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Executive SummaryWith an increasing variety of radiopharmaceuticals for diagnostic or therapeutic nuclear medicine as valuable diagnostic or treatment option, radiobiology plays an important role in supporting optimizations. This comprises particularly safety and efficacy of radionuclide therapies, specifically tailored to each patient. As absorbed dose rates and absorbed dose distributions in space and time are very different between external irradiation and systemic radionuclide exposure, distinct radiation-induced biological responses are expected in nuclear medicine, which need to be explored. This calls for a dedicated nuclear medicine radiobiology. Radiobiology findings and absorbed dose measurements will enable an improved estimation and prediction of efficacy and adverse effects. Moreover, a better understanding on the fundamental biological mechanisms underlying tumor and normal tissue responses will help to identify predictive and prognostic biomarkers as well as biomarkers for treatment follow-up. In addition, radiobiology can form the basis for the development of radiosensitizing strategies and radioprotectant agents. Thus, EANM believes that, beyond in vitro and preclinical evaluations, radiobiology will bring important added value to clinical studies and to clinical teams. Therefore, EANM strongly supports active collaboration between radiochemists, radiopharmacists, radiobiologists, medical physicists, and physicians to foster research toward precision nuclear medicine.

Peanuts are Leguminosae, commonly known as the legume or pea family, and peanut allergy is among the most common food allergies and the most common cause of fatal food reactions and anaphylaxis.The prevalence of peanut allergy increased 3.5-fold over the past two decades reaching 1.4–2% in Europe and the United States. The reasons for this increase in prevalence are likely multifaceted. Sensitization via the skin appears to be associated with the development of peanut allergy and atopic eczema in infancy is associated with a high risk of developing peanut allergy.Until recently, the only possible management strategy for peanut allergy was strict allergen avoidance and emergency treatment including adrenaline auto-injector in cases of accidental exposure and reaction.This paper discusses the various factors that impact the risks of peanut allergy and the burden of self-management on peanut-allergic children and their caregivers.

Marked mix-nets were introduced by Pereira and Rivest as a mechanism to allow very efficient mixing that ensures privacy but at the cost of not guaranteeing integrity. This is useful in a number of e-voting schemes such as STAR-Vote and Selene. However, the proposed marked mix-net construction comes with no proof of security and, as we show in this paper, does not provide privacy even in the presence of a single corrupt authority. Fortunately, the attack that we present is easy to prevent and we show several possible ways to address it. Finally while the original marked mix-net paper worked with ElGamal, we identify conditions that the adopted encryption scheme should satisfy in order to be appropriate for a marked mix-net. This opens the possibility of building marked mix-nets based on intractability assumptions which are believed to hold in the presence of a quantum computer.

The paper is about the evolution of paper mills in relation to the technological evolution of machines and mechanism for the production of paper. Industrial production techniques is a theme that involves the building and its development. The principles, technology, and even cultural aspects were analyzed in this paper to define the relationship between industrial building and paper making evolution. A Modern documentation needs identified the potential of Industrial Archeology researches in the recent years. Many architects, archaeologists, conservationists, engineers document and purpose possible solution to manage Industrial Archeology structures. The latest years, there are many developments in the Industrial Archeology field. In this review article, following a brief historic background for the papermaking, the analysis of the development factors in the territory of South Lazio focusing also on the cultural background, and of changes in the layout of industrial buildings due to the development of faster and more efficient machinery and methods to produce paper. The conclusion focuses on the future perspective to manage Industrial Archeology.

Non-radiologist point-of-care ultrasonography (US) is increasingly implemented in paediatric care because it is believed to facilitate a timely diagnosis, such as in ascites or dilated renal pelvicalyceal systems, and can be used to guide interventional procedures. To date, all policy statements have been published by non-radiologic societies. The European Society of Paediatric Radiology hereby issues a position statement on paediatric non-radiologist point-of-care US from the point of view of those leading on children’s imaging, i.e. paediatric radiologists. In this position statement, we will address the boundaries, education, credentialing, quality control, reporting and storage of images in paediatric practice.

A waste-based alternative activated carbon (AAC) was produced from paper mill sludge under optimized conditions. Aiming its application in tertiary wastewater treatment, AAC was used for the removal of carbamazepine, sulfamethoxazole, and paroxetine from biologically treated municipal wastewater. Kinetic and equilibrium adsorption experiments were run under batch operation conditions. For comparison purposes, they were also performed in ultrapure water and using a high-performance commercial AC (CAC). Adsorption kinetics was fast for the three pharmaceuticals and similar onto AAC and CAC in either wastewater or ultrapure water. However, matrix effects were observed in the equilibrium results, being more remarkable for AAC. These effects were evidenced by Langmuir maximum adsorption capacities (qm, mg g-1): for AAC, the lowest and highest qm were 194 ± 10 (SMX) and 287 ± 9 (PAR), in ultrapure water, and 47 ± 1 (SMX) and 407 ± 14 (PAR), in wastewater, while for CAC, the lowest and highest qm were 118 ± 7 (SMX) and 190 ± 16 (PAR) in ultrapure water and 123 ± 5 (SMX) and 160 ± 7 (CBZ) in wastewater. It was found that the matrix pH played a key role in these differences by controlling the surface electrostatic interactions between pharmaceutical and AC. Overall, it was evidenced the need of adsorption results in real matrices and demonstrated that AAC is a promising option to be implemented in tertiary wastewater treatments for pharmaceuticals' removal. Graphical abstract Production of an alternative activated carbon (AC) comparing favourably with a commercial AC in the removal of neutral and positive pharmaceuticals from wastewater. published

The British paper trade history was defined since the mid-1850s by a quest for a new raw material to replace rags. The requirements of the paper trade were first met by a discovery that esparto grass from Spain, and later from North Africa, could be utilised in British mills. Beginning in the late 1870s, the success of using esparto encouraged mill developments in British India. The increased dependence on imported wood pulp, the likelihood of a pulp famine, and the consequent increase in price for imported wood pulp drew attention to the possibility of making commercial volumes of good quality pulp from indigenous Indian grasses. Bamboo began being treated after the First World War, when the Government of India offered financial incentives to induce the creation of a bamboo pulp and paper industry. The bamboo pulping process entered the period of commercial production in 1922 but developed in an economically viable manner only after tariff protection had become effective in 1925. The technology was developed under British auspices, but was later adopted by Indian paper producers in response to the rising costs of imported wood pulp. peerReviewed

Our life depends more and more on intelligent machines that help us carry out our work or have completely taken our place in tasks which used to be wholly human. This also applies to the field of care and assistance for the sick and fragile: indeed, carebots are increasingly present by the patient’s bed and can collaborate in care work. However carebots are not objects like others that we use in our everyday life: unlike the tools through which we do things, robots have (and will more and more have) some level of autonomy. We intend to consider the type of relationship it is right to build with these devices and ask whether intelligent robots deserve some moral and legal relevance. The robot may be seen as a slave or an entity with which we can form friendships or loving relationships: we will maintain that it is our responsibility to prepare for future scenarios in which increasingly intelligent, autonomous machines will be not mere tools, but significant life companions.

The declining cost of sea transport has been a necessary condition for the growth of the global pulp and paper industry, especially in regions remote from economic centres. Thus, pulp and paper industries and international shipping have coevolved, especially since the 1960s, enabling producers to tap global markets and develop global production chains. The paper products trade flows, however, have changed a number of times over the last 400 years. This chapter describes and explains these developments and shows how the technological solutions in global shipping and strategic choices among the pulp and paper companies have been interdependent, especially since the 1960s. peerReviewed

This chapter describes the general history of research and development work in the Finnish pulp and paper industry from the mid-nineteenth century until roughly 1990, a period that witnessed it undergo drastic changes because of the altered political environment in Europe and general globalization. In addressing its subject, this chapter is mainly concerned with the operation of paper mills, but it also addresses the related subjects of technical research, formal higher education and work-related, practical learning. In addition, it briefly discusses the challenges inherent in researching the development of technology because of its research traditions. peerReviewed

The cerebellum is involved in multiple closed-loops circuitry which connect the cerebellar modules with the motor cortex, prefrontal, temporal, and parietal cortical areas, and contribute to motor control, cognitive processes, emotional processing, and behavior. Among them, the cerebello-thalamo-cortical pathway represents the anatomical substratum of cerebellum-motor cortex inhibition (CBI). However, the cerebellum is also connected with basal ganglia by disynaptic pathways, and cerebellar involvement in disorders commonly associated with basal ganglia dysfunction (e.g., Parkinson’s disease and dystonia) has been suggested. Lately, cerebellar activity has been targeted by non-invasive brain stimulation (NIBS) techniques including transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) to indirectly affect and tune dysfunctional circuitry in the brain. Although the results are promising, several questions remain still unsolved. Here, a panel of experts from different specialties (neurophysiology, neurology, neurosurgery, neuropsychology) reviews the current results on cerebellar NIBS with the aim to derive the future steps and directions needed. We discuss the effects of TMS in the field of cerebellar neurophysiology, the potentials of cerebellar tDCS, the role of animal models in cerebellar NIBS applications, and the possible application of cerebellar NIBS in motor learning, stroke recovery, speech and language functions, neuropsychiatric and movement disorders.

There are many sets of information in the literature (e.g., papers, books and websites) about the great achievements that are expected for aerospace gas turbine engines by the employment of ceramic matrix composites (CMCs) and thermally sprayed environmental barrier coatings (EBCs) in their hot zones (e.g., combustion chambers, vanes, shrouds, blades and afterburners). Among these achievements, it is typically highlighted (i) turbine weight reduction, (ii) reduced fuel consumption, (iii) higher operation temperatures, (iv) superior thrust-to-weight ratio and (v) lower emission of toxic gases to the atmosphere. Although these achievements are true, they are generally not well-explained to the reader on how together they come to be. In addition, according to “conventional wisdom”, some of these engineering feats are in fact opposing each other (e.g., higher operation temperatures versus lower emissions). The objective of this tutorial paper is to present the reader how these feats are achieved by the concomitant combination of imaginative engineering. It will explain the non-stop driving force for increasing combustion temperatures; show the basic concepts of CMCs, the paramount need of EBCs, and the complexity of creating EBC architectures via air plasma spray (APS). Finally, highlights on how EBCs/CMCs are tested at high temperature will be provided. The content of this paper shall be understood by anyone with basic knowledge in materials processing and surface engineering.

Perforated diverticulitis is an emergent clinical condition and its management is challenging and still debated. The aim of this position paper was to critically review the available evidence on the management of perforated diverticulitis and generalized peritonitis in order to provide evidence-based suggestions for a management strategy. Four Italian scientific societies (SICCR, SICUT, SIRM, AIGO), selected experts who identified 5 clinically relevant topics in the management of perforated diverticulitis with generalized peritonitis that would benefit from a multidisciplinary review. The following 5 issues were tackled: 1) Criteria to decide between conservative and surgical treatment in case of perforated diverticulitis with peritonitis; 2) Criteria or scoring system to choose the most appropriate surgical option when diffuse peritonitis is confirmed 3); The appropriate surgical procedure in hemodynamically stable or stabilized patients with diffuse peritonitis; 4) The appropriate surgical procedure for patients with generalized peritonitis and septic shock and 5) Optimal medical therapy in patients with generalized peritonitis from diverticular perforation before and after surgery. In perforated diverticulitis surgery is indicated in case of diffuse peritonitis or failure of conservative management and the decision to operate is not based on the presence of extraluminal air. If diffuse peritonitis is confirmed the choice of surgical technique is based on intraoperative findings and the presence or risk of severe septic shock. Further prognostic factors to consider are physiological derangement, age, comorbidities, and immune status. In hemodynamically stable patients, emergency laparoscopy has benefits over open surgery. Options include resection and anastomosis, Hartmann’s procedure or laparoscopic lavage. In generalized peritonitis with septic shock, an open surgical approach is preferred. Non-restorative resection and/or damage control surgery appear to be the only viable options, depending on the severity of hemodynamic instability. Multidisciplinary medical management should be applied with the main aims of controlling infection, relieving postoperative pain and preventing and/or treating postoperative ileus. In conclusion, the complexity and diversity of patients with diverticular perforation and diffuse peritonitis requires a personalized strategy, involving a thorough classification of physiological derangement, staging of intra-abdominal infection and choice of the most appropriate surgical procedure.

In this paper, we introduce a normative, multi-agent perspective on the field of industrial symbiosis research and propose normative institutions as a key technology for operating Industrial Symbiotic Networks (ISNs), both as a framework to represent and reason about dynamic behaviour of ISNs and as a platform for design and maintenance of such networks. We discuss the requirements of normative agent-based frameworks for ISNs with respect to agent interactions, joint commitments, and the organisation to monitor interactions in ISNs.

The excellence shift is proposed, which shows universities’ ability to produce highly cited papers as measured against their basic academic research efficiency. To demonstrate our approach, we use data from 50 US universities.

The ever-increasing number of published scientific articles has prompted the need for automated, data-driven approaches to summarizing the content of scientific articles. The Computational Linguistics Scientific Document Summarization Shared Task (CL-SciSumm 2019) has recently fostered the study and development of new text mining and machine learning solutions to the summarization problem customized to the academic domain. In CL-SciSumm, a Reference Paper (RP) is associated with a set of Citing Papers (CPs), all containing citations to the RP. In each CP, the text spans (i.e., citances) have been identified that pertain to a particular citation to the RP. The task of identifying the spans of text in the RP that most accurately reflect the citance is addressed using supervised approaches. This paper proposes a new, more effective solution to the CL-SciSumm discourse facet classification task, which entails identifying for each cited text span what facet of the paper it belongs to from a predefined set of facets. It proposes also to extend the set of traditional CL-SciSumm tasks with a new one, namely the discourse facet summarization task. The idea behind is to extract facet-specific descriptions of each RP consisting of a fixed-length collection of RP’s text spans. To tackle both the standard and the new tasks, we propose machine learning supported solutions based on the extraction of a selection of discriminating words, called pivot words. Predictive features based on pivot words are shown to be of great importance to rate the pertinence and relevance of a text span to a given facet. The newly proposed facet classification method performs significantly better than the best performing CL-SciSumm 2019 participant (i.e., the classification accuracy has increased by + 8%), whereas regression methods achieved promising results for the newly proposed summarization task.

Nursing process has a relevant impact on overall quality of healthcare services and patient outcomes, however nursing contribution appears to be almost ‘invisible’. Use of an international Standardized Nursing Language (SNL), as NANDA-I NOC NIC (NNN) taxonomy, allows making nursing visible in education, practice and research with final better outcomes on patients. Electronic Health Record (EHR) could facilitate learning of standardized languages in nursing undergraduate students, but only few studies analyzed it. This paper aims to report the experience of the ‘Caring project’ utilizing a SNL in an Italian healthcare setting and to discuss potentialities of EHR in improving nursing education and practice. ‘Caring project’ was an Italian pilot observational study, conducted on 231 patients of 8 Units retrospectively (January 2018–March 2019), using a ‘paper’ assessment form with Gordon’s Functional Health Patterns (FHPs) and an Individual Care Plan (ICP), an ‘Excel® based health record prototype’. In the study a total of 484 Nursing Diagnosis (NDs) has been identified, corresponding to a mean of 2.0 ± 1.5 NDs/patient. Integration of SNL with EHRs could help nurses to use a holistic approach and, in nursing education, it could improve undergraduate students clinical reasoning skills. Further researches are necessary in this subject, in particular regarding the nursing diagnostic accuracy.

Purpose of review To give an overview of the current knowledge regarding the aetiology, epidemiology, and classification of laryngeal dysplasia (LD) and to highlight the contributions of recent literature. As most cases of dysplasia occur at the glottic level and data on diagnosis and management are almost exclusively from this location, laryngeal dysplasia in this position paper is taken to be synonymous with dysplasia of the vocal folds. Summary LD has long been recognized as a precursor lesion to laryngeal squamous cell carcinoma (SCC). Tobacco and alcohol consumption are the two single most important etiological factors for the development of LD. There is currently insufficient evidence to support a role of reflux. Although varying levels of human papillomavirus have been identified in LD, its causal role is still uncertain, and there are data suggesting that it may be limited. Dysplasia has a varying presentation including leukoplakia, erythroleukoplakia, mucosal reddening or thickening with exophytic, “tumor-like” alterations. About 50% of leukoplakic lesions will contain some form of dysplasia. It has become clear that the traditionally accepted molecular pathways to cancer, involving accumulated mutations in a specific order, do not apply to LD. Although the molecular nature of the progression of LD to SCC is still unclear, it can be concluded that the risk of malignant transformation does rise with increasing grade of dysplasia, but not predictably so. Consequently, grading systems are inherently troubled by the weak correlation between the degree of the dysplasia and the risk of malignant transformation. The best data on LD grading and outcomes come from the Ljubljana group, forming the basis for the World Health Organization classification published in 2017.

[Context and motivation] Modern software engineering processes have shifted from traditional upfront requirements engineering (RE) to a more continuous way of conducting RE, particularly including data-driven approaches. [Question/problem] However, current research on data-driven RE focuses more on leveraging certain techniques such as natural language processing or machine learning than on making the concept fit for facilitating its use in the entire software development process. [Principal ideas/results] In this paper, we propose a research agenda composed of six distinct research directions. These include a data-driven RE infrastructure, embracing data heterogeneity, context-aware adaptation, data analysis and decision support, privacy and confidentiality, and finally process integration. Each of these directions addresses challenges that impede the broader use of data-driven RE. [Contribution] For researchers, our research agenda provides topics relevant to investigate. For practitioners, overcoming the underlying challenges with the help of the proposed research will allow to adopt a data-driven RE approach and facilitate its seamless integration into modern software engineering. For users, the proposed research will enable the transparency, control, and security needed to trust software systems and software providers. This work has been supported by: the Spanish project GENESIS (TIN2016-79269-R), the Christian Doppler Forschungsgesellschaft, the Austrian Federal Ministry for Digital and Economic Affairs, the National Foundation for Research, Technology and Development, and the Austrian Science Fund (FWF) under the grant numbers J3998-N31, P28519-N31, and P30525-N31.

This review describes medium and high molecular weight organic material found in wastewaters from pulp and paper industry. The aim is to review the versatile pollutants and the analysis methods for their determination. Among other pollutants, biocides, extractives, and lignin-derived compounds are major contributors to harmful effects, such as toxicity, of industrial wastewaters. Toxicity of wastewaters from pulp and paper mills is briefly evaluated including the methods for toxicity analyses. Traditionally, wastewater purification includes mechanical treatment followed by chemical and/or biological treatment processes. A variety of methods are available for the purification of industrial wastewaters, including aerobic and anaerobic processes. However, some fractions of organic material, such as lignin and its derivatives, are difficult to degrade. Therefore, novel chemical methods, including electrochemical and oxidation processes, have been developed for separate use or in combination with biological treatment processes. peerReviewed

Logical frameworks like LF allow to specify the syntax and (natural deduction) inference rules for syntax/proof-checking a wide variety of logical systems. A crucial feature that is missing for prototyping logics is a way to specify basic proof automation. We try to alleviate this problem by generating \(\lambda \)Prolog (ELPI) inference predicates from logic specifications and controlling them by logic-independent helper predicates that encapsulate the prover characteristics. We show the feasibility of the approach with three experiments: We directly automate ND calculi, we generate tableau theorem provers and model generators.

Problem: Visions of technology, future scenarios, guiding visions (Leitbilder) represent imaginations of future states of affairs that play a functional role in processes of technological research, development and innovation—e.g. as a means to create attention, communication, coordination, or for the strategic exertion of influence. Since a couple of years there is a growing attention for such imaginations of futures in politics, the economy, research and the civil society. This trend concerns technology assessment (TA) as an observer of these processes and a consultant on the implications of technology and innovation. TA faces increasing demands to assess imaginations of futures that circulate in the present and to participate in shaping these through scenarios or foresights. More than ever, this raises the question, which propositions can be made based on these imaginations by TA and how this can be used in advisory practices. Imaginations of futures are relevant for TA not as predictions but in their significance and effectiveness in the present, which need to be understood and assessed.

Virtual reality (VR) is an emerging technology that is being used in a wide range of fields such as medicine, gaming, psychology and sociology. The use of VR is promising in the field of education and requires investigation, but research on the use of VR in education is still limited. This enables the exploration of new territories, and design education is one of them. Design education, an important part of the curriculum of architecture students who aim to conceptualize problem-solving, is still taught using traditional methodologies with touches of digital technologies. Thus, there is limited research into the implementation of VR. This study proposes using VR in basic design education and focuses on the usability of VR, especially for problem-solving activities. It presents the literature on basic design education of digital approaches, VR technologies, usability criteria and the technology acceptance model. In order to analyse the usability of VR, we conducted an experimental study with 20 first-year interior architecture and architecture students. We found that, statistically, there is a significant difference in terms of ‘the intention to use’ and ‘the perceived enjoyment’ between the VR group and the paper-based group. Moreover, there is, statistically, a difference in effectiveness within the paper-based group and the VR-based group when one compares the success of two types of design problems in the same group. Thus, one can summarize that using VR can strongly enhance problem-solving activities in interior architecture and for architecture students and that one can consider it to be a promising and complementary tool in basic design education.

This paper provides an overview of the main developments of the Tech United Eindhoven RoboCup @Home team. Tech United uses an advanced world modeling system called the Environment Descriptor. It allows straightforward implementation of localization, navigation, exploration, object detection & recognition, object manipulation and robot-robot cooperation skills based on the most recent state of the world. Other important features include object and people detection via deep learning methods, a GUI, speech recognition, natural language interpretation and a chat interface combined with a conversation engine. Recent developments that aided with obtaining the victory during RoboCup 2019 include pointing detection, usage of HSR’s display, a people detector and the addition of a custom keyboard in the chat interface.

Rapid advances in microarray and sequencing technologies are making genotyping and genome sequencing more affordable and readily available. There is an expectation that genomic sequencing technologies improve personalized diagnosis and personalized drug therapy. Concurrently, provision of direct-to-consumer genetic testing by commercial providers has enabled individuals’ direct access to their genomic data. The expanded availability of genomic data is perceived as influencing the relationship between the various parties involved including healthcare professionals, researchers, patients, individuals, families, industry, and government. This results in a need to revisit their roles and responsibilities. In a 1-day agenda-setting meeting organized by the COST Action IS1303 “Citizen’s Health through public-private Initiatives: Public health, Market and Ethical perspectives,” participants discussed the main challenges associated with the expanded availability of genomic information, with a specific focus on public-private partnerships, and provided an outline from which to discuss in detail the identified challenges. This paper summarizes the points raised at this meeting in five main parts and highlights the key cross-cutting themes. In light of the increasing availability of genomic information, it is expected that this paper will provide timely direction for future research and policy making in this area. Funding Deborah Mascalzoni is supported under Grant Agreement number 305444. Álvaro Mendes is supported by the FCT—The Portuguese Foundation for Science and Technology under postdoctoral grant SFRH/BPD/88647/2012. Isabelle Budin-Ljøsne receives support from the National Research and Innovation Platform for Personalized Cancer Medicine funded by The Research Council of Norway (NFR BIOTEK2021/ES495029) and Biobank Norway funded by The Research Council of Norway—grant number 245464. Heidi Carmen Howard is partly supported by supported by the Swedish Foundation for Humanities and Social Science under grant M13-0260:1), the Biobanking and Molecular Resource Infrastructure of Sweden (BBMRI.se) and the BBMRI-ERIC. Brígida Riso is supported by the Portuguese Foundation for Science and Technology (FCT) under the PhD grant SFRH/BD/100779/2014. Heidi Beate Bentzen receives support from the project Legal Regulation of Information Processing relating to Personalized Cancer Medicine funded by The Research Council of Norway BIOTEK2021/238999.

Reproducibility of Science is considered as one of the main principles of the scientific method, and refers to the ability of an experiment to be accurately reproduced, by third person, in complex experiment every detail matters to ensure the correct reproducibility. In the context of the ICCS 2011, Elsevier organized the executable paper grand challenge a contest to improve the way scientific information is communicated and used. While during this contest the focus was on developing methods and technique to realize the idea of executable papers, in this paper we focus on the operational issues related to the creation a viable service with a predefined QoS.

Distributed Ledgers (DLs), also known as blockchains, provide decentralised, tamper-free registries of transactions among partners that distrust each other. For the scientific community, DLs have been proposed to decentralise and make more transparent each step of the scientific workflow. For the particular case of dissemination and peer-reviewing, DLs can provide the cornerstone to realise open decentralised publishing systems where social interactions between peers are tamper-free, enabling trustworthy computation of bibliometrics. In this paper, we propose the use of DL-backed smart contracts to track a subset of social interactions for scholarly publications in a decentralised and reliable way, yielding Smart Papers. We show how our Smart Papers approach complements current models for decentralised publishing, and analyse cost implications.

This expert opinion paper on atrial fibrillation detection after ischemic stroke includes a statement of the "Heart and Brain" consortium of the German Cardiac Society and the German Stroke Society. This paper was endorsed by the Stroke Unit-Commission of the German Stroke Society and the German Atrial Fibrillation NETwork. In patients with ischemic stroke, detection of atrial fibrillation should usually lead to a change in secondary stroke prevention, since oral anticoagulation is superior to antiplatelet drugs. The detection of previously undiagnosed atrial fibrillation can be improved in patients with ischemic stroke to optimize stroke prevention. This paper summarizes the present knowledge on atrial fibrillation detection after ischemic stroke. We propose an interdisciplinary standard for a "structured analysis of ECG monitoring" on the stroke unit as well as a staged diagnostic scheme for the detection of atrial fibrillation. Since the optimal duration and mode of ECG monitoring has not yet been finally established, this paper is intended to give advice to physicians who are involved in stroke care. In line with the nature of an expert opinion paper, labeling of classes of recommendations is not provided, since many statements are based on the expert opinion, reported case series and clinical experience. Therefore, this paper is not intended as a guideline.

Technological innovation, big and small, has played a critical role in the evolution of the modern United States pulp and paper industry since its origins in the early nineteenth century. New technological knowledge and its implementation, more than anything else, gave entrepreneurs, firms, industries, and whole regions, the ability to create or capture new markets, or erect new production hubs, and to forge ahead competitors.

This concluding chapter summarizes the findings of the volume, and combines those findings with a comparative life-cycle perspective. We demonstrate how pulp and paper industry companies have emerged and exited in different countries. We highlight technology, raw materials, markets and products as factors explaining changes in industry structure and dominance. We demonstrate that industrial growth and the accumulation of technological knowledge require a certain maturity of political systems, regulation, and organization of research and development. Likewise, similarities between regions that lose their competitive advantage are characterized by saturation of demand, thereby weakening incentives to invest in production capacity, which is subsequently detrimental to the whole value network.

In digital libraries, much of the reading activity is still done on printed copies of documents. We show how digital pen and paper technologies can be used to support readers by automatically creating interactive paper versions of digital documents during the printing process that enable users to activate embedded hyperlinks to other documents and services from printed versions. The approach uses a special printer driver that allows information about hyperlinks to be extracted and stored at print time. Users can then activate hyperlinks in the printed document with a digital pen.

According to the data from the Scopus publication database, as analyzed in several recent studies, more than 70,000 papers have been published in the area of Software Engineering (SE) since late 1960’s. According to our recent work, 43% of those papers have received no citations at all. Since citations are the most commonly used metric for measuring research (academic) impact, these figures raise questions (doubts) about the (non-existing) impact of such a large set of papers. It is a reality that typical academic reward systems encourage researchers to publish more papers and do not place a major emphasis on research impact. To shed light on the issue of volume (quantity) versus citation-based impact of SE research papers, we conduct and report in this paper a quantitative bibliometrics assessment in four aspects: (1) quantity versus impact of different paper types (e.g., conference versus journal papers), (2) ratios of uncited (non-impactful) papers, (3) quantity versus impact of papers originating from different countries, and (4) quantity versus impact of papers by each of the top-10 authors (in terms of number of papers). To achieve the above objective, we conducted a quantitative exploratory bibliometrics assessment, comprised of four research questions, to assess quantity versus impact of SE papers with respect to the aspects discussed above. We extracted the data through a systematic, automated and repeatable process from the Scopus paper database, which we also used in two previous papers. Our results show that the distribution of SE publications has a major inequality in terms of impact overall, and also when categorized in terms of the above four aspects. The situation in the SE literature is similar to the other areas of science as studied by previous bibliometrics studies. Also, among our results is the fact that journal articles and conference papers have been cited 12.6 and 3.6 times on average, confirming the expectation that journal articles have more impact, in general, than conference papers. Also, papers originated from English-speaking countries have in general more visibility and impact (and consequently citations) when compared to papers originated from non-English-speaking countries. Our results have implications for improvement of academic reward systems, which nowadays mainly encourage researchers to publish more papers and usually neglect research impact. Also, our results can help researchers in non-English-speaking countries to consider improvements to increase their research impact of their upcoming papers., Vahid Garousi was partially supported by several internal grants provided by the Hacettepe University and the Scientific and Technological Research Council of Turkey (TUBITAK). Joao M. Fernandes was supported by FCT - Fundacao para a Ciencia e Tecnologia within the Project Scope UID/CEC/00319/2013.

Paper is a persistent element of financial advisory encounters, despite the increasing digitisation of the financial industry. We seek to understand the reasons behind the resilience of paper-based encounters and advisors’ resistance to change by understanding the paper’s roles in financial advisory encounters. While applying multimodal analysis to a set of field and experimental data, we point to a range of prevalent advisory practices that rely on the use of paper documents and hand-written notes. We focus on the choreography of paper and how this intersects with the participants’ institutional identities and goals. Specifically, we show how advisors’ paper-oriented actions seek to convey a positive impression about the advisor and about the bank to the client, i.e. how they engage in seemingly mundane practices to impress their clients. Paper is far more than a medium for saving and presenting information: it is an interaction resource, a semiotic resource and an institutional resource; all these aspects of paper come into play during a financial advisory encounter. The manuscript concludes with suggestions on the design of technologies that may potentially replace the paper in financial advisory encounters and assesses the likelihood of this in light of the results.

This book constitutes the refereed proceedings of the 5th Computer Games Workshop, CGW 2016, and the 5th Workshop on General Intelligence in Game-Playing Agents, GIGA 2016, held in conjunction with the 25th International Conference on Artificial Intelligence, IJCAI 2016, in New York, USA, in July 2016.The 12 revised full papers presented were carefully reviewed and selected from 25 submissions. The papers address all aspects of artificial intelligence and computer game playing. They discuss topics such as Monte-Carlo methods; heuristic search; board games; card games; video games; perfect and imperfect information games; puzzles and single player games; multi-player games; combinatorial game theory; applications; computational creativity; computational game theory; evaluation and analysis; game design; knowledge representation; machine learning; multi-agent systems; opponent modeling; planning.