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Effective supply chain management is crucial for economic growth, and sustainability is becoming a key consideration for large companies. COVID-19 has presented significant challenges to supply chains, making PCR testing a vital product during the pandemic. It detects the presence of the virus if you are infected at the time and detects fragments of the virus even after you are no longer infected. This paper proposes a multi-objective mathematical linear model to optimize a sustainable, resilient, and responsive supply chain for PCR diagnostic tests. The model aims to minimize costs, negative societal impact caused by shortages, and environmental impact, using a scenario-based approach with stochastic programming. The model is validated by investigating a real-life case study in one of Iran's high-risk supply chain areas. The proposed model is solved using the revised multi-choice goal programming method. Lastly, sensitivity analyses based on effective parameters are conducted to analyze the behavior of the developed Mixed-Integer Linear Programming. According to the results, not only is the model capable of balancing three objective functions, but it is also capable of providing resilient and responsive networks. To enhance the design of the supply chain network, this paper has considered various COVID-19 variants and their infectious rates, in contrast to prior studies that did not consider the variations in demand and societal impact exhibited by different virus variants. [ABSTRACT FROM AUTHOR]

Conditions governing industrial activities during and after global shocks with societal and economic transformations such as the COVID-19 pandemic have led to the loss of effectiveness of conventional approaches to dealing with uncertainties. The occurrence of sharp fluctuations in the essential parameters has left decision-makers in an unpredictable situation. Therefore, proactive efforts should be made to develop current approaches for adapting to new conditions. This paper establishes a strategic, tactical, and operational decision-making framework under the COVID-19 outbreak by developing a new uncertainty type called deep dynamic uncertainty. In the first step, a Mixed-Integer Linear Programming (MILP) model is proposed for the green and reliable closed-loop supply chain network design. The proposed model allows the decision-maker (DM) to manage and control co 2 emissions and e-waste generation. In the second step, a new three-step algorithm called Augmented Adjustable Column-Wise Robust Optimization (AACWRO) is first proposed. Then, by combining the proposed column-wise uncertainty with multi-stage stochastic programming (MSSP) approach, deep dynamic uncertainty is theorized for modeling the demand uncertainty under pandemic conditions. The model's performance under deep dynamic uncertainty has been carefully investigated based on the real ventilator and infusion pump supply chain network in Iran. The model under deep dynamic uncertainty, while maintaining tractability and adjustability, provides flexibility in entering data into the problem and significantly increases the coverage of modeling uncertainties. The results clearly demonstrate the efficiency of the proposed approach. The model under deep dynamic uncertainty at all levels of conservatism has on average 42.96% lower cost and 32% higher stability than the MSSP model. • Green and reliable closed-loop medical device supply chain network are studied. • A mechanism is proposed for the management of co 2 emission and e-waste generation. • Stochastic programming and novel robust optimization are considered simultaneously. • Deep dynamic uncertainty is introduced to deal with COVID-19 uncertainties. • The model efficiency is evaluated based on the ventilator and infusion pump industry. [ABSTRACT FROM AUTHOR]

COVID-19 is a highly prevalent disease that has led to numerous predicaments for healthcare systems worldwide. Owing to the significant influx of patients and limited resources of health services, there have been several limitations associated with patients' hospitalization. These limitations can cause an increment in the COVID-19-related mortality due to the lack of appropriate medical services. They can also elevate the risk of infection in the rest of the population. The present study aims to investigate a two-phase approach to designing a supply chain network for hospitalizing patients in the existing and temporary hospitals, efficiently distributing medications and medical items needed by patients, and managing the waste created in hospitals. Since the number of future patients is uncertain, in the first phase, trained Artificial Neural Networks with historical data forecast the number of patients in future periods and generate scenarios. Through the use of the K-Means method, these scenarios are reduced. In the second phase, a multi-objective, multi-period, data-driven two-stage stochastic programming is developed using the acquired scenarios in the previous phase concerning the uncertainty and disruption in facilities. The objectives of the proposed model include maximizing the minimum allocation-to-demand ratio, minimizing the total risk of disease spread, and minimizing the total transportation time. Furthermore, a real case study is investigated in Tehran, the capital of Iran. The results showed that the areas with the highest population density and no facilities near them have been selected for the location of temporary facilities. Among temporary facilities, temporary hospitals can allocate up to 2.6% of the total demand, which puts pressure on the existing hospitals to be removed. Furthermore, the results indicated that the allocation-to-demand ratio can remain at an ideal level when disruptions occur by considering temporary facilities. Our analyses focus on: (1) Examining demand forecasting error and generated scenarios in the first phase, (2) exploring the impact of demand parameters on the allocation-to-demand ratio, total time and total risk, (3) investigating the strategy of utilizing temporary hospitals to address sudden changes in demand, (4) evaluating the effect of disruption to facilities on the supply chain network. [ABSTRACT FROM AUTHOR]

The aim of this study is to estimate the optimal forest harvest considering economic and environmental objectives in an uneven-aged forest in the north of Iran. Required data were collected such as stumpage price, harvesting variable costs, growth, volume, basal area, sequestrated carbon, carbon dioxide storage, and price. The required input models for optimization were estimated using the collected data. A stochastic dynamic programming technique was used for optimization. The results indicated that the harvesting volume was higher when only the economic objective was considered instead of considering economic and environmental objectives. The results also indicated that the harvesting volume would occur at a higher level of volume per hectare if we only consider the environmental objective. The results showed that the expected present value was higher when economic and environmental objectives were considered simultaneously. The results indicated when interest rate increased, the harvesting time and the expected present value decreased. The results showed that the expected present value increases with increasing the risk. The results of this study can be a guideline for optimal forest management. [ABSTRACT FROM AUTHOR]

Today, according to the occurrence of numerous disasters in allover over the world, designing the proper and comprehensive plan for relief logistics has received a lot of attention from crisis managers and people. Besides, considering resilience capability along with operational and disruption risks leads to the robustness of the humanitarian relief chain (HRC), and this comprehensive framework ensures the essential supplies delivery to the beneficiaries and is close to real-world problems. The resilience parameters used for the second objective are obtained by a strong Best Worst Method (BWM). Another supposition of the model is the consideration of uncertainty in all stages of the proposed problem. Moreover, the multiple disasters (sub-sequent minor post disasters) which can increase the initial demand are considered. Furthermore, the proposed model is solved using three well-known metaheuristic algorithms includes non-dominated sorting genetic algorithm (NSGA-II), network reconfiguration genetic algorithm (NRGA), and multi-objective particle swarm optimization (MOPSO), and their performance is compared by several standard multi-objective measure metrics. Finally, the obtained results show the robustness of the proposed approaches, and some directions for future researches are provided. [ABSTRACT FROM AUTHOR]

• A new stochastic mixed-integer linear programming (SMILP) model is proposed for power distribution system (PDS) resilience enhancement against extreme dust storms (EDSs). • Investment and operating costs under the EDS conditions are minimized considering uncertainties and PDS financial and operational constraints. • The proposed actions for PDS resilience enhancement include pre-and post-EDS actions. • Pre-and post-EDS actions are coordinated to minimize load shedding and system performance loss in the emergency conditions. • The effect of budget constraint on the planning results is evaluated and it is determined which measures will achieve the greatest improvement in PDS resilience at each budget level. Extreme dust storms (EDSs) are rare natural disasters, occurring with a higher rate of incidence and severity in recent years in coastal areas with humid climate. EDSs can hamper the operation of power distribution systems (PDSs) and other related urban infrastructures, and damage PDS insulation equipment. In this paper, a bi-level stochastic mixed-integer linear programming model is proposed for PDS resilience enhancement against EDSs. In the proposed model, the investment cost and total expected operating costs under the EDS conditions are minimized while considering uncertainties and PDS financial and operational constraints. The proposed actions for PDS resilience enhancement include pre-and post-EDS actions. Pre-EDS actions include simultaneous hardening of lines and substations, optimal placement of sectionalizing switches, and installation of emergency generators (EGs) in critical points. Post-EDS actions include damaged lines and substations repair, optimal network reconfiguration, power dispatch of EGs and optimal load shedding. The planning results at different budget levels show that coordinating pre-and post-event actions can reduce investment costs besides reducing operational costs. Implementation of the proposed model on the IEEE 33-bus test system and a large-scale PDS in Khuzestan province, a coastal province in southwestern Iran, confirms the efficiency of the proposed method for PDS resilience enhancement planning. [ABSTRACT FROM AUTHOR]