagement activities. The I‐STEM is nonprescriptive and highlights the importance of a flexible, iterative approach to stakeholder engagement. It is developmental and will require application and validation across a range of implementation activities. Patient or Public Contribution: Patient contribution to ImpleMentAll trial was facilitated by GAMIAN‐Europe at all stages—from grant development to dissemination. GAMIAN‐Europe brings together a wide variety of patient representation organisations (local, regional and national) from almost all European countries. GAMIAN‐Europe was involved in pilot testing the ItFits‐toolkit and provided their views on the various aspects, including stakeholder engagement. Patients were also represented in the external advisory board providing support and advice on the design, conduct and interpretation of the wider project, including the development of the ItFits‐toolkit. Trial registration: ClinicalTrials.gov NCT03652883. Retrospectively registered on 29 August 2018. [ABSTRACT FROM AUTHOR]

Background: Anaphylaxis is a sudden multisystem allergic reaction which may result in a fatal outcome if not treated promptly. Guidelines worldwide suggest intramuscular adrenaline as the first‐line treatment for anaphylaxis outside a perioperative reaction. Adrenaline autoinjectors (AAIs) are widely used self‐administrable devices, especially in community settings. Different commercial AAIs have been authorized to be marketed in Europe. For an AAI to be efficacious, a rapid adrenaline delivery in patients, including those who are overweight or obese, resulting in an optimal cardiovascular (CV) response, is a key feature. AAIs are designed to achieve this requirement, which is reflected in their differing functional properties such as primary container selection, drug delivery mechanism (cartridge‐or syringe‐based), needle length, needle gauge, and adrenaline dose (150 μg, 300 μg, or 500 μg). However, the differences in functional properties across these devices may play a critical role in achieving these requirements as well as the differences in ergonomics in the handling of these devices. The purpose of this review: Considering the dynamic pharmacokinetic/pharmacodynamic (PK/PD) profiles of different AAIs marketed in Europe and their effect on adrenaline delivery, the expert panel, also serving as author for this paper have carried out a detailed analysis of the PK/PD profiles of four AAIs, namely, Anapen, Emerade, EpiPen, and Jext, to delineate the adrenaline delivery and their subsequent physiological effects on the backdrop of device characteristics, dose strength, and the skin‐to‐muscle distances of the participants. [ABSTRACT FROM AUTHOR]

Borders prevent the optimal exploitation of socio‐economic and environmental resources. A relevant obstacle due to missed integration is associated with legal and administrative barriers, which cause the emergence of untapped potentials. This paper exploits the case study of the Interreg Central Europe programme. Removing borders among countries in the area enhances scale economies due to a large market for inputs and goods, both within regions and across Central European area regions. This paper identifies untapped potentials by looking at the missed regional GDP growth due to the inefficient exploitation of regional growth assets. Results hint at a complex and heterogeneous spatial distribution of untapped potentials, involving several growth factors. [ABSTRACT FROM AUTHOR]

In Europe, 50%–70% of former natural grassland area has been destroyed during the past 30 years due to land use changes, losses are expected to increase in the future. Restoration is thought to reverse this situation by creating suitable abiotic conditions. In this paper, we investigate the effects of sod translocation with specific vegetation to facilitate the restoration of a former intensive agricultural field into a wet meadow. First, starting conditions were optimized including modification of the local hydrology, removal of the fertilized topsoil, application of liming, and translocation of fresh clippings as a seed source. The second part aimed at restoring the habitat for the butterfly species Phengaris (Maculinea) teleius, one of the species that was especially affected by the loss of wet meadows. This species engages in a complex myrmecophilous relationship with one host plant, Sanguisorba officinalis, and one obligate host ant, Myrmica scabrinodis. We used sod translocation to create islands of habitat to promote host plant and host ant colonization. After 4 years following the restoration, we observed that plants spread from the transplanted sods to the surroundings. The vegetation composition and structure of the transplanted sods attracted colonization of Myrmica ants into the restored areas. Following the increase in vegetation cover and height, Myrmica ant colonies further spread into the restored areas. Therefore, sod translocations can be considered an effective restoration method following topsoil removal in the process of restoring wet meadows to provide a starting point for ant colonization and plant dispersion. With these findings, this paper contributes to the evidence‐based restoration of wet meadows on former agricultural fields, including complex interactions between invertebrates and their required ecological relationships. [ABSTRACT FROM AUTHOR]

This paper analyzes the impact of source‐country culture on the labor supply of female immigrants in Europe. We find that the labor supply of immigrant women is positively associated with the female‐to‐male labor force participation ratio in their source country, which serves as a proxy for the country's preferences and beliefs regarding women's roles. This suggests that the culture and norms of their source country play an important role for immigrant women's labor supply. However, contradicting previous evidence for the US, we do not find evidence that the cultural effect persists through the second generation. [ABSTRACT FROM AUTHOR]

Historically, the long wavelength side (6–7.5 μm) of the mid‐infrared water vapor absorption band has been used for imaging from the geostationary perspective. This began with the 6.4 μm band on Europe's Meteosat‐1. While geostationary sounders for moisture profiling, including China's hyperspectral resolution infrared sounder and a planned sounder from Europe, are or will be measuring the short wavelength side of the water vapor band, this is not the case for geostationary imagers. Shorter wavelength (5–6 μm) spectral bands for imaging applications should be considered for observing moisture in the mid and lower troposphere because of several potential advantages offered by this spectral range. The short wavelength side of the water vapor band contains fewer additional absorbing gases that overlap the water vapor absorption lines. In addition, the shorter wavelengths would show less diffraction blurring which could enable finer spatial resolution for turbulence detection. This study considers some of the differences and potential advantages of the spectral information in the short wavelength side of the water vapor absorption band from the perspective of geostationary imaging. For dry conditions land heating could impact the qualitative use of observed brightness temperatures at 5.1 μm, while the solar reflection component over most clear‐sky scenes is small for a 5.1 μm band and essentially zero for a 5.6 μm band. Plain Language Summary: Long before images are sent back to Earth from satellites, the needed spectral bands have to be specified. The band specification includes attributes such as the wavelength centers, widths, and signal‐to‐noise ratio. This paper investigates the rationale for including data from a region of the electromagnetic spectrum that has not been used for imaging from geostationary orbit. If implemented, these short wavelength water vapor bands would provide unique information regarding low‐level moisture and mid‐level turbulence. This paper quantifies the expected reflected component from the sun and the influence of land heating on observations, both of which are relatively larger at shorter wavelengths. Key Points: Historically, the long wavelength side of the mid‐infrared water vapor absorption band has been used for imagingShort wavelength (near 5 μm) spectral bands should be considered, especially with finer spatial resolutionsOver most clear‐sky surfaces, the reflective component ranges from small to zero for 5.1 and 5.6 μm bands [ABSTRACT FROM AUTHOR]

Aim: To evaluate the methodological quality of recent systematic reviews of interventions for children with cerebral palsy in order to determine the level of confidence in the reviews' conclusions. Method: A comprehensive search of 22 databases identified eligible systematic reviews with and without meta‐analysis published worldwide from 2015 to 2019. We independently extracted data and used A Measurement Tool to Assess Systematic Reviews‐2 (AMSTAR‐2) to appraise methodological quality. Results: Eighty‐three systematic reviews met strict eligibility criteria. Most were from Europe and Latin America and reported on rehabilitative interventions. AMSTAR‐2 appraisal found critically low confidence in 88% (n=73) because of multiple and varied deficiencies. Only 7% (n=6) had no AMSTAR‐2 critical domain deficiency. The number of systematic reviews increased fivefold from 2015 to 2019; however, quality did not improve over time. Interpretation: Most of these systematic reviews are considered unreliable according to AMSTAR‐2. Current recommendations for treating children with CP based on these flawed systematic reviews need re‐evaluation. Findings are comparable to reports from other areas of medicine, despite the general perception that systematic reviews are high‐level evidence. The required use of current widely accepted guidance for conducting and reporting systematic reviews by authors, peer reviewers, and editors is critical to ensure reliable, unbiased, and transparent systematic reviews. What this paper addsConfidence was critically low in the conclusions of 88% of systematic reviews about interventions for children with cerebral palsy (CP).Quality issues in the sample were not limited to systematic reviews of non‐randomized trials, or to those about certain populations of CP or interventions.The inclusion of meta‐analysis did not improve the level of confidence in these systematic reviews.Numbers of systematic reviews on this topic increased over the 5 search years but their methodological quality did not improve. What this paper adds: Confidence was critically low in the conclusions of 88% of systematic reviews about interventions for children with cerebral palsy (CP).Quality issues in the sample were not limited to systematic reviews of non‐randomized trials, or to those about certain populations of CP or interventions.The inclusion of meta‐analysis did not improve the level of confidence in these systematic reviews.Numbers of systematic reviews on this topic increased over the 5 search years but their methodological quality did not improve. This original article is commented by Negrini et al. on page 1244 of this issue. [ABSTRACT FROM AUTHOR]

Climate change is increasing the severity and frequency of droughts around the globe, leading to tree mortality that reduces production and provision of other ecosystem services. Recent studies show that growth of mixed stands may be more resilient to drought than pure stands. The two most economically important and widely distributed tree species in Europe are Norway spruce (Picea abies (L.) Karst) and Scots pine (Pinus sylvestris L.), but little is known about their susceptibility to drought when coexist.This paper analyses the resilience (resistance, recovery rate and recovery time) at individual‐tree level using a network of tree‐ring collections from 22 sites along a climatic gradient from central Europe to Scandinavia. We aimed to identify differences in growth following drought between the two species and between mixed and pure stands, and how environmental variables (climate, topography and site location) and tree characteristics influence them.We found that both the timing and duration of drought drive the different responses between species and compositions. Norway spruce showed higher vulnerability to summer drought, with both lower resistance and a longer recovery time than Scots pine. Mixtures provided higher drought resistance for both species compared to pure stands, but the benefit decreases with the duration of the drought. Especially climate sensitive and old trees in climatically marginal sites were more affected by drought stress.Synthesis. Promoting Scots pine and mixed forests is a promising strategy for adapting European forests to climate change. However, if future droughts become longer, the advantage of mixed stands could disappear which would be especially negative for Norway spruce. [ABSTRACT FROM AUTHOR]

We focus on the extent to which polycentric urban regions can substitute for the agglomeration economies provided by large cities. Building on an open‐source software tool that helps identifying polycentric developments in urban regions, we analyse the spatial structure (in terms of size, dispersion and polycentricity) of 94 regions across 34 European countries and link this to their level of total factor productivity. We find that both more polycentric regions and more dispersed regions are associated with lower productivity levels. [ABSTRACT FROM AUTHOR]

Which role do city‐regions play in European innovation network formation? We study the evolution of innovation collaborative networks in European city‐regions outlining two opposite models: in the exclusive network model city‐regions establish a closed network of innovators among themselves; in the inclusive network models city‐regions build a network of innovators which includes the peripheral regions. Employing a temporal exponential random graph model on 248 regions for the period 2000–2016, we find that the two models coexist. We conclude that in the EU the city‐regions act as both engines of generation of innovation and integrators of innovation actors. [ABSTRACT FROM AUTHOR]

The global ocean overturning circulation, critically dependent on the global density stratification, plays a central role in regulating climate evolution. While it is well known that the global stratification profile exhibits a strong dependence to Southern Ocean dynamics and in particular to wind and buoyancy forcing, we demonstrate here that the stratification is also acutely sensitive to the mesoscale eddy energy dissipation timescale. Within the context of a global ocean circulation model with an energy constrained mesoscale eddy parameterization, it is shown that modest variations in the eddy energy dissipation timescale lead to significant variations in key metrics relating to ocean circulation, namely the Antarctic Circumpolar Current transport, Atlantic Meridional Overturning Circulation strength, and global ocean heat content, over long timescales. The results highlight a need to constrain uncertainties associated with eddy energy dissipation for climate model projections over centennial timescales and also for paleoclimate simulations over millennial timescales. Plain Language Summary: The ocean is populated by "eddies", analogous to weather systems in the atmosphere, but occurring on much smaller scales of typically 10–100 km. Recent advances in our understanding of the circulation of the Southern Ocean, which connects all of the major ocean basins to the north, have revealed a crucial role for the energy balance of Southern Ocean eddies. In this paper, we show that the timescale over which energy is removed from Southern Ocean eddies has a dramatic impact on the following: (a) the strength of the Antarctic Circumpolar Current, the largest current in the global ocean; (b) the strength of the Atlantic meridional overturning circulation, responsible in part for the relatively mild climatic conditions over northwestern Europe; and (c) global ocean heat content, a key parameter in the global climate system. These results have significant implications for both past and future climates, and highlight the importance of combining observational, theoretical and modeling efforts to better understand and constrain the energy balance of ocean eddies. Key Points: Key metrics of global ocean circulation (Antarctic Circumpolar Current transport, Atlantic Meridional Overturning Circulation strength, and Ocean Heat Content anomaly) acutely sensitive to an eddy energy dissipation timescaleModest variations in the dissipation timescale has a comparable effect to significant variations in the Southern Ocean wind forcingConstraints on the dissipation timescale critical to longtime integrations of ocean climate models such as paleoclimate scenarios [ABSTRACT FROM AUTHOR]

The influence of climate on the distribution of taxa has been extensively investigated in the last two decades through Habitat Suitability Models (HSMs). In this context, the Worldclim database represents an invaluable data source as it provides worldwide climate surfaces for both historical and future time horizons. Thousands of HSMs‐based papers have been published taking advantage of Worldclim 1.4, the first online version of this repository. In 2017, Worldclim 2.1 was released. Here, we evaluated spatially explicit prediction mismatch at continental scale, focusing on Europe, between HSMs fitted using climate surfaces from the two Worldclim versions (between‐version differences). To this aim, we simulated occurrence probability and presence‐absence across Europe of four virtual species (VS) with differing climate‐occurrence relationships. For each VS, we fitted HSMs upon uncorrelated bioclimatic variables derived from each Worldclim version at three grid resolutions. For each factor combination, HSMs attaining sufficient discrimination performance on spatially independent test data were projected across Europe under current conditions and various future scenarios, and importance scores of the single variables were computed. HSMs failed in accurately retrieving the simulated climate‐occurrence relationships for the climate‐tolerant VS and the one occurring under a narrow combination of climatic conditions. Under current climate, noticeable between‐version prediction mismatch emerged across most of Europe for these two VSs, whose simulated suitability mainly depended upon diurnal or yearly variability in temperature; differently, between‐version differences were more clustered toward areas showing extreme values, like mountainous massifs or southern regions, for VSs responding to average temperature and precipitation trends. Under future climate, the chosen emission scenarios and Global Climate Models did not evidently influence between‐version prediction discrepancies, while grid resolution synergistically interacted with VSs' niche characteristics in determining extent of such differences. Our findings could help in re‐evaluating previous biodiversity‐related works relying on geographical predictions from Worldclim‐based HSMs. [ABSTRACT FROM AUTHOR]

OBJECTIVES: The involvement of individuals and communities in health decision‐making is enshrined in WHO policies. However, migrant groups are under‐represented in health decision‐making processes. Our aim was to explore migrants' involvement in health policy, service development and research in the WHO European Region to identify levers for inclusive and meaningful practice. METHODS: We conducted a narrative review of grey literature and peer‐reviewed research on migrants' involvement in health decision‐making across the 53 countries in WHO Europe. We searched for articles published in English between 2010 and the present in two electronic databases (PubMed, Scopus), IOM MIPEX Health Strand country reports, the EU SOPHIE project and using a Google advanced search. Findings were analysed descriptively and using Normalisation Process Theory to investigate levers and barriers to implementation of policy into practice. RESULTS: Of 1,444 articles retrieved, 79 met the inclusion criteria. We identified 20 policies promoting migrants' involvement, but national‐level policies were present in only two countries. We identified 59 examples of migrants' involvement in practice from half of the WHO Europe countries (n = 27). Our Normalisation Process Theory (NPT) analysis of 14 peer‐reviewed empirical papers found that participatory research approaches are a lever to putting policy into practice in a meaningful way. CONCLUSIONS: Migrants' involvement in health decision‐making requires explicit national policies that are implemented evenly across policymaking, service provider and research activities in all countries in the WHO European Region. Participatory approaches to involvement activities are encouraged because they are a lever to perceived barriers to migrants' involvement. [ABSTRACT FROM AUTHOR]

National city ranks do not describe a settlement's local and regional relevance adequately. We introduce a method to rank settlements' centrality based on travel time and settlement size. We investigate the relationship between a settlement's size, whether it is a local or regional centre, and its service endowment. The approach explains per capita service endowments in Europe well, adding nuances that national rankings do not fully capture. In addition, it establishes a characterization of service types by empirically discernible preferences in spatial scale. Finally, results suggest that service endowment in settlements can be reshuffled because of faster road connections, with services spatially concentrating in better connected areas. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to evaluate the prevalence of primary open‐angle glaucoma (POAG) in the European population > 40 years, and to provide the expected number of POAG patients forecasted up to 2050. Methods: Two authors independently conducted a systematic literature search on PubMed/MedLine, Web of Science, and Google Scholar to identify papers analysing the prevalence of POAG in European countries. Logit transformation (PLOGIT) of the data retrieved from selected articles, and a random intercept logistic regression model (GLMM) were used to analyse the overall proportions. The population projection data retrieved from the World Population Prospects reported by the United Nations, was incorporated into the GLMM. The estimated number of patients was calculated using the prevalence figures from the random‐effects model and the corresponding population number. Results: We retrieved 9348 eligible papers from the initial electronic search and included 10 of them in the qualitative and quantitative analyses. A total of 26 993 patients were included in this meta‐analysis (11 927 male and 14 556 female). We identified 755 POAG cases (397 male and 348 female), with a pooled prevalence estimate in Europe of 2.60% (95% CI: 1.90–3.56%). Increasing odds for POAG were related to increasing age and some geographic differences in the disease distribution in the continent were identified. Statistically significant sex‐related differences in the prevalence rate of POAG were not observed in this cohort. An increase of 3.3% in the number of people (aged >40 years) with POAG is expected by 2050, when the overall figure is expected to be 10 748 137. Conclusions: POAG is a neurodegenerative disease that affects a large proportion of the older European population. In the future, the prevalence of POAG is expected to grow in Europe because of the progressive ageing populations of Western countries. [ABSTRACT FROM AUTHOR]

Our empirical analysis focuses on the effect of regional policies on migration attraction factors in Europe. We employ a regression discontinuity design to assess the causal relationship between the reception of large amounts of public funds and migration flows in the EU‐15 regions. In highly‐subsidised regions, we find a large increase in the share of foreign citizens from less‐developed countries when compared to low‐subsidised regions with similar pre‐treatment characteristics. The analysis shows that such an increase is due to the positive impact of the European regional policy on job market opportunities as well as the improvement of public goods supply. [ABSTRACT FROM AUTHOR]

More than often, studies explaining migration causes centre on economic explanations and minimize other factors' explanatory power. This research aims at creating a comprehensive model of migration determinants taking into account four dimensions: economic, social, cultural, and digital. A path model consisting of these dimensions was created and estimated through partial least squares structural equation modelling (PLS‐SEM). The PLS‐path model was applied to Romanian migration flows to 21 EU member states during 2007–2017. The findings indicate that social and technological developments have significant impacts on migration flows and that digital distance has a full mediation effect on the relationship between cultural distance and migration flows. [ABSTRACT FROM AUTHOR]

To predict the quantity and quality of food available to pollinators in various landscapes over time, it is necessary to collect detailed data on the pollen, nectar, and sugar production per unit area and the flowering phenology of plants. Similar data are needed to estimate the contribution of plants to the functioning of food webs via the flow of energy and nutrients through the soil–plant‐nectar/pollen‐consumer pathway. Current knowledge on this topic is fragmented. This database represents the first compilation of data on the various food resources produced by 1612 plant species belonging to 755 genera and 133 families, including crop plants and wild plants, annuals and perennials, animal‐ and wind‐pollinated plants, and weeds and trees growing in different ecosystems under various environmental conditions. The data set consists of 103 parameters related to the traits of plant species and geographical and environmental factors, allowing for precise calculations of the amounts of nectar, pollen, and energy provided by plants and available to consumers in the considered flora or ecosystem on a daily basis throughout the year. These parameters, gathered by us and extracted from the available literature, describe pollen, nectar, and sugar production (where applicable, in mass, volume, and concentration units), honey yield, the timing and duration of flowering, flower longevity, number of plants and flowers per unit area, weather conditions (temperature and precipitation), geographical location, landscape, and syntaxonomy. The data were obtained from various, mostly European, pedoclimatic zones, and the majority of the data were available for plant species and communities present in Central Europe, especially in Poland, where research on floral resources has a long tradition. These data are representative of the whole continent and may be used as a reference for plant communities occurring on continents other than Europe since the database allows for the consideration of differences in the production of resources by a single plant species growing in different communities. This data set provides a unique opportunity to test hypotheses related to the functioning of food webs, nutrient cycling, plant ecology, and pollinator ecology and conservation. The data are released under a CC‐BY‐NC‐SA license, and this paper must be properly cited when using the database. [ABSTRACT FROM AUTHOR]

Purpose: Diabetic Macular Œdema (DME) and Age‐related Macular Degeneration (nAMD) are the leading causes of vision loss in developed nations. Anti‐Vascular Endothelial Growth Factor (aVEGF) has revolutionized the treatment of both conditions, but access is limited by costs. Biosimilars of aVEGF can cut costs, but prescriber concerns over the lack of clinical data can slow uptake. This paper reports all biosimilar aVEGF in development for Europe and the USA, and pools the results of clinical confirmatory trials to provide statistically greater reassurance in the similarity of outcomes. Methods: Biosimilars in the clinical development phase were identified from US and EU trial registries. Results: There are 13 biosimilars of ranibizumab and aflibercept in final clinical comparative trial stage of development in Europe and the USA, recruiting 6126 patients. Five studies of intravitreal bevacizumab biosimilars are recruiting 772 patients. Equivalence outcomes are typically based on Best‐Corrected Visual Acuity (BCVA) with 90% confidence limits of −3 to +3 letters between reference and biosimilar medicines. Completed trials to date with 1166 participants analysed together show BCVA outcomes of ≤1 letter between Originator Reference Products and Biosimilars; for serious adverse events the risk ratio is 1.17, with 95% confidence intervals of 0.85–1.63, p = 0.32. Conclusions: Biosimilars of aVEGF are expected soon. There are likely sufficient brands expected to create meaningful price competition. To date, the EU/US regulatory pathway is delivering biosimilars with close equivalence of safety and efficacy outcomes. [ABSTRACT FROM AUTHOR]