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Students of European integration have produced an enormous amount of literature on the intergovernmental negotiations that led to the establishment of such organizations as the OEEC, the EEC and EFTA. However, only a few have devoted substantial attention to the international contacts between companies that attempted to undermine the integration process by building private trade barriers that would replace those that governments had agreed to remove. The paper producers began to build such barriers soon after EFTA and the EEC had been set up. Although these attempts were not always successful, the industrialists did manage to create arrangements that were substantially more extensive in their geographical and product scope than those that had existed before. The British government and the EEC were reluctant to challenge these arrangements, and in some cases even actively promoted them. The interwar decades are widely considered to be the ‘golden era’ for international cartels; but for the paper cartels, the ‘golden era’ began in the 1960s, when previous bilateral links were replaced with multilateral ones. [ABSTRACT FROM PUBLISHER]

The main objective of this paper is to handle the trajectory tracking control for a class of three-wheel mobile robot by using a novel adaptive robust control. The mobile robot consists of nonholonomic constraints and uncertainties. The uncertainties include initial condition offset, mass, and moment of inertia of the system, which are time-varying and bounded (unknown). The control force in analytical form is obtained by UK theory, and the adaptive robust control is formulated to handle the uncertainties. For estimating the unknown bounds of uncertainties, the leakage-type adaptive law is designed, which can automatically adjust its own value according to the trajectory tracking errors. Then we verify the uniform boundedness and uniform ultimate boundedness of the proposed control by Lyapunov method. Finally, numerical simulations are conducted to show the trajectory tracking effectiveness of the designed control method. [ABSTRACT FROM AUTHOR]

This article provides some information about British organization Study Group and its activities since its formal inception at the 1969 Easter BSA conference. At that time sociology of science was not really firmly established as a distinct sub-area of sociology and most people interested in it were primarily either sociologists of organizations and of education or connected with then growing "science of science" area. Papers presented at recent meetings of the group reflects a wide range of interests. Most papers profounded that a sociology of scientific knowledge is possible and the theoretical and epistemological implications of this view have been extensively discussed. A major means of demarcating this area from others has been the emphasis on theoretical aspects of understanding scientific knowledge. Some papers were concerned with issues in the sociology of knowledge and the philosophy of science, as well as with general questions of sociological theory. Science is perceived more as one part of the cultural system rather than as entity separate from society.

Discusses the history of the Arab-Israeli conflict. Catalyst to the creation of the State of Israel; Concern of the Great Britain in the Middle East; Indicator of the permanency of Zionist project.

ABSTRACT The privatization of the British electricity supply industry (ESI) in the late 1980s and early 1990s was associated with a transformation in electricity generation technology. In a sudden and unexpected 'dash for gas', previously unused combined cycle gas turbine plant was adopted for all new large power stations. Gas turbine technology, politically and institutionally excluded from the industry before privatization, gained ascendancy due to the coincidence and interaction of FSI liberalization with lower fuel prices and greater availability, improved turbine performance, pollution abatement legislation, and the manifestation of institutional tensions accumulated under nationalization. An earlier paper found that the demise of established generation technology, particularly the British nuclear power programme, exposed the inadequacies of autonomistic and deterministic notions of technological change. The present paper considers the value of a more subtle framework — Hughes' sociotechnical systems model — for analysing the rise of gas turbines in the British ESI. The systems perspective enables the dash for gas to be understood, rather than as a result of technical and economic imperatives, or structural and regulatory reform, as a contingent and largely unplanned outcome of the interplay of previously excluded international forces with latent local interests, mediated by policymaking expediency. Liberalization swiftly led to the replacement of centralized system building with fragmented 'postmodern' change. [ABSTRACT FROM AUTHOR]

This paper aims to enrich our understanding of the history and substance of cybernetics. It reviews the work of three British cyberneticians — W. Ross Ashby, Stafford Beer and Gordon Pask — paying attention particularly to the materiality of their practice — the strange and fascinating devices and systems that were at the heart of their work — and to the worldly projects they pursued — scientific, technological, artistic, organizational, political and spiritual. Connections are drawn between cybernetics and recent theoretical work in science and technology studies, in the hope of illuminating key features of both. The paper concludes by suggesting that the antidisciplinary impulse of contemporary science studies might find inspiration in the work of cyberneticians — that theory does not have to remain confined to the realm of theory. [ABSTRACT FROM AUTHOR]

Amateurs have been neglected in accounts of the rise of new specialties in science. This paper examines seven key amateurs and their relationship to the growth of astrophysics over a sixty-year period. These amateurs, five Britons and two Americans, are seen as the risk-takers of the new specialty. They pioneered in the application of photography and the use reflecting telescopes, and amassed an important body of observational material in such areas as spectroscopy. While they shared most aspects of the discipline with professionals, including access to publications, honours and awards, and the governance of scientific societies, they differed from professionals in significant ways. Because amateurs were free to take risks they sometimes came into conflict with professionals. When this happened differences between the two were magnified. By about 1900 astrophysics reached a stage where it was no longer possible for amateurs to compete. Neither wealth nor leisure could take the place of specialized training the provide access to increasingly sophisticated technologies. [ABSTRACT FROM AUTHOR]

Pica, the deliberate ingestion of non-food substances, has been described in different antenatal populations in some parts of the world. Although the aetiology remains unclear, pica has been associated with complications such as anaemia in pregnancy. Little is known regarding the existence of this phenomenon in a high-risk antenatal population such as women with diabetes in pregnancy.In this service review survey of 56 consecutive pregnant women attending our joint antenatal diabetes clinic, the practice of pica was found in 23% of the women. The commonest variant of pica in this group was pagophagy (ice) followed by amylophagy (uncooked starch). Other ingested items in this group were sand, paper, gloss paint and sponge.There is a need for increased awareness amongst antenatal health professionals regarding the existence of the phenomenon of pica. This would allow appropriate nutritional advice to be offered. Further work is required to determine the impact of the different variants of pica on glycaemic control and other important pregnancy outcomes in diabetic patients. [ABSTRACT FROM PUBLISHER]

While trust is seen as central to most social relations, most writers, including sociologists of science, assume that modern trust relations – especially those in regulatory relationships – tend towards the impersonal. Drawing on ethnographic material from one kind of scientific oversight body – research ethics committees based in the UK NHS – this paper argues that interpersonal trust is crucial to regulatory decision-making and intimately bound up with the way in which these oversight bodies work, and that as such they build on, rather than challenge, the trust-based nature of the scientific community. [ABSTRACT FROM PUBLISHER]

The nature of the learning resource areas found in Britain’s schools has changed dramatically in the last decade and a half. Traditional libraries, based around a centralized collection of books, are becoming increasingly uncommon and have been replaced in many institutions by more computer-oriented ‘study centres’. These quite different environments have provoked controversy in several quarters and pose a range of challenges to those who manage them. Although some of the emergent issues are far from new and, indeed, have been debated in library circles for decades, others are more particular to study centres. This paper explores in some detail a dozen matters, highlighting dilemmas and, on occasion, possible solutions. The questions posed are fundamental and diverse, relating to such varied aspects as the physical environment itself, the virtual world to which the study centre offers access, the role of traditional materials, the functions of staff responsible for the facility and the purposes for which the area should be used. [ABSTRACT FROM PUBLISHER]

This article examines the development of cooperative relationships in back-channel communication and their impact on intraparty negotiation. It draws on extensive newly available evidence on back-channel communication in the Irish peace process to expand the range of detailed case studies on a topic which is shrouded in secrecy and resistant to academic inquiry. The article analyses the operation of a secret back channel that linked the Irish Republican Army to the British government over a period of 20 years, drawing on unique material from the private papers of the intermediary, Brendan Duddy, and a range of other primary sources. The article finds that interaction through this back channel increased predictability and laid a foundation of extremely limited trust by providing information and increasing mutual understanding. Strong cooperative relationships developed at the intersection between the two sides, based to a great extent on strong interpersonal relationships and continuity in personnel. This in turn produced direct pressure for changes in the position of parties as negotiators acted as advocates of movement in intraparty negotiations. The article finds that this back channel was characterized by a short chain, the direct involvement of principals and the establishment of a single primary channel of communication and that these features combined with secrecy to generate the distinctive cooperative dynamics identified in this article. It concludes that the potential for the development of cooperative relationships is particularly strong in back-channel negotiation for two reasons; first, the joint project of secrecy creates an ongoing shared task that builds trust and mutual understanding regardless of progress in the negotiations. Secondly, as a shared project based on the explicit aim of bypassing spoilers, the process creates structural pressures for cooperation to manage internal opponents on both sides, pressures intensified by the secrecy of the process. [ABSTRACT FROM PUBLISHER]

This paper explores issues in relation to the contribution and importance of mandatory continuing professional development (CPD) in re-energizing and motivating the information profession. Set within the context of developing our understanding of the concept of ‘professionalism’ for the contemporary information profession, the mandatory schemes offered by professional associations in the UK and New Zealand are compared and contrasted, and an assessment made of their pros and cons in this regard. [ABSTRACT FROM PUBLISHER]

While many scholars researching the commercialization of science focus on biomedicine, this paper explores the changing commercial frameworks for meteorology in the UK and the US. The organization of meteorology in both countries increasingly reflects a political-economic approach that treats science as an economic entity in which market-based criteria can be used to allocate scientific resources. The differences are equally significant in terms of the production and dissemination of meteorological forecasts and other data to public and private services. Alongside this commercialization has been the emergence of weather derivatives markets -- financial products that enable trading on weather indices in a way similar to oil or gas futures -- which have re-shaped how some businesses interact with meteorologists. This paper explores how weather derivatives traders engage with, shape, and are frustrated by a commercialized approach to funding meteorological data and forecasts. It highlights how commercial imperatives raise questions about the collection and quality of meteorological data, and how forecasting and weather modelling is being adopted within the private sector to enable trading strategies in the weather derivatives market. The consequences for commercial actors are highly variable, suggesting that any account of commercialization of science, while recognizing extant policy shifts, must be sufficiently nuanced in its interpretation of such effects. [ABSTRACT FROM AUTHOR]

For hundreds of years, the Eastern Mediterranean island of Cyprus has been subjected to the — not always welcome — attentions of external powers, finally gaining some independence from Britain in 1960. Since then, Cyprus has been the object of three international crises, almost leading to war between NATO members Greece and Turkey. Following a Turkish invasion and occupation which continues to the present, tensions have continued, while Turkey continues to occupy over one-third of Cyprus, an EU member, while trying itself to gain entry to the organisation. Papers released by British government departments in January 2008 reveal the following: an increasingly submissive yet tetchy attitude in British foreign policy formulation vis-à-vis American pressure (mainly Kissinger) on Britain not to leave Cyprus; the question of the USA financing the British bases; British government criticism of Turkey's perceived intransigence in finding a solution to the Cyprus conundrum; British government criticism of Turkey's position on its continental-shelf dispute with Greece; Britain's strong support for Turkey's European aspirations, flying in the face of the Parliamentary Select Committee on Cyprus' recommendations; past and future President Clerides' seeming contentedness with the British military presence on Cyprus; and a marked difference between French and British views. The article concludes that the British government submitted to US demands and suggests that Cyprus remains a cat's paw of big-power politics. [ABSTRACT FROM AUTHOR]

This paper traces the efforts of a small number of ornithologists and bird surveyors to design and implement a national census for the corncrake (Crex crex), a rare migratory bird, in north-west Scotland. Drawing on concepts and methodologies from the sociology of science and the recent ethological turn in social theory, it follows corncrake scientists as they tune in to the bird's ecology and behaviour and devise and distribute a standardized set of methods for a national census. It examines how these methods were implemented in practice in the field and explores the embodied skills and emotions involved in counting corncrakes. Finally, it follows how, as the outcome of the census, the corncrake was framed for the first time as a dynamic population and given voice through a representing assemblage. The paper concludes with some more general observations about the benefits of understanding the field sciences as affective practices and draws attention to the importance of embodied skill, emotion and an ethical sensibility in the generation of scientific representations. [ABSTRACT FROM AUTHOR]

There is a growing commitment within science centres and museums to develop exhibitions that engender new forms of participation that contribute to the public's understanding of science. Information and communication systems play an important role in this regard, enabling new forms of 'interaction' with and around exhibits. In this paper we consider how visitors respond to these exhibits and explore the forms of interaction that arise within these new exhibition areas. The analysis addresses the ways in which these so-called 'interactives' create highly constrained sequences of action that prioritize the individual user while undermining the opportunities for co-participation and collaboration. It examines the ecologies of participation that arise with, around and within different types of exhibit and exhibition. The paper suggests that many 'interactive' exhibits rely upon a model of 'interaction' and the 'user' that pervades computer-based systems, a model that has been subject to sustained criticism over some years. In other words, the paper points to the ways in which 'interactivity' is conflated with social interaction and how the seemingly innovative and entertaining exhibits may fail to engender the coparticipation and collaboration that is seen as critical to learning and engagement. [ABSTRACT FROM AUTHOR]

Public participation in technological decision-making is increasingly seen as de rigueur, but the limits and purpose of such participation remain open to debate. In this paper we explore the tension between different rationales for widening participation and examine their implications for its practice. Taking debates about medical genomics in the UK as an illustrative example, we argue that more heterogeneous participation and debate have the potential to improve the scrutiny and accountability of science within representative democracies. In doing so we also argue that it is necessary to replace the language of `lay expertise' with a more systematic and rigorous treatment of the expertise or its absence that characterizes different participants. Drawing on the theoretical work of Collins & Evans (2002), we distinguish between those processes where expert knowledge is required and debate is conducted within the public domain, rather than by the public itself, and those where the views of non-expert lay citizens are needed and valued. The effect of adopting this approach is to permit a more inclusive treatment of the `technical' while also providing a positive role for non-expert citizens in the democratic control and oversight of science. [ABSTRACT FROM AUTHOR]

‘Logo’ is the name for a philosophy of education and for a continually evolving family of computer languages that aid its realization. Developed in the USA in the late 1960s, it became the material embodiment of a radical educational philosophy and a potential vehicle for the transformation of education. In the early 1980s, Logo was introduced into mainstream education in both the USA and the UK. Within an increasingly conservative social and political context with different education policy priorities, Logo was gradually stripped of its radical potential, marginalized and, where it survived, remoulded as harmless to the mainstream educational system. This paper draws on empirical research that explored the evolution of Logo between the late 1960s and the late 1990s. The paper focuses on the social processes involved in the initial development and evolution of Logo. It shows that these processes were heavily contested. Logo was the product of complex social, technical, political and economic decisions, and the product of negotiation shaped by the concerns of the social players involved. The evolution of Logo was not linear or even primarily technical. Rather, it was a seamless web in which the technical was interwoven with the social, economic and political in ways that illustrate the dialectical interaction between historical contingency and the intentions and aspirations of individuals and communities. [ABSTRACT FROM AUTHOR]

This paper compares changing patterns of science news over a period of 50 years. The study analyses a biannual corpus of 2800 news articles in Britain (the Daily Telegraph) and 5800 in Bulgaria (Rabotnichesko Delo), and shows divergent and convergent trends. Britain carries considerably more science news than Bulgaria all through the period, while the coverage shows parallel swings: increasing intensity during the 1950s, a turning point in the early 1960s, declining into the 1970s, and rising again in the 1980s and 1990s. Media coverage in both countries shows similar swings in public appeal. The trends in the medicalization of science news, the reporting of controversy and the evaluation of science diverge in the two contexts. The paper concludes with speculative explanations of these results. Similarities and differences in these long-term trends point to common factors and specific differences at work on either side of the (former) 'Iron Curtain'. [ABSTRACT FROM AUTHOR]

Examines British policy towards Germany in the period between the end of World War I and the resumption of full diplomatic relations between the two countries in June 1920. Relationship between the Foreign Office and the War Office in determining British policy; Pressures brought to bear on Lloyd George to comply with a common Allied policy towards the resumption of diplomatic relations with Germany; Foreign Office's attitudes towards Lord D'Abernon as ambassador to Berlin.

A survey was undertaken to evaluate how animal pain, suffering and distress are recognized and assessed in UK scientific procedure establishments designated under the Animals (Scientific Procedures) Act 1986. A total of 28 institutions were visited between June 1999 and April 2001, within which 137 people were interviewed including scientists, veterinarians and animal technicians. All 28 establishments use clinical observation sheets to assist the recognition of adverse effects, nine use score sheets and seven use computerized data management systems. Clinical signs used as indicators of potential pain, suffering or distress are largely subjective. The survey also addressed protocols and methods for avoiding and alleviating adverse effects, record keeping, review of policies and protocols and issues relating to team work and training. Respondents use a range of techniques for reducing suffering including analgesia, humane endpoints, ensuring competence and refining husbandry. All establishments review projects regularly but few have the time or resources formally to review adverse effects noted in practice and to compare observations with predictions made in licence applications. Training is very consistent between different establishments and most aim to achieve a 'team approach' for monitoring and assessing animals. Results are summarized in the present, abridged paper and set out in full in a report that can be downloaded at http://www.lal.org.uk/pain/(Hawkins 2002). The present paper and the full report, including its recommendations, are intended to provide a source of information, discussion topics and ideas for all establishments that need to monitor animal well-being. [ABSTRACT FROM AUTHOR]

Despite their obvious limitations as explanatory concepts, 'technological autonomy' and 'determinism' have often been associated with nuclear power. This paper reviews the persistency of notions of 'autonomy' and 'determinism' in the context of the British nuclear power programme. In the corporatist and technocratic setting of the nationalized British Electricity Supply Industry (ESl), the perceived imperatives of nuclear power technology were often allowed priority in policymaking, to the extent that an appearance of the technology's autonomy and determinism was maintained for 30 years. This had its conveniences: technical rationales disguised more contestable institutional and political interests supporting the programme. At the same time, senior politicians and scientists at times displayed a faith in the technology approximating a belief in its autonomy and deterministic power, particularly during geopolitical or industrial crises. ESl privatization was associated with the marginalization of nuclear power in Britain. Once the Government's wider mission to liberalize electricity supply was threatened by unanticipated disclosures regarding the cost of nuclear electricity, it proved willing to abandon its longstanding support for the technology. As institutional and political support for the nuclear programme was removed, the fallacy of its supposed autonomy was exposed. Whilst Langdon Winner accurately identified the preconditions necessary for the introduction of inherently political technologies such as nuclear power, in reality these were ever-present requirements, however hidden by the apparent power of the technology itself. Nevertheless, the persistence of notions of autonomy and determinism reflects a significant aspect of the sociotechnical relations of nuclear power. [ABSTRACT FROM AUTHOR]

Twenty years ago, the technology of in vitro fertilization created a new artefact: the human embryo outside the woman's body. In many countries, political debates developed around this artefact. One of the central questions in these debates is whether it is permissible to use human embryos in research and, if so, under what conditions. To date, no uniform answer to this question has been given by the governments and parliaments of the different nation states. This highlights the importance of national cultures and local dynamics in the process of crafting the space for human embryo research. In this paper I approach the issue of the national context by comparing the Dutch and British parliamentary debates on human embryos. Though some arguments used in both debates were similar, the outcomes were very different. In the UK, the Human Fertilisation and Embryology Act was passed in 1990. In the Netherlands, several bills on human embryos have been drafted, but each of them was withdrawn from the proceedings before reaching Parliament. To understand the processes which led to these different outcomes, I scrutinize the rôles in the Netherlands of the political parties, of the scientists' lobby and of women speakers, and compare them with the findings on the UK debate. I also reflect upon the rôle played by gender in these two culturally different political contexts. [ABSTRACT FROM AUTHOR]

In the 1930s the British government developed a system of air raid precautions as a measure against the aerial warfare which was increasingly becoming a feature of contemporary conflict. The air raid precautions system devised by the British government entailed, amongst other measures, the creation of a range of organizations such as the Auxiliary Fire Service and the Warden’s Service which depended upon the voluntary enrollment of British civilians for their success. This article traces the history of these organizations between 1937 and 1941, examining the discourse of citizenship which was drawn upon in their creation, recruitment campaigns and structure. Drawing on a range of primary sources, including government papers, parliamentary debates, press coverage and Mass Observation surveys, the article argues that the discourse of citizenship which was apparent in air raid precautions was complicated by issues of gender. The article concludes that the articulation of air raid precautions as an example of active citizenship had the potential to compromise the continuity of gendered identities in wartime and that the attempts visible within civil defence planning, representation and organization to preserve these identities should be understood as representing the threat that air raids, and defence against them, posed to the relationship between masculinity and femininity. [ABSTRACT FROM PUBLISHER]

The British fear of bombing in the early twentieth century has aptly been termed ‘the shadow of the bomber’. But the processes by which the public learned about the danger of bombing are poorly understood. This paper proposes that the press was the primary source of information about the threat, and examines a formative period in the evolution of public concern about airpower — the so-called air panic of 1935 — during which German rearmament was revealed and large-scale RAF expansion undertaken in response. A proposed air pact between the Locarno powers enabled a shift from support of disarmament to rearmament by newspapers on the right, while simultaneously supporting collective security. Paradoxically, after initially supporting the air pact, the left-wing press and its readers began to have doubts, for the same reason: the need to support collective security. This episode sheds new light on Britain’s early rearmament, and how the government was able to undertake it, despite the widespread feelings in the electorate in favour of disarmament. [ABSTRACT FROM PUBLISHER]

Pharmaceuticals are not permitted on to the market unless they are granted regulatory approval. The regulatory process is, therefore, crucial in whether or not a drug is widely prescribed. Regulatory agencies have developed standards of performance that pharmaceuticals are supposed to meet before entering the market. Regulation of technologies is often discussed by reference to the precautionary principle. In contrast, this paper develops the concept of the 'permissive principle' as a way of understanding the departure of regulators' practices from standards of drug efficacy to which regulatory agencies themselves subscribe. By taking a case study of antidepressant regulation in the UK and the USA, the mechanisms of permissive regulatory practices are examined. An STS methodology of both spatial (international) and temporal comparisons of regulatory practices with regulatory standards is employed to identify the nature and extent of the permissive regulation. It is found that the permissive principle was adopted by drug regulators in the UK and the USA, but more so by the former than the latter. Evidently, permissive regulation, which favours the commercial interests of the drug manufacturer, but is contrary to the interests of patients, may penetrate to the heart of regulatory science. On the other hand, permissive regulation of specific drugs should not be regarded as an inevitable result of marketing strategies and concomitant networks deployed by powerful pharmaceutical companies, because the extent of permissive regulation may vary according to the intra-institutional normative commitments of regulators to uphold their technical standards against the commercial interests of the manufacturer. Likely sociological factors that can account for such permissive regulatory practices are 'corporate bias', secrecy and excessive regulatory trust in the pharmaceutical industry in the UK, political expediency and ideological capture in the USA, combined in both countries with some regulatory deference to the clinical autonomy of the psychiatry profession. [ABSTRACT FROM AUTHOR]

As the search for human genetic variation has become a priority for biomedical science, debates have resurfaced about the use of race and ethnicity as scientific classifications. In this paper we consider the relationship between race, ethnicity and genetics, using insights from science and technology studies (STS) about processes of classification and standardization. We examine how leading biomedical science journals attempted to standardize the classifications of race and ethnicity, and analyse how a sample of UK genetic scientists used the concepts in their research. Our content analysis of 11 editorials and related guidelines reveals variations in the guidance on offer, and it appears that there has been a shift from defining the concepts to prescribing methodological processes for classification. In qualitative interviews with 17 scientists, the majority reported that they had adopted socio-political classification schemes from state bureaucracy (for example, the UK Census) for practical reasons, although some scientists used alternative classifications that they justified on apparently methodological grounds. The different responses evident in the editorials and interviews can be understood as reflecting the balance of flexibility and stability that motivate standardization processes. We argue that, although a genetic concept of race and ethnicity is unlikely to wholly supplant a socio-political one, the adoption of census classifications into biomedical research is an alignment of state bureaucracy and science that could have significant consequences. [ABSTRACT FROM AUTHOR]

Describes and analyses the experience of applying the IFLA Checklist, Access to libraries for persons with disabilities to an academic library: the Fife Campus Library at the School of Nursing and Midwifery, University of Dundee, Scotland. An introduction to disability legislation in the United Kingdom provides the legal framework for this paper. In the United Kingdom, this legislation has been recognized as an important incentive for libraries to improve their services to disabled people. This paper considers a number of physical and attitudinal barriers to good practice and the value of using the IFLA Checklist in overcoming some of these barriers. [ABSTRACT FROM AUTHOR]

Focuses on how dissent was combated not just in the first world war but particularly in Great Britain. Contest of societies; Nature of British dissent; Rise of dissent out of consideration of principle.

This paper compares the development of genetic testing for breast cancer (BRCA testing) in the USA and the UK. It argues that national political cultures played an important role in how these genetic testing technologies were shaped, and that the shapes of these technologies had important implications for the users of these systems. In order to demonstrate the roles of national social and political elements in the development of new genetic testing technologies, I introduce the concept of a technology's architecture, which is made up of component and the specific ways in which these components are assembled to fulfill particular functions. In the USA, four very different BRCA testing systems initially emerged. However, one biotechnology company, Myriad Genetics, eventually used its legal and economic position to become the sole provider of testing. It offered BRCA testing the way many other laboratory tests were provided in the USA, available to anyone through any physician. The shape of this testing service had important implications for its participants, defining the client as a consumer who could demand access to any of Myriad's laboratory services, but could not choose among testing systems. In the UK, the government-run National Health Service provided testing through regional genetics clinics, using family history information to assess risks and triage care. Clients in the UK were defined as citizens and patients, who had the right to equal access to the testing system but could not demand any specific services. [ABSTRACT FROM AUTHOR]

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Prior to controlled clinical trials in human volunteers or patients it is required that novel pharmaceuticals are evaluated for pre-clinical safety in a rodent and a non-rodent ('second') species. In most cases the rodent species used has been the rat and the second species has been the dog or macaque (usually cynomolgus or rhesus) monkey. However, there is an increasing trend within the United Kingdom (UK) pharmaceutical industry to use the common marmoset (Callithrix jacchus) for pre-clinical toxicology programmes. This paper examines the practicality of using the common marmoset (henceforth referred to as 'the marmoset') in toxicological testing and reviews metabolic and pharmacodynamic similarities between this species and humans. It then discusses some of the advantages and disadvantages of the use of this species when compared with two other alternatives to the dog and macaque, namely the ferret and minipig. In particular, the marmoset has clear advantages over the macaque in terms of animal welfare and practicality. There is regulatory acceptance of this species for Investigational New Drug (IND), Clinical Trial Exemption (CTX), New Drug Application (NDA) and Marketing Authorization Application (MAA) registrations. Whilst the dog is likely to be maintained as the primary non-rodent species in toxicology, the marmoset has been, and will likely continue to be, adopted as an additional non-rodent species in pre-clinical toxicology programmes where appropriate. [ABSTRACT FROM AUTHOR]

This paper presents a case study in the production and interpretation of regulatory science, focusing on the conflicting British and American clinical risk assessments of triazolam (Halcion) — the most controversial sleeping pill in the world. The regulation of triazolam is shown to be more permissive in the USA than in the UK. Six principal socio-political factors are put forward to explain this: differential regulatory trust; regulators' socio-technical data selections; medico-scientific disciplinary influences; organizational and professional interests; conflicts of interest of expert advisers; and the growth of the neo-liberal regulatory state. The risk assessments of both the British and American regulatory agencies are shown to be complacent relative to technical standards which the agencies themselves later accepted. It is suggested that, when the interests of pharmaceutical manufacturers and patients diverge, regulatory assessments are crucially affected by whether regulators are predisposed to award the benefit of the scientific doubts to the manufacturers or patients, and by the balance of such predispositions both within and between regulatory institutions of scientific expertise. The triazolam case indicates that the amount of trust placed in the pharmaceutical industry by the British and American regulatory systems may hamper detection of flaws in manufacturers' medical data in a timely manner and, as a consequence, compromise patients' interests. Some policy implications for drug regulation are sketched. [ABSTRACT FROM AUTHOR]

DNA 'fingerprinting' and other methods of genetic profiling have been used in connection with hundreds of criminal trials in the UK, USA and other nations. These molecular biological techniques are employed by the prosecution (and less often by the defense) to produce forensic evidence. By means of these techniques, selected DNA fragments extracted from a suspect's blood sample or cheek swab are compared with residues of blood, semen, skin, excreta, saliva and hair follicles collected at a crime scene. DNA-profiling evidence has been successfully challenged in a few highly publicized cases, but in the vast majority of cases such evidence has been accepted. The extensive testimony and documentation arising from cases like the 1994-95 double-murder trial of OJ Simpson in Los Angeles enable a close study of how the credibility of experts and their practices is fashioned and undermined in testimony. The arguments by the Simpson defense team delved into the practical contingencies and sources of uncertainty associated with forensic uses of DNA-profiling techniques. These arguments resemble many of the general conceptions of scientific practice within the sociology of scientific knowledge. Indeed, the resemblance is so close that the paper faces an interesting dilemma: what can be said about this case that has not already been said as part of the production and public discussion of its details? [ABSTRACT FROM AUTHOR]

This paper examines some fundamental issues pertaining to the use of, as well as to the distinctive characteristics of, information technology in relation to the development of information systems within the UK National Health Service (NHS). The paper refers to the current Resource Management initiative in the NHS, which involves the fabrication of information systems to connect medical activity to resource usage, and thus to costs. Examining the features of some of the rival inscriptions undergoing development of make this connection visible, the paper highlights the properties of information technology in enhancing their mobilization. It also addresses the immutability and combinability of these inscriptions, and discusses some of the implications, in terms of medical practice and knowledge, which may follow from their use. [ABSTRACT FROM AUTHOR]

The purpose of this paper is to show how the founders of British mechanics Institutes thought a scientific education would aid in the social control of those artisans who were their designated target. The study of Mechanics' Institute movement of Great Britain has always been marginal to three academic communities, the history of education, the history of science and the history of technology. The history of these institutes has been no more than a peripheral concern for the history of science. Included in the designation Mechanics' Institute was a variety of early to mid-nineteenth-century foundations, all initially created to teach aspects of the sciences to sections of the British working classes. The study of the Institutes is still in its infancy there is still no modern book-length account of any individual British Institute, and many of the questions one shall raise go perhaps too far beyond what can be resolved by available empirical studies, Still, sufficient work has now been done to establish many features of the movement's history.

Particular decisions about nuclear weapons are made by individuals on the basis of a set of assumptions. These assumptions are rarely revealed in official publications which explain or support those decisions. But wit bout knowing what these assumptions are it is impossible to test the validity of the decision-makers' arguments, or to know what kind of debate with them is likely to be fruitful or effective. This paper describes the assumptions made by a small group of influential British nuclear weapons decision-makers. The research on which it was based was carried out in four stages. First each decision-maker was interviewed at length. Next, the statements made in the interview were assembled into a cognitive map in order to find those assumptions which were not articulated or which were hidden in chains of reasoning, the use of analogies or the structure of the whole system of thought. Next the maps were compared to find the commonalities shared by all decision-makers and to isolate the critical assumptions. Finally, the identification of these assumptions as critical was tested by interviews with knowledgeable critics of nuclear defence policy. The most important assumptions are as follows. Nuclear weapons are not qualitatively different from conventional weapons. Decision-makers in all the nuclear nations are rational and in control of the weapons. Because they are rational it is assumed that the system of deterrence as a whole works rationally and is stable. Indeed, it is so stable that any change is dangerous and it should remain unaffected, in particular, by any reduction in the perceived threat. The paper does not discuss the validity of these assumptions, but considers their implications for change. [ABSTRACT FROM AUTHOR]

In recent years, personality disorders – psychiatric constructs understood as enduring dysfunctions of personality – have come into ever-greater focus for British policymakers, mental health professionals and service-users. Disputes have focussed largely on highly controversial attempts by the UK Department of Health to introduce mental health law and policy (now enshrined within the 2007 Mental Health Act of England and Wales). At the same time, clinical framings of personality disorder have dramatically shifted: once regarded as untreatable conditions, severe personality disorders are today thought of by many clinicians to be responsive to psychiatric and psychological intervention. In this article, I chart this transformation by means of a diachronic analysis of debates and institutional shifts pertaining to both attempts to change the law, and understandings of personality disorder. In so doing, I show how mental health policy and practice have mutually constituted one another, such that the aims of clinicians and policymakers have come to be closely aligned. I argue that it is precisely through these reciprocally constitutive processes that the profound reconfiguration of personality disorder from being an obdurate to a plastic condition has occurred; this demonstrates the significance of interactions between law and the health professions in shaping not only the State’s management of pathology, but also perceptions of its very nature. [ABSTRACT FROM PUBLISHER]

Approaches to visual skilling from anthropology and STS have tended to highlight the forces of discipline and control in understanding how shared visual accounts of the world are created in the face of potential differences brought about by multi-sensorial perception. Drawing upon a range of observational and interview material from an immersion in naturalist training and biological recording activities between 2003 and 2009, I focus upon jizz, a distinct form of gestalt perception much coveted by naturalist communities in the UK. Jizz is described as a tacit and embodied way of seeing that instantaneously reveals the identity of a species, relying upon but simultaneously suspending the arduous and meticulous study of an organism’s diagnostic characteristics. I explore the potential and limitations of jizz to allow for both visual precision and an enchanted and varied form of encounter with nature. In so doing, I explore how the specific characteristics of wild, intangible and irreverent virtuoso performance work closely together with disciplining taxonomic standards. As such, discipline and irreverence work together, are mutually enabling, and allow for an accommodation rather than a segregation of potential difference brought about by perceptual variety. [ABSTRACT FROM PUBLISHER]

We explore the local negotiation of regulatory practice at the UK Stem Cell Bank, the first Bank of its type in the world. Basing our empirical work on a detailed analysis of one aspect of the Bank’s regulatory commitment – the completion of the Cell Line Information form – we make visible the necessary judgements and labour involved in interpreting and operationalizing externally imposed regulation. The discussion opens by detailing the problems encountered when the Bank completes the form: reconciling a bureaucratic system of accountability with craft-like laboratory skills involving multiple kinds of tacit knowledge. We follow this by explicating the emergent ‘bridging strategies’ pursued by the Bank to address these issues, highlighting their reliance upon the formation of trust and social networks. The closing discussion emphasizes the contingent assembly of regulatory practices that emerge in the local setting. [ABSTRACT FROM PUBLISHER]

Refinement of scientific procedures carried out on protected animals is an iterative process, which begins with a critical evaluation of practice. The process continues with objective assessment of the impact of the procedures, identification of areas for improvement, selection and implementation of an improvement strategy and evaluation of the results to determine whether there has been the desired effect, completing the refinement loop and resulting in the perpetuation of good practice. Refinements may be science-driven (those which facilitate getting high-quality results) or welfare-driven or may encompass both groups, but whatever the driver, refinements almost always result in benefits to both welfare and science. Refinements can be implemented in all aspects of animal use: improved methodology in invasive techniques, housing and husbandry, and even statistical analyses can all benefit animal welfare and scientific quality. If refinement is not actively sought, outdated and unnecessarily invasive techniques may not be replaced by better methods as they become available, and thus outdated information is passed down to the next generation, causing perpetuation of old-fashioned methods. This leads to a spiral of ignorance, leading ultimately to poor practice, poor animal welfare and poor-quality scientific data. Refinement is a legal and ethical requirement, yet refinements may not always be implemented. There are numerous obstacles to the implementation of refinement, which may be real or perceived. Either way, in order to take refinement forward, it is important to coordinate the approach to refinement, validate the science behind refinement, ensure there is adequate education and training in new techniques, improve liaison between users and make sure there is feedback on suitability of refinements for use. Overall, refinement requires a coordinated ongoing process of critical appraisal of practice and active scrutiny of resources for likely improvements. In the busy world of biomedical research, this process needs help. In order to develop these themes further, a workshop was held at the LASA Winter Meeting 2006, UK, to assist in identifying potential obstacles to refinement, and then to explore and develop strategies for overcoming these obstacles in key areas. A range of strategies appropriate to different circumstances was identified, which should facilitate the implementation of refinements. [ABSTRACT FROM AUTHOR]

Discusses British Minister of State at the Foreign Office Selwyn Lloyd's defense of Foreign Office officials against grave imputations of misconduct in June 1953. Accusations against Lord Vansittart, the former Permanent Undersecretary at the Foreign Office; Claim that Vansittart allowed an excessive degree of Treasury interference which had neutered Foreign Office contributions to policy-making.

Examines Great Britain's war policy and strategy in 1917 during World War I after a year of defeats. Definition of war aims; Level of military planning; Formulation of war aims; Doubts about defeating the German-led coalition; Causes of pessimism; Role of the U.S. entry into the war in 1917 on British optimism; Decisions by Lloyd George after becoming prime minister in December 1916.

Explores the efforts of Great Britain foreign secretary Ernest Bevin to form a spiritual federation of the western union from 1945 to 1948. Impact of the actions of Bevin on the status of the Cold War; Transmogrification of Christianity into a politicized doctrine; Implication of the spiritual concept for the Anglo-American relations.

Discusses the history of the establishment of a Ministry of Information (MOI) during the Second World War by Great Britain. Attitude of historians to the MOI; Replacement of the MOI with the Central Office of Information; Transitional role of the MOI in the development of official information services after the Second World War.

This paper addresses the proposition put forward by Solly Zuckerman that the nuclear arms race has been driven by scientists and engineers. The history of British nuclear weapons developments is described with particular attention to both their changing organizational relationships and the fluctuating interface between the UK and the USA on the exchange of nuclear weapons assistance. The relationships between the nuclear weapons communities and their governments in the UK and USA are briefly compared, and it is concluded that Zuckerman's thesis cannot be sustained. Technologists do engage in 'heterogeneous engineering' in pursuit of their goals, but they are far from all-powerful in achieving these goals. [ABSTRACT FROM AUTHOR]

It is usual in science studies to focus attention on either science policy or laboratory practice. This paper examines the mutual shaping of science and policy through the case of the Human Genome Mapping Project in the UK. It is argued that the evolution of policy was not merely a series of administrative choices. The strategies, boundaries and accounting methods of the programme, together with eh organization and conception research among grant-holders, can be shown to reflect the, often competing, demands from the worlds of science to support was translated into debates over the best way to do science, what scientific knowledge was for and what was to count as worthwhile knowledge. [ABSTRACT FROM AUTHOR]

Actor-network theory has, until recently, narrated the co-evolution of science and society in terms of dramatic triumphs and betrayals. This paper attempts to incorporate 'ambivalence' into the process of enrolment and black-boxing so central to the construction and continuation of actor-networks. Though ambivalence towards one's own and others' attributed roles in the network would seem to threaten the integrity of a given network, we suggest that it might reinforce it. Drawing upon fieldwork on the UK Cervical Screening Programme (CSP), we show how General Practitioners seriously problematize their own roles and the black-boxed status of the Cervical Smear Test within the CSP network. However, we also show that it is this very problematization that serves to render the network durable and workable. [ABSTRACT FROM AUTHOR]

The object of this paper is examine possible reasons for the emergence of the Cambridge Mathematical Tripos, an institution which was to serve as a model for the introduction of competitive examinations throughout nineteenth-century Britain. After tracing the evolution of the Tripos, the links between this examination and the changing pattern of teaching within the Univesity are investigated and the possible influence of the threatened parliamentary visitation of 1749 on the formation of the Tripos is also discussed. The degree to which the early Tripos served meritocratic ideals is investigated through an analysis of the pattern of appointment to fellowships and college livings. Lastly, the reasons why mathematics loomed so large in Cambridge's early examination system are explored and the situation there contrasted with that at Oxford where logic, rather than mathematics, remained pre-eminent. [ABSTRACT FROM AUTHOR]

STS teaching is at present underdeveloped at the level of secondary education in Britain. This paper suggests that while integrated curricula undeniably present the best opportunity for future STS curriculum design, other possibilities exist which remain substantially unexploited. These possibilities can be ascertained from an analysis of models of secondary school science. Three models -- 'product', 'inquiry' and 'relevance' -- are considered, and suggestions are made about how STS teaching can be developed in each. [ABSTRACT FROM AUTHOR]